Human Genetics of Diabetic Retinopathy: Current Perspectives by Daniel P. K. Ng

“…Harnessing new genetic technologies and resources such as the upcoming 1000 Genomes Project will help advance this field of research, and potentially lead to a rich harvest of insights into the biological mechanisms underlying this debilitating complication.…”
Get full text

Analysis of the Thymidylate Synthase Gene Structure in Colorectal Cancer Patients and Its Possible Relation with the 5-Fluorouracil Drug Response by A. Calascibetta, Flavia Contino, S. Feo, G. Gulotta, M. Cajozzo, A. Antona, G. Sanguedolce, R. Sanguedolce

“…In the future we intend to widen the TS structure analysis to the metastatic CRCs, because due to their higher genomic instability, they could present a TS variant form responsible of the fluoropyrimidines drug resistance and the worse prognosis.…”
Get full text

THE HETEROPLASMIC AND HOMOPLASMIC STATES OF MITOCHONDRIAL AND CHLOROPLAST DNA REGIONS IN THE PROGENIES OF WIDE HYBRIDS OF COMMON WHEAT OF DIFFERENT ORIGINS by N. V. Trubacheeva, L. A. Kravtsova, E. P. Devyatkina, T. T. Efremova, M. G. Sinyavskaya, V. K. Shumny, L. A. Pershina

“…It has been found that the transition of mt- and cpDNA heteroplasmy, barley homoplasmy of chloroplast regions to wheat homoplasmy is associated with complete fertility restoration and barley chromosome elimination from the newly developed nuclear genomes of alloplasmic lines.…”
Get full text

Unraveling the Effect of Immunogenicity on the PK/PD, Efficacy, and Safety of Therapeutic Proteins by Alison Smith, Hugh Manoli, Stacey Jaw, Kimberley Frutoz, Alan L. Epstein, Leslie A. Khawli, Frank-Peter Theil

“…Biologics have emerged as a powerful and diverse class of molecular and cell-based therapies that are capable of replacing enzymes, editing genomes, targeting tumors, and more. As this complex array of tools arises a distinct set of challenges is rarely encountered in the development of small molecule therapies. …”
Get full text

Discovery of Evolutionary Loss of the Ubiquitin-like Autophagy-Related ATG12 System in a Lineage of Apicomplexa by Xiaoxia X. Lin, Yun D. Bai, Sichang T. Wang, Akira Nozawa, Tatsuya Sawasaki, Tatsunori Masatani, Kenji Hikosaka, Masahito Asada, Hirokazu Sakamoto

“…Here, we show that all genes associated with the ATG12 system are absent in piroplasmida, a lineage within Apicomplexa. Comparative genomics of ATGs further shows that piroplasm ATG3 has lost the region necessary for ATG12 binding. …”
Get full text

Computational Methods to Work as First-Pass Filter in Deleterious SNP Analysis of Alkaptonuria by R. Magesh, C. George Priya Doss

“…Discovering these functional SNPs is one of the main goals of modern genetics and genomics studies. There is a need to effectively and efficiently identify functionally important nsSNPs which may be deleterious or disease causing and to identify their molecular effects. …”
Get full text

INTERNALIZATION OF EXOGENOUS DNA INTO INTERIOR COMPARTMENTS OF MURINE BONE MARROW CELLS by E. V. Dolgova, V. P. Nicolin, N. A. Popova, A. S. Proskurina, K. E. Orishchenko, E. A. Alyamkina, Y. R. Efremov, E. R. Chernykh, A. A. Ostanin, E. M. Malkova, O. S. Taranov, V. A. Rogachev, S. V. Sidorov, S. S. Bogachev, M. A. Shurdov

“…Moreover, fragments localizedin BMCnuclei are suggestedto integrate into chromosome(s) ofrecipient mouse genomes when treatedwithCP andexogenous DNA.…”
Get full text

Alaninaminotransferase and specific viral hepatitis markers in the blood of donors by Zh. K. Burkitbayev, G. A. Yesenbayeva, S. A. Abdrakhmanova, Zh. Zh. Bibekov, Ye. B. Zhiburt

“…No relation of ALT activity to results of parenteral virus genomes screen was revealed.…”
Get full text

Proposals for consideration at IMC12 to modify provisions related solely to fungi in Chapter F of the International Code of Nomenclature for algae, fungi, and plants by Tom W. May, David L. Hawksworth

“…The topics addressed relate to: fungi whose morph-names have the same epithet; the listing of synonyms under entries for protected names in the Code Appendices; the processes of protection and rejection; the use of DNA sequences as nomenclatural types; the use of genomes as nomenclatural types; and the designation of fungi known only from DNA sequences. …”
Get full text

Modern Genetic Education: How Does It Meet Students’ Requests? by T. A. Sedykh, L. A. Amirova, L. A. Gaysina, G. F. Galikeeva, A. I. Fazlutdinova, N. V. Sukhanova

“…It was found that despite the satisfaction of the majority of the surveyed students with the quality of genetic education, there are problems in understanding modern sections of genetics, such as molecular genetics, toxicological genetics, genomics. The students are not sufficiently involved in scientific research, most of them prefer the traditional forms of teaching and learning, only few of them are aware of modern online resources and MOOCs. …”
Get full text

Two Cases of γ-Heavy Chain Disease and a Review of the Literature by I. Ramasamy, Z. Rudzki

“…Studies on the clonal evolution of the disease may provide insight into therapeutic implications and the genomic complexity of the disease.…”
Get full text

Ultrasound Radiogenomics-based Prediction Models for Gene Mutation Status in Breast Cancer by Zhai Yue, Tan Dianhuan, Lin Xiaona, Lv Heng, Chen Yan, Li Yongbin, Luo Haiyu, Dan Qing, Zhao Chenyang, Xiang Hongjin, Zheng Tingting, Sun Desheng

“…Ultrasound radiogenomics, an emerging field at the intersection of radiology and genomics, employs high-throughput methods to convert radiological images into high-dimensional data, which are then processed to extract and analyze radiomic features. …”
Get full text

Cytogenomic Characterization of Giant Ring or Rod Marker Chromosome in Four Cases of Well-Differentiated and Dedifferentiated Liposarcoma by Hongyan Chai, Fang Xu, Autumn DiAdamo, Brittany Grommisch, Huanzhi Mao, Peining Li

“…Chromosome and array comparative genomic hybridization (aCGH) analyses were performed on two cases of well-differentiated liposarcoma (WDLPS) and two cases of dedifferentiated liposarcoma (DDLPS). …”
Get full text

Understanding cancer predisposition in Singapore: what’s next by Jianbang Chiang, Tarryn Shaw, Joanne Ngeow

“…All stakeholders in healthcare should be empowered with genetic knowledge to fully leverage the potential of novel genomic insights and implement them to provide better care for our patients.…”
Get full text

Role of New Biomarkers: Functional and Structural Damage by Evdoxia Tsigou, Vasiliki Psallida, Christos Demponeras, Eleni Boutzouka, George Baltopoulos

“…Innovative technologies such as genomics and proteomics have contributed to the discovery of new biomarkers, such as neutrophil gelatinase-associated lipocalin (NGAL), cystatin C (Cys C), kidney injury molecule-1 (KIM-1), interleukin-18 (IL-18), and liver-type fatty acid binding protein (L-FABP). …”
Get full text

Algebraic and topological indices of molecular pathway networks in human cancers by Peter Hinow, Edward A. Rietman, Sara Ibrahim Omar, Jack A. Tuszyński

“…Protein-protein interaction networks associated with diseases have gained prominence as an area of research.We investigate algebraic and topological indices for protein-protein interaction networks of 11 human cancers derived from the Kyoto Encyclopedia of Genes and Genomes (KEGG) database. We find a strong correlationbetween relative automorphism group sizes and topological network complexities on the one hand and five year survival probabilities on the other hand. …”
Get full text

Emergence of Fusarium incarnatum and Fusarium avenaceum in wilt affected solanaceous crops of the Northern Himalayas by Tasmeen J. Parihar, Madeeha Naik, Shafqat Mehraj, Syed Inam ul Haq, Maqsooda Perveen, Ishfaq Ahmed Malla, Taniya Abid, Nadia Gul, Khalid Z. Masoodi

“…Through both morphological and molecular analyses, including DNA barcoding of the ITS, TEF, RPB1, and RPB2 genomic regions, Fusarium incarnatum and Fusarium avenaceum were identified as the primary causal agents of wilt in tomato and brinjal, and chili, respectively. …”
Get full text

The Role of Plant DNA Methylation in Development, Stress Response, and Crop Breeding by Shuai Qiao, Wei Song, Wentao Hu, Fang Wang, Anzhong Liao, Wenfang Tan, Songtao Yang

“…DNA methylation, an evolutionarily conserved epigenetic mechanism, is crucial for controlling gene activity and ensuring genomic integrity. Altered methylation patterns can profoundly affect plant development, often resulting in atypical phenotypes. …”
Get full text

The treasure trove of yeast genera and species described by Johannes van der Walt (1925-2011) by Maudy Th. Smith, Marizeth Groenewald

“…This pioneering work led to the discovery of many new genera and species, which were deposited in the Centraalbureau voor Schimmelcultures (CBS) collections for future studies in taxonomy, genomics, and industrial uses. These treasures collected during more than 60 years provide an outstanding legacy to the yeast community and will continue to exist in his absence. …”
Get full text

Analysis on the Susceptibility Genes in Two Chinese Pedigrees with Familial Parkinson's Disease by Changshui Xu, Jun Xu, Yanmin Zhang, Jianjun Ma, Hideshi Kawakami, Hirofumi Maruyama, Masaki Kamada

“…To screen the susceptibility genes in Chinese pedigrees with early-onset familial Parkinson's disease (FPD). Methods. Fifty-one genomic DNA samples extracted from two Chinese pedigrees with FPD, the alpha-synuclein genes (SNCA), the leucine-rich repeat kinase 2(LRRK2), PINK1(PTEN-induced putative kinase 1), PARK7(Protein DJ1), PARK2(Parkinson juvenile disease protein 2), the glucocerebrosidase (GBA), and ATP(Ezrin-binding protein PACE-1), were sequenced by the use of polymerase chain reaction (PCR) technique. …”
Get full text