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2641
Applications of Healthcare Robots in Combating the COVID-19 Pandemic
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2642
DNAPred_Prot: Identification of DNA-Binding Proteins Using Composition- and Position-Based Features
Published 2022-01-01“…In the domain of genome annotation, the identification of DNA-binding protein is one of the crucial challenges. …”
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2643
Cell migration in dense microenvironments
Published 2023-09-01“…The nucleus has been viewed as a passenger during cell migration that functions merely to protect the genome. However, increasing evidence shows that the nucleus is an active organelle, constantly sensing the surrounding environment and translating extracellular mechanical inputs into intracellular signaling. …”
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2644
The Role of the Pathoanatomical Diagnosis «Chronic Gastritis» in the System of Personified Cancer Prevention
Published 2018-09-01“…The activity of gastritis (infiltration of the mucosa with neutrophilic leukocytes) of any etiology is the theoretical justification for the use of bismuth tripotassium dicitrate pharmacological preparation to protect the genome of stem cells of the gastric epithelium as a secondary prevention of gastric cancer.…”
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2645
THE SUITABILITY OF THE BMY2 AND WAXY GENES AND INTERNAL TRANSCRIBED SPACERS OF RRNA AS MARKERS FOR STUDYING GENETIC VARIABILITY IN ELYMUS SPECIES
Published 2015-01-01“…This variation makes it useful in investigating the genome constitutions of novel Elymus species. Finally, systematical status of E. kamczadalorum as a species was proven valid.…”
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2646
The Relevance of HLA Sequencing in Population Genetics Studies
Published 2014-01-01“…In this review, we first explain how HLA sequencing allows a better assessment of the HLA diversity in human populations, taking also into account the methodological difficulties it introduces at the statistical level; secondly, we show how analyzing HLA sequence variation may improve our comprehension of population genetic relationships by facilitating the identification of demographic events that marked human evolution; finally, we discuss the interest of both HLA and genome-wide sequencing and genotyping in detecting functionally significant SNPs in the MHC region, the latter having also contributed to the makeup of the HLA molecular diversity observed today.…”
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2647
Gene Technology for Papaya Ringspot Virus Disease Management
Published 2014-01-01“…This review discusses the genome and the genetic diversity of PRSV, host range determinants, molecular diagnosis, disease management strategies, the development of transgenic papaya, environmental issues, issues in the adoption of transgenic papaya, and future directions for research.…”
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2648
Integrins identified as potential prognostic markers in osteosarcoma through multi-omics and multi-dataset analysis
Published 2025-01-01“…The IRS’s utility in predicting overall survival was confirmed using data from The Cancer Genome Atlas, underscoring its potential in personalized cancer management.…”
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2649
Long journey of 16S rRNA‐amplicon sequencing toward cell‐based functional bacterial microbiota characterization
Published 2024-09-01“…Furthermore, we present the prospects for further technical development, including the combined use of high‐throughput methods and other informative analyses, such as whole‐genome sequencing in the common unit of the cell, which enables bacterial microbiota characterization based on both the number of cells and their functions.…”
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2650
A Network Pharmacology Study on the Cervix Prescription for Treatment of Cervical Cancer
Published 2022-01-01“…Gene ontology (GO) and Kyoto Gene and Genome Encyclopedia (KEGG) pathway enrichment analysis of overlapping targets were performed using DAVID 6.8 online tool. …”
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2651
8q22.2q22.3 Microdeletion Syndrome Associated with Hearing Loss and Intractable Epilepsy
Published 2019-01-01“…A minimal/maximal deletion of 5.238 Mb and 5.374Mb, respectively, at 8q22.2q22.3 was diagnosed using a genome-wide array. The clinical phenotype is similar to the others seven patients previously reported; however, the severity of epilepsy and the concomitant hearing loss is remarkable, characteristics previously observed independently in only two patients. …”
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2652
Structural insights into HIV-2 CA lattice formation and FG-pocket binding revealed by single-particle cryo-EM
Published 2025-02-01“…Summary: One of the striking features of human immunodeficiency virus (HIV) is the capsid, a fullerene cone comprised of pleomorphic capsid protein (CA) that shields the viral genome and recruits cofactors. Despite significant advances in understanding the mechanisms of HIV-1 CA assembly and host factor interactions, HIV-2 CA assembly remains poorly understood. …”
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2653
Fatal Hypogammaglobulinemia 3 Years after Rituximab in a Patient with Immune Thrombocytopenia: An Underlying Genetic Predisposition?
Published 2019-01-01“…The heterozygous mutation in the FASL gene, not present in the Genome Aggregation Database or ClinVar database, could suggest atypical Autoimmune LymphoProliferative Syndrome and its role in this patient’s immunodepression is discussed. …”
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2654
Identification of the Immune Cell Infiltration Landscape in Head and Neck Squamous Cell Carcinoma (HNSC) for the Exploration of Immunotherapy and Prognosis
Published 2022-01-01“…An analysis of the Cancer Genome Atlas (TCGA) database revealed gene expression profiles and corresponding clinical information. …”
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2655
Functions and applications of RNA interference and small regulatory RNAs
Published 2024-11-01“…Small regulatory RNAs play a variety of crucial roles in eukaryotes, influencing gene regulation, developmental timing, antiviral defense, and genome integrity via a process termed RNA interference (RNAi). …”
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2656
Inactivation of the CMAH gene and deficiency of Neu5Gc play a role in human brain evolution
Published 2025-02-01“…Abstract During human evolution, some genes were lost or silenced from the genome of hominins. These missing genes might be the key to the evolution of humans’ unique cognitive skills. …”
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2657
Modern and future forestry based on biotechnology
Published 2023-03-01“…In the last 2 decades, advances in biotechnologies such as high‐throughput sequencing and genome editing are transforming tree breeding and forestry. …”
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2658
Bach2: A Key Regulator in Th2-Related Immune Cells and Th2 Immune Response
Published 2022-01-01“…Furthermore, studies in various animal models show that Bach2 knockout animals spontaneously develop Th2 inflammation in the airway and gastrointestinal tract. Genome-wide association studies have identified various susceptibility loci of Bach2 which are linked with Th2 inflammatory diseases such as asthma and inflammatory bowel disease. …”
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2659
Exploring the maternal inheritance transmitted by the oocyte to its progeny
Published 2024-06-01“…Interestingly, while the sperm mostly transmits its haploid genome, the oocyte transmits not only its haploid set of chromosomes but also its huge cytoplasm to its progeny. …”
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2660
Genotype-phenotype insights of pediatric dilated cardiomyopathy
Published 2025-01-01“…Research has shown that DCM exhibits notable genetic heterogeneity, with over 100 DCM-related genes identified to date, primarily involving functions such as calcium handling, the cytoskeleton, and ion channels. As human genomic variations are linked to phenotypes, DCM phenotypes are influenced by numerous genetic variations across the entire genome. …”
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