A network-based systems genetics framework identifies pathobiology and drug repurposing in Parkinson’s disease by Lijun Dou, Zhenxing Xu, Jielin Xu, Chengxi Zang, Chang Su, Andrew A. Pieper, James B. Leverenz, Fei Wang, Xiongwei Zhu, Jeffrey Cummings, Feixiong Cheng

“…First, we leveraged non-coding genome-wide association studies (GWAS) loci effects on five types of brain-specific quantitative trait loci (xQTLs, including expression, protein, splicing, methylation and histone acetylation) under the protein–protein interactome (PPI) network. …”
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Proteomic profiling identifies muscle-invasive bladder cancers with distinct biology and responses to platinum-based chemotherapy by A. Contreras-Sanz, G. L. Negri, M. J. Reike, H. Z. Oo, J. M. Scurll, S. E. Spencer, K. Nielsen, K. Ikeda, G. Wang, C. L. Jackson, S. Gupta, M. E. Roberts, D. M. Berman, R. Seiler, G. B. Morin, P. C. Black

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Comparative transcriptomic and phenotypic analysis of monoclonal and polyclonal Populus deltoides genotypes by Macy Gosselaar, Macy Gosselaar, Mark A. Arick, Chuan-Yu Hsu, Heidi Renninger, Courtney M. Siegert, Waqar Shafqat, Daniel G. Peterson, Austin Himes

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Improved growth performance, food efficiency, and lysine availability in growing rats fed with lysine-biofortified rice by Qing-Qing Yang, Pui Kit Suen, Chang-Quan Zhang, Wan Sheung Mak, Ming-Hong Gu, Qiao-Quan Liu, Samuel Sai-Ming Sun

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The extremely halotolerant black yeast Hortaea werneckii - a model for intraspecific hybridization in clonal fungi by Polona Zalar, Jerneja Zupančič, Cene Gostinčar, Janja Zajc, G. Sybren de Hoog, Filomena De Leo, Armando Azua-Bustos, Nina Gunde-Cimerman

“…The use of these genes was hampered by ambiguous sequences obtained by Sanger sequencing, as a consequence of the diploid and highly heterozygous genome of many H. werneckii strains. Analysis of the BTB and MCM7 genes showed that in some cases two copies of the gene from the same genome are positioned in distant phylogenetic clusters of the intraspecific gene tree. …”
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Real-time IncuCyte® Assay for the Dynamic Assessment of Live and Dead Cells in 2D Cultures by Arlene Gidda, Suganthi Chittaranjan, Sharon Gorski

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Fitness landscapes of human microsatellites. by Ryan J Haasl, Bret A Payseur

“…Advances in DNA sequencing technology and computation now enable genome-wide scans for natural selection to be conducted on unprecedented scales. …”
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Inflammatory Nasal Swelling due to Leishmania tropica by Hajiba Fellah, Maryam Hakkour, Bouchra Delouane, Asmae Hmamouch, Abdelhakim Bouyahya, Faiza Sebti, Abderrahim Sadak

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Transcriptome analysis provides insights into the role of TLP16 in Musa acuminata Resistance to Fusarium oxysporum f. sp. cubense wilt by Yi-le Huo, Si-wen Liu, Huo-qing Huang, Zai-yuan Li, Mudassar Ahmad, Meng-xia Zhuo, Wen-juan Chen, Chun-yu Li, Bo Liu, Ya-dong Li

“…Conclusion This study conducted a comprehensive genome-wide identification and systematic analysis of the TLP gene family in bananas. …”
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MOLECULAR MARKERS: IMPLEMENTATION IN CROP PLANT BREEDING FOR IDENTIFICATION, INTROGRESSION, AND GENE PYRAMIDING by I. N. Leonova

“…To date, the main practical application of molecular markers is related to germplasm characterization, introgression and pyramiding of genome fragments associated with agronomically important traits controlled by major genes. …”
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Modes and mechanisms for the inheritance of mitochondria and plastids in pathogenic protists. by Sophie L Collier, Sarah N Farrell, Christopher D Goodman, Geoffrey I McFadden

“…However, mutations within the organellar genomes of mitochondria and plastids can lead to drug resistance. …”
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Devilish Details in Apes and Atoms

“…Nature leads with a preview of an upcoming workshop on sequencing the ape genome. Science leads off this week with a story about a new measurement that comes tantalizingly close to overturning the longstanding Standard Model of particle physics.…”
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GH inhibits ALV-J replication and restricts cell cycle by activating PI3K/Akt signaling pathway by Junliang Xia, Ling Lin, Rongyang Ju, Chengxun Xu, Guodong Mo, Xiquan Zhang

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Synergistic effect of inhibiting CHK2 and DNA replication on cancer cell growth by Flavie Coquel, Sing-Zong Ho, Keng-Chang Tsai, Chun-Yen Yang, Antoine Aze, Julie Devin, Ting-Hsiang Chang, Marie Kong-Hap, Audrey Bioteau, Jerome Moreaux, Domenico Maiorano, Philippe Pourquier, Wen-Chin Yang, Yea-Lih Lin, Philippe Pasero

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ROR1 CAR-T cells and ferroptosis inducers orchestrate tumor ferroptosis via PC-PUFA2 by Dan Li, Wenjie Zhang, Ruiheng Wang, Shufeng Xie, Yixin Wang, Wanxin Guo, Zixuan Huang, Chaoqun Lu, Liang Shan, Han Liu, Lifang Ma, Xumin Hou, Zhenshu Xu, Jiayi Wang

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Biallelic SLC13A1 loss-of-function variants result in impaired sulfate transport and skeletal phenotypes, including short stature, scoliosis, and skeletal dysplasia by Christina G. Tise, Katie Ashton, Lachlan de Hayr, Kun-Di Lee, Omkar L. Patkar, Emma Krzesinski, Jennifer A. Bassetti, Erin M. Carter, Cathleen Raggio, Andreas Zankl, Anas M. Khanshour, Kristhen N. Atala, Jonathan J. Rios, Carol A. Wise, Ying Zhu, Futao Zhang, Tony Roscioli, Michael Buckley, Robert J. Harvey, Paul A. Dawson

“…Methods: Probands were identified by exome or genome sequencing and GeneMatcher. Sulfate levels were quantified using ion chromatography. …”
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Prospects for mineral biofortification of wheat: classical breeding and agronomy by I. N. Leonova, E. V. Ageeva, V. K. Shumny

“…Despite the promise of transgenesis and genome editing, these labor-intensive methods require significant investments, so these technologies, when applied to wheat, are still at the development stage and cannot be applied routinely. …”
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Human microbiome, applied to clinical practice by V. T. Ivashkin, K. V. Ivashkin

“…The Human microbiome project was designed for identification and characterization of set of human microorganisms as well as for studying the changes in the human health due to microbiome changes. The Human Genome Project assumes: development of the human genome variations database (HapMap; Human Variome Project), interpretation of human phenotype differences (Encyclopedia Of DNA Elements), modeling of human phenomenon (RECON), interpretation of epigenetic variants and hereditary changes in phenotypical manifestations. …”
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Expanding the Diversity of <i>Actinobacterial Tectiviridae</i>: A Novel Genus from <i>Microbacterium</i> by Jacqueline M. Washington, Holly Basta, Angela Bryanne De Jesus, Madison G. Bendele, Steven G. Cresawn, Emily K. Ginser

“…The phages have linear dsDNA genomes 15,438–15,636 bp with 112–120 bp inverted terminal repeats. …”
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Pseudomonas azotoformans and Pseudomonas putida: Novel kiwifruit-native biological control agents against Pseudomonas syringae pv. actinidiae by Cristiana Correia, Antonio Cellini, Irene Donati, Panagiotis Voulgaris, Adebayo Ebenezer Obafemi, Elia Soriato, Elodie Vandelle, Conceição Santos, Francesco Spinelli

“…Moreover, several biosynthetic gene clusters of secondary metabolites, were predicted in the genome of both strains, including non-ribosomal peptides, and the bacteriocin pyocin was predicted in the genome of BG1. …”
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