The Progression of Mycosis Fungoides During Treatment with Mogamulizumab: A BIO-MUSE Case Study of the Tumor and Immune Response in Peripheral Blood and Tissue by Angelica Johansson, Eirini Kalliara, Emma Belfrage, Teodor Alling, Paul Theodor Pyl, Anna Sandström Gerdtsson, Urban Gullberg, Anna Porwit, Kristina Drott, Sara Ek

“…<b>Methods:</b> We applied 10× genomics-based single-cell RNA sequencing to CD3+ peripheral T-cells, combined with T-cell receptor sequencing, to samples collected at multiple timepoints during the progression of the disease. …”
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Expression of genes of cytokines, transcription factors and differentiation antigens in human dendritic cells activated by double-stranded DNA by A. S. Proskurina, K. E. Orishchenko, E. A. Potter, E. V. Dolgova, A. V. Spaselnikova, G. S. Ritter, N. A. Varaksin, T. G. Ryabicheva, O. Y. Leplina, A. A. Ostanin, E. R. Chernykh, S. S. Bogachev

“…It was for the first time shown that genomic “self” double-stranded DNA as a mono agent activates mRNA synthesis of cytokines IFN-α, IFN-β, IFN-γ, IL­8, IL­10, and VEGF in DCs at 6 hours of induction.…”
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Low-Level Zoonotic Transmission of Clade C MERS-CoV in Africa: Insights from Scoping Review and Cohort Studies in Hospital and Community Settings by Andrew Karani, Cynthia Ombok, Silvia Situma, Robert Breiman, Marianne Mureithi, Walter Jaoko, M. Kariuki Njenga, Isaac Ngere

“…Ongoing research focuses on genomic comparisons between clade C and the more virulent clades A and B, alongside the surveillance of viral evolution. …”
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Clinical Report of a 17q12 Microdeletion with Additionally Unreported Clinical Features by Jennifer L. Roberts, Stephanie K. Gandomi, Melissa Parra, Ira Lu, Chia-Ling Gau, Majed Dasouki, Merlin G. Butler

“…Subsequently, a 400 K array-based comparative genomic hybridization (aCGH) + SNP analysis was performed which identified a de novo suspected pathogenic deletion on chromosome 17q12 encompassing 28 genes. …”
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Comprehensive Pan-Cancer Analysis and Functional Studies Reveal SLC2A6 as a Ferroptosis Modulator in Hepatocellular carcinoma by Guohong Yan, Hailian Huang, Ziyan Lu, Meifeng Chen, Xiang Wang, Pei Zhong, Chongjiu Qin, Shutian Mo, Chuangye Han, Xiaoling Luo, Xinping Ye

“…Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were conducted. …”
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Applications and Challenges of High-Throughput Phenotyping of Crops at Ground and Aviation Scales by Longyue CHEN, Dandan DUAN, Weibing XU, Zuolin LI, Chong ZHAO, Yi JIANG, Yonggang GAO, Wenqing ZUO

“…However, with the increasing development of cutting-edge technologies such as cloud big data processing platforms and artificial intelligence, which have great advantages in processing large-volume and high-complexity data, combined with biotechnology and genomics research methods, HTP of crops will play a pivotal role in combating food shortages caused by global environmental changes and population increase.…”
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Identification and Characterization of the <i>ROP GTPase</i> Gene Family in Strawberry and the Positive Role of <i>FveROP4</i> in Fruit Resistance to Gray Mold by Shuai Zhao, Baode Zhu, Zhijun Zou, Yushan Zhai, Sufeng Liao, Ming Xu, Kunyang Li, Nasir Mehmood, Xiong Liao

“…In this study, we identified 53 <i>ROP</i> genes across the genomes of six Rosaceae species. Based on sequence homology, they were classified into three distinct phylogenetic clades. …”
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Estimation of population structure in emmer wheat germplasm conserved in the National Genebank of India by Jatin Tanwar, Sandhya Tyagi, Shivani Sharma, Preeti Jakhar, Gaurav Kumar, Sherry R. Jacob, Amit Kumar Singh, Shailendra K. Jha, Jyoti Kumari

“…Indigenous and exotic collections were categorized into distinct subclusters within the same cluster with some overlapping suggesting limited genomic differentiation between these collections. …”
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Identifiability of mathematical models in medical biology by S. I. Kabanikhin, D. A. Voronov, A. A. Grodz, O. I. Krivorotko

“…Analysis of biological data is a key topic in bioinformatics, computational genomics, molecular modeling and systems biology. The methods covered in this article could reduce the cost of experiments for biological data. …”
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Multidisciplinary approach to functional somatic syndromes: study protocol for a population-based prospective cohort study by Hamidreza Roohafza, Harold Snieder, Fatemeh Hadizadeh, Peyman Adibi, Alireza Ani, Ahmad Vaez

“…Human DNA genotyping, microbial amplicon sequencing and urine analysis is under progress for genomics, microbiota and metabolomics profiling, respectively. …”
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Clinical relevance and druggability of sole reciprocal kinase fusions: A large‐scale study by Jiao Feng, Tonghui Ma, Chunyang Wang, Baoming Wang, Qian Liu, Zhengchuang Liu, Houquan Tao, Zaiyuan Ye

“…Abstract Background Building on our prior work that RNA alternative splicing modulates the druggability of kinase fusions, this study probes the clinical significance of sole reciprocal fusions. These rare genomic arrangements, despite lacking kinase domains at the DNA level, demonstrated potential RNA‐level druggability in sporadic cases from our prior research. …”
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The development of a new bread wheat genotype carrying two loci for endosperm softness by A. V. Simonov, A. K. Chistyakova, E. V. Morozova, L. V. Shchukina, A. Börner, T. A. Pshenichnikova

“…In addition, these lines may serve as a genetic model for the study of the functional activity of homoeoallelic genes in the complex polyploid genomes of plants.…”
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Drug repurposing screen for the rare disease ataxia-telangiectasia by Namrata Jayanth, Gurvan Mahé, Matthew Campbell, Mike Lipkin, Shushant Jain, Rhea van de Bospoort, Jennifer Thornton, Brad Margus, David F. Fischer

“…It is caused by bi-allelic mutations impacting a gene encoding a serine/threonine kinase ATM (Ataxia Telangiectasia Mutated), which plays a crucial role in DNA repair and maintenance of genomic stability. The disorder primarily affects the nervous system, leading to a range of neurological issues, including cerebellar ataxia. …”
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Simple and Fail-safe Method to Transform Miniprep Escherichia coli Strain K12 Plasmid DNA Into Viable Agrobacterium tumefaciens EHA105 Cells for Plant Genetic Transformation by Beenzu Siamalube, Emmanuel Ehinmitan, Maina Ngotho, Justus Onguso, Steven Runo

“…It enables the introduction of foreign DNA into plant genomes. Conventionally, plant genetic transformation has relied on time-consuming, costly, and technically demanding procedures, such as electroporation and chimeric viruses or biolistic methods, which usually yield variable transformation efficiencies. …”
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Extreme Environment Streptomyces: Potential Sources for New Antibacterial and Anticancer Drug Leads? by Periyasamy Sivalingam, Kui Hong, John Pote, Kandasamy Prabakar

“…It is because of technical advances in isolation, fermentation, spectroscopy, and genomic studies which led to the efficient recovering of Streptomyces and their new chemical compounds with distinct activities. …”
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Bioprospecting of a Native Plant Growth-Promoting Bacterium <i>Bacillus cereus</i> B6 for Enhancing Uranium Accumulation by Sudan Grass (<i>Sorghum sudanense</i> (Piper) Stapf) by Longyuan Wu, Lijuan Zhang, Ning Wang, Wei Huang, Yanzhi Wang, Meng Sun, Guofeng Zheng, Wei Wang, Chong Shi

“…The bacterium was identified as Bacillus cereus. Genomic analyses and assessment of uranium tolerance-promoting properties showed that strain B6 not only exhibited high uranium tolerance, but also possessed beneficial properties such as phosphorus solubilization and iron-producing carriers. …”
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Characterization of Microbiota in Endometrial Fluid and Vaginal Secretions in Infertile Women with Repeated Implantation Failure by Kotaro Kitaya, Yoko Nagai, Wataru Arai, Yoshiyuki Sakuraba, Tomomoto Ishikawa

“…On days 6-8 in the luteal phase of the natural, oocyte-pickup, or hormone replacement cycle, the paired EF and VS samples were obtained separately. Extracted genomic DNA was pyrosequenced for the V4 region of 16S ribosomal RNA using a next-generation sequencer. …”
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Identification of Differentially Expressed lncRNAs in a CpG ODN-Activated Macrophage by Ying Zheng, Xi Luo, Zailong Qin, Zhiguang Zhou

“…Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) biological pathway analyses were performed to predict the functions of dysregulated genes. …”
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OMIC Technologies and Vaccine Development: From the Identification of Vulnerable Individuals to the Formulation of Invulnerable Vaccines by Nicola Cotugno, Alessandra Ruggiero, Veronica Santilli, Emma Concetta Manno, Salvatore Rocca, Sonia Zicari, Donato Amodio, Manuela Colucci, Paolo Rossi, Ofer Levy, Federico Martinon-Torres, Andrew J. Pollard, Paolo Palma

“…This review describes innovative and experimental approaches that can help identify specific genomic profiles defining nonresponder individuals for whom specific interventions might be needed. …”
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Characterization and functional analysis of chicken hnRNP protein by Ke Wang, Manzi Huang, Qinghua Zeng, Huansheng Wu

“…In this study, multiple chicken hnRNPs were identified to interact with genomic dsRNA. Initially, these hnRNPs were found to be exclusively localized in the nucleus before IBDV infection. …”
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