Real-time IncuCyte® Assay for the Dynamic Assessment of Live and Dead Cells in 2D Cultures by Arlene Gidda, Suganthi Chittaranjan, Sharon Gorski

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The enigma of cancer polyploidy as deciphered by evolutionary cancer cell biology (ECCB) by Vladimir F. Niculescu, Eugenia R. Niculescu

“…The cells lose their stemness and differentiation potential but persist in proliferation as low-grade polyploids (4n) through defective symmetric cell division (DSCD). Genomic integrity can be restored through homotypic cell and nuclear fusion, resulting in the formation of high-grade polyploids known as multinucleated genome repair syncytia, or by inductive hyperpolyploidization of more than 64n, as observed in single-celled polyploid giant cancer cells. …”
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DNA methylation and its influence on the pathogenesis of osteoarthritis: a systematic literature review by Thomas Nau, Samira Cutts, Nerissa Naidoo

“…Others reported on the association between OA risk genes and DNA methylation. Genome-wide methylation studies reported on differentially methylated regions (DMRs) comparing OA and non-OA chondrocytes. …”
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Author Correction: Synthetic augmentation of cancer cell line multi-omic datasets using unsupervised deep learning by Zhaoxiang Cai, Sofia Apolinário, Ana R. Baião, Clare Pacini, Miguel D. Sousa, Susana Vinga, Roger R. Reddel, Phillip J. Robinson, Mathew J. Garnett, Qing Zhong, Emanuel Gonçalves

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Human microbiome, applied to clinical practice by V. T. Ivashkin, K. V. Ivashkin

“…The Human microbiome project was designed for identification and characterization of set of human microorganisms as well as for studying the changes in the human health due to microbiome changes. The Human Genome Project assumes: development of the human genome variations database (HapMap; Human Variome Project), interpretation of human phenotype differences (Encyclopedia Of DNA Elements), modeling of human phenomenon (RECON), interpretation of epigenetic variants and hereditary changes in phenotypical manifestations. …”
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The landscape of nucleotide diversity in Drosophila melanogaster is shaped by mutation rate variation by Barroso, Gustavo V, Dutheil, Julien Y

“…What shapes the distribution of nucleotide diversity along the genome? Attempts to answer this question have sparked debate about the roles of neutral stochastic processes and natural selection in molecular evolution. …”
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AAV-based vectors for human diseases modeling in laboratory animals by Timur I. Aliev, Dmitry V. Yudkin

“…This review analyzes the features of the adeno-associated virus genome that make it an advantageous vector for transgenesis. …”
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Simultaneous Inference of Past Demography and Selection from the Ancestral Recombination Graph under the Beta Coalescent by Korfmann, Kevin, Sellinger, Thibaut Paul Patrick, Freund, Fabian, Fumagalli, Matteo, Tellier, Aurélien

“…The reproductive mechanism of a species is a key driver of genome evolution. The standard Wright-Fisher model for the reproduction of individuals in a population assumes that each individual produces a number of offspring negligible compared to the total population size. …”
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The distribution of allele frequencies of the 15 Short Tandem Repeats loci in Elazığ population, Turkiye by Aziz Aksoy, Mehmet Tokdemi̇r, Vahit Konar

“…The DNA within the Human Genome involves loci with high polymorphism such as short tandem repeats (STR). …”
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Sequence-based GWAS in 180,000 German Holstein cattle reveals new candidate variants for milk production traits by Ana-Marija Križanac, Christian Reimer, Johannes Heise, Zengting Liu, Jennie E. Pryce, Jörn Bennewitz, Georg Thaller, Clemens Falker-Gieske, Jens Tetens

“…In order to fully exploit the power of GWAS, one should aim at very large samples combined with whole-genome sequence data. These can also come with both computational and time burdens, as presented in our study. …”
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Ontology-based expansion of virtual gene panels to improve diagnostic efficiency for rare genetic diseases by Jaemoon Shin, Toyofumi Fujiwara, Hirotomo Saitsu, Atsuko Yamaguchi

“…Abstract Background Virtual Gene Panels (VGP) comprising disease-associated causal genes are utilized in the diagnosis of rare genetic diseases to evaluate candidate genes identified by whole-genome and whole-exome sequencing. VGPs generated by the PanelApp software were utilized in a UK 100,000 Genome Project pilot study to filter candidate genes, thus enhancing diagnostic efficiency for rare diseases. …”
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Synthetic augmentation of cancer cell line multi-omic datasets using unsupervised deep learning by Zhaoxiang Cai, Sofia Apolinário, Ana R. Baião, Clare Pacini, Miguel D. Sousa, Susana Vinga, Roger R. Reddel, Phillip J. Robinson, Mathew J. Garnett, Qing Zhong, Emanuel Gonçalves

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A paradoxical population structure of var DBLα types in Africa. by Mun Hua Tan, Kathryn E Tiedje, Qian Feng, Qi Zhan, Mercedes Pascual, Heejung Shim, Yao-Ban Chan, Karen P Day

“…The var multigene family encodes Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1), central to host-parasite interactions. Genome structure studies have identified three major groups of var genes by specific upstream sequences (upsA, B, or C). …”
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FDA-approved kinase inhibitors: a promising therapeutic avenue for traumatic brain injury by Dezhu Gao, Yu Shi, Zhiliang Wang, Weiming Liu

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Revisiting pangenome openness with k-mers by Parmigiani, Luca, Wittler, Roland, Stoye, Jens

“…Pangenomics is the study of related genomes collectively, usually from the same species or closely related taxa. …”
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Global biogeography and projection of antimicrobial toxin genes by Ya Liu, Yu Geng, Yiru Jiang, Jingyu Sun, Peng Li, Yue-zhong Li, Zheng Zhang

“…Results Here, we identified 4400 ATG clusters from 149 families by correlating 10,000 samples worldwide with over 200,000 microbial genome data. We demonstrated that global microbial communities universally encode complex and diverse ATGs, with widespread differences across various habitats. …”
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Evolution of SARS-CoV-2 in white-tailed deer in Pennsylvania 2021-2024. by Andrew D Marques, Matthew Hogenauer, Natalie Bauer, Michelle Gibison, Beatrice DeMarco, Scott Sherrill-Mix, Carter Merenstein, Ronald G Collman, Roderick B Gagne, Frederic D Bushman

“…From the 165 SARS-CoV-2 positive WTD, we recovered 25 whole genome sequences and an additional 17 spike-targeted amplicon sequences. …”
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The beneficial effects of thymoquinone on viability and differentiation of human adipose tissue-derived mesenchymal stem cells by Ahsen Erginsoy, Nur Seda Gokdemir, Venhar Cinar, Eda Koseoglu, Zeynep Burcin Gonen, Tuba Dilay Kokenek Unal

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Natural selection and adaptive traits in the Maniq, a nomadic hunter-gatherer society from Mainland Southeast Asia by Tobias Herzog, Maximilian Larena, Wibhu Kutanan, Helmut Lukas, Martin Fieder, Helmut Schaschl

“…Using genome-wide approaches, including iHS, xp-EHH, PBE, and beta statistics, we identified signatures of positive and balancing selection. …”
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Galloping into the Future: Genetic Tips and Tools for the Horse Owner by Laura Patterson Rosa, Carissa Wickens, Samantha A. Brooks

“… This 4-page fact sheet discusses the equine genome, determining the genotype of a horse, breeding for certain traits, and the future of genetic tools. …”
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