The spatial landscape of cancer hallmarks reveals patterns of tumor ecological dynamics and drug sensitivity by Mustafa Sibai, Sergi Cervilla, Daniela Grases, Eva Musulen, Rossana Lazcano, Chia-Kuei Mo, Veronica Davalos, Arola Fortian, Adrià Bernat, Margarita Romeo, Collin Tokheim, Jordi Barretina, Alexander J. Lazar, Li Ding, Enrique Grande, Francisco X. Real, Manel Esteller, Matthew H. Bailey, Eduard Porta-Pardo, Enrique Grande, Teresa Alonso-Gordoa, Mario Álvarez-Maestro, Elena Andrada, Ainara Azueta, Raquel Benítez Javier Burgos, Daniel Castellano, M. Angel Climent, Mario Domínguez, Ignacio Durán Albert Font, Isabel Galante, Patricia Galván, Juan F. García, Xavier García del Muro, Félix Guerrero-Ramos, Núria Malats, Miriam Marqués, Pablo Maroto, Jaime Martínez de Villarreal, Ane Moreno-Oya, Jesús M. Paramio, Alvaro Pinto, Aleix Prat, Javier Puente, Oscar Reig, Francisco X. Real

“…Additionally, we discover that genomic distance between tumor subclones correlates with differences in hallmark activity, even leading to clone-hallmark specialization. …”
Get full text

Palaeogenetic study of human migrations around the Caspian Sea during protohistory by Perle Guarino-Vignon

“…Our analyses based on modern and ancient DNA genomic data show that the present-day Indo-Iranian-speaking populations, the Tajiks and the Yaghnobis, display a strong genetic continuity with the Iron Age populations of southern Central Asia. …”
Get full text

Molecular characterization of the TUBG1 meshwork's influence on Cytoskeletal organization by Darina Malycheva, Maria Alvarado-Kristensson

“…The γ-tubulin (TUBG) meshwork is a central regulator of cellular architecture, orchestrating processes such as microtubule nucleation, mitochondrial organization, and genomic integrity. This study investigates the molecular impact of TUBG depletion on the cytoskeleton. …”
Get full text

State of the art and new directions using DNA and other molecular markers in forensic entomology by David Haymer

“…Beginning with the use of single mitochondrial genes, the range of DNA-based markers available to forensic entomologists has grown to include a wide variety of individual mitochondrial and nuclear genes, and has further expanded to include the analysis of whole genomes and transcriptomes. The use of these new sets of markers has significantly enhanced the ability of forensic entomologists to identify insects associated with human cadavers and to provide improved estimates of the time elapsed since death, commonly referred to as the postmortem interval (PMI), along with other valuable information for crime scene investigations. …”
Get full text

Differential diagnosis of fasciola hepatica from different animal hosts by pcr by Osman Selcuk Aldemir, Mederle Narcisa

“…These parasites were washed several times with pH:7.4 phosphate-buffered saline and phenol extraction/ ethanol precipitation method was employed in genomic DNA extraction. In order to optimization of the PCR conditions, five primers were selected to amplify the DNA of each F. hepatica.…”
Get full text

Pitfalls in Genetic Testing for Consanguineous Pediatric Populations by Maha Saleh, Samantha Colaiacovo, Melanie P. Napier, Asuri N. Prasad, C. Anthony Rupar, Chitra Prasad

“…Our case further supports the recent American College of Medical Genetics and Genomics (ACMG) recommendation of WES as a first or second-tier test for patients with developmental delay, particularly in a population where the chances of dual diagnosis is high.…”
Get full text

Specialized Bacteroidetes dominate the Arctic Ocean during marine spring blooms by Álvaro Redondo-Río, Christopher J. Mundy, Javier Tamames, Carlos Pedrós-Alió

“…These proteins were used to identify polysaccharide-utilization loci that clustered transporters and polysaccharide-active enzymes, showing a higher level of specialization toward polysaccharide use. Altogether, these genomic features point to the genetic adaptations that promote the dominance of Bacteroidetes during phytoplankton blooms.…”
Get full text

Sex and neo-sex chromosome evolution in beetles. by Ryan Bracewell, Anita Tran, Kamalakar Chatla, Doris Bachtrog

“…We generated a whole-chromosome assembly of Tribolium confusum, which has a neo-sex chromosome, and utilize eleven additional beetle genomes to reconstruct karyotype evolution across Coleoptera. …”
Get full text

Lake salinization on the Qinghai–Tibetan Plateau alters viral community composition and lifestyles by Yuan-Guo Xie, Yan-Ling Qi, Zhen-Hao Luo, Yan-Ni Qu, Jian Yang, Shi-Qiang Liu, Hai-long Yang, Dan-Wei Xie, Zimeng Wang, Hong-Chen Jiang, Zheng-Shuang Hua

“…These shifts are mirrored in the prokaryotic communities, with Alphaproteobacteria and their infecting temperate viruses, notably Casadabanvirus, becoming more prevalent in higher salinity zones. Viral genomes encode genes associated with osmotic stress adaptation, DNA recombination, and nutrient transport, which may facilitate host adaptation to saline stress. …”
Get full text

Machine learning and multi-omics in precision medicine for ME/CFS by Katherine Huang, Brett A. Lidbury, Natalie Thomas, Paul R. Gooley, Christopher W. Armstrong

“…In this review, we explore how machine learning and multi-omics (genomics, transcriptomics, proteomics, and metabolomics) can transform precision medicine in ME/CFS research and healthcare. …”
Get full text

Screen of propionate-producing probiotic strains in attenuating murine colitis by modulating immune response and restoring the intestinal barrier by Ting Shu, Xizi Song, Silu Zhang, Xiaoli Zhou, Zhizhu Zhang, Pengfei Wang, Hu Canying, Jie Pan, Xiaoshuang Dai, Yan Tan, Wu Xiyang, Huicui Meng, Guoxun Xiao, Huaijie Hao

“…Probiotics produce propionate, a short-chain fatty acid that restores intestinal balance and reduces inflammation.Comparative genomic analysis of propionate pathway integrity was performed to nominate 41 candidate strains. …”
Get full text

Decoding the mechanisms behind second primary cancers by Meiyuan Zeng, Anqi Lin, Aimin Jiang, Zhengang Qiu, Hongman Zhang, Shifu Chen, Mingyan Xu, Zaoqu Liu, Quan Cheng, Jian Zhang, Peng Luo

“…This review summarizes recent studies on the mechanisms of SPCs, including the roles of genomic changes after first primary cancer (FPC) treatments, stromal cell phenotypic and metabolic changes, hormone levels and receptor expression, immunosuppression, aberrant gene methylation, EGFR signaling, and cell-free DNA in SPC development. …”
Get full text

How the Knowledge of Interactions between Meningococcus and the Human Immune System Has Been Used to Prepare Effective Neisseria meningitidis Vaccines by R. Gasparini, D. Panatto, N. L. Bragazzi, P. L. Lai, A. Bechini, M. Levi, P. Durando, D. Amicizia

“…In the last decades, tremendous advancement in dissecting the mechanisms of pathogenicity of Neisseria meningitidis at a molecular level has been achieved, exploiting converging approaches of different disciplines, ranging from pathology to microbiology, immunology, and omics sciences (such as genomics and proteomics). Here, we review the molecular biology of the infectious agent and, in particular, its interactions with the immune system, focusing on both the innate and the adaptive responses. …”
Get full text

The glucose-sensing transcription factor MLX balances metabolism and stress to suppress apoptosis and maintain spermatogenesis. by Patrick A Carroll, Brian W Freie, Pei Feng Cheng, Sivakanthan Kasinathan, Haiwei Gu, Theresa Hedrich, James A Dowdle, Vivek Venkataramani, Vijay Ramani, Xiaoying Wu, Daniel Raftery, Jay Shendure, Donald E Ayer, Charles H Muller, Robert N Eisenman

“…This is concomitant with dysregulation of the expression of male-specific GC transcripts and proteins. Our genomic and functional analyses identify loci directly bound by MLX involved in these processes, including metabolic targets, obligate components of male-specific GC development, and apoptotic effectors. …”
Get full text

Classifications of triple-negative breast cancer: insights and current therapeutic approaches by Ziqi Chen, Yumeng Liu, Minchuan Lyu, Chi Ho Chan, Meiheng Sun, Xin Yang, Shuangying Qiao, Zheng Chen, Sifan Yu, Meishen Ren, Aiping Lu, Ge Zhang, Fangfei Li, Yuanyuan Yu

“…Additionally, TNBC exhibits significant heterogeneity at histopathological, proteomic, transcriptomic, and genomic levels, further complicating the development of effective treatments. …”
Get full text

High Prevalence of Candida Yeast in Milk Samples from Cows Suffering from Mastitis in Poland by Bozena Dworecka-Kaszak, Alicja Krutkiewicz, Daniel Szopa, Miroslaw Kleczkowski, Malgorzata Biegańska

“…Seven different species classified as Candida were identified basing on phenotypic properties, and the dominating species was C. parapsilosis. Genomic DNA was isolated and amplified in PCR with ITS1 and NL2 primers. …”
Get full text

Metabonomics Research Progress on Liver Diseases by Mengqian Yu, Ying Zhu, Qingwei Cong, Chunyan Wu

“…Metabolomics as the new omics technique develops after genomics, transcriptomics, and proteomics and has rapid development at present. …”
Get full text

Modelling the Effect of SPION Size in a Stent Assisted Magnetic Drug Targeting System with Interparticle Interactions by Adil Mardinoglu, P. J. Cregg

“…Cancer is a leading cause of death worldwide and it is caused by the interaction of genomic, environmental, and lifestyle factors. Although chemotherapy is one way of treating cancers, it also damages healthy cells and may cause severe side effects. …”
Get full text

Species-Specific Gene, spt5, in the Qualitative and Quantitative Detection of Boletus reticulatus by Zhan Lei, Chen Zhang, Yinjiao Li, Lunzhao Yi, Ying Shang

“…Meanwhile, SYBR Green I based quantitative PCR results were highly sensitive, and the limit of detection was 0.04 ng of genomic DNA. These experiments illustrated that spt5 is an ideal species-specific gene for the quantitative and qualitative detection of B. reticulatus. …”
Get full text

Primary Ovarian Choriocarcinoma: Rare Entity by Mequanent Tariku Adow, Shimelis Fantu Gebresilasie, Natnael Alemayehu Abebe

“…In patients with adnexal mass presenting with nonspecific symptoms especially with high Doppler blood flow of the mass on ultrasound evaluation, serum beta-human chorionic gonadotropin determination is recommended before laparotomy. In setups where the genomic test is not available, histological and clinical effort to differentiate gestational versus nongestational choriocarcinoma is useful for specific management decision.…”
Get full text