Genetics of Childhood Obesity by Jianhua Zhao, Struan F. A. Grant

“…Besides environmental factors, genetic factors are known to play an important role in the pathogenesis of obesity. Genome-wide association studies (GWAS) have revealed strongly associated genomic variants associated with most common disorders; indeed there is general consensus on these findings from generally positive replication outcomes by independent groups. …”
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The Role of Poly(ADP-ribose) Polymerase-1 in Rheumatoid Arthritis by Samuel García, Carmen Conde

“…Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme with a crucial role in the maintenance of genomic stability. In addition to the role of PARP-1 in DNA repair, multiple studies have also demonstrated its involvement in several inflammatory diseases, such as septic shock, asthma, atherosclerosis, and stroke, as well as in cancer. …”
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C-Reactive Protein and Coronary Heart Disease: All Said—Is Not It? by Frederik Strang, Heribert Schunkert

“…This review will highlight the complex results of genomic, epidemiological, and experimental studies on CRP and will show why further studies investigating the relationship between CRP and atherosclerosis might be needed.…”
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PPAR𝛾, PTEN, and the Fight against Cancer by Rosemary E. Teresi, Kristin A. Waite

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BRCA2 Heterozygosity Delays Cytokinesis in Primary Human Fibroblasts by Asta Björk Jonsdottir, Maaike P. G. Vreeswijk, Ron Wolterbeek, Peter Devilee, Hans J. Tanke, Jorunn E. Eyfjörd, Karoly Szuhai

“…So far, most studies have focused on the role of BRCA-pathways in the maintenance of genomic stability.…”
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On the sensitivity of feature ranked lists for large-scale biological data by Danuta Gaweł, Krzysztof Fujarewicz

“…The problem of feature selection for large-scale genomic data, for example from DNA microarray experiments, is one of the fundamental and well-investigated problems in modern computational biology.From the computational point of view, a selected gene list should be characterized by good predictive power and should be understood and well explained from the biological point of view.Recently, another feature of selected gene lists is increasingly investigated, namely their stability which measures how the content and/or the gene order change when the data are perturbed.In this paper we propose a new approach to analysis of gene list stability, termed the sensitivity index, that does not require any data perturbationand allows the gene list that is most reliable in a biological sense to be chosen.…”
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Two Cases of γ-Heavy Chain Disease and a Review of the Literature by I. Ramasamy, Z. Rudzki

“…Studies on the clonal evolution of the disease may provide insight into therapeutic implications and the genomic complexity of the disease.…”
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The role of oestrogen and oestrogen-calcium axis in endometrial carcinoma by Jingyi Zhou, Jianliu Wang, Xuerun Liu

“…In recent years, a series of studies by our team revealed that the non-genomic transcriptional effects of oestrogen can influence the progression of endometrial carcinoma by regulating calcium ions, suggesting that inhibiting calcium ion channel proteins could serve as an adjuvant therapy for endometrial cancer. …”
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Charcot-Marie-Tooth disease: A case report initially manifested by bilateral vocal cord paralysis by Seyed Hossein Mirlohi, Sanaz Tajfirooz, Mitra Rouhi

“…Diagnosis was confirmed through whole genome sequencing, revealing mutations in genes associated with the disorder.…”
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Molecular Basis of Triple Negative Breast Cancer and Implications for Therapy by Parvin F. Peddi, Matthew J. Ellis, Cynthia Ma

“…Recent genomewide gene expression and DNA sequencing studies indicate that this cancer type is composed of a molecularly heterogeneous group of diseases that carry multiple somatic mutations and genomic structural changes. These findings have implications for therapeutic target identification and the design of future clinical trials for this aggressive group of breast cancer.…”
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Feline T-Cell Receptor 𝛾 V- and J-Region Sequences Retrieved from the Trace Archive and from Transcriptome Analysis of Cats by Alexander Thomas Andreas Weiss, Werner Hecht, Manfred Reinacher

“…Here we describe additional variants of V- and J-region genes of the feline T-cell receptor 𝛾 (TRG) as well as the corresponding RSSs retrieved from Trace Archive of feline genomic sequences. Additionally, an unusually recombined TRGV-domain containing a partial inverted repeat of the included J-region and a short interspersed element of the CAN-SINE family located within the feline T-cell receptor 𝛾 locus are also described.…”
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Understanding cancer predisposition in Singapore: what’s next by Jianbang Chiang, Tarryn Shaw, Joanne Ngeow

“…All stakeholders in healthcare should be empowered with genetic knowledge to fully leverage the potential of novel genomic insights and implement them to provide better care for our patients.…”
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Comprehensive cDNA cloning and putative feature analysis of endogenous cellulases possessed by the Pacific oyster, Crassostrea gigas. by Manabu Wen-Liu Tanimura, Kazuhiko Koike, Motoki Kayama, Kazumi Matsuoka

“…Therefore, our objective was to identify the cellulases present in C. gigas through transcriptome and genomic analyses. The results showed that there are 10 cellulase orthologs, seven of which are endogenous. …”
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Molecular Mechanisms and Functions of lncRNAs in the Inflammatory Reaction of Diabetes Mellitus by Linjuan Huang, Xiaolei Hu

“…Long noncoding RNAs (lncRNAs), a new area of genomic research for gene regulation, have complex biological functions in various aspects of cellular biological activity. …”
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FLAVONOID BIOSYNTHESIS GENES IN WHEAT by E. K. Khlestkina, O. Y. Shoeva, E. I. Gordeeva

“…Owing to the development of molecular and genomic methods in recent years, considerable progress is made in the understanding of the molecular and genetic mechanisms underpinning flavonoid biosynthesis in bread wheat (Triticum aestivum L.). …”
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Genetics of Keratoconus: Where Do We Stand? by Khaled K. Abu-Amero, Abdulrahman M. Al-Muammar, Altaf A. Kondkar

“…Keratoconus has a complex multifactorial etiology, with environmental, behavioral, and multiple genetic components contributing to the disease pathophysiology. Using genome-wide and candidate gene approaches several genomic loci and genes have been identified that highlight the complex molecular etiology of this disease. …”
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Alternative Splicing in Self-Renewal of Embryonic Stem Cells by Clara Y. Cheong, Thomas Lufkin

“…Progressing beyond the limitations of a fixed genomic sequence, alternative splicing offers an additional layer of complexity to produce protein variants that may differ in function and localization that can direct embryonic stem cells to specific differentiation pathways. …”
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The Immunohistochemical Prognostic Value of Nuclear and Cytoplasmic Silent Information Regulator 1 Protein Expression in Saudi Patients with Breast Cancer by Bayan Alharbi, Alia Aldahlawi, Mourad Assidi, Fatemah Basingab, Kawther Zaher, Jehan Alrahimi, Sara Mokhtar, Jaudah Al-Maghrabi, Abdelbaset Buhmeida, Kaltoom Al-Sakkaf

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Plastome data provides new insights into population differentiation and evolution of Ginkgo in the Sichuan Basin of China by Liyun Nie, Fangling Liu, Meixia Wang, Zhuying Jiang, Jiali Kong, Luke R. Tembrock, Shenglong Kan, Penghao Wang, Jie Wang, Zhiqiang Wu, Xiaoli Liu

“…This study provides crucial genomic resources for understanding Ginkgo’s evolution and informs conservation strategies for this endangered species.…”
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MDM4 Isoform Expression in Melanoma Supports an Oncogenic Role for MDM4-A by Abdullah Alatawi, SoonJye Kho, Michael P. Markey

“…Here, we examine the expression of the two primary inhibitors of p53, MDM2 and MDM4, in genomic databases and biopsy specimens. We find that MDM4 is frequently overexpressed. …”
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