Emergence of a novel porcine pestivirus with potential for cross-species transmission in China, 2023 by Li-shuang Deng, Tong Xu, Zhi-wen Xu, Ling Zhu

“…Viremia has been detected in both piglets and mice, with high viral genome loads found in various organs. In vitro results revealed that PAAPeV replicates in ST cells and, to a lesser extent, in human (A549 and HepG2) and monkey (Vero) cells. …”
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Investigating the role of iron status in the development of coeliac disease: a Mendelian randomisation study by Isabel A Hujoel, Margaux Louise Anna Hujoel

“…The SNPs were drawn from a meta-analysis of three genome-wide association studies (GWAS). The association between these SNPs and coeliac disease was assessed using GWAS summary statistics from the UK Biobank. …”
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Prevalence of Coxiella burnetii in unpasteurized dairy products in west of Iran by Soheila Mohammadkhanifard, Amin Jaydari, Ehsan Rashidian, Nemat Shams, Peyman Khademi

“…A total of 100 samples of traditional yogurt and unpasteurized cheese were collected from various regions. To analyze the genome of C. burnetii, DNA was purified and molecular detection was performed using nested PCR with primers specific to the IS1111 transposon gene. …”
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Estimation of translational importance of mammalian mRNA nucleotide sequence characteristics based on ribosome profiling data by O. A. Volkova, Yu. V. Kondrakhin, R. N. Sharipov

“…Thanks to ribosome profiling technology, genome-wide experimental data of translation efficiency have been obtained for many eukaryotic mRNAs. …”
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Unraveling the genetic connections for mitochondrial DNA control region and breast cancer susceptibility by Namra Khalid, Muhammad Umer Khan, Raima Rehman, Shamsa Kanwal, Tazeen Zahid, Muhammad Usman Ghani, Ayesha Iftikhar, Qurban Ali, Muhammad Arshad Javed

“…The study reveals a significant abundance of haplogroup M in breast cancer cases by analyzing breast cancer patients and healthy controls through mitochondrial control region genome sequencing (p < 0.001). Increased frequencies of haplogroups M, H, and R in patients compared to controls suggest their potential role in breast cancer susceptibility. …”
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Bioinformatics Method Was Used to Analyze the Highly Expressed Gene FAM83A of Breast Cancer in Young Women by Yongzhe Tang, Hao Wang, Qi He, Yuanyuan Chen, Jie Wang

“…Digital gene representation of the Tumor Genome Project Data Library was used to select differentially expressed genes in breast cancer tissue and breast benign tumor tissue. …”
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Multiomic machine learning on lactylation for molecular typing and prognosis of lung adenocarcinoma by Mengmeng Hua, Tao Li

“…LRG mRNA and long non-coding RNA transcriptomes, epigenetic methylation data, and somatic mutation data from The Cancer Genome Atlas LUAD cohort were analyzed to identify lactylation cancer subtypes (CSs) using 10 multiomics ensemble clustering techniques. …”
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Lessons from SARS-CoV, MERS-CoV, and SARS-CoV-2 Infections: What We Know So Far by Radi Taha Alsafi

“…Therefore, this review summarizes the state-of-the-art information and compares the similarities and dissimilarities between SARS-CoV, MERS-CoV, and SARS-CoV-2, in terms of their evolution trait, genome organization, host cell entry mechanisms, tissue infectivity tropisms, transmission routes and contagiousness, and the clinical characteristics, laboratory features, and immunological abnormalities of their related illnesses. …”
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Efficiency of SSR and PawS markers for evaluation of genetic polymorphism among red clover (Trifolium pratense L.) cultivars by I. A. Klimenko, S. I. Kostenko, Yu. M. Mavlyutov, A. O. Shamustakimova

“…Marker techniques based on SSR loci and PawS markers were evaluated for their efficiency in revealing the DNA polymorphism in Russian red clover cultivars, and the research results are presented in this publication.Materials and Methods. The total genome DNA was extracted by a modified SDS method from 30 seedlings per each cultivar. …”
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Research Note: Novel reassortant avian influenza A(H9N2) Viruses in Wild Birds in Shanghai, China, 2020–2023 by Jie Hu, Yuting Xu, Min Ma, Chenyao Zhao, Yue Yuan, Guimei He

“…To better understand the genetic characteristics of these H9N2 viruses in Shanghai, the whole genome sequences were analyzed. Phylogenetical analysis showed that the nine H9N2 viruses have undergone complicated reassortment with waterfowl viruses along the East Asian-Australasian flyways. …”
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Integrated TWAS, GWAS, and RNAseq results identify candidate genes associated with reproductive traits in cows by Sevda Hosseinzadeh, Seyed Abbas Rafat, Lingzhao Fang

“…The identified genes serve as markers for genomic selection aimed at enhancing reproductive traits in cow.…”
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Mapping chromatin remodelling in glioblastoma identifies epigenetic regulation of key molecular pathways and novel druggable targets by Claire Vinel, James Boot, Weiwei Jin, Nicola Pomella, Alexandra Hadaway, Charles Mein, Nicolae Radu Zabet, Silvia Marino

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Identification of Aberrantly Expressed miRNAs in Gastric Cancer by Dan Liu, Xiaowei Hu, Hongfeng Zhou, Guangyue Shi, Jin Wu

“…The noncoding components of the genome, including miRNA, can contribute to pathogenesis of gastric cancer. …”
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Effective in vivo binding energy landscape illustrates kinetic stability of RBPJ-DNA binding by Duyen Huynh, Philipp Hoffmeister, Tobias Friedrich, Kefan Zhang, Marek Bartkuhn, Francesca Ferrante, Benedetto Daniele Giaimo, Rhett A. Kovall, Tilman Borggrefe, Franz Oswald, J. Christof M. Gebhardt

“…We determine the binding kinetics, transcriptional activity, and genome-wide chromatin occupation of RBPJ and mutant variants by live-cell single-molecule tracking, reporter assays, and ChIP-Seq. …”
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TRIM28 is an essential regulator of three-dimensional chromatin state underpinning CD8+ T cell activation by Kun Wei, Ruifeng Li, Xiaohong Zhao, Bowen Xie, Tian Xie, Qinli Sun, Yongzhen Chen, Peng Wei, Wei Xu, Xinyi Guo, Zixuan Zhao, Han Feng, Ling Ni, Chen Dong

“…Here, we show extensive changes in the three-dimensional genome during CD8+ T cell activation, associated with changes in gene transcription. …”
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Adenovirus Vectors Target Several Cell Subtypes of Mammalian Inner Ear In Vivo by Yilai Shu, Yong Tao, Wenyan Li, Jun Shen, Zhengmin Wang, Zheng-Yi Chen

“…To identify adenovirus vectors that target specific cell subtypes in the inner ear, we studied three adenovirus vectors, carrying a reporter gene encoding green fluorescent protein (GFP) from two vendors or with a genome editing gene Cre recombinase (Cre), by injection into postnatal days 0 (P0) and 4 (P4) mouse cochlea through scala media by cochleostomy in vivo. …”
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“One Ring to Bind Them All”—Part II: Identification of Promising G-Quadruplex Ligands by Screening of Cyclophane-Type Macrocycles by Anton Granzhan, David Monchaud, Nicolas Saettel, Aurore Guédin, Jean-Louis Mergny, Marie-Paule Teulade-Fichou

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Exploring Unique Extracellular Vesicles Associated Signatures: Prognostic Insights, Immune Microenvironment Dynamics, and Therapeutic Responses in Pancreatic Adenocarcinoma by Kai Nan, Ming Zhang, Zilong Geng, Yuankai Zhang, Lin Liu, Zhi Yang, Peng Xu

“…Initially, we identified differentially expressed lncRNAs (DELs) from The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) project datasets. …”
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Comprehensive Analysis of microRNA Methylation Profiles and Determination of Their Functional Significance in Colorectal Cancer: A Study Protocol by Nurul Syakima Ab Mutalib, Imilia Ismail, Muhammad Redha Abdullah Zawawi, Nadiah Abu, Siti Aishah Sulaiman, Loh Teng-Hern Tan, Learn-Han Lee

“…This study aims to investigate the genome-wide methylome profiles of microRNA and clarify their roles in CRC. …”
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Mendelian randomization analysis reveals genetic evidence for a causal link between inflammatory bowel disease and uterine cervical neoplasms by Chunge Cao, Xiaorui Sun, Xiaohu Chen, Ying Zhang, Chaoyan Yue

“…We aimed to evaluate the causal relationship between IBD and uterine cervical neoplasm using a bidirectional Mendelian randomization analysis.MethodsWe derived instrumental variables for IBD, including Crohn’s disease and ulcerative colitis, from the IEU Open genome-wide association study (GWAS) database, and for the histological subtypes of uterine cervical neoplasm from the FinnGen repository’s GWAS data. …”
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