Intestinal Organoids in Colitis Research: Focusing on Variability and Cryopreservation by Talke F. zur Bruegge, Andrea Liese, Sören Donath, Stefan Kalies, Maike Kosanke, Oliver Dittrich-Breiholz, Sandra Czech, Verena N. Bauer, André Bleich, Manuela Buettner

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The potential for gene-editing to increase muscle growth in pigs: experiences with editing myostatin by A. C. Dilger, X. Chen, L. T. Honegger, B. M. Marron, J. E. Beever

“…Reducing the percentage of the cloned genome by outcrossing successfully improved viability of MSTN +/+ and MSTN ± pigs, but not of MSTN −/− pigs. …”
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Novel protein-based prognostic signature linked to immunotherapeutic efficiency in ovarian cancer by Shuo-Fu Chen, Liang-Yun Wang, Yi-Sian Lin, Cho-Yi Chen

“…Methods The workflow was demonstrated based on the Reverse Phase Protein Array (RPPA) and RNA-sequencing profiles of ovarian cancer patients from The Cancer Genome Atlas (TCGA). The algorithm began by clustering patients using immune-related gene sets, which allowed us to identify immune-related proteins of interest. …”
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Metatranscriptomes-based sequence similarity networks uncover genetic signatures within parasitic freshwater microbial eukaryotes by Arthur Monjot, Jérémy Rousseau, Lucie Bittner, Cécile Lepère

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Water-Soluble Mn(III)-Porphyrins with High Relaxivity and Photosensitization by Tamas Nemeth, Agnès Pallier, Çetin Çelik, Zoltán Garda, Naoko Yoshizawa-Sugata, Hisao Masai, Éva Tóth, Yoko Yamakoshi

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Incidence and Survival for Gastric and Esophageal Cancer Diagnosed in British Columbia, 1990 to 1999 by Morteza Bashash, Amil Shah, Greg Hislop, Angela Brooks-Wilson, Nhu Le, Chris Bajdik

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Reply by Denis Vincent, MD, PhD, Ludovic Martin, MD, PhD, Sven Cichon, PhD, Christian Drouet, PharmD, PhD, Arije Ghannam, MD PhD

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Successful treatment of life-threatening mycobacteriosis using adjunctive gamma-interferon therapy with genetic analysis by P. Confalonieri, S. Maiocchi, F. Salton, B. Ruaro, C. Rizzardi, M. C. Volpe, D. Licastro, L. Braga, M. Confalonieri

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Genetic Polymorphism in Peripartum Cardiomyopathy by Ivana Purnama Dewi, Johanes Nugroho

“…Many evidence supporting a contribution from gene mutations in PPCM includes genome-wide association studies, familial occurrence, variable prevalence among different regions and ethnicities, and more recent investigations of panels of genes for mutations among women with PPCM. …”
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Coleopteran Antimicrobial Peptides: Prospects for Clinical Applications by Monde Ntwasa, Akira Goto, Shoichiro Kurata

“…Recently, the complete genome sequence of Tribolium was published, boosting research on coleopteran immunity and leading to the identification of Tribolium AMPs that are shared by Drosophila and mammals, as well as other AMPs that are unique. …”
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Human Genetics of Diabetic Retinopathy: Current Perspectives by Daniel P. K. Ng

“…Harnessing new genetic technologies and resources such as the upcoming 1000 Genomes Project will help advance this field of research, and potentially lead to a rich harvest of insights into the biological mechanisms underlying this debilitating complication.…”
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Characterization and comparison of gut microbiota in patients with acute pancreatitis by metagenomics and culturomics by Liang Gong, Xue Li, Li Ji, Guorong Chen, Ziying Han, Lei Su, Dong Wu

“…Our research has contributed to the expanded understanding of the genome, diversity, and function of the intestinal microbiota in patients with AP and provided some reference for selecting culture medium and sample processing methods.…”
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THE HETEROPLASMIC AND HOMOPLASMIC STATES OF MITOCHONDRIAL AND CHLOROPLAST DNA REGIONS IN THE PROGENIES OF WIDE HYBRIDS OF COMMON WHEAT OF DIFFERENT ORIGINS by N. V. Trubacheeva, L. A. Kravtsova, E. P. Devyatkina, T. T. Efremova, M. G. Sinyavskaya, V. K. Shumny, L. A. Pershina

“…It has been found that the transition of mt- and cpDNA heteroplasmy, barley homoplasmy of chloroplast regions to wheat homoplasmy is associated with complete fertility restoration and barley chromosome elimination from the newly developed nuclear genomes of alloplasmic lines.…”
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Unraveling the Effect of Immunogenicity on the PK/PD, Efficacy, and Safety of Therapeutic Proteins by Alison Smith, Hugh Manoli, Stacey Jaw, Kimberley Frutoz, Alan L. Epstein, Leslie A. Khawli, Frank-Peter Theil

“…Biologics have emerged as a powerful and diverse class of molecular and cell-based therapies that are capable of replacing enzymes, editing genomes, targeting tumors, and more. As this complex array of tools arises a distinct set of challenges is rarely encountered in the development of small molecule therapies. …”
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Discovery of Evolutionary Loss of the Ubiquitin-like Autophagy-Related ATG12 System in a Lineage of Apicomplexa by Xiaoxia X. Lin, Yun D. Bai, Sichang T. Wang, Akira Nozawa, Tatsuya Sawasaki, Tatsunori Masatani, Kenji Hikosaka, Masahito Asada, Hirokazu Sakamoto

“…Here, we show that all genes associated with the ATG12 system are absent in piroplasmida, a lineage within Apicomplexa. Comparative genomics of ATGs further shows that piroplasm ATG3 has lost the region necessary for ATG12 binding. …”
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Towards a Molecular Understanding of the Fanconi Anemia Core Complex by Charlotte Hodson, Helen Walden

“…The accumulation of ICL damage results in genome instability and patients having a high predisposition to cancers. …”
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Computational Methods to Work as First-Pass Filter in Deleterious SNP Analysis of Alkaptonuria by R. Magesh, C. George Priya Doss

“…Discovering these functional SNPs is one of the main goals of modern genetics and genomics studies. There is a need to effectively and efficiently identify functionally important nsSNPs which may be deleterious or disease causing and to identify their molecular effects. …”
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INTERNALIZATION OF EXOGENOUS DNA INTO INTERIOR COMPARTMENTS OF MURINE BONE MARROW CELLS by E. V. Dolgova, V. P. Nicolin, N. A. Popova, A. S. Proskurina, K. E. Orishchenko, E. A. Alyamkina, Y. R. Efremov, E. R. Chernykh, A. A. Ostanin, E. M. Malkova, O. S. Taranov, V. A. Rogachev, S. V. Sidorov, S. S. Bogachev, M. A. Shurdov

“…Moreover, fragments localizedin BMCnuclei are suggestedto integrate into chromosome(s) ofrecipient mouse genomes when treatedwithCP andexogenous DNA.…”
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Alaninaminotransferase and specific viral hepatitis markers in the blood of donors by Zh. K. Burkitbayev, G. A. Yesenbayeva, S. A. Abdrakhmanova, Zh. Zh. Bibekov, Ye. B. Zhiburt

“…No relation of ALT activity to results of parenteral virus genomes screen was revealed.…”
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Proposals for consideration at IMC12 to modify provisions related solely to fungi in Chapter F of the International Code of Nomenclature for algae, fungi, and plants by Tom W. May, David L. Hawksworth

“…The topics addressed relate to: fungi whose morph-names have the same epithet; the listing of synonyms under entries for protected names in the Code Appendices; the processes of protection and rejection; the use of DNA sequences as nomenclatural types; the use of genomes as nomenclatural types; and the designation of fungi known only from DNA sequences. …”
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