Reverse-engineering the FLT3-PI3K/AKT axis to enhance TILs function and improve prognosis in ovarian and cervical cancers by Feng Hao, Zhang Yan, Luo Shen, Wang Hui, Qiu Ling, Yang Xiaoyu, Jiang Hua

“…FLT3 expression was mapped with spatial data from 10 × Genomics. Results FLT3, identified as a regulator through the PI3K/AKT pathway, showed positive correlations with T cells, NK cells, and B cells. …”
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Penicillium psychrofluorescens sp. nov., a naturally autofluorescent Antarctic fungus by Alinta Furnell, Nicole Benaud, Xabier Vázquez-Campos, Edward C.Y. Liew, Allison Mertin, Jordan A. Vink, Kate Montgomery, Marc R. Wilkins, Brett A. Summerell, Belinda C. Ferrari

“…Penicillium psychrofluorescens is named for its intense autofluorescence derived from a combination of compounds that may include NADPH, porphyrins, and secondary metabolites, such as polyketides. Comparative genomics with both Antarctic and mesophilic Penicillium spp. shows that Penicillium psychrofluorescens has a wide repertoire of glycoside hydrolases, but almost no polysaccharide lyases, has comparably large effector proteins, lacks the machinery to use nitrate as an N-source, but has the genes for the assimilation of phosphorus from phosphonates via oxidative pathway. …”
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Molecular and pharmacological heterogeneity of ETV6::RUNX1 acute lymphoblastic leukemia by Zhenhua Li, Huanbin Zhao, Wenjian Yang, Maud Maillard, Satoshi Yoshimura, Yu-Chih Hsiao, Xin Huang, Yoshihiro Gocho, Lauren Rowland, Anthony Brown, Landon Choi, Kristine R. Crews, Charles G. Mullighan, Samuel W. Brady, Cheng Cheng, Ti-Cheng Chang, Gang Wu, Mignon L. Loh, Allen Eng Juh Yeoh, Federico Antillon-Klussmann, Sima Jeha, Hiroto Inaba, Jiyang Yu, Ching-Hon Pui, Seth E. Karol, William E. Evans, Jun J. Yang

“…Abstract ETV6::RUNX1 is the most common fusion gene in childhood acute lymphoblastic leukemia (ALL) associated with favorable prognosis, but the optimal therapy for this subtype remains unclear. Profiling the genomic and pharmacological landscape of 194 pediatric ETV6::RUNX1 ALL cases, we uncover two transcriptomic clusters, C1 (61%) and C2 (39%). …”
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A COMPREHENSIVE REVIEW ON-APPLICATION AND FUTURE PROSPECT OF CYTOPLASMIC MALE STERILITY by Sujan Chapagain

“…Cytoplasmic male sterility (CMS) is a plant’s inability to reproduce fertile pollen due to nuclear and mitochondrial genomic incompatibility. In CMS plants, pollen production is disrupted, but this can be restored by nuclear fertility (Rf) genes, while the function of the female organ is typically unaffected. …”
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Molecular Identification of Fasciola Isolated from the Liver of Meat Animals in Fars Province, Iran by Aminallah Saadatnia, Kavous Solhjoo, Mohamad Hasan Davami, Saber Raeghi, Ahmad Abolghazi

“…Sixty Fasciola spp. samples were collected from infected slaughtered animals in three counties of Fars province, Iran (Jahrom, Nourabad Mamasani, and Kazeroun).Genomic DNA was extracted by the conventional phenol-chloroform method. …”
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Incontinentia Pigmenti Misdiagnosed as Neonatal Herpes Simplex Virus Infection by Fahimeh Abdollahimajd, Minoo Fallahi, Mohammad Kazemian, Yalda Nilipour, Mitra Radfar, Sedigheh Tahereh Tehranchi

“…Occasionally, typical IP may occur in boys due to Klinefelter syndrome or a genomic mosaicism. Skin lesions are observed in 4 stages: blistering, verrucous linear plaques, swirling macular hyperpigmentation, followed by linear hypopigmentation that develop during adolescence and early adulthood. …”
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A Toolbox for Predicting G-Quadruplex Formation and Stability by Han Min Wong, Oliver Stegle, Simon Rodgers, Julian Leon Huppert

“…At its core, this site has a detailed database (QuadDB) of predicted G-quadruplexes in the human and other genomes, together with the predictive algorithm used to identify them. …”
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Novel Genes Potentially Involved in Fibroblasts of Diabetic Wound by Weirong Zhu, Qin Fang, Zhao Liu, Qiming Chen

“…Furthermore, the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways involved in type 2 diabetes were retrieved from miRWalk. …”
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Three Siblings with Prader-Willi Syndrome: Brief Review of Sleep and Prader-Willi Syndrome by Arina Bingeliene, Colin M. Shapiro, Sharon A. Chung

“…PWS is the first human disorder to be attributed to genomic imprinting. Prevalence varies in the literature, ranging from 1 in 8,000 in the Swedish population to 1 in 54,000 in the United Kingdom. …”
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Antimicrobial Potential of Secalonic Acids from Arctic-Derived <i>Penicillium chrysogenum</i> INA 01369 by Yulia A. Roshka, Natalia N. Markelova, Sofia D. Mashkova, Kseniya V. Malysheva, Marina L. Georgieva, Igor B. Levshin, Vladimir I. Polshakov, Alexander M. Arutyunian, Alexey S. Vasilchenko, Vera S. Sadykova

“…The antimicrobial activity of secalonic acids D and F has been evaluated against a diverse range of microorganisms, including Gram-positive multidrug-resistant <i>Staphylococcus aureus</i>, Gram-negative <i>Escherichia coli</i> ATCC 25922, <i>Pseudomonas aeruginosa</i> ATCC 27853, the phytopathogen <i>Pectobacterium carotovorum</i> VKM-B1247, and the fungi <i>Fusarium oxysporum</i> VKPM F 890, <i>Aspergillus fumigatus</i> VKM F-37, and <i>A. niger</i> ATCC 16404. Genomic and chemical analyses further support <i>P. chrysogenum</i> INA 13460 as a promising natural source for antimicrobial drug discovery and biological control applications.…”
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Human microbiomes in cancer development and therapy by Chenglai Xia, Jiyan Su, Can Liu, Zhikai Mai, Shuanghong Yin, Chuansheng Yang, Liwu Fu

“…Abstract Colonies formed by bacteria, archaea, fungi, and viral groups and their genomes, metabolites, and expressed proteins constitute complex human microbiomes. …”
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Induced Pluripotent Stem Cells in Cardiovascular Medicine by Toru Egashira, Shinsuke Yuasa, Keiichi Fukuda

“…Human iPS cells are currently generated by transgene introduction principally through viral vectors, which integrate into host genomes, although the associated risk of tumorigenesis is driving research into nonintegration methods. …”
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Detection of Chromosome X;18 Breakpoints and Translocation of the Xq22.3;18q23 Regions Resulting in Variable Fertility Phenotypes by Attila Szvetko, Nicole Martin, Chris Joy, Andrea Hayward, Bob Watson, Andrew Cary, Stephen Withers

“…Maternal inheritance and various genomic events contributed to the resultant genotypes. …”
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The association of codon 392 polymorphism in ESR2 gene with breast cancer in Iran by Sakineh Abbasi, Samira Kalbasi

“…Epidemiological studies revealed that the pattern of age onset of breast cancer in the Middle East region differ from those in Caucasians. Therefore, genomic data for ESR2 (ER-?) is of the value in the clinical setting for that ethnic group and the aim of the current investigation is investigated whether polymorphisms in the ER-? …”
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MftG is crucial for ethanol metabolism of mycobacteria by linking mycofactocin oxidation to respiration by Ana Patrícia Graça, Vadim Nikitushkin, Mark Ellerhorst, Cláudia Vilhena, Tilman E Klassert, Andreas Starick, Malte Siemers, Walid K Al-Jammal, Ivan Vilotijevic, Hortense Slevogt, Kai Papenfort, Gerald Lackner

“…Here, we show that MftG enzymes are almost exclusively found in genomes containing mycofactocin biosynthetic genes and are present in 75% of organisms harboring these genes. …”
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Gastric Cancer in Young Adults: A Different Clinical Entity from Carcinogenesis to Prognosis by Jian Li

“…According to molecular classifications, the cancer of most GCYA patients belongs to the genomically stable or microsatellite stable/epithelial-mesenchymal transition subtype, with the common genetic aberrations being mutations in CDH1. …”
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Global evolution of research on autohydrolysis (hydrothermal) pretreatment as a green technology for biorefineries: A bibliometric analysis by Yuxin Yu, Wenhui Pei, Xiaoxue Zhao, Aldo Joao Cárdenas-Oscanoa, Caoxing Huang

“…Concurrently, the domain of hydrothermal pretreatment has progressively become more cross-disciplinary, intertwining with the sectors of microbial populations and genomes.…”
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STUDY OF Bacillus licheniformis BACTERIA AS A BIO-CONTROL AGENT IN REDUCING AFLATOXIN B1 TOXICITY IN DRIED GRAPE SAMPLES by H. Z. Hussein, E. K. Abdul-Karim, M. I. Alghannoum

“…The isolate with the highest toxin production was identified through nucleotide sequences deposited in the World Genomic Organization's Gene Bank under accession number OR192858. …”
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Amino Acid-Mediated Metabolism: A New Power to Influence Properties of Stem Cells by Jilan Liu, Xianyun Qin, Dongfeng Pan, Bin Zhang, Feng Jin

“…This review summarizes the metabolic characteristics and regulation pathways of AA in different stem cells, not only from the nutritional perspective but also from the genomic perspective that have been reported in the recent five years. …”
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Advances in PIWI-piRNA function in female reproduction in mammals by Lv Xiaolong, Zhang Hongdao, Wu Ligang

“…PIWI-interacting RNAs (piRNAs), which associate with PIWI clade Argonaute proteins to form piRNA-induced <sc>silencing</sc> complexes (piRISCs) in germline cells, are responsible for maintaining genomic integrity and reproductive function through transcriptional or post-transcriptional suppression of transposable elements and regulation of protein-coding genes. …”
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