The Genetic Landscape of Human Glioblastoma and Matched Primary Cancer Stem Cells Reveals Intratumour Similarity and Intertumour Heterogeneity by Chiara Pesenti, Stefania Elena Navone, Laura Guarnaccia, Andrea Terrasi, Jole Costanza, Rosamaria Silipigni, Silvana Guarneri, Nicola Fusco, Laura Fontana, Marco Locatelli, Paolo Rampini, Rolando Campanella, Silvia Tabano, Monica Miozzo, Giovanni Marfia

“…Glioblastoma (GBM) is the most malignant human brain tumour, characterized by rapid progression, invasion, intense angiogenesis, high genomic instability, and resistance to therapies. …”
Get full text

2′-Hydroxycinnamaldehyde induces ROS-mediated apoptosis in cancer cells by targeting PRX1 and PRX2 by Yae Jin Yoon, Yu-Jin Lee, Jiyeon Choi, Seung-Wook Chi, Sangku Lee, Kyung Chan Park, Byoung-Mog Kwon, Dong Cho Han

Get full text

Reconstruction and computational analysis of the microRNA regulation gene network in wheat drought response mechanisms by M. A. Kleshchev, A. V. Maltseva, E. A. Antropova, P. S. Demenkov, T. V. Ivanisenko, Y. L. Orlov, H. Chao, M. Chen, N. A. Kolchanov, V. A. Ivanisenko

Get full text

DYRK1A (Dual-Specificity Tyrosine-Phosphorylated and -Regulated Kinase 1A): A Gene with Dosage Effect During Development and Neurogenesis by M. Dierssen, M. Martínez de Lagrán

Get full text

Evolution of intrinsic disorder in the structural domains of viral and cellular proteomes by Fizza Mughal, Gustavo Caetano-Anollés

“…Viral proteomes evolve disorder for economy of genomic material and multifunctionality. On the other hand, cellular proteomes evolve disorder to advance functionality with increasing genomic complexity. …”
Get full text

A Report on a Family with TMTC3-Related Syndrome and Review by Sayeeda Hana, Deepak karthik, Jingxuan Shan, Stephany El Hayek, Lotfi Chouchane, André Megarbane

Get full text

Prenatal Diagnosis of Cystic Hygroma related to a Deletion of 16q24.1 with Haploinsufficiency of FOXF1 and FOXC2 Genes by Matthew J. Garabedian, Donna Wallerstein, Nubia Medina, James Byrne, Robert J. Wallerstein

“…This case highlights the power of whole genomic aCGH to further delineate the etiology of birth defects.…”
Get full text

Non-B DNA Secondary Structures and Their Resolution by RecQ Helicases by Sudha Sharma

“…Increasing evidence suggests that genomic instabilities induced by non-B DNA secondary structures result in predisposition to diseases. …”
Get full text

Hairy transcriptional repression targets and cofactor recruitment in Drosophila. by Daniella Bianchi-Frias, Amir Orian, Jeffrey J Delrow, Julio Vazquez, Alicia E Rosales-Nieves, Susan M Parkhurst

“…This approach identified 40 novel genomic targets for Hairy in Kc cells, as well as 155 loci recruiting Groucho, 107 loci recruiting dSir2, and wide genomic binding of dCtBP to 496 loci. …”
Get full text

The influence of combinations of alien translocations on <i>in vitro</i> androgenesis in spring common wheat (<i>Triticum aestivum</i> L.) by E. M. Timonova, I. G. Adonina, E. A. Salina

“…The aim of this study was to develop a set of DH wheat lines containing a wheat-alien translocation in the genome and study the effect of alien translocations on androgenesis of anther culture in such lines.Materials and methods. …”
Get full text

Tell me y: anticipation of sex discrepancies in cell-free DNA testing due to maternal genetic abnormalities: a case report by Nuria Balaguer, Emilia Mateu-Brull, Jose Antonio Martínez-Conejero, Ana Cervero, Roser Navarro, Jorge Jiménez-Almazán, Miguel Milán

“…Amplification of these regions in the DNA isolated from the white blood cells fraction confirmed the presence of Y-chromosome insertions in the maternal genome. This study highlights a new source of discrepancy in cfDNA testing due to maternal genomic variations. …”
Get full text

Human phospholipases A2: a functional and evolutionary analysis by I. I. Turnaev, M. E. Bocharnikova, D. A. Afonnikov

“…Localization of the PLA2 genes in human genome showed they are placed on 12 human chromosomes, some of them forming clusters. …”
Get full text

Interaction of human neutrophils with Trichomonas vaginalis protozoan highlights lactoferrin secretion by Wei-Hung Cheng, Ruei-Min Chen, Seow-Chin Ong, Yuan-Ming Yeh, Po-Jung Huang, Chi-Ching Lee

Get full text

Phosphorylation-dependent WRN-RPA interaction promotes recovery of stalled forks at secondary DNA structure by Alessandro Noto, Pasquale Valenzisi, Flavia Di Feo, Federica Fratini, Tomasz Kulikowicz, Joshua A. Sommers, Benedetta Perdichizzi, Maurizio Semproni, Valentina Palermo, Marco Crescenzi, Robert M. Brosh Jr, Annapaola Franchitto, Pietro Pichierri

Get full text

Analysis of Nucleotide Variations in Genes of Iron Management in Patients of Parkinson's Disease and Other Movement Disorders by Emanuela Castiglioni, Dario Finazzi, Stefano Goldwurm, Gianni Pezzoli, Gianluca Forni, Domenico Girelli, Federica Maccarinelli, Maura Poli, Maurizio Ferrari, Laura Cremonesi, Paolo Arosio

Get full text

Computational identification of promising genetic markers associated with molecular mechanisms of reduced rice resistance to <i>Rhizoctonia solani</i> under excess nitrogen fertili... by E. A. Antropova, A. R. Volyanskaya, A. V. Adamovskaya, P. S. Demenkov, I. V. Yatsyk, T. V. Ivanisenko, Y. L. Orlov, Ch. Haoyu, M. Chen, V. A. Ivanisenko

Get full text

Gene networks for use in metabolomic data analysis of blood plasma from patients with postoperative delirium by V. A. Ivanisenko, N. V. Basov, A. A. Makarova, A. S. Venzel, A. D. Rogachev, P. S. Demenkov, T.  V. Ivanisenko, M. A. Kleshchev, E. V. Gaisler, G. B. Moroz, V. V. Plesko, Y. S. Sotnikova, Y. V. Patrushev, V. V. Lomivorotov, N. A. Kolchanov, A. G. Pokrovsky

Get full text

Good practice for assignment of breeds and populations—a review by H. Wilmot, H. Wilmot, N. Gengler

“…With the purpose to organize methodologies found in (recent) papers focusing on the development of genomic breed/population assignment tools, this review proposes to highlight good practice for the development of such tools. …”
Get full text

Glioblastoma drives protease-independent extracellular matrix invasion of microglia by Chia-Wen Chang, Ashwin Bale, Rohit Bhargava, Brendan A.C. Harley

Get full text

Virulence factor discovery identifies associations between the Fic gene family and Fap2+ fusobacteria in colorectal cancer microbiomes by Geicho Nakatsu, Duhyun Ko, Monia Michaud, Eric A. Franzosa, Xochitl C. Morgan, Curtis Huttenhower, Wendy S. Garrett

“…Advances in omics analyses provide an opportunity to profile and identify microbial genomic features that correlate with the cancer-associated bacterial virulence factor Fap2. …”
Get full text