Genetics of Keratoconus: Where Do We Stand? by Khaled K. Abu-Amero, Abdulrahman M. Al-Muammar, Altaf A. Kondkar

“…Keratoconus has a complex multifactorial etiology, with environmental, behavioral, and multiple genetic components contributing to the disease pathophysiology. Using genome-wide and candidate gene approaches several genomic loci and genes have been identified that highlight the complex molecular etiology of this disease. …”
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The Transcribed-Ultraconserved Regions: A Novel Class of Long Noncoding RNAs Involved in Cancer Susceptibility by Paola Scaruffi

“…A large proportion of the transcriptional output is represented by protein noncoding RNAs (ncRNAs) that arise from the “dark matter” of the genome. Focus on such sequences has revealed numerous RNA subtypes with several functions in RNA processing and gene expression regulation, and deep sequencing studies imply that many remain to be discovered. …”
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Genetics and Epigenetics of Parkinson's Disease by Fabio Coppedè

“…The majority of PD cases are however sporadic “idiopathic” forms, and the recent application of genome-wide screening revealed almost 20 genes that might contribute to disease risk. …”
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Deep R-gene discovery in HLB resistant wild Australian limes uncovers evolutionary features and potentially important loci for hybrid breeding by Jianyang Liu, Khushwant Singh, Matthew Huff, Christopher Gottschalk, Michael Do, Margaret Staton, Manjunath L. Keremane, Robert Krueger, Chandrika Ramadugu, Chris Dardick

“…The aim of this study was to gain insight into the genomic features of R-genes in Australian limes, in comparison to susceptible citrus cultivars. …”
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Metabolomic approach to search for fungal resistant forms of <i>Aegilops tauschii</i> Coss. from the VIR collection by T. V. Shelenga, L. L. Malyshev, Yu. A. Kerv, T. V. Diubenko, A. V. Konarev, V. I. Horeva, M. K. Belousova, M. A. Kolesova, N. N. Chikida

“…This species, believed to be the donor of D genome of common wheat (T. aestivum L.), is a source of some traits important for breeding. …”
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The Identification of Molecular Ploidy Status of Abnormal Pronuclear Zygotes Reveals a Significant Number of Euploid Blastocysts Available for Conception by Blair R. McCallie, Mary E. Haywood, Lauren N. Henry, Rachel M. Lee, William B. Schoolcraft, Mandy G. Katz-Jaffe

“…Biopsied trophectoderm cells were then lysed, and the isolated DNA was whole-genome amplified followed by library preparation. …”
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Epidemiology of pediatric dengue virus infection, Scenario from a tertiary level hospital in Bangladesh by Kinkar Ghosh, Selim Reza Tony, Khaleda Islam, Reaz Mobarak, Md. Jahangir Alam, Md. Kamruzzaman, Sumaira Alam, Muhammad Talha, Abdullah Al Faisal, Nahidul Islam, Md Mobarok Hossain, Mst. Noorjahan Begum, Mustafizur Rahman

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Characterizing immune biomarkers and effector CD8+ T-cell exhaustion in pancreatic adenocarcinoma via single-cell RNA sequencing profiling by Rawaa AlChalabi, Raghda Makia, Semaa A. Shaban, Ahmed AbdulJabbar Suleiman

“…Methods: We employed a multi-omics approach, integrating single-cell RNA sequencing data with whole genome sequencing to identify dysregulated exhaustion-related immune markers in CD8+ T-cells in PDAC. …”
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Degenerated vision, altered lipid metabolism, and expanded chemoreceptor repertoires enable Lindaspio polybranchiata to thrive in deep-sea cold seeps by Yujie Yan, Inge Seim, Yang Guo, Xupeng Chi, Zhaoshan Zhong, Dantong Wang, Mengna Li, Haining Wang, Huan Zhang, Minxiao Wang, Chaolun Li

“…We sequenced and assembled the genome of L. polybranchiata and performed comparative genomic analyses to investigate the genetic basis of adaptation to the deep sea. …”
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Co-obligate symbioses have repeatedly evolved across aphids, but partner identity and nutritional contributions vary across lineages by Manzano-Marín, Alejandro, Coeur d’acier, Armelle, Clamens, Anne-Laure, Cruaud, Corinne, Barbe, Valérie, Jousselin, Emmanuelle

“…Lastly, patterns of Buchnera genome evolution reveal that small losses affecting a few key genes can be the onset of these dual systems, while large gene losses can occur without any co-obligate symbiont acquisition. …”
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Construction of a radiogenomic signature based on endoplasmic reticulum stress for predicting prognosis and systemic combination therapy response in hepatocellular carcinoma by Huai-Yu Wu, Shu-Ya Cao, Zheng-Gang Xu, Tian- Wang, Gu-Wei Ji, Ke Wang

“…Methods Using data from The Cancer Genome Atlas Program (TCGA) as a training cohort and data from International cancer genome consortium (ICGC) as a testing cohort. …”
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Detection of genetic sex using a qPCR-based method in the bigfin reef squid (Sepioteuthis lessoniana) by Yi-Chien Lee, Li-Lun Tang, Yu-Chen Yeh, Hau-Wen Li, Huei-Mien Ke, Cheng-Ju Yang, Chun-I Chiang, Chia-Hui Wang, Yung-Che Tseng, Ching-Fong Chang, Isheng Jason Tsai, Guan-Chung Wu

“…Analysis of the female and male genome coverage along the assembly confirms a ZZ/Z0 female hemizygous sex-determination system in bigfin reef squid. …”
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Animal Brucellosis in Egypt: Review on Evolution, Epidemiological Situation, Prevalent <i>Brucella</i> Strains, Genetic Diversity, and Assessment of Implemented National Control Me... by Ahmed M. S. Menshawy, Acacia Ferreira Vicente, Yamen M. Hegazy, Vitomir Djokic, Mahmoud E. R. Hamdy, Luca Freddi, Essam M. Elbauomy, Ashraf E. Sayour, Claire Ponsart, Nour H. Abdel-Hamid

“…This review delves deeply into brucellosis’s current epidemiological situation and potential sources of livestock infection in Egypt during the last two decades. MLVA-16 and Whole Genome Sequencing based on core-genome SNP analyses confirm the presence of different <i>B. abortus</i> and <i>B. melitensis</i> outbreak strains, both older widely disseminated <i>Brucella</i> strains and newly introduced ones. …”
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Exploring the role of inflammatory biomarkers in trigeminal neuralgia by Shenglong Lai, Haiyang Li, Yazhou Xing, Du Wu, Lin Wang, Qinghua Liang

“…Instrumental variables (IVs) were selected based on genome-wide significance and clumping thresholds to avoid linkage disequilibrium. …”
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Pantoea eucrina: Catheter‐Related Bloodstream Infection in a Woman With Short Bowel Syndrome by Ida Saksenborg Kølle, Lars Vinter‐Jensen, Morten Eneberg Nielsen, Hans Linde Nielsen

“…Despite presenting with only minor clinical symptoms, blood cultures from both central and peripheral sites confirmed the presence of P. eucrina, identified by matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry (MALDI‐TOF MS) and whole‐genome sequencing. The infection was successfully cleared following a 13‐day course of gentamicin lock therapy and intravenous piperacillin–tazobactam, after which the catheter was removed.…”
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Discovery of paradoxical genes: reevaluating the prognostic impact of overexpressed genes in cancer by Dequan Liu, Lei Liu, Xiangyu Che, Guangzhen Wu

“…Analyzing The Cancer Genome Atlas (TCGA) confirmed the widespread presence of paradoxical genes, and KEGG analysis revealed their role in regulating tumor metabolism. …”
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iMetaOmics: Advancing human and environmental health through integrated meta‐omics by Chun‐Lin Shi, Tong Chen, Canhui Lan, Ren‐You Gan, Jun Yu, Fangqing Zhao, Yong‐Xin Liu

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A Mathematical Model for DNA Damage and Repair by Philip S. Crooke, Fritz F. Parl

“…In cells, DNA repair has to keep up with DNA damage to maintain the integrity of the genome and prevent mutagenesis and carcinogenesis. …”
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DNA Methylation: Its Role and Interaction with Epigenetic Modifications in Cancer by Nasreddine El Omari, Saad Bakrim, Mohamed Bakha, Abdelaali Balahbib, Abdelhakim Bouyahya, Chrismawan Ardianto, Long Chiau Ming, Hooi Leng Ser

“…DNMTs play a central role in the epigenetic regulation of the human genome, both in normal and pathological processes. …”
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Deconstruction of Vulnerability to Complex Diseases: Enhanced Effect Sizes and Power of Intermediate Phenotypes by David Goldman, Francesca Ducci

“…Systematic searches for genes influencing complex disorders, including bipolar disorder, have recently been completed using whole genome association (WGA), identifying a series of validated loci. …”
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