Whole Exome Sequencing Reveals Compound Heterozygosity for Ethnically Distinct PEX7 Mutations Responsible for Rhizomelic Chondrodysplasia Punctata, Type 1 by Jessie C. Jacobsen, Emma Glamuzina, Juliet Taylor, Brendan Swan, Shona Handisides, Callum Wilson, Michael Fietz, Tessa van Dijk, Bart Appelhof, Rosamund Hill, Rosemary Marks, Donald R. Love, Stephen P. Robertson, Russell G. Snell, Klaus Lehnert

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Machine learning-driven identification of critical gene programs and key transcription factors in migraine by Lei Zhang, Yujie Li, Yunhao Xu, Wei Wang, Guangyu Guo

“…Methods We utilized single-nucleus RNA sequencing (snRNA-seq) data from 43 brain regions, along with genome-wide association study (GWAS) data, to investigate susceptibility to migraine. …”
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Evolution of the umbilical cord blood proteome across gestational development by Leena B. Mithal, Nicola Lancki, Ted Ling-Hu, Young Ah Goo, Sebastian Otero, Nathaniel J. Rhodes, Byoung-Kyu Cho, William A. Grobman, Judd F. Hultquist, Denise Scholtens, Karen K. Mestan, Patrick C. Seed

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Comprehensive phenotypic analysis of multiple gene deletions of α-glucan synthase and Crh-transglycosylase gene families in Aspergillus niger highlighting the versatility of the fu... by Katharina J. Ost, Mark Arentshorst, Bruno M. Moerschbacher, Mareike E. Dirks-Hofmeister, Arthur F.J. Ram

“…Multiple paralogs are found in the fungal genomes for several genes that encode proteins involved in cell wall biosynthesis. …”
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Amorphous calcium phosphate-coated surfaces as a model for bone microenvironment in prostate cancer by Rebeca San Martin, Prijoyit Das, Tianchun Xue, Morgan Rose Brown, Renata Dos Reis Marques, Michael Essington, Adrian Gonzalez, Rachel Patton McCord

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Epigenetics of suicidal behavior by R. N. Mustafin, A. V. Kazantseva, R. F. Enikeeva, Yu. D. Davydova, S. B. Malykh, V. V. Viktorov, E. K. Khusnutdinova

“…To solve this problem and interpret the missing relationship between the environment and the genome, promising results were obtained from a study of epigenetic factors, which affected the expression of a number of candidate genes involved in brain functioning in suicidal behavior. …”
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Molecular Epidemiology and Genetic Evolution of Porcine Reproductive and Respiratory Syndrome Virus in Northern China During 2021–2023 by Na Yuan, Zuofeng Yang, Fengxia Lv, Lina Dou, Xiangqing Li, Baokai Zhao, Shishan Dong

“…Moreover, the 27 whole-genome sequences were analyzed. As indicated, 24 of them were exposed to gene recombination, and L1.8 provided the backbone for recombination events. …”
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GADD45β Determines Chemoresistance and Invasive Growth of Side Population Cells of Human Embryonic Carcinoma by Toshihiko Inowa, Keiichi Hishikawa, Yumi Matsuzaki, Takayuki Isagawa, Takumi Takeuchi, Hiroyuki Aburatani, Tadaichi Kitamura, Toshiro Fujita

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Surveillance of SARS-CoV-2 variants in Henan, China from 2023 to 2024 by Yun Song, Bicong Wu, Hongxia Ma, Yafei Li, Su Yan, Jingjing Pan, Haifeng Wang, Ying Ye, Xueyong Huang, Wanshen Guo

“…Genome sequence analysis was performed with CLC Genomics Workbench, and genotyping and sequence alignment were carried out using the Nextclade platform. …”
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In Silico Exploration of Staphylococcal Cassette Chromosome <i>mec</i> (SCC<i>mec</i>) Evolution Based on Phylogenetic Relationship of <i>ccrAB/C</i> by Huawei Wang, Jinxing He

“…The CUB of <i>mecA</i>, <i>ccrAB/C</i> of 12 SCC<i>mec</i> types and core genome of 33 staphylococci species were subsequently compared; the phylogenetic relationship of <i>ccrAB/C</i> was observed via SCC<i>mec</i> typing on a temporal and geographical scale; and the duplicate appearance of <i>ccrAB/C</i> was illustrated by comparing SCC<i>mec</i> compositions. …”
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Ten Candidate Genes Were Identified to Be Associated with the Great Growth Differentiation in the Three-Way Cross Hybrid Abalone by Qizhen Xiao, Shihai Gong, Zekun Huang, Wenzhu Peng, Zhaofang Han, Yang Gan, Yawei Shen, Weiwei You, Caihuan Ke, Xuan Luo

“…In this study, a total of 89 SNPs and 97 candidate genes were identified to be associated with growth-related traits of abalone using whole-genome resequencing and a genome-wide association study (GWAS) analysis. …”
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Human phospholipases A2: a functional and evolutionary analysis by I. I. Turnaev, M. E. Bocharnikova, D. A. Afonnikov

“…Localization of the PLA2 genes in human genome showed they are placed on 12 human chromosomes, some of them forming clusters. …”
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A transgenic cell line with inducible transcription for studying (CGG)n repeat expansion mechanisms by I. V. Grishchenko, A. A. Tulupov, Y. M. Rymareva, E. D. Petrovskiy, A. A. Savelov, A. M. Korostyshevskaya, Y. V. Maksimova, A. R. Shorina, E. M. Shitik, D. V. Yudkin

“…In addition, a criterion was developed for the quantif ication of exogenous (CGG)n repeat instability in the transgenic cell lines’ genome.…”
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Unveiling the signal valve specifically tuning the TGF-β1 suppression of osteogenesis: mediation through a SMAD1-SMAD2 complex by Ying-Wen Wang, Ching-Wei Luo

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Evaluation of synthetic wheat lines (Triticum durum/Aegilops tausсhii) for vegetative period and resistance to diseases by V. P. Shamanin, I. V. Pototskaya, S. S. Shepelev, V. E. Pozherukova, A. Yu. Truschenko, A. S. Chursin, A. I. Morgunov

“…The results of a phenotypic evaluation of the synthetic hexaploid wheat lines of CIMMYT breeding created by crossing durum wheat varieties from Institute of Breeding and Genetics (Odessa, Ukraine) and variety Pandur from Romania (T. durum Desf., AB genome) with Aegilops (Ae. tausshii Coss., D genome), and also 15 synthetic wheat lines of Kyoto University breeding (Japan) created by crossing durum wheat variety Langdon with different ecological forms Aegilops are presented. …”
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Identification of novel PfEMP1 variants containing domain cassettes 11, 15 and 8 that mediate the Plasmodium falciparum virulence-associated rosetting phenotype. by Florence E McLean, Brian R Omondi, Nouhoum Diallo, Stanley Otoboh, Carolyne Kifude, Abdirahman I Abdi, Rivka Lim, Thomas D Otto, Ashfaq Ghumra, J Alexandra Rowe

“…However, making functional sense of genomic data relies on the ability to infer binding phenotype from var gene sequence. …”
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Global prevalence of platelet-type von Willebrand disease by Omid Seidizadeh, Andrea Cairo, Maha Othman, Flora Peyvandi

“…Methods: We used available exome and genome sequencing data of 807,162 (730,947 exomes and 76,215 genomes) subjects from the Genome Aggregation Database (gnomAD-v4.1). …”
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The potential for gene-editing to increase muscle growth in pigs: experiences with editing myostatin by A. C. Dilger, X. Chen, L. T. Honegger, B. M. Marron, J. E. Beever

“…Reducing the percentage of the cloned genome by outcrossing successfully improved viability of MSTN +/+ and MSTN ± pigs, but not of MSTN −/− pigs. …”
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Design and structure of overlapping regions in PCA via deep learning by Yan Zheng, Xi-Chen Cui, Fei Guo, Ming-Liang Dou, Ze-Xiong Xie, Ying-Jin Yuan

“…This comprehensive approach facilitates streamlined and efficient investigations into the genome synthesis.…”
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Metatranscriptomes-based sequence similarity networks uncover genetic signatures within parasitic freshwater microbial eukaryotes by Arthur Monjot, Jérémy Rousseau, Lucie Bittner, Cécile Lepère

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