The features of Tat protein of human immunodeficiency virus type 1 (Retroviridae: <i>Lentivirus: Lentivirus humimdef1</i>) non-A6 variants, characteristic for the Russian Federatio... by Anna I. Kuznetsova, Anastasiia A. Antonova, Aleksey V. Lebedev, Ekaterina N. Ozhmegova, Anastasia V. Shlykova, Ilya A. Lapovok, Oxana V. Galzitskaya

“…Tat protein is a trans-activator of HIV-1 genome transcription, with additional functions including the ability to induce the chronic inflammatory process. …”
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The protein structurome of Orthornavirae and its dark matter by Pascal Mutz, Antonio Pedro Camargo, Harutyun Sahakyan, Uri Neri, Anamarija Butkovic, Yuri I. Wolf, Mart Krupovic, Valerian V. Dolja, Eugene V. Koonin

“…ABSTRACT Metatranscriptomics is uncovering more and more diverse families of viruses with RNA genomes comprising the viral kingdom Orthornavirae in the realm Riboviria. …”
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Molecular characterization and lineage analysis of canine astrovirus strains from dogs with gastrointestinal disease in Ecuador based on ORF-2 gene analysis by Anthony Loor-Giler, Anthony Loor-Giler, Silvana Santander-Parra, Sara Castillo-Reyes, Martín Campos, Martín Campos, Renan Mena-Perez, Renan Mena-Perez, Santiago Prado-Chiriboga, Santiago Prado-Chiriboga, Luis Nunez, Luis Nunez

“…Canine Astrovirus (CaAstV) part of the Astroviridae family and genus Mamastrovirus, is a linear RNA virus with a genome of approximately 6.6 kb with three open reading frames (ORF): ORF1a and ORF1b, which code for the most conserved non-structural proteins, and ORF2, which code for the capsid protein, the most variable region of the genome. …”
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HIV-1 transcription start sites usage and its impact on unspliced RNA functions in people living with HIV by Saiful Islam, Frank Maldarelli, Olga A. Nikolaitchik, Zetao Cheng, Robert Gorelick, Maria A. Nikolaitchik, Vinay K. Pathak, Wei-Shau Hu

“…ABSTRACT HIV-1 unspliced RNA serves two distinct functions during viral replication: it is packaged into particles as the viral genome, and it is translated to generate Gag/Gag-Pol polyproteins required for virus assembly. …”
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Exploratory analysis of molecular traits of the mitochondrial DNA of leafcutting ants to infer taxonomic characters towards an integrative taxonomy by Perpetua Ndubuisi Onyinyechi, Natália Martins Travenzoli, Maykon Passos Cristiano, Danon Clemes Cardoso

“…., 2020, Atta Fabricius, 1804 and Acromyrmex Mayr, 1865 as models to evaluate a mitochondrial genome fragment regularly applied in phylogenetic and evolutionary studies. …”
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First isolation and characterization of SARS-CoV-2 from COVID-19 patient of North East India by Aniruddha Jakharia, Biswajyoti Borkakoty, Sumi Pait, Gautam Baruah, Rahul Hazarika, Dipankar Biswas

“…Phylogenetic analyses of the whole genome sequences of the SARS-CoV-2 isolate (EPI_ISL_2501532 | 2020-05-19) showed monophyletic clade G and lineage B.1.1.…”
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ANALYSIS OF PNEUMONIAASSOCIATED MORTALITY OF MONKEYS IN CAPTIVITY AND THE ROLE OF METHICILLIN-SENSITIVE STAPHYLOCOCCUS AUREUS (MRSA) IN THE RECOVERED MICROFLORA SPECTRUM by V. A. Kalashnikova, A. V. Demerchyan

“…All recovered S. aureus cultures were methicillin-sensitive and did not have gene mecA in their genome. During performance of bacteriological tests of autopsy material the lung tissue samples can get contaminated with the foreign flora that’s why it’s quite difficult to speak about the role of these and those microorganisms as major disease agents.…”
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Transcriptional Regulation of the p53 Tumor Suppressor Gene in S-Phase of the Cell-Cycle and the Cellular Response to DNA Damage by David Reisman, Paula Takahashi, Amanda Polson, Kristy Boggs

“…The p53 tumor suppressor induces the transcription of genes that negatively regulate progression of the cell cycle in response to DNA damage or other cellular stressors and thus participates in maintaining genome stability. Numerous studies have demonstrated that p53 transcription is activated before or during early S-phase in cells progressing from G0/G1 into S-phase through the combined action of two DNA-binding factors RBP-Jκ and C/EBPβ-2. …”
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Susceptibility Genes in Thyroid Autoimmunity by Yoshiyuki Ban, Yaron Tomer

“…Various techniques have been employed to identify the genes contributing to the etiology of AITD, including candidate gene analysis and whole genome screening. These studies have enabled the identification of several loci (genetic regions) that are linked with AITD, and in some of these loci, putative AITD susceptibility genes have been identified. …”
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Resistify: A Novel NLR Classifier That Reveals Helitron-Associated NLR Expansion in Solanaceae by Moray Smith, John T Jones, Ingo Hein

“…Nucleotide-binding domain leucine-rich repeat (NLR) proteins are a key component of the plant innate immune system. In plant genomes, NLRs exhibit considerable presence/absence variation and sequence diversity. …”
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Coleopteran Antimicrobial Peptides: Prospects for Clinical Applications by Monde Ntwasa, Akira Goto, Shoichiro Kurata

“…Recently, the complete genome sequence of Tribolium was published, boosting research on coleopteran immunity and leading to the identification of Tribolium AMPs that are shared by Drosophila and mammals, as well as other AMPs that are unique. …”
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PD-L1 knockout or ZG16 overexpression inhibits PDAC progression and modulates TAM polarization by Hui Meng, Manman Nan, Yizhen Li, Yi Ding, Xiaokun Fang, Weiqian Ma, Mingzhi Zhang

“…CRISPR/Cas9-mediated genome editing has the potential to delete PD-L1 both on the cell surface and inside the cell, thereby inhibiting tumor growth and migration and overcoming immunosuppression. …”
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Big Data Analytics for Healthcare Industry: Impact, Applications, and Tools by Sunil Kumar, Maninder Singh

“…We also explore the conceptual architecture of big data analytics for healthcare which involves the data gathering history of different branches, the genome database, electronic health records, text/imagery, and clinical decisions support system.…”
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Advance technologies for DNA-protein interactions and future research prospect by Chengyi Qu, Hao Du

“…DNA-protein interactions (DPIs) are essential for genome functioning, with billions of years of evolution shaping specific patterns of protein-DNA interactions to regulate gene networks in response to various stimuli. …”
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Are There Mutator Polymerases? by Miguel Garcia-Diaz, Jose F. Ruiz, Raquel Juarez, Gloria Terrados, Luis Blanco

“…DNA polymerases are involved in different cellular events, including genome replication and DNA repair. In the last few years, a large number of novel DNA polymerases have been discovered, and the biochemical analysis of their properties has revealed a long list of intriguing features. …”
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Molecular profiling and detection methods of microRNA in cancer research by Nurul-Syakima Ab Mutalib, Imilia Ismail, Hooi-Leng Ser

“… A large portion of human genome was believed to be “useless” and termed as “junk DNA” in the past, given that these sequences did not have any protein coding role. …”
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Interspecies In Vitro Evaluation of Stereoselective Protein Binding for 3,4-Methylenedioxymethamphetamine by Wan Raihana Wan Aasim, Soo Choon Tan, Siew Hua Gan

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Targeting Toll-Like Receptors for Treatment of SLE by Christopher G. Horton, Zi-jian Pan, A. Darise Farris

“…Activation of these TLRs results in the production of inflammatory cytokines and type I interferon. Genome-wide association studies, single nucleotide polymorphism analyses as well as experimental mouse models have provided evidence of TLR signaling involvement in SLE and other autoimmune diseases. …”
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The Regulation and Functions of Endogenous Retrovirus in Embryo Development and Stem Cell Differentiation by Yangquan Xiang, Hongqing Liang

“…Endogenous retroviruses (ERVs) are repetitive sequences in the genome, belonging to the retrotransposon family. During the course of life, ERVs are associated with multiple aspects of chromatin and transcriptional regulation in development and pathological conditions. …”
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The Ecology and Evolutionary Biology of Cancer: A Review of Mathematical Models of Necrosis and Tumor Cell Diversity by John D. Nagy

“…Recent evidence elucidating the relationship between parenchyma cells and otherwise ''healthy'' cells in malignant neoplasms is forcing cancer biologists to expand beyond the genome-centered, ''one-renegade-cell'' theory of cancer. …”
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