Association of PD-1 and PD-L1 Genetic Polymorphyisms with Type 1 Diabetes Susceptibility by Chenyue Qian, Heming Guo, Xiaohong Chen, Aiming Shi, Sicheng Li, Xin Wang, Jie Pan, Chen Fang

“…In total, 166 T1DM patients and 100 healthy controls were enrolled into the study. Genomic DNA was extracted from 4 mL peripheral blood samples collected from each subject. …”
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Study on association of nuclear factor kappa B gene polymorphism with bacterial load in pulmonary tuberculosis by Pallavi Baliarsingh, Pratima Kumari Sahu, Paresh Nath Mohanty, Roma Rattan, Monalisa Mohapatro

“…Bacterial load estimation was done from the sputum sample. Genomic deoxyribonucleic acid (DNA) was extracted for NF-κB gene. …”
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Investigation of Chemokine Receptor CCR2V64Il Gene Polymorphism and Migraine without Aura in the Iranian Population by Alireza Zandifar, Maryam Taheriun, Samira Soleimani, Faraidoon Haghdoost, Mohamadhasan Tajaddini, Shaghayegh Haghjooy Javanmard

“…We assessed 103 patients with newly diagnosed migraine and 100 healthy subjects. Genomic DNA samples were extracted from peripheral blood and genotypes of CCR2V64Il gene polymorphism were determined. …”
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Inovirus-Encoded Peptides Induce Specific Toxicity in <i>Pseudomonas aeruginosa</i> by Juehua Weng, Yunxue Guo, Jiayu Gu, Ran Chen, Xiaoxue Wang

“…However, filamentous prophages (Pfs) commonly found in <i>P. aeruginosa</i> encode genes with phage defense activity, thereby reducing the efficacy of phage therapy. Through a genomic analysis of the Pf4 prophage, we identified a 102 bp gene co-transcribed with the upstream gene responsible for phage release (<i>zot</i> gene), giving rise to a 33-amino-acid polypeptide that we have named Pf4-encoded toxic polypeptide (PftP4). …”
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Analysis of TGFBI Gene Mutations in Three Chinese Families with Corneal Dystrophy by Feng Zhao, Yuan Liu, Tao Guan

“…Peripheral blood was collected from 24 patients and 76 phenotypically normal members in three Chinese families as well as from 100 healthy controls. Genomic DNA was extracted. All 17 exons of the TGFBI gene, and the exon-intron junctions were examined by polymerase chain reaction (PCR) and direct DNA sequencing to identify and analyse gene mutations. …”
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Characterisation of IGF-1 (rs7136446) and IL-6 (rs1800795) polymorphisms among breast cancer patients in western Algeria by Fatima Zohraa Boussouf, Asmahane Medjdoub, Zineb Tahari, Moussa Messatfa, Noria Bouras, Chahinez Amira Dahmani, Sonia Amal Seddiki, Tewfik Sahraoui

“…This case-control study included 109 BC patients and 112 healthy controls. Genomic DNA was extracted from peripheral blood samples. …”
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Mycobacterium neoaurum Bloodstream Infection Associated with a Totally Implanted Subclavian Port in an Adult with Diabetes and History of Colon Cancer by Jack E. Moseley Jr., Sharanjeet K. Thind

“…Bloodstream infections due to rapidly growing NTM, such as M. neoaurum, have been infrequently reported; however, improved isolation and identification techniques based on genomic testing are resulting in a more in-depth recognition of these widely scattered environmental microbes in human infections. …”
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Severe Psychomotor Delay in a Severe Presentation of Cat-Eye Syndrome by Guillaume Jedraszak, Aline Receveur, Joris Andrieux, Michèle Mathieu-Dramard, Henri Copin, Gilles Morin

“…The use of array comparative genomic hybridization ruled out the involvement of another chromosomal imbalance in the neurological phenotype. …”
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Generation of Human-Induced Pluripotent Stem Cells by a Nonintegrating RNA Sendai Virus Vector in Feeder-Free or Xeno-Free Conditions by Chad C. MacArthur, Andrew Fontes, Namritha Ravinder, David Kuninger, Jasmeet Kaur, Matthew Bailey, Antje Taliana, Mohan C. Vemuri, Pauline T. Lieu

“…However, a major obstacle to the use of iPSC for therapeutic applications is the potential of genomic modifications caused by insertion of viral transgenes in the cellular genome. …”
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The cell cycle regulatory gene polymorphisms TP53 (rs1042522) and MDM2 (rs2279744) in lung cancer: a meta-analysis by O. Bulgakova, A. Kussainova, R. Bersimbaev

“…The tumor suppressor p53 plays a crucial role in maintaining genomic stability and tumor prevention. MDM2 is a critical regulator of the p53 protein. …”
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Molecular genetics of idiopathic pulmonary fibrosis by R. N. Mustafin

“…Aging is a significant risk factor for IPF, and the mechanisms of aging (telomere depletion, genomic instability, mitochondrial dysfunction, loss of proteostasis) are involved in the pathogenesis of IPF. …”
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Streptomyces learnhanii sp. nov., unveiling a Mangrove-Derived Novel “Modern Actinobacteria” in Malaysia by Jodi Woan-Fei Law, Vengadesh Letchumanan, Kar-Wai Hong, Sunny Hei Wong, Nurul Syakima Ab Mutalib, Ya-Wen He, Kok-Gan Chan, Loh Teng-Hern Tan

“…Strain MUM 203JT has a genome size of 6,446,886 bp, with DNA G + C content of 72.26 mol%. …”
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CRISPR-Cas9 in basic and translational aspects of cancer therapy by Maryam Samareh Salavatipour, Zahra Poursalehi, Negin Hosseini Rouzbahani, Sohaib Mohammadyar, Mohammad Vasei

“…Introduction: The discovery of gene editing techniques has opened a new era within the field of biology and enabled scientists to manipulate nucleic acid molecules. CRISPR-Cas9 genome engineering has revolutionized this achievement by successful targeting the DNA molecule and editing its sequence. …”
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Improvements in pig agriculture through gene editing by Kristin M. Whitworth, Jonathan A. Green, Bethany K. Redel, Rodney D. Geisert, Kiho Lee, Bhanu P. Telugu, Kevin D. Wells, Randall S. Prather

“…Concordant with the developments in genomic sequencing approaches, progress among germline editing efforts is expected to reach feverish pace. …”
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Generation of donor organs in chimeric animals via blastocyst complementation by T. I. Babochkina, L. A. Gerlinskaya, M. P. Moshkin

“…The proposed technology is the interspecific blastocyst complementation method in combination with genomic editing for obtaining “free niches” and pluripotent stem cell production methods. …”
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Biological features and cultivation of sesame (a review) by N. V. Kishlyan, M. Sh. Asfandiyarova, Y. V. Yakusheva, A. G. Dubovskaya

“…Recently, thanks to the deciphering of the sesame nuclear genome and the development of various genomic resources, including molecular markers for qualitative and quantitative characters, molecular breeding has become possible for such agronomic traits as high oil content and its composition, drought resistance, resistance to waterlogging, disease resistance, and high yield. …”
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Genotype B of deformed wing virus and related recombinant viruses become dominant in European honey bee colonies by Fabrice Sircoulomb, Eric Dubois, Frank Schurr, Pierrick Lucas, Marina Meixner, Alicia Bertolotti, Yannick Blanchard, Richard Thiéry

“…Chimeric sequencing reads were used to locate the recombinant junctions along the DWV genome. These were not randomly distributed, but mainly clustered in three genomic areas: the 5’UTR, leader peptide and helicase coding sequences. …”
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Cancer multi-omics-based differential expression analysis and prognostic potential of identified hub targets of myco-metabolites for breast carcinoma and lung carcinoma by Singh Shreya, Debadatta Mohapatra, Gaurav Gopal Naik, Pooja Kathait, Soki Malang, Pradeep Patel, Shambhavi, Gulzar Alam, Alakh N. Sahu

“…In the present work, web servers UALCAN, GEPIA2, and KM plotter were used to explore the genomic and proteomic expression of these hub targets, along with their prognosis potential in BC and LC. …”
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Molecular cloning of EZH2 oncogene in chronic myeloid leukemia and therapeutic prospects by Juliana Costa Gaspar, Lucas Santos de Santana, Camila Menezes Freire de Souza, Marcos Montani Caseiro, Rosane Rezende de Souza Giuliani, Cleide Barbieri de Souza

“…For this reason, the EZH2 gene was isolated from peripheral blood genomic DNA from CML patients and cloned in prokaryotic systems. …”
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FishPi: a bioinformatic prediction tool to link piRNA and transposable elements by Alice M. Godden, Benjamin Rix, Simone Immler

“…Through complementary seed region binding with transposable elements (TEs), piRNAs protect the genome from transposition. A tool to link piRNAs with complementary TE targets will improve our understanding of the role of piRNAs in genome maintenance and gene regulation. …”
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