Chromatin environment-dependent effects of DOT1L on gene expression in male germ cells by Manon Coulée, Alberto de la Iglesia, Mélina Blanco, Clara Gobé, Clémentine Lapoujade, Côme Ialy-Radio, Lucia Alvarez-Gonzalez, Guillaume Meurice, Aurora Ruiz-Herrera, Pierre Fouchet, Julie Cocquet, Laïla El Khattabi

“…This coincides with a significant increase in DOT1L expression at this stage and a genome-wide acquisition of H3K79me2, particularly on the sex chromosomes. …”
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Healthy lifestyle reduces cardiovascular risk in women with genetic predisposition to hypertensive disorders of pregnancy by Sang‑Hyuk Jung, Haemin Kim, Young Mi Jung, Manu Shivakumar, Brenda Xiao, Jaeyoung Kim, Beomjin Jang, Jae-Seung Yun, Hong-Hee Won, Chan-Wook Park, Joong Shin Park, Jong Kwan Jun, Dokyoon Kim, Seung Mi Lee

“…We evaluate the genetic risk for hypertensive disorders of pregnancy using a genome-wide polygenic risk score derived from a large-scale GWAS. …”
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Detection and Phylogenetic Characterization of Influenza D in Swedish Cattle by Ignacio Alvarez, Fereshteh Banihashem, Annie Persson, Emma Hurri, Hyeyoung Kim, Mariette Ducatez, Erika Geijer, Jean-Francois Valarcher, Sara Hägglund, Siamak Zohari

“…Phylogenetic analysis was performed by the maximum likelihood estimation method on the whole IDV genome sequence from 16 samples. The IDV strains collected in 2021 (n = 7) belonged to the D/OK clade, whereas samples from 2023 (n = 4) and 2024 (n = 5) consisted of reassortants between the D/OK and D/660 clades, for the PB2 gene. …”
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Novel protein-based prognostic signature linked to immunotherapeutic efficiency in ovarian cancer by Shuo-Fu Chen, Liang-Yun Wang, Yi-Sian Lin, Cho-Yi Chen

“…Methods The workflow was demonstrated based on the Reverse Phase Protein Array (RPPA) and RNA-sequencing profiles of ovarian cancer patients from The Cancer Genome Atlas (TCGA). The algorithm began by clustering patients using immune-related gene sets, which allowed us to identify immune-related proteins of interest. …”
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Phylogenetic Analysis of Spike and Envelope Proteins for a Number of Bat Coronaviruses for Understanding the Hypothesis of Possible Origin for the Novel 2019- nCoV by Salar Ibrahim Ali

“…Therefore, this study aims to investigate the evolution and analysis of molecular epidemiology for both Spike and Envelope proteins of 20 available complete genome sequences of different bat coronaviruses including 2019-nCoV in order to find out which type of bat coronaviruses is more likely to be the origin of this new 2019-nCoV and also multiple amino acid sequences of Envelope protein for all bat coronaviruses were aligned for the purpose of finding the greater probability of novel 2019-nCoV original host   among bat coronaviruses. …”
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Spatial and seasonal distribution of selected nitrogen cycle genes in deep waters of the Baltic Proper by Michał Grabski, Michał Grabski, Ewa Kotlarska, Aneta Łuczkiewicz, Konrad Hryniewicz, Grzegorz Węgrzyn, Beata Szymczycha

“…Ammonia oxidation products likely fueled the production of nitrous oxide (N2O), with nitric oxide reductase (NOR)—an enzyme encoded by the Thioglobaceae genome—being responsible for further reduction. Anammox-related genes were not present within sites, thus denitrification pathway enzymes, namely, NOR and N2O reductase (NOS) were responsible for nitrogen loss. …”
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Multi-omics analysis reveals novel causal pathways in psoriasis pathogenesis by Hua Guo, Jinyang Gao, Liping Gong, Yanqing Wang

“…Methods We conducted SMR analyses integrating genome-wide association study (GWAS) summary statistics with methylation quantitative trait loci (mQTL), expression quantitative trait loci (eQTL), and protein quantitative trait loci (pQTL) data. …”
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Immune gene features and prognosis in colorectal cancer: insights from ssGSEA typing by Anwen Huang, Jinxiu Wu, Jiakuan Wang, Chengwen Jiao, Yunfei Yang, Huaiwen Xiao, Li Yao

“…Methods We obtained and merged RNA-Seq data along with clinical details for colorectal cancer (CRC) from The Cancer Genome Atlas (TCGA) repository, and then performed immunocluster typing on all CRC specimens. …”
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Breeding value of prolific maize varieties with nicking of parental lines by E. B. Khatefov, R. A. Kudaev, R. S. Kushkhova

“…The studied prolific maize lines developed by involving the Chalko teosinte genome appeared to be effective donors of the multiple-ear feature in crosses with single-ear maize. …”
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G-quadruplex-forming small RNA inhibits coronavirus and influenza A virus replication by Ryoya Sekine, Kouki Takeda, Tsukasa Suenaga, Satsuki Tsuno, Takumi Kaiya, Maki Kiso, Seiya Yamayoshi, Yoshihide Takaku, Shiho Ohno, Yoshiki Yamaguchi, Seiichi Nishizawa, Kazuhiro Sumitomo, Kazufumi Ikuta, Teru Kanda, Yoshihiro Kawaoka, Hidekazu Nishimura, Shusuke Kuge

“…Unlike previous antiviral strategies that target the G-quadruplexes of the viral genome, we now show that excess exogenous G-quadruplex-forming small RNA displaces genomic RNA from ribonucleoprotein, effectively inhibiting viral replication. …”
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Cyclin-dependent protein kinases and cell cycle regulation in biology and disease by Ilenia Pellarin, Alessandra Dall’Acqua, Andrea Favero, Ilenia Segatto, Valentina Rossi, Nicole Crestan, Javad Karimbayli, Barbara Belletti, Gustavo Baldassarre

“…In reality, the human genome contains 20 different CDKs, which can be divided in at least three different sub-family with different functions, mechanisms of regulation, expression patterns and subcellular localization. …”
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Development of Virus-Like Particles (VLPs) for Hepatitis C Virus genotype 4: a novel approach for vaccine development in Egypt by Ahmed A. Ali, Rasha A. M. Azouz, Nahla A. Hussein, Reem El-Shenawy, Naiera M. Helmy, Yasmine S. El-Abd, Ashraf A. Tabll

“…Methods Lentiviral-based vectors were constructed and employed to integrate the full-length sequence of Core, E1, E2, and P7 genes of HCV genotype 4 into the genome of Human Embryonic Kidney cells (HEK293T). …”
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Genetic diversity and breeding value of synthetic hexaploid wheat introduced into the VIR collection by A. G. Khakimova, N. K. Gubareva, V. А. Koshkin, O. P. Mitrofanova

“…It is possible that the instability of accessions  is the result of genome rearrangement in SHWs. SHW accessions  and the forms isolated from them are considered as sources of new genetic variability to improve common wheat.…”
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Single-cell RNA-seq analysis reveals microenvironmental infiltration of myeloid cells and pancreatic prognostic markers in PDAC by Yanying Fan, Lili Wu, Xinyu Qiu, Han Shi, Longhang Wu, Juan Lin, Jie Lin, Tianhong Teng

“…Methods Single-cell RNA sequencing (scRNA-seq) data were downloaded from t the Tumor Immune Single-cell Hub and gene expression data were retrieved from The Cancer Genome Atlas (TCGA) database and the Gene Expression Omnibus (GEO) database. …”
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Exploring the genetic correlation and causal relationships between breast cancer and meningioma using bidirectional Mendelian randomization by Lu Ding, Bo Chen, Zhou Zhou, Zhaojun Mei, Kan Cao, Xinyu Lu, Wei Chen

“…Genetic instrumental variables (IVs) for BC were identified from the Breast Cancer Association Consortium (BCAC), the Discovery Biology and Risk of Inherited Variants in Breast Cancer Consortium (DRIVE), the Collaborative Oncological Gene-environment Study (iCOGS), and 11 other BC genome-wide association studies (GWAS). Meningioma GWAS data were obtained from the FinnGen consortium and were further divided into intracranial and spinal meningioma groups for analysis. …”
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Heterogeneity of avian infectious bronchitis virus population by Ye. V. Ovchinnikova, L. O. Scherbakova, S. N. Kolosov, A. N. Andriyasova, N. G. Zinyakov, Z. B. Nikonova, A. A. Kozlov, P. B. Akshalova, D. A. Altunin, D. B. Andreychuk

“…Due to the lack of mechanisms to correct errors during genome replication, the virus can quickly mutate and generate new strains. …”
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Multivariate Statistical Analysis for the Classification of Sausages Based on Physicochemical Attributes, Using Attenuated Total Reflectance-Fourier Transform Infrared (ATR-FTIR) a... by Quang Minh Bui, Quang Trung Nguyen, Thanh Thao Nguyen, Ha My Nguyen, Thi Tinh Phung, Viet Anh Le, Ngoc Minh Truong, The Vinh Mac, Tien Dat Nguyen, Le Tuan Anh Hoang, Ha Minh Duc Tran, Van Nhan Le, Minh Duc Nguyen

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Polymorphism of the <i> FaOMT </i> and <i> FaFADl </i> genes for fruit flavor volatiles in strawberry varieties and wild species from the genetic collection of the Michurin Federal... by A. S. Lyzhin, I. V. Luk’yanchuk, E. V. Zhbanova

“…The use of molecular markers allows highly reliable detection of target gene alleles in a genome at early developmental stages. This study involves molecular genotyping of Fragaria L. varieties for the FaOMT and FaFADl genes, analysis of polymorphism of the loci in question, and identification of genotypes valuable for breeding. …”
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Microglia modulate the cerebrovascular reactivity through ectonucleotidase CD39 by Zhongxiao Fu, Mallikarjunarao Ganesana, Philip Hwang, Xiao Tan, Melissa Marie Kinkaid, Yu-Yo Sun, Emily Bian, Aden Weybright, Hong-Ru Chen, Katia Sol-Church, Ukpong B. Eyo, Clare Pridans, Francisco J. Quintana, Simon C. Robson, Pankaj Kumar, B. Jill Venton, Anne Schaefer, Chia-Yi Kuan

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The development and study of common wheat introgression lines derived from the synthetic form RS7 by R. O. Davoyan, I. V. Bebyakina, E. R. Davoyan, D. S. Mikov, Yu. S. Zubanova, D. M. Boldakov, E. D. Badaeva, I. G. Adonina, E. A. Salina, A. N. Zinchenko

“…Synthetic recombination form RS7 (BBAAUS), in which the first two genomes, A and B, originate from common wheat, and the third recombinant genome consists of Aegilops speltoides (S) and Ae. umbellulata (U) chromosomes, was obtained from crossing synthetic forms Avrodes (BBAASS) and Avrolata (BBAAUU). …”
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