Challenges in Emerging Vaccines and Future Promising Candidates against SARS-CoV-2 Variants by Tanmay Ghildiyal, Nishant Rai, Janhvi Mishra Rawat, Maargavi Singh, Jigisha Anand, Gaurav Pant, Gaurav Kumar, Amrullah Shidiki

“…The review provides an integrative discussion on the current state of knowledge on the type of vaccines developed against SARS-CoV-2, the safety and efficacy of COVID-19 vaccines concerning the VOCs, and prospects of novel universal, chimeric, and bivalent mRNA vaccines efficacy to fend off existing variants and other emerging coronaviruses. Genomic variation can be quite significant, as seen by the notable differences in impact, transmission rate, morbidity, and death during several human coronavirus outbreaks. …”
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Shallow-water mussels (Mytilus galloprovincialis) adapt to deep-sea environment through transcriptomic and metagenomic insights by Luyang Sun, Xiaolu Liu, Li Zhou, Hao Wang, Chao Lian, Zhaoshan Zhong, Minxiao Wang, Hao Chen, Chaolun Li

“…Abstract Recent studies have unveiled the deep sea as a rich biosphere, populated by species descended from shallow-water ancestors post-mass extinctions. Research on genomic evolution and microbial symbiosis has shed light on how these species thrive in extreme deep-sea conditions. …”
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Molecular Characterization and Expression of <i>unc-13d</i> in the Sex Reversal of <i>Monopterus albus</i> by Zitong Lian, Fang Meng, Xueping Xia, Junchao Fang, Haifeng Tian, Qiaomu Hu

“…</i> We found that the genomic structure of <i>unc-13d</i> was different from other species. …”
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Genetic Analysis of CYP2C9 with Reference to Drug Response in Epilepsy Patients of Pakistan by Hafsa Maqbool, Tayyaba Saleem, Nadeem Sheikh, Aqsa Ashfaq

“…The current study included 337 individuals including 100 control subjects, 110 drug-resistant subjects, and 127 drug responders. Genomic DNA was isolated from blood, and amplification of rs1799853 (430C > T) and rs1057910 was carried out by polymerase chain reaction. …”
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Gender Variations in the Oral Microbiomes of Elderly Patients with Initial Periodontitis by Jie Zhao, Ying-Hui Zhou, Ya-Qiong Zhao, Yao Feng, Fei Yan, Zheng-Rong Gao, Qin Ye, Yun Chen, Qiong Liu, Li Tan, Shao-Hui Zhang, Jing Hu, Marie Aimee Dusenge, Yun-Zhi Feng, Yue Guo

“…Kyoto Encyclopedia of Genes and Genomes analysis showed that predicting changes in the female oral microbiota may be related to the immune system and immune system diseases are the main factor in males. …”
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Case report: Discovery of novel CTNNB1 mutations and comparison of clinical characteristics in two patients with NEDSDV by Eojin Lee, Ja Young Choi, Shin-Seung Yang

“…Both patients shared common NEDSDV features; however, distinct phenotypic variations were observed depending on the type of genomic variant. NGS is crucial for the diagnosis of global developmental delay, particularly when brain magnetic resonance imaging (MRI) results appear normal. …”
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Inkjet-based oligonucleotide synthesis reagents: Formulation optimization and comparison of acetonitrile and propylene carbonate applications by Yu Xiao, Yongjin Peng, Zhen Rong, Xiaoyang He, Fei Sun, Shengqi Wang

“…With the rapid development of synthetic biology and genomic research, the demand for high-throughput DNA synthesis has been steadily increasing. …”
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Obesity increases DNA damage in the breast epithelium by Mohamed Gaber, Arnaud Quentel, Julia Holmes, Cassandra Lepetit, Hana Triki, Adam Wilson, Valerie Payne, Iliana Tenvooren, Cloé Dehours, Abigail Peoples, Mary L. Duet, Adam J. Katz, Thierry Pécot, Gwenola Bougras-Cartron, Pierre-François Cartron, Katherine L. Cook, Pierre-Alexandre Vidi

“…The results highlight a connection between premalignant genomic alterations in the breast epithelium and metabolic health modulated by obesity and ancestry. …”
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Unlocking biological complexity: the role of machine learning in integrative multi-omics by Ravindra Kumar, Rajrani Ruhel, Andre J. van Wijnen

“…Integrative multi-omics approaches use multi-layered datasets such as genomic, transcriptomic, proteomic, and metabolomic data to understand biological processes much more comprehensively compared to the single-omics analysis and to provide a comprehensive view of cellular and molecular processes. …”
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Genetic Evidence of Killer Whale Predation on White Sharks in Australia by Isabella M. M. Reeves, Andrew R. Weeks, Alison V. Towner, Rachael Impey, Jessica J. Fish, Zach S. R. Clark, Paul A. Butcher, Lauren Meyer, David M. Donnelly, Charlie Huveneers, Nicky Hudson, Adam D. Miller

“…Visual inspection of the carcass revealed that the liver, digestive, and reproductive organs were missing, and the presence of four distinctive bite wounds, one of which was characteristic of killer whale liver extraction as seen in South Africa. Genomic analyses performed on swabs taken from the bite wounds confirmed the presence of killer whale DNA in the major bite area, while the other bites were embedded with genetic material from the scavenging broadnose sevengill shark (Notorynchus cepedianus). …”
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Identification of the Key Genes and Pathways in Esophageal Carcinoma by Peng Su, Shiwang Wen, Yuefeng Zhang, Yong Li, Yanzhao Xu, Yonggang Zhu, Huilai Lv, Fan Zhang, Mingbo Wang, Ziqiang Tian

“…Gene Ontology (GO) enrichment, Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment, and protein-protein interaction (PPI) network construction were performed to obtain the biological roles of DEGs in EC. …”
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Stage-specific expression and divergent functions of two insulinase-like proteases associated with host infectivity in Cryptosporidium. by Yue Huang, Shifeng Pei, Xin Lv, Fuxian Yang, Xiaoqing Gong, Na Li, Yaqiong Guo, Yaoyu Feng, Lihua Xiao

“…Results from recent comparative genomic studies suggest that gains and losses of multicopy subtelomeric genes encoding insulinase-like proteases (INS-19 and INS-20 in Cryptosporidium parvum and their orthologs in closely related species) may potentially contribute to these differences.…”
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Development of a Loop Mediated Isothermal Amplification for Diagnosis of Ascaris lumbricoides in Fecal Samples by Esther A. Shiraho, Agola L. Eric, Ibrahim N. Mwangi, Geoffrey M. Maina, Joseph M. Kinuthia, Martin W. Mutuku, Robert M. Mugambi, Jackson M. Mwandi, Gerald M. Mkoji

“…Ascaris adult and ova were obtained from naturally infected school children, whose parents/guardians gave consent for their participation in the study. Genomic DNA was extracted using alkaline lysis method and amplified by LAMP at 63°C for 45 minutes. …”
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Enhancing the Therapeutic Potential of Peptide Antibiotics Using Bacteriophage Mimicry Strategies by Hongping Wan, Xinyi Zhong, Shinong Yang, Jiarong Deng, Xu Song, Yong Liu, Yuanfeng Li, Zhongqiong Yin, Xinghong Zhao

“…Here, nanodelivery systems have been developed by mimicking the mechanisms bacteriophages use to deliver their genomes to host bacteria. These systems utilize bacteriophage receptor‐binding proteins conjugated to loading modules, enabling efficient targeting of bacterial pathogens. …”
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Etiopathogenesis of Sheehan’s Syndrome: Roles of Coagulation Factors and TNF-Alpha by Halit Diri, Elif Funda Sener, Fahri Bayram, Nazife Tascioglu, Yasin Simsek, Munis Dundar

“…Standard methods were used to extract the genomic DNAs. Factor II (G20210A), Factor V (G1691A), and MTHFR (C677T and A1298C) polymorphisms were identified by real-time PCR. …”
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Establishment of Novel Limbus-Derived, Highly Proliferative ABCG2+/ABCB5+ Limbal Epithelial Stem Cell Cultures by Eung Kweon Kim, Ga-Hyun Lee, Boram Lee, Yong-Sun Maeng

“…In addition, cultured LESCs expressed high levels of the stem cell markers Sox2, Oct4, c-Myc, and Klf4, had high telomerase activity, and had stable, normal genomes. These results suggest that our novel cultivation protocol affects the phenotype and differentiation capacity of LESCs. …”
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Identification of Microbial and Proteomic Biomarkers in Early Childhood Caries by Thomas C. Hart, Patricia M. Corby, Milos Hauskrecht, Ok Hee Ryu, Richard Pelikan, Michal Valko, Maria B. Oliveira, Gerald T. Hoehn, Walter A. Bretz

“…The purpose of this study was to provide a univariate and multivariate analysis of genomic microbial data and salivary mass-spectrometry proteomic profiles for dental caries outcomes. …”
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Genetic analysis of pathways regulated by the von Hippel-Lindau tumor suppressor in Caenorhabditis elegans. by Tammie Bishop, Kah Weng Lau, Andrew C R Epstein, Stuart K Kim, Min Jiang, Delia O'Rourke, Christopher W Pugh, Jonathan M Gleadle, Martin S Taylor, Jonathan Hodgkin, Peter J Ratcliffe

“…However, persisting differential gene expression in hif-1 versus hif-1; vhl-1 double mutant worms clearly distinguished HIF-1-independent effects of VHL-1 inactivation. Genomic clustering, predicted functional similarities, and a common pattern of dysregulation in both vhl-1 worms and a set of mutants (dpy-18, let-268, gon-1, mig-17, and unc-6), with different defects in extracellular matrix formation, suggest that dysregulation of these genes reflects a discrete HIF-1-independent function of VHL-1 that is connected with extracellular matrix function.…”
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Latest Approved Therapies for Metastatic Melanoma: What Comes Next? by Farid Menaa

“…Eventually, multidisciplinary approaches are still requested (e.g., genomics for personalized medicine, nanomedicine to overcome low free-drug bioavailability and targeting, systematic search of “melanoma stem cells” to enhance the prognosis and develop more valuable theranostics). …”
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Rule-Based Knowledge Acquisition Method for Promoter Prediction in Human and Drosophila Species by Wen-Lin Huang, Chun-Wei Tung, Chyn Liaw, Hui-Ling Huang, Shinn-Ying Ho

“…The rapid and reliable identification of promoter regions is important when the number of genomes to be sequenced is increasing very speedily. …”
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