Polyploidization-driven transcriptomic dynamics in Medicago sativa neotetraploids: mRNA, smRNA and allele-specific gene expression by D. F. Santoro, G. Marconi, S. Capomaccio, M. Bocchini, A. W. Anderson, A. Finotti, M. Confalonieri, E. Albertini, D. Rosellini

“…Abstract Whole genome duplication (WGD) is a powerful evolutionary mechanism in plants. …”
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Epigenome-wide association study of Chinese monozygotic twins identifies DNA methylation loci associated with estimated glomerular filtration rate by Xueting Qi, Jingjing Wang, Tong Wang, Weijing Wang, Dongfeng Zhang

“…GeneMANIA was used to analyze the gene interaction network. The Genomic Regions Enrichment of Annotations Tool enriched biological functions and pathways. …”
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Insight into the codon usage patterns and adaptation of Tembusu Virus by Fucheng Guo, Huiming Tan, Jinjin Yang, Rumin Jia, Ruichen Wang, Lie Wu, Fengzhi Pan, Kai Kang, Weitian Xie, Youquan Li, Kewei Fan

“…Analysis of dinucleotide distribution reveals significant suppression of CpG and UpA dinucleotides in the TMUV genome, reflecting adaptive pressures to evade vertebrate immune responses. …”
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An association between type A porcine endogenous retrovirus copy number and hematological parameters and gender in miniature pigs by R. B. Aitnazarov, S. V. Nikitin, G. V. Kontsevaya, M. I. Voevoda, N. S. Yudin

“…Selection for animals with low copy number of retroviruses in the genome using simple phenotypic indications is required for the widespread implementation of xenotransplantation. …”
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Phylogenomic analysis reveals exceptions to the co-evolution of ZAR1 and ZRK immune gene families in plants by Li Yang, Shengyi Liu, M. Eric Schranz, Klaas Bouwmeester

“…All analysed monocot genomes thus far examined, except for the aroid Colocasia esculenta, were previously reported to lack both ZAR1-A and ZRKs. …”
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Identification and validation of prognostic biomarkers in ccRCC: immune-stromal score and survival prediction by Fang Lyu, Yuxin Zhong, Qingliu He, Wen Xiao, Xiaoping Zhang

“…Methods Data from the Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) were subjected to analysis to compute immune and stromal scores utilizing the ESTIMATE algorithm. …”
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Mono-allelic epigenetic regulation of polycistronic transcription initiation by RNA polymerase II in Trypanosoma brucei by Rudo Kieft, Laura Cliffe, Haidong Yan, Robert J. Schmitz, Stephen L. Hajduk, Robert Sabatini

“…ABSTRACT Unique for a eukaryote, protein-coding genes in trypanosomes are arranged in polycistronic transcription units (PTUs). This genome arrangement has led to a model where Pol II transcription of PTUs is unregulated and changes in gene expression are entirely post-transcriptional. …”
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Identification of two new genetic loci for high-resolution genotyping of Enterocytozoon bieneusi by Meng Xinan, Ou Yonglin, Jiang Wen, Guo Yaqiong, Xiao Lihua, Feng Yaoyu, Li Na

“…In this study, comparison of a clinical genome sequence (C44566) with the whole genome sequence of an E. bieneusi isolate (H348) in GenBank led to the selection of the hypothetical protein 1 (hp1) and tubulin 1 (tub1) loci. …”
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GWAS identifies a polyembryony locus in mango: development of KASP and PACE markers for marker-assisted breeding by Gul Shad Ali, Shamseldeen Eltaher, Shamseldeen Eltaher, Jin Li, Barbie Freeman, Sukhwinder Singh

“…Comparative genomic analyses revealed synteny between the citrus and the mango polyembryony loci, suggesting a common evolutionary mechanism for this trait. …”
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An Enigmatic Wild Passerine Mortality Event in the Eastern United States by Sabrina S. Greening, Julie C. Ellis, Nicole L. Lewis, David B. Needle, Cristina M. Tato, Susan Knowles, Valerie Shearn-Bochsler, Jaimie L. Miller, Daniel A Grear, Jeffrey M. Lorch, David S. Blehert, Caitlin Burrell, Lisa A. Murphy, Erica A. Miller, C. Brandon Ogbunugafor, Andrea J. Ayala, W. Kelley Thomas, Joseph L. Sevigny, Lawrence M. Gordon, Tessa Baillargeon, Lusajo Mwakibete, Megan Kirchgessner, Christine L. Casey, Ethan Barton, Michael J. Yabsley, Eman Anis, Roderick B. Gagne, Patrice Klein, Cindy Driscoll, Chelsea A. Sykes, Robert H. Poppenga, Nicole M. Nemeth

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Genetic Polymorphism in Peripartum Cardiomyopathy by Ivana Purnama Dewi, Johanes Nugroho

“…Many evidence supporting a contribution from gene mutations in PPCM includes genome-wide association studies, familial occurrence, variable prevalence among different regions and ethnicities, and more recent investigations of panels of genes for mutations among women with PPCM. …”
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Genetics of Childhood Obesity by Jianhua Zhao, Struan F. A. Grant

“…Besides environmental factors, genetic factors are known to play an important role in the pathogenesis of obesity. Genome-wide association studies (GWAS) have revealed strongly associated genomic variants associated with most common disorders; indeed there is general consensus on these findings from generally positive replication outcomes by independent groups. …”
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Design of therapeutic siRNAs for potential application to infection with chikungunya virus by Ahmed Ahsan Adib, Muhammad Manjurul Karim

“…Here, we considered various parts of the CHIKV genome encoding different essential protein-coding genes for designing siRNAs with a view to silencing them, thereby rendering the virus inactive. …”
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The Role of RaxST, a Prokaryotic Sulfotransferase, and RaxABC, a Putative Type I Secretion System, in Activation of the Rice XA21-Mediated Immune Response by Pamela C. Ronald

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Targeting EBV Episome for Anti-Cancer Therapy: Emerging Strategies and Challenges by Febri Gunawan Sugiokto, Renfeng Li

“…The presence of EBV in tumor cells provides a unique advantage in targeting the viral genome (also known as episome), to develop anti-cancer therapeutics. …”
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Charcot-Marie-Tooth disease: A case report initially manifested by bilateral vocal cord paralysis by Seyed Hossein Mirlohi, Sanaz Tajfirooz, Mitra Rouhi

“…Diagnosis was confirmed through whole genome sequencing, revealing mutations in genes associated with the disorder.…”
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Contribution of Genetic Factors to Sjögren’s Syndrome and Sjögren’s Syndrome Related Lymphomagenesis by Adrianos Nezos, Clio P. Mavragani

“…Genes within the major histocompatibility complex (MHC) locus previously considered conferring increased susceptibility to SS development have been also revealed as important contributors in recent genome wide association studies. Moreover, genetic variations outside the MHC locus involving genes in type I interferon pathway, NF-κB signaling, B- and T-cell function and methylation processes have been shown to be associated with both SS and SS-related lymphoma development. …”
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Substrates, regulation, cellular functions, and disease associations of P4-ATPases by Hye-Won Shin, Hiroyuki Takatsu

“…These enzymes are conserved across all eukaryotes, and the human genome encodes 14 distinct P4-ATPases. Initially identified as aminophospholipid translocases, P4-ATPases have since been found to translocate other phospholipids, including phosphatidylcholine, phosphatidylinositol, and even glycosphingolipids. …”
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Antibody-Dependent Cellular Cytotoxicity and NK Cell-Driven Immune Escape in HIV Infection: Implications for HIV Vaccine Development by Gamze Isitman, Ivan Stratov, Stephen J. Kent

“…The HIV-1 genome is malleable and a difficult target tot vaccinate against. …”
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The Possible Role of Epigenetics in Gestational Diabetes: Cause, Consequence, or Both by J. L. Fernández-Morera, S. Rodríguez-Rodero, E. Menéndez-Torre, M. F. Fraga

“…Several risk factors of GDM depend on environmental factors that are thought to regulate the genome through epigenetic mechanisms. Thus, epigenetic regulation could be involved in the development of GDM. …”
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