Showing 3,741 - 3,760 results of 5,161 for search '"genome"', query time: 0.07s Refine Results
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    High-throughput method characterizes hundreds of previously unknown antibiotic resistance mutations by Matthew J. Jago, Jake K. Soley, Stepan Denisov, Calum J. Walsh, Danna R. Gifford, Benjamin P. Howden, Mato Lagator

    Published 2025-01-01
    “…Abstract A fundamental obstacle to tackling the antimicrobial resistance crisis is identifying mutations that lead to resistance in a given genomic background and environment. We present a high-throughput technique – Quantitative Mutational Scan sequencing (QMS-seq) – that enables quantitative comparison of which genes are under antibiotic selection and captures how genetic background influences resistance evolution. …”
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    The long non-coding RNA Cerox1 is a post transcriptional regulator of mitochondrial complex I catalytic activity by Tamara M Sirey, Kenny Roberts, Wilfried Haerty, Oscar Bedoya-Reina, Sebastian Rogatti-Granados, Jennifer Y Tan, Nick Li, Lisa C Heather, Roderick N Carter, Sarah Cooper, Andrew J Finch, Jimi Wills, Nicholas M Morton, Ana Claudia Marques, Chris P Ponting

    Published 2019-05-01
    “…To generate energy efficiently, the cell is uniquely challenged to co-ordinate the abundance of electron transport chain protein subunits expressed from both nuclear and mitochondrial genomes. How an effective stoichiometry of this many constituent subunits is co-ordinated post-transcriptionally remains poorly understood. …”
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