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3981
IL-23 tunes inflammatory functions of human mucosal-associated invariant T cells
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3982
ATP1B3 may promote glioma proliferation and migration through MAPK/NF-KB signaling pathway
Published 2025-02-01“…ObjectiveTo investigate the function of ATPase Na+/K+ Transporting Subunit Beta 3 (ATP1B3) in gliomas and the molecular mechanisms associated with them in order to identify a novel target and approach for glioma clinical diagnosis and treatment.MethodsThe Cancer Genome Atlas (TCGA), a public tumor database, and the Chinese Glioma Genome Atlas (CGGA) were used to evaluate the differential expression of ATP1B3 in glioma cells of various grades. …”
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3983
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3984
Enigma of Retrotransposon Biology in Mammalian Early Embryos and Embryonic Stem Cells
Published 2018-01-01“…Retrotransposons comprise a significant fraction of mammalian genome with unclear functions. Increasing evidence shows that they are not just remnants of ancient retroviruses but play important roles in multiple biological processes. …”
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3985
A Resource for the Transcriptional Signature of Bona Fide Trophoblast Stem Cells and Analysis of Their Embryonic Persistence
Published 2015-01-01“…To define the transcriptional signature of bona fide TSCs, we used inducible gain- and loss-of-function alleles of Eomes or Cdx2, and EomesGFP, to manipulate and monitor the core maintenance factors of TSCs, followed by genome-wide expression profiling. Combinatorial analysis of resulting expression profiles allowed for defining novel TSC marker genes that might functionally contribute to the maintenance of the TSC state. …”
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3986
Mechanism of Repeat-Associated MicroRNAs in Fragile X Syndrome
Published 2012-01-01“…The majority of the human genome is comprised of non-coding DNA, which frequently contains redundant microsatellite-like trinucleotide repeats. …”
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3987
Gene Structures, Classification, and Expression Models of the DREB Transcription Factor Subfamily in Populus trichocarpa
Published 2013-01-01“…We analyzed gene structures, phylogenies, domain duplications, genome localizations, and expression profiles. The phylogenic construction suggests that the PtrDREB gene subfamily can be classified broadly into six subtypes (DREB A-1 to A-6) in Populus. …”
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3988
Application of Next-Generation Sequencing Technology Based on Single Gene Locus in Species Identification of Mixed Meat Products
Published 2021-01-01“…The primers designed from mitochondrial 16S rRNA and nuclear genome gene (growth hormone receptor, GHR), respectively, were used to detect these meats. …”
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3989
Search for Anti-EA(D) Antibodies in Subjects with an “Isolated VCA IgG” Pattern
Published 2010-01-01“…The presence of an “isolated viral capsid antigen (VCA) IgG” pattern in serum is not easy to interpret without the aid of further tests, such as specific immunoblotting or a virus genome search, that often give rise to organisational and economic problems. …”
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3990
MFGE8, ALB, APOB, APOE, SAA1, A2M, and C3 as Novel Biomarkers for Stress Cardiomyopathy
Published 2020-01-01“…Then, the DEGs were used for Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. Finally, the protein-protein interaction (PPI) network was constructed and Cytoscape was used to find the key genes. …”
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3991
Novel Mutations in the MKKS, BBS7, and ALMS1 Genes in Iranian Children with Clinically Suspected Bardet–Biedl Syndrome
Published 2022-01-01“…All variants were interpreted as pathogenic according to American College of Medical Genetics and Genomics (ACMG) guidelines and confirmed through Sanger sequencing. …”
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3992
Quantitative Proteomic Analysis of Hepatic Tissue of T2DM Rhesus Macaque
Published 2017-01-01“…This study is the first to explore genome-wide protein expression in hepatic tissue of diabetes macaque model using HPLC-Q-TOF/MS technology. …”
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3993
Comparative Analysis of Deep Learning Algorithm for Cancer Classification using Multi-omics Feature Selection
Published 2022-10-01“…The multi-omics data used in this study includes genomics, methylomics, transcriptomics and clinical data for a case study of lung squamous cell carcinoma. …”
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3994
Metagenomic Detection of Multiple Viruses in Monk Parakeet (Myiopsitta monachus) in Australia
Published 2024-11-01“…Virus enrichment and nucleic acid extraction were performed on the faecal samples, followed by high‐throughput sequencing at the Australian Genome Research Facility (AGRF). Results Utilising an established pipeline for high‐throughput sequencing data analysis, this study revealed the presence of three viruses of the families Circoviridae, Parvoviridae and Adenoviridae. …”
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3995
Introgressions of Vitis rotundifolia Michx. to obtain grapevine genotypes with complex resistance to biotic and abiotic stresses
Published 2021-12-01“…As a result, almost all recombinant genotypes that received a resistant allele from the paternal genome are highly resistant to powdery mildew.…”
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3996
The PRC2.1 subcomplex opposes G1 progression through regulation of CCND1 and CCND2
Published 2025-02-01“…We found that PRC2.1 (MTF2), but not PRC2.2 (JARID2), was critical for promoting H3K27me3 deposition at CpG islands genome-wide and in promoters. This included the CpG islands in the promoter of the CDK4/6 cyclins CCND1 and CCND2, and loss of MTF2 lead to upregulation of both CCND1 and CCND2. …”
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3997
Effects of reproductive technologies and SPF status on some physiological and behavioral characteristics in rats with arterial hypertension (ISIAH strain)
Published 2015-12-01“…On the other hand, assisted reproductive technologies (ART) are widely used in modern medicine for human infertility treatment as well as for genome resource banking. In the present study, a comparison of body weight, blood pressure (BP) and behavior in the «elevated plus maze» (EPM) test was made between three groups of ISIAH (inherited stress induced arterial hypertension) rats: a group of animals that were born and raised in a conventional animal facility and two groups from an SPF animal facility (one with animals born naturally and another with animals resulting from ART). …”
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3998
N7-methylguanosine modification in cancers: from mechanisms to therapeutic potential
Published 2025-01-01“…On one hand, m7G modification-associated modulate tumour progression and affect malignant biological characteristics, including sustained proliferation signalling, resistance to cell death, activation of invasion and metastasis, reprogramming of energy metabolism, genome instability, and immune evasion. This suggests that they may be novel therapeutic targets for cancer treatment. …”
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3999
Re-evaluation of mastodon material from Oregon and Washington, USA, Alberta, Canada, and Hidalgo and Jalisco, Mexico
Published 2025-01-01“…The Alberta specimen referred to M. pacificus is the same tooth found to have a Pliocene divergence time from M. americanum based on mitochondrial genome data from a previous study, suggesting a deep divergence time between the two taxa. …”
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4000
PGC-1α activation to enhance macrophage immune function in mycobacterial infections.
Published 2025-01-01“…Mitochondrial transcription factor A (TFAM) is a protein essential for mitochondrial DNA (mtDNA) genome stability, integrity, and metabolism. Both PGC-1α and TFAM regulate mitochondrial biogenesis and activity, and their disruption is linked to inflammatory signaling and altered macrophage function. …”
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