Suggested Topics within your search.
Suggested Topics within your search.
- Biochemistry 3
- Genetics 3
- Genetic Phenomena 2
- Genetic Techniques 2
- Molecular biology 2
- Biochemical Phenomena 1
- Clinical biochemistry 1
- Diagnostic Techniques and procedure 1
- Droit 1
- Genanalyse 1
- Genetic Structures 1
- Genetik 1
- Genome stability 1
- Genomics 1
- Germ cells-development 1
- Immunohistochemistry 1
- Medical laws and legislation 1
- Methodology 1
- Microbiology 1
- Molecular Biology 1
- Molecular genetics 1
- Médecine 1
- Research 1
- biology 1
- gene control 1
- neoplasm-diagnosis 1
-
4061
RNASeq analysis of drought-stressed guayule reveals the role of gene transcription for modulating rubber, resin, and carbohydrate synthesis
Published 2021-11-01“…To better understand how drought influences rubber biosynthesis at the molecular level, a comprehensive transcriptome database was built from drought-stressed guayule stem tissues using de novo RNA-seq and genome-guided assembly, followed by annotation and expression analysis. …”
Get full text
Article -
4062
The O-glycosyltransferase C1GALT1 promotes EWSR1::FLI1 expression and is a therapeutic target for Ewing sarcoma
Published 2025-02-01“…Factors that promote EWSR1::FLI1 expression, and thus whose inhibition would reduce EWSR1::FLI1 protein levels and function, are potential drug targets. Here, using genome-scale CRISPR/Cas9 knockout screening, we identify C1GALT1, a galactosyltransferase required for the biosynthesis of many O-glycoproteins, as a factor that promotes EWSR1::FLI1 expression. …”
Get full text
Article -
4063
The R203M and D377Y mutations of the nucleocapsid protein promote SARS-CoV-2 infectivity by impairing RIG-I-mediated antiviral signaling.
Published 2025-01-01“…Studies indicate that nucleocapsid (N) protein of SARS-CoV-2 participates in viral genome assembly, intracellular signal regulation and immune interference. …”
Get full text
Article -
4064
Gender Variations in the Oral Microbiomes of Elderly Patients with Initial Periodontitis
Published 2021-01-01“…Kyoto Encyclopedia of Genes and Genomes analysis showed that predicting changes in the female oral microbiota may be related to the immune system and immune system diseases are the main factor in males. …”
Get full text
Article -
4065
Robust collection and processing for label-free single voxel proteomics
Published 2025-01-01“…Abstract With advanced mass spectrometry (MS)-based proteomics, genome-scale proteome coverage can be achieved from bulk tissues. …”
Get full text
Article -
4066
Expression of cell-wall related genes is highly variable and correlates with sepal morphology
Published 2023-09-01“…We produced a dataset composed of morphological parameters and genome-wide transcriptome obtained from 27 individual sepals from wild-type plants with nearly identical genetic backgrounds, environment, and developmental stage. …”
Get full text
Article -
4067
Single-cell sequencing provides clues about the developmental genetic basis of evolutionary adaptations in syngnathid fishes
Published 2025-02-01“…The developmental genetic and cellular changes that led to the evolution of these traits are largely unknown. Recent syngnathid genome assemblies revealed suggestive gene content differences and provided the opportunity for detailed genetic analyses. …”
Get full text
Article -
4068
Beyond the Comfort Zone: Strenuous Sports as a Preventive Tactic Against Benign Prostatic Hyperplasia
Published 2025-02-01“…The study utilizes single nucleotide polymorphisms (SNPs) associated with strenuous sports obtained from published genome-wide association studies (GWAS), alongside summarized genetic data related to benign prostatic hyperplasia (BPH) from published GWAS. …”
Get full text
Article -
4069
Revealing study and breeding implications for production traits and tail characteristics in Simmental cattle by GWAS
Published 2025-01-01“…The study recorded phenotype data from 183 Simmental cattle and performed a Genome-Wide Association Study (GWAS) analysis to elucidate the genetic mechanisms underlying milk production, body size traits, and tail characteristics. …”
Get full text
Article -
4070
DNA methylation biomarker analysis from low-survival-rate cancers based on genetic functional approaches
Published 2025-01-01“…This study integrated genome-wide DNA methylation profiles and comorbidity patterns to identify the common biomarkers with multi-functional analytics across the aforementioned five cancer types. …”
Get full text
Article -
4071
CRISPR screen reveals modifiers of rAAV production including known rAAV infection genes playing an unexpected role in vector production
Published 2025-03-01“…Specifically, we performed a CRISPR-based genome-wide knockout (KO) screen in human embryonic kidney (HEK) 293 cells using an antibody specific to intact AAV2 capsids coupled with flow cytometry to identify genes that modulate rAAV production. …”
Get full text
Article -
4072
The protoplast two-way fusions and fusant characteristics of Antrodia cinnamomea and Cordyceps militaris
Published 2022-09-01“…The protoplasts of A. cinnamomea were inactivated by heat to inactivate biochemical processes and enzymatic activities in the cytoplasm, and the protoplasts of C. militaris were inactivated by UV radiation to invalidate their genome function, then they were fused under optimal conditions to get a fusion rate as (7.42 ± 0.8) × 10-6 fusants/mL; the new fusants were abbreviated as Ac-Cm. …”
Get full text
Article -
4073
The genetic architecture of local adaptation in a cline
Published 2023-02-01“…It has been repeatedly proposed that the localization of these genes in the genome may not be random, but could be an evolved feature. …”
Get full text
Article -
4074
Uncovering the genetic basis of antiviral polyketide limocrocin biosynthesis through heterologous expression
Published 2025-01-01“…No other natural products have been isolated from this bacterium so far, despite the presence of a rich repertoire of specialized metabolite biosynthesis gene clusters (smBGCs) within its genome. Heterologous expression of smBGCs in suitable chassis speeds up the discovery of the natural products hidden behind these sets of genes. …”
Get full text
Article -
4075
A gene expression atlas of Nicotiana tabacum across various tissues at transcript resolution
Published 2025-02-01“…In this study, we collected 599 tobacco RNA-seq datasets from 35 projects. 207,689 transcripts were identified in this study, of which 35,519 were annotated in the reference genome, while 172,170 transcripts were newly annotated. …”
Get full text
Article -
4076
HAVCR1 Affects the MEK/ERK Pathway in Gastric Adenocarcinomas and Influences Tumor Progression and Patient Outcome
Published 2019-01-01“…We first determined the expression of HAVCR1 in GAC tissues compared with normal gastric tissues based on the Cancer Genome Atlas (TCGA) database using bioinformatics analysis methods. …”
Get full text
Article -
4077
Detection and Phylogenetic Characterization of Influenza D in Swedish Cattle
Published 2024-12-01“…Phylogenetic analysis was performed by the maximum likelihood estimation method on the whole IDV genome sequence from 16 samples. The IDV strains collected in 2021 (n = 7) belonged to the D/OK clade, whereas samples from 2023 (n = 4) and 2024 (n = 5) consisted of reassortants between the D/OK and D/660 clades, for the PB2 gene. …”
Get full text
Article -
4078
Association Analysis of NALCN Polymorphisms rs1338041 and rs61973742 in a Chinese Population with Isolated Cervical Dystonia
Published 2016-01-01“…Background. A genome-wide association study (GWAS) demonstrated a possible association between cervical dystonia (CD) and a sodium leak channel, nonselective (NALCN) gene. …”
Get full text
Article -
4079
Identification of the Key Genes and Pathways in Esophageal Carcinoma
Published 2016-01-01“…Gene Ontology (GO) enrichment, Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment, and protein-protein interaction (PPI) network construction were performed to obtain the biological roles of DEGs in EC. …”
Get full text
Article -
4080
Enhancing the Therapeutic Potential of Peptide Antibiotics Using Bacteriophage Mimicry Strategies
Published 2025-01-01“…Here, nanodelivery systems have been developed by mimicking the mechanisms bacteriophages use to deliver their genomes to host bacteria. These systems utilize bacteriophage receptor‐binding proteins conjugated to loading modules, enabling efficient targeting of bacterial pathogens. …”
Get full text
Article