Analysis of mutations in CDC27, CTBP2, HYDIN and KMT5A genes in carotid paragangliomas by E. N. Lukyanova, A. V. Snezhkina, D. V. Kalinin, A. V. Pokrovsky, A. L. Golovyuk, O. A. Stepanov, E. A. Pudova, G. S. Razmakhaev, M. V. Orlova, A. P. Polyakov, M. V. Kiseleva, A. D. Kaprin, A. V. Kudryavtseva

“…Paired histologically normal tissues or blood were unavailable, so potentially germline mutations were excluded from the analysis with strong filtering conditions using 1000 Genomes Project and ExAC databases. In this work, ten genes (ZNF717, CDC27, FRG2C, FAM104B, CTBP2, HLA-DRB1, HYDIN, KMT5A, MUC3A, and PRSS3) characterized by the highest level of mutational load were analyzed. …”
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Monitoring of hepatitis E virus infection and replication by functional tagging of the ORF2 protein by Maliki Ankavay, Nathalie Da Silva, Angela Pollán, Noémie Oechslin, Katja Dinkelborg, Patrick Behrendt, Darius Moradpour, Jérôme Gouttenoire

“…Based on a screening approach to identify viable insertion sites in the viral genome, we describe a versatile system for preparing recombinant viruses harboring split-reporter tags, i.e. luciferase and GFP. …”
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Oral Microbiome and Treatment Resistance Status in Schizophrenia: A Cross-sectional Study by Anoop Sankaranarayanan, Preethi Ramanathan, Martha Zakrzewski, Deepali Vasani, Ramanathan Ganapathy, Vlasios Brakoulias, Mark W. Douglas

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Kernel Sliced Inverse Regression: Regularization and Consistency by Qiang Wu, Feng Liang, Sayan Mukherjee

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Meningococcal B Vaccination (4CMenB) in Infants and Toddlers by Susanna Esposito, Claudia Tagliabue, Samantha Bosis

“…Serogroup B has long been a challenge but the discovery of the complete genome sequence of an MenB strain has allowed the development of a specific four-component vaccine (4CMenB). …”
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A Rare Interstitial Duplication of 8q22.1–8q24.3 Associated with Syndromic Bilateral Cleft Lip/Palate by Regina Ferreira Rezek, Ana Angélica Rodrigues Abbas, Juliana Forte Mazzeu, Siliana Maria Duarte Miranda, Cibele Velloso-Rodrigues

“…We have compared this case with other “pure” trisomies of 8q patients reported in the literature and with genome wide association studies recently published. …”
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Big Data Analytics for Healthcare Industry: Impact, Applications, and Tools by Sunil Kumar, Maninder Singh

“…We also explore the conceptual architecture of big data analytics for healthcare which involves the data gathering history of different branches, the genome database, electronic health records, text/imagery, and clinical decisions support system.…”
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Deconstruction of Vulnerability to Complex Diseases: Enhanced Effect Sizes and Power of Intermediate Phenotypes by David Goldman, Francesca Ducci

“…Systematic searches for genes influencing complex disorders, including bipolar disorder, have recently been completed using whole genome association (WGA), identifying a series of validated loci. …”
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Precision oncology through next generation sequencing in hepatocellular carcinoma by Sayali Shinde, Carola Maria Bigogno, Ana Simmons, Nikita Kathuria, Aruni Ghose, Vedika Apte, Patricia Lapitan, Shania Makker, Aydin Caglayan, Stergios Boussios

“…Next-Generation Sequencing (NGS) plays a crucial role in overcoming this issue by sequencing both viral and host genomes to identify mutations and genetic heterogeneity. …”
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Targeting EBV Episome for Anti-Cancer Therapy: Emerging Strategies and Challenges by Febri Gunawan Sugiokto, Renfeng Li

“…The presence of EBV in tumor cells provides a unique advantage in targeting the viral genome (also known as episome), to develop anti-cancer therapeutics. …”
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Epigenetic Application of ATAC-Seq Based on Tn5 Transposase Purification Technology by Wangchun Li, U Tim Wu, Yu Cheng, Yanhao Huang, Lipeng Mao, Menghan Sun, Congling Qiu, Lin Zhou, Lijuan Gao

“…Assays of transposase accessible chromatin sequencing (ATAC-seq) is an efficient assay to investigate chromatin accessibility, which depends on the activity of a robust Tn5 transposase to fragment the genome while cutting in the sequencing adapters. Methods. …”
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Substrates, regulation, cellular functions, and disease associations of P4-ATPases by Hye-Won Shin, Hiroyuki Takatsu

“…These enzymes are conserved across all eukaryotes, and the human genome encodes 14 distinct P4-ATPases. Initially identified as aminophospholipid translocases, P4-ATPases have since been found to translocate other phospholipids, including phosphatidylcholine, phosphatidylinositol, and even glycosphingolipids. …”
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The Regulation and Functions of Endogenous Retrovirus in Embryo Development and Stem Cell Differentiation by Yangquan Xiang, Hongqing Liang

“…Endogenous retroviruses (ERVs) are repetitive sequences in the genome, belonging to the retrotransposon family. During the course of life, ERVs are associated with multiple aspects of chromatin and transcriptional regulation in development and pathological conditions. …”
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Transmission Electron Microscopy Studies of Cellular Responses to Entry of Virions: One Kind of Natural Nanobiomaterial by Zheng Liu, Shuyu Liu, Jinming Cui, Yurong Tan, Jian He, Jingqiang Zhang

“…The bacteriophage-bacteria interactions are also introduced to elucidate how the bacteriophage conquers the barrier of cell walls in the prokaryotic cells to transport genome into the host.…”
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Sanger validation of WGS variants by Arina Kopernik, Mariia Sayganova, Gaukhar Zobkova, Natalia Doroschuk, Anna Smirnova, Daria Molodtsova-Zolotukhina, Olesya Sagaydak, Oxana Ryzhkova, Sergey Kutsev, Olga Groznova, Lyusya Melikyan, Elizaveta Bondarchuk, Mary Woroncow, Eugene Albert, Viktor Bogdanov, Pavel Volchkov

“…Despite that, no works to date report the concordance between variants from whole genome sequencing and their gold-standard Sanger validation. …”
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Fleming's penicillin producing strain is not Penicillium chrysogenum but P. rubens by J. Houbraken, J.C. Frisvad, R.A. Samson

“…Fleming's original penicillin producing strain and the full genome sequenced strain of P. chrysogenum are re-identified as P. rubens. …”
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GENETIC DIVERSITY OF BREAD WHEAT LANDRACES COLLECTED BY SCIENTIFIC EXPEDITIONS IN AFGHANISTAN by O. P. Mitrofanova, P. P. Strelchenko, E. V. Zuev, K. Street, J. Konopka, M. Mackay

“…Hexaploid 42-chromosomal wheat with the genome constitution AABBDD was also attributed to that center. …”
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The Transcribed-Ultraconserved Regions: A Novel Class of Long Noncoding RNAs Involved in Cancer Susceptibility by Paola Scaruffi

“…A large proportion of the transcriptional output is represented by protein noncoding RNAs (ncRNAs) that arise from the “dark matter” of the genome. Focus on such sequences has revealed numerous RNA subtypes with several functions in RNA processing and gene expression regulation, and deep sequencing studies imply that many remain to be discovered. …”
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A Novel Partial Sequence Alignment Tool for Finding Large Deletions by Taner Aruk, Duran Ustek, Olcay Kursun

“…Finding large deletions in genome sequences has become increasingly more useful in bioinformatics, such as in clinical research and diagnosis. …”
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Sharks in Macaronesia and Cabo Verde: species richness, conservation status and anthropogenic pressures by Jaquelino Varela, Jaquelino Varela, Catarina Pereira Santos, Catarina Pereira Santos, Catarina Pereira Santos, Emanuel Nunes, Emanuel Nunes, Vasco Pissarra, Vasco Pissarra, Stiven Pires, Bárbara P. Ribeiro, Bárbara P. Ribeiro, Eduarda Vieira, Eduarda Vieira, Tiago Repolho, Tiago Repolho, Nuno Queiroz, Nuno Queiroz, Rui Freitas, Rui Rosa, Rui Rosa, Rui Rosa

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