A Hybrid Approach of Using Wavelets and Fuzzy Clustering for Classifying Multispectral Florescence In Situ Hybridization Images by Yu-Ping Wang, Ashok Kumar Dandpat

“…Multicolor or multiplex fluorescence in situ hybridization (M-FISH) imaging is a recently developed molecular cytogenetic diagnosis technique for rapid visualization of genomic aberrations at the chromosomal level. By the simultaneous use of all 24 human chromosome painting probes, M-FISH imaging facilitates precise identification of complex chromosomal rearrangements that are responsible for cancers and genetic diseases. …”
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MONITORING OF Aegilops L. LOCAL SPECIES GENETIC DIVERSITY OF KAZAKHSTAN’S FLORA by R. Urazaliev, M. Yessimbekova, K. Mukin, A. Chirkin, G. Ismagulova

“…For the most informative markers the presence of 5 and 6 respective allelic variations was found. A bank of genomic DNA was created and kept in ex situ storage (–70 °С, long-term) in the IMBB of the MES of RK.…”
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Impact of trainability on telomere dynamics of pet dogs (Canis lupus familiaris): An explorative study in aging dogs. by Julia Weixlbraun, Durga Chapagain, Jessica Svea Cornils, Steve Smith, Franz Schwarzenberger, Franz Hoelzl

“…Telomeres, essential for maintaining genomic integrity, undergo shortening with each cell division, leading to cellular senescence. …”
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Molecular Characterization of Chicken Anemia Virus Circulating in Chicken Flocks in Egypt by Mohammed AboElkhair, Alaa G. Abd El-Razak, Abd Elnaby Y. Metwally

“…Although many previous studies reported detection of chicken anemia virus (CAV) in Egypt since 1990, genomic characterization of this circulating CAV has not been published. …”
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H2AX Phosphorylation: Its Role in DNA Damage Response and Cancer Therapy by Monika Podhorecka, Andrzej Skladanowski, Przemyslaw Bozko

“…Double-strand breaks (DSBs) are the most deleterious DNA lesions, which, if left unrepaired, may have severe consequences for cell survival, as they lead to chromosome aberrations, genomic instability, or cell death. Various physical, chemical, and biological factors are involved in DSB induction. …”
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In Silico Evolution of Gene Cooption in Pattern-Forming Gene Networks by Alexander V. Spirov, Marat A. Sabirov, David M. Holloway

“…Such re-arrangement of pre-existing networks is likely more common for increasing genomic complexity than the creation of new genes. …”
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Development of animal models to study aggressive thyroid cancers by Shovan Dutta, Jeffrey A Knauf

“…Recent studies exploring the genomic landscape of advanced thyroid cancer have identified several cooperating mutations, which are secondary genetic alterations that work alongside driver mutations to promote thyroid tumor progression. …”
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Mutations in Mycobacterium tuberculosis Isolates with Discordant Results for Drug-Susceptibility Testing in Peru by L. Solari, D. Santos-Lazaro, Z. M. Puyen

“…Obtained sequences were aligned “through reference” (genomic mapping) using the program BWA with the algorithm “mem”, using as a reference the genome of the M. tuberculosis H37Rv strain. …”
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Single-Cell Sequencing Technology in Oncology: Applications for Clinical Therapies and Research by Baixin Ye, Qingping Gao, Zhi Zeng, Creed M. Stary, Zhihong Jian, Xiaoxing Xiong, Lijuan Gu

“…Single-cell sequencing (SCS) technology has been recently employed for analyzing the genetic polymorphisms of individual cells at the genome-wide level. SCS requires (1) precise isolation of the single cell of interest; (2) isolation and amplification of genetic material; and (3) descriptive analysis of genomic, transcriptomic, and epigenomic data. …”
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Analysis on the Susceptibility Genes in Two Chinese Pedigrees with Familial Parkinson's Disease by Changshui Xu, Jun Xu, Yanmin Zhang, Jianjun Ma, Hideshi Kawakami, Hirofumi Maruyama, Masaki Kamada

“…To screen the susceptibility genes in Chinese pedigrees with early-onset familial Parkinson's disease (FPD). Methods. Fifty-one genomic DNA samples extracted from two Chinese pedigrees with FPD, the alpha-synuclein genes (SNCA), the leucine-rich repeat kinase 2(LRRK2), PINK1(PTEN-induced putative kinase 1), PARK7(Protein DJ1), PARK2(Parkinson juvenile disease protein 2), the glucocerebrosidase (GBA), and ATP(Ezrin-binding protein PACE-1), were sequenced by the use of polymerase chain reaction (PCR) technique. …”
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Challenges in Emerging Vaccines and Future Promising Candidates against SARS-CoV-2 Variants by Tanmay Ghildiyal, Nishant Rai, Janhvi Mishra Rawat, Maargavi Singh, Jigisha Anand, Gaurav Pant, Gaurav Kumar, Amrullah Shidiki

“…The review provides an integrative discussion on the current state of knowledge on the type of vaccines developed against SARS-CoV-2, the safety and efficacy of COVID-19 vaccines concerning the VOCs, and prospects of novel universal, chimeric, and bivalent mRNA vaccines efficacy to fend off existing variants and other emerging coronaviruses. Genomic variation can be quite significant, as seen by the notable differences in impact, transmission rate, morbidity, and death during several human coronavirus outbreaks. …”
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Microscopic Analysis of Severe Structural Rearrangements of the Plant Endoplasmic Reticulum and Golgi Caused by Overexpression of Poa semilatent virus Movement Protein by Andrey G. Solovyev, Joachim Schiemann, Sergey Y. Morozov

“…Three movement proteins coded by the “triple gene block” (TGB) and named TGBp1, TGBp2 and TGBp3 have distinct functions in viral transport. TGBp1 binds viral genomic RNAs to form ribonucleoprotein complexes representing the transport form of viral genome, while TGBp2 and TGBp3 are necessary for intracellular delivery of such complexes to plasmodesmata. …”
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SARS and MERS as learning tools for addressing the 2019-nCoV epidemic: A mini-review by Udit DAVE, Ashwin PALANIAPPAN

“…Coronaviruses are classified by their distinct genomic make-up and have been in the spotlight due to their ability to cause fatal epidemics across national borders. …”
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Effect of UHT Thermal Treatment on the Secondary Structures of Milk Proteins: Insights From FTIR Analysis and Potential Allergenic Activity by Sergio-Miguel Acuña-Nelson, Leslie-Patricia Henríquez-González, Vieroska-Belén Sepúlveda-Villagra, Mauricio Opazo-Navarrete, Samuel Durán-Agüero, Julio-Enrique Parra-Flores

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Nonlinear-Model-Based Analysis Methods for Time-Course Gene Expression Data by Li-Ping Tian, Li-Zhi Liu, Fang-Xiang Wu

“…Such gene expression data has been proved useful in genomic disease diagnosis and drug design. The challenge is how to uncover useful information from such data by proper analysis methods such as significance analysis and clustering analysis. …”
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Case Reports in Oncological Medicine Myoepithelioma: A New Rearrangement Involving the LPP Locus in a Case of Multiple Bone and Soft Tissue Lesions by Géraldine Pairet, Gaëlle Tilman, Rafaël Sciot, Thomas Schubert, Vasiliki Perlepe, Hélène A. Poirel, Christine Galant

“…We report a case of multiple myoepithelioma with synchronous bone and soft tissue tumors, associated with a new genomic alteration of the LPP locus. The lesions occurred in the foot by presenting one lump in the plantar soft tissue, and three lesions were detected in the calcaneus and in the navicular bone. …”
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Genetic analysis of pathways regulated by the von Hippel-Lindau tumor suppressor in Caenorhabditis elegans. by Tammie Bishop, Kah Weng Lau, Andrew C R Epstein, Stuart K Kim, Min Jiang, Delia O'Rourke, Christopher W Pugh, Jonathan M Gleadle, Martin S Taylor, Jonathan Hodgkin, Peter J Ratcliffe

“…However, persisting differential gene expression in hif-1 versus hif-1; vhl-1 double mutant worms clearly distinguished HIF-1-independent effects of VHL-1 inactivation. Genomic clustering, predicted functional similarities, and a common pattern of dysregulation in both vhl-1 worms and a set of mutants (dpy-18, let-268, gon-1, mig-17, and unc-6), with different defects in extracellular matrix formation, suggest that dysregulation of these genes reflects a discrete HIF-1-independent function of VHL-1 that is connected with extracellular matrix function.…”
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A Case of Non-Small Cell Lung Cancer with Mutually Exclusive <i>EGFR</i> and <i>KRAS</i> Mutations by Abhimanyu Tushir, Israh Akhtar, Anjali Seth

“…These co-occurring tumor genomic alterations are not necessarily mutually exclusive, and evidence suggests that multiple clonal and sub-clonal cancer cell populations can co-exist and contribute to <i>EGFR</i> TKI resistance. …”
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Comparison of Classification Algorithms with Wrapper-Based Feature Selection for Predicting Osteoporosis Outcome Based on Genetic Factors in a Taiwanese Women Population by Hsueh-Wei Chang, Yu-Hsien Chiu, Hao-Yun Kao, Cheng-Hong Yang, Wen-Hsien Ho

“…An essential task in a genomic analysis of a human disease is limiting the number of strongly associated genes when studying susceptibility to the disease. …”
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Sorafenib as Adjuvant Therapy Post–Liver Transplant: A Single-center Experience by Hala Hassanain, MD, Ashton A. Connor, MD, PhD, Elizabeth W. Brombosz, PhD, Khush Patel, MD, MS, Ahmed Elaileh, MD, Tamneet Basra, MD, Sudha Kodali, MD, MSPH, David W. Victor, III, MD, Caroline J. Simon, MD, Yee Lee Cheah, MD, Mark J. Hobeika, MD, Constance M. Mobley, MD, PhD, Ashish Saharia, MD, Sadhna Dhingra, MD, Mary Schwartz, MD, Anaum Maqsood, MD, Kirk Heyne, MD, Ahmed O. Kaseb, MD, Jean-Nicolas Vauthey, MD, A. Osama Gaber, MD, Maen Abdelrahim, MD, PhD, R. Mark Ghobrial, MD, PhD

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