Genetic Insights Into the Role of Cathepsins in Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Sclerosis: Evidence From Mendelian Randomization Study by Yanhong Jiang, Wenhui Fan, Yaxin Li, Hua Xue

“…Conclusion Our study provides new genetic insights into the role of cathepsin H in AD and cathepsin B in PD. …”
Get full text

A Case of Congenital Nephrotic Syndrome with Crescents Caused by a Novel Compound Heterozygous Pairing of NPHS1 Genetic Variants by Kyle N. Goodman, Pongpratch Puapatanakul, Kevin T. Barton, Mai He, Jeffrey H. Miner, Joseph P. Gaut

“…We present a child who developed severe nephrotic syndrome at two weeks of age and eventually required a bilateral nephrectomy. Genetic testing revealed compound heterozygous variants in NPHS1 including a known pathogenic variant and a missense variant of uncertain significance. …”
Get full text

The association of lipids and novel non-statin lipid-lowering drug target with osteoporosis: evidence from genetic correlations and Mendelian randomization by Qingcong Zheng, Rongjie Lin, Du Wang, Rongsheng Chen, Weihong Xu

“…This study aimed to investigate the genetic associations between lipids, novel non-statin lipid-lowering drug target genes, and OP and BMD. …”
Get full text

Vitamin D Receptor Genetic Variations May Associate with the Risk of Developing Late Fracture-Related Infection in the Chinese Han Population by Xing-qi Zhao, Kun Chen, Hao-yang Wan, Si-ying He, Han-jun Qin, Bin Yu, Nan Jiang

“…This study investigated associations between genetic variations in the VDR and susceptibility to late FRI in the Chinese Han population. …”
Get full text

Gene Set Analyses of Genome-Wide Association Studies on 49 Quantitative Traits Measured in a Single Genetic Epidemiology Dataset by Jihye Kim, Ji-sun Kwon, Sangsoo Kim

“…Comparison of the gene sets obtained for a variety of traits measured from a single genetic epidemiology dataset may give insights into the biological mechanisms underlying these traits. …”
Get full text

A comparative approach for the optimal design of steel structures using biogeography-based optimization (BBO) algorithm and genetic algorithm (GA) by Laid Amamra, Mohamed Bensoula, Sadek Bahar

Subjects: Get full text

APPLYING THE GENETIC ALGORITHM AND QUANTUM CHEMICAL CALCULATIONS TO STUDY THE STRUCTURE OF THE Sc2B6 CLUSTER AND ITS CO ADSORPTION by Minh Thao Nguyen, Tho Thanh Bui, Trung Cang Phan, Sy Linh Ho

Subjects: Get full text

Retraction Note: Enhancing MPPT performance for partially shaded photovoltaic arrays through backstepping control with Genetic Algorithm-optimized gains by Serge Raoul Dzonde Naoussi, Kenfack Tsobze Saatong, Reagan Jean Jacques Molu, Wulfran Fendzi Mbasso, Mohit Bajaj, Mohamed Louzazni, Milkias Berhanu, Salah Kamel

Get full text

Comparative Study of Genetic Algorithms and Particle Swarm Optimization for Flexible Power Point Tracking in Photovoltaic Systems under Partial Shading by Ouatman Hamid, Boutammachte Nour-Eddine

“…This study conducts a comparative analysis of Genetic Algorithms (GA) and Particle Swarm Optimization (PSO) for Flexible Power Point Tracking (FPPT) in photovoltaic (PV) systems. …”
Get full text

Clinical and genetic analysis of a Chinese family with GM1 gangliosidosis caused by a novel mutation in GLB1 gene by Biao Zhang, Xiao-li Huang, Xin-xin Lu, Heng-bin Huang, Yan-an Wu

“…The mutant c.1058_1059delinsAA retained β-galactosidase activity at 0% of wild-type GLB1.ConclusionThis study identified a novel mutation of the GLB1 gene in a Chinese family with GM1 gangliosidosis and provided new insights into the molecular characteristics and genetic counseling of GM1 gangliosidosis.…”
Get full text

Genetic Diversity of Melipona mandacaia SMITH 1863 (Hymenoptera, Apidae), an Endemic Bee Species from Brazilian Caatinga, Using ISSR by Elder Assis Miranda, Henrique Batalha-Filho, Priscila Santos Oliveira, Rogério Marcos Oliveira Alves, Lucio Antonio Oliveira Campos, Ana Maria Waldschmidt

“…In order to evaluate the genetic diversity and structure of Melipona mandacaia, we analyzed 104 colonies collected in 12 localities in Bahia state, northeastern Brazil, using ISSR-PCR. …”
Get full text

Protocol for functional screening of CFTR-targeted genetic therapies in patient-derived organoids using DETECTOR deep-learning-based analysis by Mattijs Bulcaen, Ronald B. Liu, Kasper Gryspeert, Sam Thierie, Anabela S. Ramalho, François Vermeulen, Xavier Casadevall I Solvas, Marianne S. Carlon

Get full text

Exploring QSAR for Antimalarial Activities and Drug Distribution within Blood of a Series of 4-Aminoquinoline Drugs Using Genetic-MLR by Amir Najafi, Soheil Sobhanardakani, Mehdi Marjani

“…QSAR modeling of the antimalarial activity and blood-to-plasma concentration ratio of Chloroquine and a new series of 4-aminoquinoline derivatives were developed using genetic algorithms with multiple linear regression (GA-MLR) method. …”
Get full text

Integration of a Large-Scale Genetic Analysis Workbench Increases the Accessibility of a High-Performance Pathway-Based Analysis Method by Sungyoung Lee, Taesung Park

Subjects: “…genetic association studies…”
Get full text

RETRACTED ARTICLE: Enhancing MPPT performance for partially shaded photovoltaic arrays through backstepping control with Genetic Algorithm-optimized gains by Serge Raoul Dzonde Naoussi, Kenfack Tsobze Saatong, Reagan Jean Jacques Molu, Wulfran Fendzi Mbasso, Mohit Bajaj, Mohamed Louzazni, Milkias Berhanu, Salah Kamel

Subjects: Get full text

Genetic Analysis of Cytokine Promoters in Nonhuman Primates: Implications for Th1/Th2 Profile Characteristics and SIV Disease Pathogenesis by Pavel Bostik, Melanie Watkins, Francois Villinger, Aftab A. Ansari

Get full text

Healthy Chilean Adolescents with HOMA-IR ≥ 2.6 Have Increased Cardiometabolic Risk: Association with Genetic, Biological, and Environmental Factors by R. Burrows, P. Correa-Burrows, M. Reyes, E. Blanco, C. Albala, S. Gahagan

“…We tested the influence of genetic, biological, and environmental factors on IR using logistic regression analyses. …”
Get full text

Metatranscriptomic time series insight into antibiotic resistance genes and mobile genetic elements in wastewater systems under antibiotic selective pressure by An-Dong Li, Yuanfang Chen, Lei Han, Ye Li, Ming Xu, Baoli Zhu

Get full text

Genetic polymorphism of CYP1A1 and CYP2D6 in populations of Buryats, Teleuts and Russians of Eastern Siberia by L. E. Tabikhanova, L. P. Osipova, T. V. Churkina, E. N. Voronina, M. L. Filipenko

“…The study of the gene polymorphism of the system of biotransformation of xenobiotics is an important area of modern medical and genetic research. The aim of this work is to study the frequency of the alleles of the CYP1A1 (A2455G (*2C), rs1048943), CYP2D6 (A2549del (*3), rs35742686); G1846A (*4), rs3892097) genes of Teleuts (n = 115), Eastern Buryats (n = 132), Western Buryats (n = 280), their Métis (n = 56), and Russians of East Siberia (n = 122). …”
Get full text

Distribution and frequency of genetic mutations in three insecticide targets in field populations of Culex tritaeniorhynchus in Mianyang City, Sichuan Province, China by Hongwei Xie, Meilin Tang, Hongying Sun, Zhengzheng Huang, Mengmeng Dong, Xianying Wen

Get full text