Telomere Biology: Key to unlocking the fountain of youth…A Systematic Review. by Anirban Poddar, Anup Kumar Rana, Ranjita Santra, Phalguni Chakrabarti

“…Deterioration of physiological functions is typically associated with ageing process.This often manifests as various diseases which eventually creates a burden on health infrastructure.Telomere attrition is a phenomenon which involves shortening of telomeres with each cycle of cell division.The phenomenon of “Telomere Attrition” is a “Bi edged sword” as while being a protective shield for the genome on one hand, it also is the cause of many senility related degenerative disorders. …”
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The Hsf1-sHsp cascade has pan-antiviral activity in mosquito cells by Jieqiong Qu, Michelle Schinkel, Lisa Chiggiato, Samara Rosendo Machado, Gijs J. Overheul, Pascal Miesen, Ronald P. van Rij

“…By integrating multi-omics data, we find that heat shock factor 1 (Hsf1) regulates eight small heat shock protein (sHsp) genes within one topologically associated domain in the genome of the Aedes aegypti mosquito. This Hsf1-sHsp cascade acts as an early response against chikungunya virus infection and shows pan-antiviral activity against chikungunya, Sindbis, and dengue virus as well as the insect-specific Agua Salud alphavirus in Ae. aegypti cells and against chikungunya virus and O’nyong-nyong virus in Aedes albopictus and Anopheles gambiae cells, respectively. …”
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The TIR Domain Containing Locus of Enterococcus faecalis Is Predominant among Urinary Tract Infection Isolates and Downregulates Host Inflammatory Response by Thomas Daniel Kraemer, Orlando Daniel Quintanar Haro, Eugen Domann, Trinad Chakraborty, Svetlin Tchatalbachev

“…Based on Toll/interleukin-1 receptor (TIR) domain structure homology, we detected a previously uncharacterized gene encoding for a TIR domain containing protein (Tcp) in the genome of Enterococcus faecalis. We assigned this gene the name tcpF (as in Tcp of E. faecalis). …”
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Reverse-engineering the FLT3-PI3K/AKT axis to enhance TILs function and improve prognosis in ovarian and cervical cancers by Feng Hao, Zhang Yan, Luo Shen, Wang Hui, Qiu Ling, Yang Xiaoyu, Jiang Hua

“…FLT3 expression was mapped with spatial data from 10 × Genomics. Results FLT3, identified as a regulator through the PI3K/AKT pathway, showed positive correlations with T cells, NK cells, and B cells. …”
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Effects of mode of reproduction on genetic polymorphism and divergence in wild yams (Dioscoreaceae: Dioscorea) by Xin Wang, Qing-Hong Feng, Zhi-Hua Zeng, Zhi-Qiang Zhang, Jie Cai, Gao Chen, De-Zhu Li, Hong Wang, Wei Zhou

“…Evolutionary transitions from sexual to asexual reproduction should have significant influences on genetic divergence and polymorphism at the genome level. Plant lineages with diverse reproductive systems provide opportunities to investigate this question using comparative approaches and studies of molecular evolution. …”
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Penicillium psychrofluorescens sp. nov., a naturally autofluorescent Antarctic fungus by Alinta Furnell, Nicole Benaud, Xabier Vázquez-Campos, Edward C.Y. Liew, Allison Mertin, Jordan A. Vink, Kate Montgomery, Marc R. Wilkins, Brett A. Summerell, Belinda C. Ferrari

“…Penicillium psychrofluorescens is named for its intense autofluorescence derived from a combination of compounds that may include NADPH, porphyrins, and secondary metabolites, such as polyketides. Comparative genomics with both Antarctic and mesophilic Penicillium spp. shows that Penicillium psychrofluorescens has a wide repertoire of glycoside hydrolases, but almost no polysaccharide lyases, has comparably large effector proteins, lacks the machinery to use nitrate as an N-source, but has the genes for the assimilation of phosphorus from phosphonates via oxidative pathway. …”
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Single‐egg comet assay: A protocol to quantify DNA damage in natural bioarchives by Rejin Salimraj, Alessio Perotti, Marcin W. Wojewodzic, Dagmar Frisch

“…More generally, the SE‐CA is applicable to testing DNA integrity in individual propagules prior to genome sequencing or to quantify environmental impacts on natural sedimentary biobanks.…”
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Microarray Profiling of Lymphocytes in Internal Diseases With an Altered Immune Response: Potential and Methodology by Anatoliy Gladkevich, S. Adriaan Nelemans, Henk F. Kauffman, Jakob Korf

“…Lymphocytes express more than 75% of the human genome, and, being an important part of the immune system, they play a central role in the pathogenesis of asthma, RA, and SLE. …”
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Idiopathic Central Precocious Puberty Associated with 11 Mb De Novo Distal Deletion of the Chromosome 9 Short Arm by Mariangela Cisternino, Erika Della Mina, Laura Losa, Alexandra Madè, Giulia Rossetti, Lorenzo Andrea Bassi, Giovanni Pieri, Baran Bayindir, Jole Messa, Orsetta Zuffardi, Roberto Ciccone

“…We report a girl with a de novo distal deletion of 9p affected by idiopathic central precocious puberty and intellectual disability. Genome-wide array-CGH revealed a terminal deletion of about 11 Mb, allowing to define her karyotype as 46; XX, del(9)(p23-pter). …”
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Effects of POPs-induced SIRT6 alteration on intestinal mucosal barrier function: A comprehensive review by Guangcan Chen, Tengyang Huang, Yifeng Dai, Xia Huo, Xijin Xu

“…Sirtuin 6 (SIRT6), a sirtuin family member, is pivotal in genome and telomere stability, inflammation regulation, and metabolic processes. …”
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Urothelial Cancer Stem Cells by Irena Dimov, Milan Visnjic, Vladisav Stefanovic

“…The rapid development of the CSC field, shoulder to shoulder with powerful genome-wide screening techniques, has provided cause for optimism for the development of more reliable therapies in the future. …”
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Prevalence of Coxiella burnetii in unpasteurized dairy products in west of Iran by Soheila Mohammadkhanifard, Amin Jaydari, Ehsan Rashidian, Nemat Shams, Peyman Khademi

“…A total of 100 samples of traditional yogurt and unpasteurized cheese were collected from various regions. To analyze the genome of C. burnetii, DNA was purified and molecular detection was performed using nested PCR with primers specific to the IS1111 transposon gene. …”
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A Toolbox for Predicting G-Quadruplex Formation and Stability by Han Min Wong, Oliver Stegle, Simon Rodgers, Julian Leon Huppert

“…At its core, this site has a detailed database (QuadDB) of predicted G-quadruplexes in the human and other genomes, together with the predictive algorithm used to identify them. …”
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Novel Genes Potentially Involved in Fibroblasts of Diabetic Wound by Weirong Zhu, Qin Fang, Zhao Liu, Qiming Chen

“…Furthermore, the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways involved in type 2 diabetes were retrieved from miRWalk. …”
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Effective in vivo binding energy landscape illustrates kinetic stability of RBPJ-DNA binding by Duyen Huynh, Philipp Hoffmeister, Tobias Friedrich, Kefan Zhang, Marek Bartkuhn, Francesca Ferrante, Benedetto Daniele Giaimo, Rhett A. Kovall, Tilman Borggrefe, Franz Oswald, J. Christof M. Gebhardt

“…We determine the binding kinetics, transcriptional activity, and genome-wide chromatin occupation of RBPJ and mutant variants by live-cell single-molecule tracking, reporter assays, and ChIP-Seq. …”
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Novel Insights into the Nobilamide Family from a Deep-Sea <i>Bacillus</i>: Chemical Diversity, Biosynthesis and Antimicrobial Activity Towards Multidrug-Resistant Bacteria by Vincenza Casella, Gerardo Della Sala, Silvia Scarpato, Carmine Buonocore, Costanza Ragozzino, Pietro Tedesco, Daniela Coppola, Giovanni Andrea Vitale, Donatella de Pascale, Fortunato Palma Esposito

“…Finally, in silico analysis of <i>Bacillus halotolerans</i> BCP32 genome revealed nobilamide biosynthesis to be directed by a previously unknown heptamodular nonribosomal peptide synthetase.…”
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Human microbiomes in cancer development and therapy by Chenglai Xia, Jiyan Su, Can Liu, Zhikai Mai, Shuanghong Yin, Chuansheng Yang, Liwu Fu

“…Abstract Colonies formed by bacteria, archaea, fungi, and viral groups and their genomes, metabolites, and expressed proteins constitute complex human microbiomes. …”
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Improved 11α-hydroxycanrenone production by modification of cytochrome P450 monooxygenase gene in Aspergillus ochraceus by Li Qianqian, Shi Li, Liu Yingying, Guan Shimin, Zhang Shuo, Cai Baoguo, Rong Shaofeng

“…To improve the efficiency of 11α-hydroxycanrenone production, the CYP monooxygenase-coding gene of MF018 was predicted and cloned based on whole-genome sequencing results. A recombinant A. ochraceus strain MF010 with the high expression of CYP monooxygenase was then obtained through homologous recombination. …”
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Induced Pluripotent Stem Cells in Cardiovascular Medicine by Toru Egashira, Shinsuke Yuasa, Keiichi Fukuda

“…Human iPS cells are currently generated by transgene introduction principally through viral vectors, which integrate into host genomes, although the associated risk of tumorigenesis is driving research into nonintegration methods. …”
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MftG is crucial for ethanol metabolism of mycobacteria by linking mycofactocin oxidation to respiration by Ana Patrícia Graça, Vadim Nikitushkin, Mark Ellerhorst, Cláudia Vilhena, Tilman E Klassert, Andreas Starick, Malte Siemers, Walid K Al-Jammal, Ivan Vilotijevic, Hortense Slevogt, Kai Papenfort, Gerald Lackner

“…Here, we show that MftG enzymes are almost exclusively found in genomes containing mycofactocin biosynthetic genes and are present in 75% of organisms harboring these genes. …”
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