Passive infusion of an S2-Stem broadly neutralizing antibody protects against SARS-CoV-2 infection and lower airway inflammation in rhesus macaques. by Christopher T Edwards, Kirti A Karunakaran, Elijah Garcia, Nathan Beutler, Matthew Gagne, Nadia Golden, Hadj Aoued, Kathryn L Pellegrini, Matthew R Burnett, Christopher Cole Honeycutt, Stacey A Lapp, Thang Ton, Mark C Lin, Amanda Metz, Andrei Bombin, Kelly Goff, Sarah E Scheuermann, Amelia Wilkes, Jennifer S Wood, Stephanie Ehnert, Stacey Weissman, Elizabeth H Curran, Melissa Roy, Evan Dessasau, Mirko Paiardini, Amit A Upadhyay, Ian N Moore, Nicholas J Maness, Daniel C Douek, Anne Piantadosi, Raiees Andrabi, Thomas R Rogers, Dennis R Burton, Steven E Bosinger

“…We observed a significant reduction in inflammatory cytokines and macrophages within the lower airway of animals infused with 10mg/kg and 1mg/kg doses of CC40.8. Viral genome sequencing demonstrated a lack of escape mutations in the CC40.8 epitope. …”
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Characterization of the Cannabis sativa glandular trichome epigenome by Lee J. Conneely, Bhavna Hurgobin, Sophia Ng, Muluneh Tamiru-Oli, Mathew G. Lewsey

“…Conclusion We report the first genome-wide histone post-translational modification maps for C. sativa glandular trichomes, and more broadly for glandular trichomes in plants. …”
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ANALYSIS OF GENETIC CHARACTERISTICS OF INFLUENZA VIRUS A/CHICKEN/CHELYABINSK/30/2019 H9N2 ISOLATED IN CHELYABINSK OBLAST by N. G. Zinyakov, Щю S. Osipova, P. B. Akshalova, V. Yu. Sosipatorova, A. V. Andriyasov, D. B. Andreychuk, I. A. Chvala

“…The complete nucleotide genome sequence of the studied pathogen was determined. …”
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Targeting Nrf2/KEAP1 signaling pathway using bioactive compounds to combat mastitis by Muhammad Zahoor Khan, Liangliang Li, Yandong Zhan, Huang Binjiang, Xiaotong Liu, Xiyan Kou, Adnan Khan, Abdul Qadeer, Qudrat Ullah, Khalid J. Alzahrani, Tongtong Wang, Changfa Wang, Muhammad Zahoor

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Potential biomarkers and immune infiltration linking endometriosis with recurrent pregnancy loss based on bioinformatics and machine learning by Jianhui Chen, Qun Li, Xiaofang Liu, Fang Lin, Yaling Jing, Jiayan Yang, Lianfang Zhao

“…Moreover, immune cell infiltration was estimated using CIBERSORTx, and the Cancer Genome Atlas (TCGA) database was employed to elucidate the role of key genes in endometrial carcinoma (EC).Results26 common differentially expressed genes (DEGs) were screened in both diseases, three of which were identified as common core genes (MAN2A1, PAPSS1, RIBC2) through the combination of WGCNA, PPI network, and machine learning-based feature selection. …”
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The Characteristic of Biofilm Formation in ESBL-Producing K. pneumoniae Isolates by Xiaofang Gao, Haili Wang, Zhijuan Wu, Pan Sun, Wei Yu, Donghua Chen, Yuhua Mao, Lili Fang, Jia Qian, Li Li, Qian Peng, Yanping Han

“…In this study, we investigated the genome homology and biofilm formation capacity of ESBL-producing K. pneumoniae. …”
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Single-cell sequencing uncovers the mechanistic role of DAPK1 in glioma and its diagnostic and prognostic implications by Tian-Hang Yu, Yan-Yu Ding, Yan-Yu Ding, Si-Guo Zhao, Jie-Hui Zhao, Yu Gu, Dong-Hui Chen, Fang Zhang, Wen-Ming Hong, Wen-Ming Hong

“…However, the precise role and underlying mechanisms of DAPK1 in gliomas remain inadequately understood.MethodsWe performed analyses on RNA-seq and microarray datasets from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO), in addition to single-cell RNA sequencing (scRNA-seq) data from glioma patients available in GEO. …”
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Comprehensive Analysis of the Mechanism of Anoikis in Hepatocellular Carcinoma by Dongqian Li, Qian Bao, Shiqi Ren, Haoxiang Ding, Chengfeng Guo, Kai Gao, Jian Wan, Yao Wang, MingYan Zhu, Yicheng Xiong

“…This paper’s data (TCGA-HCC) were retrieved from the database of the Cancer Genome Atlas (TCGA). Differential gene expression with prognostic implications for anoikis was identified by performing both the univariate Cox and differential expression analyses. …”
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The frequency of mutations in advanced thyroid cancer in Japan: a single-center study by Soji Toda, Hiroyuki Iwasaki, Yoichiro Okubo, Hiroyuki Hayashi, Mei Kadoya, Hiroyuki Takahashi, Tomoyuki Yokose, Yukihiko Hiroshima, Katsuhiko Masudo

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A Rare Case of Mosaic 3pter and 5pter Deletion-Duplication with Autism Spectrum Disorder and Dyskinesia by Luna Bajracharya, Meena Lall, Sunita Bijarnia-Mahay, Praveen Kumar, Imran Mushtaq, Pushpa Saviour, Preeti Paliwal, Anju Joshi, Shruti Agarwal, Praveen Suman

“…The two cell lines (50% each) seem to have balanced out at the whole genome level. Occupational, sensory integration, and behavior modification therapy were initiated for his autistic features, and anticholinergic trihexiphenidyl was prescribed for hyperkinetic movements. …”
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Aberrant heterochromatin silences immune response genes in chronic lymphocytic leukemia by Olivia M. Depies, Qianqian Guo, Yuan Gao, Sutapa Sinha, Zhenqing Ye, Weiguo Han, Kari G. Rabe, Mingma S. Hoel, Heather C. Darby, Chuanhe Yu, Esteban Braggio, Sameer A. Parikh, Susan L. Slager, Neil E. Kay, Zhiquan Wang

“…Here, we characterized the genome-wide histone modification landscapes of CLL using patient-derived samples across the disease course. …”
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Activation of three targets by a TAL effector confers susceptibility to bacterial blight of cotton by Brendan W. Mormile, Yan Yan, Taran Bauer, Li Wang, Rachel C. Rivero, Sara C. D. Carpenter, Catherine Danmaigona Clement, Kevin L. Cox, Lin Zhang, Xiyu Ma, Terry A. Wheeler, Jane K. Dever, Ping He, Adam J. Bogdanove, Libo Shan

“…To understand the pathogenicity and host adaptation of Xanthomonas citri pv. malvacearum (Xcm), we assemble the genome and the TALE repertoire of three recent Xcm Texas isolates. …”
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Diversity Assessment of Some Sesame (Sesamum indicum L.) Genotypes Cultivated in Northern Ghana Using Morphological and Simple Sequence Repeat (SSR) Markers by Raphael Adu-Gyamfi, Ruth Prempeh, Issahaku Zakaria

“…Molecular genetic diversity was assessed by using thirty eight SSR markers widely distributed across sesame genome to characterize the materials. Twenty-one out of the 38 primers were polymorphic. …”
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Association of AFF3 Gene Polymorphism rs10865035 with Rheumatoid Arthritis: A Population-Based Case-Control Study on a Pakistani Cohort by Yasir Ali, Suleman Khan, Yangchao Chen, Nadia Farooqi, Zia-Ul Islam, Mehran Akhtar, Aamir, Aisha Aman, Aftab Ali Shah, Muhsin Jamal, Fazal Jalil

“…Rheumatoid arthritis (RA) is one of the complex diseases with the involvement of the genetic as well as environmental factors in its onset and severity. Different genome-wide association and candidate gene studies have shown the role of several genetic variants in multiple loci/genes with ethnical and geographical variations. …”
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SARS-CoV-2 Remained Airborne for a Prolonged Time in a Lockdown Confined Space by Xinyue Li, Xiao Qi, Jianxin Ma, Yang Pan, Tian Tian, Yue Zhang, Zhen Li, Wenjing Li, Lingli Sun, Lu Zhang, Zheng Zhang, Quanyi Wang, Maosheng Yao

“…The traveler did not have any contacts with the two employees; however, genome sequencing showed that SARS-CoV-2 variants from three patients and two environmental surface samples belonged to 20B viral clade, sharing a nucleic acid identity of more than 99.9%. …”
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Detection of Delafloxacin Resistance Mechanisms in Multidrug-Resistant <i>Klebsiella pneumoniae</i> by András Kubicskó, János Juhász, Katalin Kamotsay, Dora Szabo, Béla Kocsis

“…Four delafloxacin-resistant <i>K. pneumoniae</i> strains were selected for whole-genome sequencing (WGS). <b>Results:</b> The MIC50 values for the 43 <i>K. pneumoniae</i> strains were as follows: ciprofloxacin 0.5 mg/L, levofloxacin 0.25 mg/L, moxifloxacin 0.5 mg/L, and delafloxacin 0.25 mg/L. …”
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Novel Insights into the Nobilamide Family from a Deep-Sea <i>Bacillus</i>: Chemical Diversity, Biosynthesis and Antimicrobial Activity Towards Multidrug-Resistant Bacteria by Vincenza Casella, Gerardo Della Sala, Silvia Scarpato, Carmine Buonocore, Costanza Ragozzino, Pietro Tedesco, Daniela Coppola, Giovanni Andrea Vitale, Donatella de Pascale, Fortunato Palma Esposito

“…Finally, in silico analysis of <i>Bacillus halotolerans</i> BCP32 genome revealed nobilamide biosynthesis to be directed by a previously unknown heptamodular nonribosomal peptide synthetase.…”
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Modeling compositional heterogeneity resolves deep phylogeny of flowering plants by Yongli Wang, Yan-Da Li, Shuo Wang, Erik Tihelka, Michael S. Engel, Chenyang Cai

“…Here we show that, although plastid and mitochondrial genomes lack sufficient phylogenetic signal for resolving deeper phylogeny, the relationships among five mesangiosperm lineages can be confidently resolved under better-fitting models using genome-scale data. …”
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Activin levels correlate with lymphocytic infiltration in epithelial ovarian cancer by Elizabeth T. Evans, Emily F. Page, Alex Seok Choi, Zainab Shonibare, Andrea G. Kahn, Rebecca C. Arend, Karthikeyan Mythreye

“…Immune gene expression profile was further explored within the TCGA‐OV cohort derived from The Cancer Genome Atlas (TCGA). Immunohistochemical analysis was performed to evaluate activin A and T‐cell markers CD8 and FoxP3 at the protein level. …”
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Characterization of the First Marine Pestivirus, Phocoena Pestivirus (PhoPeV) by Lars Söder, Denise Meyer, Olaf Isken, Norbert Tautz, Matthias König, Alexander Postel, Paul Becher

“…No degradation of IRF3 and an increased expression of the type 1 interferon-stimulated antiviral protein Mx1 was observed in porcine cells infected with PhoPeV whose genome lacks the N^pro encoding region. …”
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