Nidoviruses associated with aquatic animals by L. P. Buchatsky, V. V. Makarov

“…Data on the distribution of nidoviruses among aquatic animals in different global aquatic systems are presented, clinical signs of the disease are described, a brief description of nidoviruses and their genomes is given. Nidoviruses of aquatic animals as the earliest members of the animal kingdom are supposed to have played a possible role in the evolution of terrestrial animal nidoviruses. …”
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Synaptosomal Protein of 25 kDa (Snap25) Polymorphisms Associated with Glycemic Parameters in Type 2 Diabetes Patients by Nasser M. Al-Daghri, Andrea S. Costa, Majed S. Alokail, Milena Zanzottera, Amal M. Alenad, Abdul Khader Mohammed, Mario Clerici, Franca R. Guerini

“…A possible role of Snap25 polymorphisms in type 2 diabetes mellitus (T2DM) was evaluated by analyzing three SNPs within intron 1 in a region known to affect the gene expression in vitro. Genomic DNA from 1019 Saudi individuals (489 confirmed T2DM and 530 controls) was genotyped for SNPs rs363039, rs363043, and rs363050 in Snap25 using the TaqMan Genotyping Assay. …”
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Association of PD-1 and PD-L1 Genetic Polymorphyisms with Type 1 Diabetes Susceptibility by Chenyue Qian, Heming Guo, Xiaohong Chen, Aiming Shi, Sicheng Li, Xin Wang, Jie Pan, Chen Fang

“…In total, 166 T1DM patients and 100 healthy controls were enrolled into the study. Genomic DNA was extracted from 4 mL peripheral blood samples collected from each subject. …”
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High Prevalence of Autoimmune Diabetes and Poor Glycaemic Control among Adults in Madagascar: A Brief Report from a Humanitarian Health Campaign in Ambanja by Ernesto Maddaloni, Giovanlorenzo Pastore, Marco Giuseppe Del Buono, Aldostefano Porcari, Mario Fittipaldi, Francesco Garilli, Claudio Tiberti, Silvia Angeletti, Paolo Pozzilli, Giovanni Mottini, Nicola Napoli

“…Madagascar is a geographically isolated country considered a biodiversity hotspot with unique genomics. Both the low-income and the geographical isolation represent risk factors for the development of diabetes. …”
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Molecular markers in the genetic diversity studies of representatives of the genus <i>Rubus</i> L. and prospects of their application in breeding by A. M. Kamnev, O. Yu. Antonova, S. E. Dunaeva, T. A. Gavrilenko, I. G. Chukhina

“…Modern breeding and genetic programs increasingly use the achievements of molecular genetics and genomics. This paper reviews the literature data on the application of molecular markers in fundamental and applied research aimed at studying the genetic diversity of cultivated and wild species of the genus Rubus. …”
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Polymorphism of the <i>Rca2</i> anthracnose resistance gene in strawberry cultivars (<i>Fragaria × ananassa</i>) by A. S. Lyzhin, I. V. Lukyanchuk, E. V. Zhbanova

“…Biological material was represented by strawberry cultivars (Fragaria × ananassa Duch.) of various ecological and geographical origin. Total genomic DNA was extracted from the fresh leaves using the CTAB methods according to Puchooa (2004). …”
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Prenatal Diagnosis of Bilateral Ectrodactyly and Radial Agenesis Associated with Trisomy 10 Mosaicism by Jonathan Lévy, Jean-Marie Jouannic, Julien Saada, Ferdinand Dhombres, Jean-Pierre Siffroi, Marie-France Portnoï

“…They represent a clinically and genetically heterogeneous disorder, with both sporadic and familial cases. Most of the genomic rearrangements identified to date in some forms of SHFM are autosomal dominant traits, involving various chromosome regions. …”
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RatDEGdb: a knowledge base of differentially expressed genes in the rat as a model object in biomedical research by I. V. Chadaeva, S. V. Filonov, K. A. Zolotareva, B. M. Khandaev, N. I. Ershov, N. L. Podkolodnyy, R. V. Kozhemyakina, D. A. Rasskazov, A. G. Bogomolov, E. Yu. Kondratyuk, N. V. Klimova, S. G. Shikhevich, M. A.  Ryazanova, L. A. Fedoseeva, О. Е. Redina, О. S. Kozhevnikova, N. A. Stefanova, N. G. Kolosova, A. L. Markel, M. P. Ponomarenko, Yu. D. Oshchepkov

“…RatDEGdb may be interesting first of all to human geneticists, molecular biologists, clinical physicians, genetic advisors as well as experts in biopharmaceutics, bioinformatics and personalized genomics. RatDEGdb is publicly available at https://www.sysbio.ru/RatDEGdb.…”
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Inovirus-Encoded Peptides Induce Specific Toxicity in <i>Pseudomonas aeruginosa</i> by Juehua Weng, Yunxue Guo, Jiayu Gu, Ran Chen, Xiaoxue Wang

“…However, filamentous prophages (Pfs) commonly found in <i>P. aeruginosa</i> encode genes with phage defense activity, thereby reducing the efficacy of phage therapy. Through a genomic analysis of the Pf4 prophage, we identified a 102 bp gene co-transcribed with the upstream gene responsible for phage release (<i>zot</i> gene), giving rise to a 33-amino-acid polypeptide that we have named Pf4-encoded toxic polypeptide (PftP4). …”
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New insights into the mechanism of triphenyl phosphate and its metabolite diphenyl phosphate in diabetic kidney disease by Ting Fang, Qiaoyan Liu, Xinxin Huangfu, Hongkai Zhu, Hongwen Sun, Liming Chen

“…Additionally, the study explored the targets of action for TPHP and DPHP using network toxicity analysis, conducted protein interaction analysis, and explored the functional aspects of action through Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis. Furthermore, the study identified key proteins involved in the action and conducted experimental verification by treating cells with TPHP and DPHP. …”
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Integrating AI into Cancer Immunotherapy—A Narrative Review of Current Applications and Future Directions by David B. Olawade, Aanuoluwapo Clement David-Olawade, Temitope Adereni, Eghosasere Egbon, Jennifer Teke, Stergios Boussios

“…Results: AI has significantly contributed to identifying biomarkers that predict immunotherapy efficacy by analyzing genomic, transcriptomic, and proteomic data. It also optimizes combination therapies by predicting the most effective treatment protocols. …”
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Characterization of Broad Spectrum Bacteriophage vB ESM-pEJ01 and Its Antimicrobial Efficacy Against Shiga Toxin-Producing <i>Escherichia coli</i> in Green Juice by Eun Jeong Park, Seungki Lee, Jong Beom Na, Ye Bin Kim, Kee Man Lee, Seon Young Park, Ji Hyung Kim

“…Moreover, the phage demonstrated strong anti-biofilm efficacy even at low concentrations. Genomic analysis revealed that the phage was similar to the well-characterized RB49 phage (T4-like phage) but possesses distinct host-specificity-related genes that potentially contribute to its extensive host range. …”
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Genotypic Characterization of Azotobacteria Isolated from Argentinean Soils and Plant-Growth-Promoting Traits of Selected Strains with Prospects for Biofertilizer Production by Esteban Julián Rubio, Marcela Susana Montecchia, Micaela Tosi, Fabricio Darío Cassán, Alejandro Perticari, Olga Susana Correa

“…The genetic diversity among 31 putative Azotobacter isolates obtained from agricultural and non-agricultural soils was assessed using rep-PCR genomic fingerprinting and identified to species level by ARDRA and partial 16S rRNA gene sequence analysis. …”
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Metagenomic Insights into Pigeon Gut Microbiota Characteristics and Antibiotic-Resistant Genes by Wei Dai, Haicong Zhu, Junhong Chen, Hui Chen, Dingzhen Dai, Jian Wu

“…Besides the shared metabolic pathways and biosynthesis of secondary metabolites, biosynthesis of amino acids was the most abundant Kyoto Encyclopedia of Genes and Genomes (KEGG) function in young pigeons, while microbial metabolism in diverse environments was abundant in older pigeons. …”
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The effect of tumour necrosis factor-α (TNF-α) muteins on human neutrophils in vitro by H. Tchorzewski, K. Zeman, J. Kantorski, E. Paleolog, M. Kahan, M. Feldmann, M. Kwinkowski, P. Guga, B. Szymanska, P. Parniewski, A. Wilk, J. Jarosz

“…To verify the suggestion that the receptor binding domain includes the region close to the N-terminus of the TNF-α molecule, four TNF-α derivatives termed muteins were constructed, using a synthetic cDNA fragment substituting the N-terminal 3–7 selected hydrophilic or hydrophobic amino acids in the original TNF-α genomic DNA. Binding of muteins to PMN was assessed using monoclonal antibodies recognizing either the 55 kDa (p55) or the 75 kDa (p75) TNF receptor subtypes. …”
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Genetic advancements in breast cancer treatment: a review by Marzieh Shokoohi, Sadaf Sedaghatshoar, Homaira Arian, Milad Mokarami, Fatemeh Habibi, Fatemeh Bamarinejad

“…Personalized medicine, guided by genomic profiling, further enhances treatment precision by identifying patient-specific mutations, such as BRCA1 and BRCA2, allowing for more tailored and effective interventions. …”
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The Role of Gut Microbiota in Tumor Immunotherapy by Miao Wu, Jiawei Bai, Chengtai Ma, Jie Wei, Xianjin Du

“…With the maturity of genomics and metabolomics technologies, the effect of intestinal microbiota in tumor development and treatment has gradually been recognized. …”
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VCAM-1 Promotes Angiogenesis of Bone Marrow Mesenchymal Stem Cells Derived from Patients with Trauma-Induced Osteonecrosis of the Femoral Head by Regulating the Apelin/CCN2 Pathway by Yiming Shao, Lei Sun, Baodong Ma, Ranran Jin, Yueyao Ban, Ruibo Li, Jianfa Wang, Hongkai Lian, Han Yue

“…Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis revealed that upregulated DEGs were engaged in the Apelin signaling pathway. …”
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A Comprehensive Resource for Exploring Antiphage Defense: DefenseFinder Webservice,Wiki and Databases by Tesson, Florian, Planel, Rémi, Egorov, Artyom A, Georjon, Héloïse, Vaysset, Hugo, Brancotte, Bryan, Néron, Bertrand, Mordret, Ernest, Atkinson, Gemma Catherine, Bernheim, Aude, Cury, Jean

“…To overcome these challenges, we present a hub of resources on defense systems, including: 1) an updated version of DefenseFinder with a web-service search function, 2) a community-curated repository of knowledge on the systems, and 3) precomputed databases, which include annotations done on RefSeq genomes and structure predictions generated by AlphaFold. …”
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Computational identification and experimental validation of novel Saccharum officinarum microRNAs along with their targets through RT-PCR approach by Abdul Baqi, Samiullah, Jadoon Khan, Asma Sadiq, Yousaf Khan, Shahid Ali, Syed Nadeem ul Hassan Mohani, Naqeebullah Khan, Tawaf Ali Shah, Khalid S. Almaary, Youssouf Ali Younous, Mohammed Bourhia

“…This was accomplished by predicting novel conserved miRNAs in sugarcane plants using a variety of genomics-based techniques like BLASTn, MFOLD, psRNA Target, sequence logo, Weblogo, primer-3, etc. and annotated using miRBase and NCBI. …”
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