THE NUMBER OF HOMOLOGS OF SOME ENZYMES IN THE TRYPTOPHAN BIOSYNTHESIS PATHWAY CORRELATES WITH THE PROPORTION OF PROTEINS ASSOCIATED WITH TRANSCRIPTION IN PLANTS by I. I. Turnaev, I. R. Akberdin, V. V. Suslov, D. A. Afonnikov

“…We identified TBP enzyme paralogs in plant species with fully sequenced genomes and estimated the relationship between its number and organismal complexity. …”
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First Trimester Diagnosis of Holoprosencephaly Secondary to a Ring Chromosome 7 by Lindsay B. Henderson, Virginia L. Corson, Daniel O. Saul, Cynthia Anderson, Sarah Millard, Denise A. S. Batista, Karin J. Blakemore, Cheryl DeScipio

“…To our knowledge, this is the first report of a prenatally identified r(7), molecularly characterized using array comparative genomic hybridization.…”
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Personalization of thiopurine therapy: Current recommendations and future perspectives by Urbančič Dunja, Pasha Flaka, Šmid Alenka, Mlinarič-Raščan Irena

“…In addition, the article takes a critical look at emerging research in the field of thiopurine pharmaco genomics featuring novel genetic markers and technological developments in genetic testing. …”
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Generation of an induced pluripotent stem cell line (UCLi026-A) from a patient with ADCY5-related disease carrying the heterozygous variant c.1253G > A; (p. Arg418Gln) by Sharmin Alhaque, Dimitri Budinger, Barbara Garavaglia, Giovanna Zorzi, Serena Barral, Manju A. Kurian

“…This line was further characterised for pluripotency, differentiation potential and genomic integrity. This cell line, UCLi026-A (UCL-NG-ADCY5-001) can be utilized for in vitro disease modelling of ADCY5-related diseases, as well as for the development of novel therapeutic approaches.…”
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Editorial: Exploring novel approaches to small molecule kinase inhibitors in cancer treatment by Anna Carbone, Rafael M. Couñago, Cristian O. Salas, Alessandra Moltalbano

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Molecular Epidemiology of Human Norovirus Variants from Outbreaks in Zhejiang Province, China, during 2021 by Yi Sun, Yongjuan Yuan, Haiyan Mao, Lingxuan Su, Qiong Ge, Jian Gao, Changping Xu, Liming Gong

“…Furthermore, the whole genomes of positive samples were sequenced, enabling the characterization of both nucleotide and amino acid differences within the virus. …”
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Generation of iPSCs by Nonintegrative RNA-Based Reprogramming Techniques: Benefits of Self-Replicating RNA versus Synthetic mRNA by Heidrun Steinle, Marbod Weber, Andreas Behring, Ulrike Mau-Holzmann, Christian Schlensak, Hans Peter Wendel, Meltem Avci-Adali

“…Using both RNA-based methods, integration-free iPSCs without genomic alterations were obtained. The pluripotency characteristics identified by specific marker detection and the in vitro and in vivo trilineage differentiation capacity were comparable. …”
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Epsin3 promotes non-small cell lung cancer progression via modulating EGFR stability by Huiling Su, Jie Shen, Chenzi Gao, Yue Zhao, Wanyu Deng, Bo Qin, Xin Zhang, Juan Lai, Qian Wang, Jie Dou, Min Guo

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Nanopore adaptive sampling accurately detects nucleotide variants and improves the characterization of large‐scale rearrangement for the diagnosis of cancer predisposition by Sandy Chevrier, Corentin Richard, Marie Mille, Denis Bertrand, Romain Boidot

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Rare Manifestation of a c.290 C>T, p.Gly97Glu VCP Mutation by Nivedita U. Jerath, Cameron D. Crockett, Steven A. Moore, Michael E. Shy, Conrad C. Weihl, Tsui-Fen Chou, Tiffany Grider, Michael A. Gonzalez, Stephan Zuchner, Andrea Swenson

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Single-cell transcriptomics identify a novel macrophage population associated with bone invasion in pituitary neuroendocrine tumors by Xinzhi Wu, Xueshuai Han, Haibo Zhu, Mingxuan Li, Lei Gong, Sicheng Jing, Weiyan Xie, Zhaoqi Liu, Chuzhong Li, Yazhuo Zhang

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Novel PITX2 Mutations including a Mutation Causing an Unusual Ophthalmic Phenotype of Axenfeld-Rieger Syndrome by Liqin Huang, Yong Meng, Xiangming Guo

“…The ocular manifestations of both eyes of each patient were recorded. Genomic DNA was prepared from venous leukocytes. All coding exons of PITX2 and FOXC1 were amplified by polymerase chain reaction (PCR) from genomic DNA and subjected to direct DNA sequencing. …”
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Holarctic phylogeographic structure of Eurasian wigeon (Mareca penelope) by I. V. Kulikova, Y. N. Zhuravlev, I. G. Korobitsyn, G. A. Nemkova, K. G. McCracken, J. L. Peters

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Microvascular disease and heart failure with reduced and preserved ejection fraction in type 2 diabetes by Ify R. Mordi, Aaron Tee, Colin N. Palmer, Rory J. McCrimmon, Alexander S.F. Doney, Chim C. Lang

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Wheat landraces as sources of high grain quality and nutritional properties by V. P. Shamanin, I. V. Pototskaya, S. A. Esse, M. S. Gladkih, S. S. Shepelev, E. V. Zuev, N. A. Vinichenko, H. Koksel, A. I. Morgounov

“…Mineral composition in the grain of the studied landraces was analyzed at the Kurchatov Genomic Center, Novosibirsk, using atomic absorption spectrometry techniques.Results. …”
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Epigene functional diversity: isoform usage, disordered domain content, and variable binding partners by Leroy Bondhus, Aileen A. Nava, Isabelle S. Liu, Valerie A. Arboleda

“…This specialized group of proteins is responsible for controlling the organization of genomic DNA in a cell-type specific fashion, controlling normal development in a spatial and temporal fashion. …”
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Prioritization of biological processes based on the reconstruction and analysis of associative gene networks describing the response of plants to adverse environmental factors by P. S. Demenkov, E. A. Oshchepkova, T. V. Ivanisenko, V. A. Ivanisenko

“…This is largely due to the development of technologies to solve problems in marker-oriented and genomic selection, which requires knowledge of the molecular genetic mechanisms underlying the formation of agriculturally valuable traits. …”
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Intermediate-Term Outcomes of Dual Adult versus Single-Kidney Transplantation: Evolution of a Surgical Technique by Ana K. Islam, Richard J. Knight, Wesley A. Mayer, Adam B. Hollander, Samir Patel, Larry D. Teeter, Edward A. Graviss, Ashish Saharia, Hemangshu Podder, Emad H. Asham, A. Osama Gaber

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Triple-negative breast cancer modifies the systemic immune landscape and alters neutrophil functionality by Noor A. M. Bakker, Hannah Garner, Ewald van Dyk, Elisa Champanhet, Chris Klaver, Maxime Duijst, Leonie Voorwerk, Iris Nederlof, Rosie Voorthuis, Marte C. Liefaard, Marja Nieuwland, Iris de Rink, Onno B. Bleijerveld, Hendrika M. Oosterkamp, Lodewyk F. A. Wessels, Marleen Kok, Karin E. de Visser

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Heterogeneity analysis provides evidence for a genetically homogeneous subtype of bipolar-disorder. by Caroline C McGrouther, Aaditya V Rangan, Arianna Di Florio, Jeremy A Elman, Nicholas J Schork, John Kelsoe, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium

“…We first apply this covariate-corrected biclustering algorithm to a cohort of 2524 BD cases and 4106 controls from the Bipolar Disease Research Network (BDRN) within the Psychiatric Genomics Consortium (PGC). We find evidence of genetic heterogeneity delineating a statistically significant bicluster comprising a subset of BD cases which exhibits a disease-specific pattern of differential-expression across a subset of SNPs. …”
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