Digestive cancers: mechanisms, therapeutics and management by Tianzuo Zhan, Johannes Betge, Nadine Schulte, Lena Dreikhausen, Michael Hirth, Moying Li, Philip Weidner, Antonia Leipertz, Andreas Teufel, Matthias P. Ebert

“…Over the last decade, genomic and functional studies have provided unprecedented insights into the biology of digestive cancers, identifying genetic drivers of tumor progression and key interaction points of tumor cells with the immune system. …”
Get full text

RECQL4 requires PARP1 for recruitment to DNA damage, and PARG dePARylation facilitates its associated role in end joining by Mansoor Hussain, Prabhat Khadka, Komal Pekhale, Tomasz Kulikowicz, Samuel Gray, Alfred May, Deborah L. Croteau, Vilhelm A. Bohr

“…Abstract RecQ helicases, highly conserved proteins with pivotal roles in DNA replication, DNA repair and homologous recombination, are crucial for maintaining genomic integrity. Mutations in RECQL4 have been associated with various human diseases, including Rothmund–Thomson syndrome. …”
Get full text

Dysbiosis and extraintestinal cancers by Ruishan He, Pingqian Qi, Linzhen Shu, Yidan Ding, Peng Zeng, Guosheng Wen, Ying Xiong, Huan Deng

“…The oncogenic cascade always engages in the disruption of hormonal regulation and inflammatory responses, the induction of genomic instability and mutations, and the dysregulation of adult stem cell proliferation. …”
Get full text

Mitochondrial trifunctional protein deficiency caused by a deep intronic deletion leading to aberrant splicing by Thomas Cassini, Sarah Silverstein, Molly Behan, Cynthia J. Tifft, May Christine Malicdan, David R. Adams, Undiagnosed Diseases Network, Sun‐Young Ahn, Debra S. Regier

“…Subsequent evaluation by the Undiagnosed Diseases Network with genome and transcriptome sequencing revealed a rare maternally inherited 17 base pair deletion in HADHB, NM_000183.3:c.1390‐515_1390‐499del, located in the final intron and resulting in a pseudoexon that harbors a premature termination codon. …”
Get full text

Altered Viral Replication and Cell Responses by Inserting MicroRNA Recognition Element into PB1 in Pandemic Influenza A Virus (H1N1) 2009 by Xiaoyue Shen, Wenkui Sun, Yi Shi, Zheng Xing, Xin Su

“…Engineering mutant viruses by inserting cell-specific miRNA recognition element (MRE) into viral genome may alter viral infectivity and host responses in vital tissues and organs infected with pandemic influenza A virus (H1N1) 2009 (H1N1pdm). …”
Get full text

Faecalibacterium prausnitzii regulates carbohydrate metabolic functions of the gut microbiome in C57BL/6 mice by Peiling Geng, Ni Zhao, Yufan Zhou, Reuben S. Harris, Yong Ge

“…The probiotic impact of microbes on host metabolism and health depends on both host genetics and bacterial genomic variation. Faecalibacterium prausnitzii is the predominant human gut commensal emerging as a next-generation probiotic. …”
Get full text

Orthoweb: a software package for evolutionary analysis of gene networks by R. A. Ivanov, A. M. Mukhin, F. V. Kazantsev, Z. S. Mustafin, D. A. Afonnikov, Y. G. Matushkin, S. A. Lashin

“…Furthermore, it offers tools for SNP enrichment analysis, enabling the users to assess the evolutionary significance of genetic variants within specific genomic regions. A key feature of Orthoweb is its ability to integrate these indices with gene network analysis. …”
Get full text

Development of source material for pea breeding through chemical mutagenesis and evaluation of its genetic diversity using SSR markers by K. P. Gainullina, B. R. Kuluev, F. A. Davletov

“…Molecular genetic polymorphism of the М2 plants and the original cultivar was assessed using 10 SSR markers from the microsatellite genomic library (Agrogene®, France).Results. Optimal concentrations of sodium azide and the duration of seed treatment with it were identified: 1–5 mM for 3 h. …”
Get full text

Genetic diversity assessment in pea cultivars and lines using the SSR analysis by K. P. Gainullina, B. R. Kuluev, F. A. Davletov

“…Microsatellite analysis was performed using 5 SSR markers from the genomic library of microsatellites (Agrogene®, France).Results. …”
Get full text

Influence of human peripheral blood samples preprocessing on the quality of Hi-C libraries by M. M. Gridina, E. Vesna, M. E. Minzhenkova, N. V. Shilova, O. P. Ryzhkova, L. P. Nazarenko, E. O. Belyaeva, I. N. Lebedev, V. S. Fishman

“…The genome-wide variant of the chromatin conformation capture technique (Hi-C) is a powerful tool for revealing patterns of genome spatial organization, as well as for understanding the effects of their disturbance on disease development. …”
Get full text

Prebreeding studies of leaf rust resistant <i>Triticum aestivum/T. timopheevii</i> line L624 by S. N. Sibikeev, I. G. Adonina, A. E. Druzhin, O. A. Baranova

Get full text

Detection and Characterization of Shiga Toxin Producing Escherichia coli, Salmonella spp., and Yersinia Strains from Human, Animal, and Food Samples in San Luis, Argentina by Gabriela Isabel Favier, Cecilia Lucero Estrada, Teresa Inés Cortiñas, María Esther Escudero

“…The antimicrobial susceptibility of all the strains was studied, the genomic relationships among isolates of the same species were determined by PFGE, and the potencial virulence of Y. enterocolitica strains was analyzed. …”
Get full text

Insights into the molecular mechanisms and nanoparticle-based therapies for gastric cancer: A review by Smarika Chauhan, Eswar Marcharla, Sneha Hariharan, Saranya Vinayagam, Thanigaivel Sundaram, Priya SD, Swamynathan Ganesan, Maximilian Lackner

“…This review aims to explore the role of nanoparticles in the prognosis and diagnosis of gastric cancer. We have analysed genomic pathways linked with gastric carcinoma and explored the utilisation of nanoparticles for multimodal imaging techniques, precise drug delivery and efficient therapeutic approaches. …”
Get full text

Low-Level Zoonotic Transmission of Clade C MERS-CoV in Africa: Insights from Scoping Review and Cohort Studies in Hospital and Community Settings by Andrew Karani, Cynthia Ombok, Silvia Situma, Robert Breiman, Marianne Mureithi, Walter Jaoko, M. Kariuki Njenga, Isaac Ngere

“…Ongoing research focuses on genomic comparisons between clade C and the more virulent clades A and B, alongside the surveillance of viral evolution. …”
Get full text

Effects of the auxin-dependent degradation of the cohesin and condensin complexes on the repair of distant DNA double-strand breaks in mouse embryonic stem cells by A. V. Smirnov, A. S. Ryzhkova, A. M. Yunusova

“…Cohesin knockdown was recently shown to stimulate frequencies of genomic deletions produced by distant paired DSBs, but does not affect DNA repair of a single or close DSBs. …”
Get full text

Correlation among blastocoel fluid DNA level, apoptotic genes expression and preimplantation aneuploidy by Fattaneh Khajehoseini, Zahra Noormohammadi, Poopak Eftekhari-Yazdi, Hamid Gourabi, Reza Pazhoomand, Shirzad Hosseinishenatal, Masood Bazrgar

“…Following BF aspiration and whole genome amplification, BF-DNA level was quantified. …”
Get full text

Estimation of population structure in emmer wheat germplasm conserved in the National Genebank of India by Jatin Tanwar, Sandhya Tyagi, Shivani Sharma, Preeti Jakhar, Gaurav Kumar, Sherry R. Jacob, Amit Kumar Singh, Shailendra K. Jha, Jyoti Kumari

“…Indigenous and exotic collections were categorized into distinct subclusters within the same cluster with some overlapping suggesting limited genomic differentiation between these collections. …”
Get full text

Analysis of significantly associated regions and candidate genes for dwarf stem trait in Brassica napus based on BSA-sequencing by ZHAO Weiguo, TA Na, WANG Hao, YANG Zelin

“…[Results] (1) The dwarf trait of B. napus DW1 was a quality trait and was controlled by one pair of incomplete dominant genes. (2) Twenty-two genomic regions significantly associated with dwarf trait were identified within the 21.78-23.88 Mb region on chromosome A06, with the maximum interval of 46.71 kb and the minimum interval of 0.64 kb. (3) Potential candidate genes, including BnaA06g27050D, BnaA06g34100D, BnaA06g34810D, BnaA06g35080D , and BnaA06g36480D , were identified in significantly associated regions on chromosome A06, which were related to the regulation of auxin and gibberellin signal transduction, respectively. …”
Get full text

Epigene functional diversity: isoform usage, disordered domain content, and variable binding partners by Leroy Bondhus, Aileen A. Nava, Isabelle S. Liu, Valerie A. Arboleda

“…This specialized group of proteins is responsible for controlling the organization of genomic DNA in a cell-type specific fashion, controlling normal development in a spatial and temporal fashion. …”
Get full text

Characterization of phenolic compounds and evaluation of anti-diabetic potential in Cannabis sativa L. seeds: In vivo, in vitro, and in silico studies by El-Mernissi Rafik, El Menyiy Naoual, Metouekel Amira, Zouhri Aziz, El-Mernissi Yahya, Siddique Farhan, Nadeem Sumaira, Amhamdi Hassan, Abboussi Oualid, Alsahli Abdulaziz Abdullah, Bourhia Mohammed, Dauelbait Musaab, Shazly Gamal A., Hajji Lhoussain

Get full text