Experience and role of Italian nurses working in genetic clinics: a descriptive phenomenological qualitative study by Lea Godino, Camilla Elena Magi, Carla Bruzzone, Stefano Bonora, Marco Seri, Liliana Varesco, Daniela Turchetti

“…This could be achieved through the definition of standard activities and the implementation of formal education in genetics and genomic fields.…”
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IGN: Invariable gene set-based normalization for chromatin accessibility profile data analysis by Shengen Shawn Hu, Hai-Hui Xue, Chongzhi Zang

“…Chromatin accessibility profiles generated using ATAC-seq or DNase-seq carry functional information of the regulatory genome that controls gene expression. Appropriate normalization of ATAC-seq and DNase-seq data is essential for accurate differential analysis when studying chromatin dynamics. …”
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Tumor Reduction with Pazopanib in a Patient with Recurrent Lumbar Chordoma by Maurício Fernando Silva Almeida Ribeiro, Micelange Carvalho de Sousa, Samir Abdallah Hanna, Marcos Vinicius Calfat Maldaun, Ceci Obara Kurimori, Luiz Guilherme Cernaglia Aureliano de Lima, Romulo Loss Mattedi, Rodrigo Ramella Munhoz

“…He ultimately developed multifocal recurrence not amenable to complete excision or reirradiation. A comprehensive genomic profiling assay was performed and revealed nondrugable alterations. …”
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Acorus shannai (Acoraceae), a new species from Southern China by Zhuo Cheng, Xinyu Liu, Nianting Yu, Weizhe Chen, Haofeng Zhao, Feifei Li, Chunlin Long

“…Based on morphological and plastid genomic data, this study formally describes and illustrates Acorus shannai, distributed in the Qiandongnan area of Guizhou Province and its surroundings, confirming it as a new species within the genus Acorus. …”
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The Microbiota Profile Analysis of Combined Periodontal-Endodontic Lesions Using 16S rRNA Next-Generation Sequencing by Ping Sun, Zhiyong Guo, Daiping Guo, Jian Wang, Tingting Wu, Tingjun Li, Jiannan Liu, Xinhua Liu

“…Samples were collected from teeth diagnosed as chronic periodontics (PE), ulcerative pulpitis (PU), and retrograde pulpitis (RE). Genomic DNA was extracted. The quantitative polymerase chain reaction, targeting the 16S ribosomal RNA (rRNA), was adopted for the quantification of bacteria. …”
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Intercellular communication is crucial in the regulation of healthy aging via exosomes by Huifang Sun, Tengyuan Xia, Shuting Ma, Tao Lv, Yuhong Li

“…The hallmarks of aging encompass a variety of molecular categories (genomic, telomeric, and epigenetic), organelles (proteostasis, autophagy, and mitochondria), cellular components (including stem cells), systems (such as intercellular communication and chronic inflammation), and environmental factors (dysbiosis and nutrient sensing). …”
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Potential links between human bloodstream infection by Salmonella enterica serovar Typhimurium and international transmission to Colombia. by Yan Li, Caisey V Pulford, Paula Díaz, Blanca M Perez-Sepulveda, Carolina Duarte, Alexander V Predeus, Magdalena Wiesner, Darren Heavens, Ross Low, Christian Schudoma, Angeline Montaño, Neil Hall, Jaime Moreno, Jay C D Hinton

“…We used whole-genome sequencing to analyse multidrug-resistant (MDR) profiles, plasmid distribution, and to define phylogenetic relationships. …”
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PARP4 deficiency enhances sensitivity to ATM inhibitor by impairing DNA damage repair in melanoma by Yuehua Li, Yu Liu, Jingjing Ma, Yuqi Yang, Qiao Yue, Guannan Zhu, Weinan Guo, Tianwen Gao, Qiong Shi, Chunying Li

“…Abstract Besides the important pathogenic mechanisms of melanoma, including BRAF-driven and immunosuppressive microenvironment, genomic instability and abnormal DNA double-strand breaks (DSB) repair are significant driving forces for its occurrence and development. …”
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The role of PM2.5 exposure in lung cancer: mechanisms, genetic factors, and clinical implications by Chi-Yuan Chen, Kuo-Yen Huang, Chin-Chuan Chen, Ya-Hsuan Chang, Hsin-Jung Li, Tong-Hong Wang, Pan-Chyr Yang

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Association of COMT Val158Met Polymorphism with Fibromyalgia in Khartoum State, Sudan by Safaa Mamoun Abdelmageid, Faisal Mousa Alamir, Hassan Yousif Abdelrahman, Hind Mohamed Abushama

“…We aimed in this study to investigate the frequency of COMT Val 158 Met polymorphism among patients with FM, rheumatoid arthritis, and in healthy individuals. Genomic DNA from forty female volunteers was analyzed: twenty were from primary and secondary FM patients, ten were from rheumatoid arthritis patients, and ten were from healthy control. …”
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Chitosan and its derivatives as promising plant protection tools by A. B. Shcherban

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Replication and Meta-Analysis of 13,000 Cases Defines the Risk for Interleukin-23 Receptor and Autophagy-Related 16-Like 1 Variants in Crohn’s Disease by Lynn Cotterill, Debbie Payne, Scott Levison, John McLaughlin, Emma Wesley, Mark Feeney, Hilary Durbin, Simon Lal, Alistair Makin, Simon Campbell, Stephen A Roberts, Catherine O’Neill, Cathryn Edwards, William G Newman

“…Both genes were identified through genome-wide association scans and subsequent studies have validated these associations. …”
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Revisiting pangenome openness with k-mers by Parmigiani, Luca, Wittler, Roland, Stoye, Jens

“…Pangenomics is the study of related genomes collectively, usually from the same species or closely related taxa. …”
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Overcoming immunotherapy resistance in gastric cancer: insights into mechanisms and emerging strategies by Dingtian Luo, Jing Zhou, Shuiliang Ruan, Binzhong Zhang, Huali Zhu, Yangming Que, Shijie Ying, Xiaowen Li, Yuanmin Hu, Zhengwei Song

“…We also discuss emerging strategies to overcome resistance, including combination therapies, novel immunotherapeutic approaches, and personalized treatment strategies based on tumor genomics and the immune microenvironment. By highlighting these key areas, this review aims to inform future research directions and clinical practice, ultimately improving outcomes for GC patients undergoing immunotherapy.…”
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التشخيص الجزيئي لنبات البوثس Epipremnum aureum المستزرع في محافظة نينوى لاول مرة في العراق by شهد ابراهيم, جهان الحاتم, انوار الطائي

“…تم في هذا البحث دراسة المؤشر الوراثي الجزيئي للنبات المدروس البوثس Epipremnum aureum باستعمال تقنية تفاعل التضاعفي المتخصص Specific - PCR اذ تم مكاثرة قطع الDNA باستعمال الكت الموصى به Favor PrepTM (Genomic DNA Extraction Mini Kit) وتضمينها من خلال تفاعل البلمرة المتسلسل Polymerase Chain Reaction واظهرت نتيجة الكشف عند المستوى الجزيئي لجينوم اوراق نبات البوثس أن حجوم الحزم الناتجة كان مطابقاً لما جاء في تصميم زوج البوادئ (ITS1F: 5:TCCGTAGGTGAACCTGCGG-3)) (ITS4R:5:TCCTCCGCTTATTGATAGC-3) المسؤول كمحدد عن وجود المورث قيد الدراسة وظهرت الحزم اثناء الترحيل الكهربائي بحجم 473 زوج قاعدة , أدخلت تسلسلات القواعد النتروجينية في برنامج NCBI-BLAST وبرنامج MEGA 6.0 لبيان مدى تقاربها مع المورثات الموجودة والمسجلة في بنك الجينات Gene Bank . …”
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Geographic variation in abundance and diversity of Acinetobacter baumannii Vieuvirus bacteriophages by Dafne Arellano-Maciel, Juan Manuel Hurtado-Ramírez, Laura Carolina Camelo-Valera, Santiago Castillo-Ramírez, Alejandro Reyes, Gamaliel López-Leal

“…These were analyzed with 967 prophages identified from various isolates worldwide, plus 21 genomes of other phages infecting A. baumannii previously reported in NCBI. …”
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Detection of multidrug resistant Vibrio parahaemolyticus and anti-Vibrio Streptomyces sp. MUM 178J by Ke-Yan Loo, Loh Teng-Hern Tan, Jodi Woan-Fei Law, Priyia Pusparajah, Learn-Han Lee, Vengadesh Letchumanan

“…Further identification with genomic analyses confirmed that 64% (64/100) of the isolates were V. parahaemolyticus. …”
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Incontinentia Pigmenti Misdiagnosed as Neonatal Herpes Simplex Virus Infection by Fahimeh Abdollahimajd, Minoo Fallahi, Mohammad Kazemian, Yalda Nilipour, Mitra Radfar, Sedigheh Tahereh Tehranchi

“…Occasionally, typical IP may occur in boys due to Klinefelter syndrome or a genomic mosaicism. Skin lesions are observed in 4 stages: blistering, verrucous linear plaques, swirling macular hyperpigmentation, followed by linear hypopigmentation that develop during adolescence and early adulthood. …”
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From threats to solutions: A literature review of climate adaptation in anadromous salmon and trout by Lisa G. Crozier, Jared E. Siegel

“…By capitalizing on new tools for sequencing, genomic analysis, and automated field data collection, we can establish baselines for tracking evolutionary responses to climate change. …”
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Prenatal Identification and Molecular Characterization of Two Simultaneous De Novo Interstitial Duplications of Chromosomal Regions 7p22.1p21.1 and 15q24.1 by Sabrina C. Burn, Kali Swift, Maria Palmquist

“…Cytogenetic analysis of cultured amniocytes by conventional chromosome analysis, comparative genomic hybridization, and fluorescence in situ hybridization revealed two interstitial duplications of the chromosomal regions 7p22.1p21.1 and 15q24.1, leading to partial trisomy of 7p and 15q and karyotype 46,XY,dup(7)(p22.1-p21.1),dup (15)(q24.1). …”
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