CGH, cDNA and Tissue Microarray Analyses Implicate FGFR2 Amplification in a Small Subset of Breast Tumors by Mervi Heiskanen, Juha Kononen, Maarit Bärlund, Joachim Torhorst, Guido Sauter, Anne Kallioniemi, Olli Kallioniemi

“…Multiple regions of the genome are often amplified during breast cancer development and progression, as evidenced in a number of published studies by comparative genomic hybridization (CGH). …”
Get full text

Variations in the composition and frequency of celiac disease epitopes among synthetic wheat lines by Rahman Ebrahimzadegan, Ghader Mirzaghaderi

“…Generally, the immunogenic load of lines with the D-genome originating from Ae. crassa was much lower than those with the D-genome from Ae. tauschii. …”
Get full text

Inhibition of the invasive plant Ambrosia trifida by Sigesbeckia glabrescens extracts by Lijuan Yin, Guangzhong Zhang, Haoyu Zhao, Yuxin Zhang, Jiaozi Wangchen, Fanghao Wan, Bo Liu, Wanqiang Qian

Get full text

Comprehensive analysis of metabolomics and transcriptomics reveals varied tepal pigmentation across Gloriosa varieties by Yue Sun, Pinli Hu, Yanan Jiang, Zhenzhen Wang, Jiaxing Chang, Yiwei Zhou, Haojing Shao

Get full text

Life stage impact on the human skin ecosystem: lipids and the microbial community by Martin P. Pagac, Bala Davient, Luca Antonio Plado, Hilbert Yuen In Lam, Shi Mun Lee, Aarthi Ravikrishnan, Wee Ling Esther Chua, Sneha Muralidharan, Aishwarya Sridharan, Antony S. Irudayaswamy, Ramasamy Srinivas, Stephen Wearne, Ahmad Nazri Mohamed Naim, Eliza Xin Pei Ho, H. Q. Amanda Ng, Junmei Samantha Kwah, Eileen Png, Anne K. Bendt, Markus R. Wenk, Federico Torta, Niranjan Nagarajan, John Common, Yap Seng Chong, Elizabeth Huiwen Tham, Lynette Pei-Chi Shek, Evelyn Xiu Ling Loo, John Chambers, Yik Weng Yew, Marie Loh, Thomas L. Dawson

Get full text

Towards Creating the Perfect In Vitro Cell Model by Malin K. B. Jonsson, Toon A. B. van Veen, Jane Synnergren, Bruno Becker

Get full text

A dual role of Cohesin in DNA DSB repair by Michael Fedkenheuer, Yafang Shang, Seolkyoung Jung, Kevin Fedkenheuer, Solji Park, Davide Mazza, Robin Sebastian, Hiroyuki Nagashima, Dali Zong, Hua Tan, Sushil Kumar Jaiswal, Haiqing Fu, Anthony Cruz, Supriya V. Vartak, Jan Wisniewski, Vittorio Sartorelli, John J. O’Shea, Laura Elnitski, Andre Nussenzweig, Mirit I. Aladjem, Fei-Long Meng, Rafael Casellas

“…Defects in repairing double-stranded breaks (DSBs) can lead to genomic instability, contributing to cancer, genetic disorders, immunological diseases, and developmental defects. …”
Get full text

Leveraging AI to automate detection and quantification of extrachromosomal DNA to decode drug responses by Kohen Goble, Aarav Mehta, Damien Guilbaud, Jacob Fessler, Jingting Chen, William Nenad, William Nenad, Christina G. Ford, Oliver Cope, Darby Cheng, William Dennis, Nithya Gurumurthy, Yue Wang, Kriti Shukla, Elizabeth Brunk, Elizabeth Brunk, Elizabeth Brunk, Elizabeth Brunk, Elizabeth Brunk

Get full text

Using the synthetic form RS5 to obtain new introgressive lines of common wheat by R. O. Davoyan, I. V. Bebyakina, E. R. Davoyan, Y. S. Zubanova, D. M. Boldakov, D. S. Mikov, V. A. Bibishev, A. N. Zinchenko, E. D. Badaeva

“…/Ae. tauschii (BBAADt Dt ), in which the D genome from Ae. tauschii was added to the BBAA genomes of the durum wheat cultivar Mutico italicum. …”
Get full text

An Enhanced End-to-End Object Detector for Drone Aerial Imagery by Quan Yu, Qiang Tong, Lin Miao, Lin Qi, Xiulei Liu

Get full text

Rational Primer and Probe Construction in PCR-Based Assays for the Efficient Diagnosis of Drifting Variants of SARS-CoV-2 by Divya RSJB Rana, Nischal Pokhrel, Santosh Dulal

“…The genome sequence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been evolving via genomic drifts resulting in “emerging/drifting variants” circulating worldwide. …”
Get full text

Molecular cytological analysis of alien introgressions in common wheat lines created by crossing of <i>Triticum aestivum</i> with <i>T. dicoccoides</i> and <i>T. dicoccum</i> by О. A. Orlovskaya, I. N. Leonova, L. A. Solovey, N. I. Dubovets

“…A molecular cytogenetic analysis of introgression wheat lines indicated that the inclusion of the genetic material of wild and domesticated emmer was carried out mainly in the form of whole arms or large fragments in the chromosomes of the B genome and less extended inserts in the A genome. …”
Get full text

Prophage-DB: a comprehensive database to explore diversity, distribution, and ecology of prophages by Etan Dieppa-Colón, Cody Martin, James C. Kosmopoulos, Karthik Anantharaman

“…Temperate phages adopt the lysogenic mode of infection, where the genome integrates into the host cell genome forming a prophage. …”
Get full text

Effects of yttrium addition on microstructure and mechanical property of Nb-1Zr-0.1C alloy by Wanxin Liu, Shengjie Wang, Xiaoxin Zhang, Yanchang Liu, Bin Liang, Shilei Li

Get full text

Pseudocitrobacter cyperus, a novel bacterial species recovered from Cyperus alternifolius in Egypt by Samira M. Hamed, Mai A. Amer

“…To confirm its taxonomic classification, the draft genome of Cyp38ST was generated using DNBseq, and the genome-based taxonomic evaluation was conducted by calculating the overall genome-relatedness indices (OGRIs) such as Average Nucleotide Identity (ANI), digital DNA-DNA hybridization (dDDH), and the tetra-nucleotide signatures (Tetra). …”
Get full text

Unique North American isolates of severe metastatic hypervirulent Klebsiella pneumoniae strain infections with hepatic abscesses seen in young patients within Texas. by Junaid M Alam, Eric N Riha, Haris Ahmed, Hong M Thai, Kevin Garnepudi, Ramesh B Kesavan, Gnananandh Jayaraman, Anna Sangster, Dylan Curry, Heidi A Butz, Lori Smith, Maureen Vowles, Kelly F Oakeson, Erin L Young, Siva T Sarva

“…<h4>Methods</h4>Whole genome sequencing was performed using both paired-end Illumina MiSeq and nanopore sequencing to obtain a Completed genome for both isolates.…”
Get full text

Simple Meets Single: The Application of CRISPR/Cas9 in Haploid Embryonic Stem Cells by Zixi Yin, Lingyi Chen

“…The CRISPR/Cas9 system provides a powerful method for the genetic manipulation of the mammalian genome, allowing knockout of individual genes as well as the generation of genome-wide knockout cell libraries for genetic screening. …”
Get full text

Cell-free assays reveal that the HIV-1 capsid protects reverse transcripts from cGAS immune sensing. by Tiana M Scott, Lydia M Arnold, Jordan A Powers, Delaney A McCann, Ana B Rowe, Devin E Christensen, Miguel J Pereira, Wen Zhou, Rachel M Torrez, Janet H Iwasa, Philip J Kranzusch, Wesley I Sundquist, Jarrod S Johnson

“…However, the extent to which HIV-1 shields its genome from cGAS recognition remains unclear. To study this process in mechanistic detail, we reconstituted reverse transcription, genome release, and innate immune sensing of HIV-1 in a cell-free system. …”
Get full text

Distribution and genetic diversity of three apple viruses in Belarus by P. V. Kuzmitskaya, O. Yu. Urbanovich

“…Virus-infected apple trees were identified by RT- PCR in modern horticultural plantations and were not found among old trees aged more than 50 years. The genome fragments of the ACLSV, ASPV, and ASGV viruses detected were cloned and sequenced. …”
Get full text

Synthesis, antimycobacterial and antifungal evaluation of new 4-(furan-2-ylmethyl)-6-methylpyridazin-3(2H)-ones by Karayavuz Burcu, Vagolu Siva Krishna, Kart Didem, Tønjum Tone, Unsal-Tan Oya

Get full text