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Multimodal Magnetic Resonance Findings in Parkinson’s Disease With “Antecedent Essential Tremor”: A Case Series of a Large Kindred
Published 2025-01-01“…The clinical characteristics, genetic testing and multimodal MRI data of 16 family members were collected. …”
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13944
Tracking hydrothermal infiltration within light oil reservoirs using organic geochemical proxies in the Shunbei area of Tarim Basin in China
Published 2025-01-01“…The studied crude oils are characterized by uniform organic indicators of paraffin, terpanes, steranes, and light hydrocarbons, implying that crude oils are derived from the same source rock. Genetic binary diagrams, such as dibenzothiophene/phenanthrene (DBT/P) vs. …”
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CHANNELING: SEARCH OF THE METAANTHROPOLOGIC MEAS-UREMENTS OF MIND BEING IN THE UNIVERSE (based on the World Wide Web)
Published 2014-06-01“…Retrospection channeling as cultural practices show his obedience to the law of the cultural series: a temporary phenomenon in the long-range specific chronotope culture is defined by its inclusion in the actually exist-ing set of genetically related forms.…”
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13947
Intricate interplay of CRISPR-Cas systems, anti-CRISPR proteins, and antimicrobial resistance genes in a globally successful multi-drug resistant Klebsiella pneumoniae clone
Published 2025-01-01“…Conclusions Our results indicated a complex interplay between CRISPR-Cas, anti-CRISPR, and mobile genetic elements that shape the evolution of CG147. …”
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13948
Interleukin IL1a and IL6 gene polymorphism: search for association with APOE genotype and clinical course of sporadic Alzheimer’s disease
Published 2019-09-01“…There is evidence that genetic polymorphisms of important proinflammatory cytokines IL1α and IL6 are associated with the risk of Alzheimer’s disease (AD). …”
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13949
Exploring the Impact of Systemic Inflammatory Regulators on Rosacea Risk: A Bidirectional Mendelian Randomization Analysis
Published 2025-01-01“…This study employed a two-sample bidirectional Mendelian randomization (MR) analysis to investigate the causal links between systemic inflammatory regulators and rosacea.Methods: Data on 41 cytokines and growth factors were analyzed from a genome-wide association study (GWAS) meta-analysis involving 8293 individuals and genetic data from the FinnGen database, comprising 1195 rosacea cases and 211,139 controls. …”
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Deciphering Immunometabolic Landscape in Rheumatoid Arthritis: Integrative Multiomics, Explainable Machine Learning and Experimental Validation
Published 2025-01-01“…Finally, a phenome-wide association study (PheWAS) was conducted to evaluate potential side effects of drugs targeting the hub genes.Results: Causalities were found between six plasma metabolites, five immune cells and RA in genetically determined levels. Notably, DC mediated 18% of the protective effect of PE on RA. …”
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13951
Gluten-Free Diet Adherence Evaluation in Adults with Long-Standing Celiac Disease
Published 2024-12-01“…Background: Celiac disease (CD) is an autoimmune disease that results from the interaction of genetic, immune, and environmental factors. According to the 2020 European Society for Pediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) guidelines, an elimination diet (i.e., excluding products that may contain gluten) is the basic method of treating celiac disease. …”
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13952
Digital mapping of soil salinity with time-windows features optimization and ensemble learning model
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13953
Human Leucocyte Antigen Class II Risk and Protective Alleles in Women with Cervical Intraepithelial Neoplasia
Published 2024-03-01“…The aim of the study was to assess an association between HLA-DQA1*; DQB1*; DRB1* allele’s genetic variants between women with cervical precancerous lesions and healthy controls in Latvia.Materials and methods: From January until April 2017 we enrolled 84 consecutive patients referred for colposcopy to Riga East University Hospital (Latvia) due to abnormal cervical cytology results. 57 women who came for a regular check-up and had normal cytology smears were included in the control group. …”
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Clinical characteristics and outcomes of surgical resection for brain metastases from lung adenocarcinoma
Published 2025-01-01“…The intracranial location of BM was mostly in the frontal lobe (54, 26.0%) and the metastatic sites were mostly single (117, 56.3%); the metastatic tumor size was mostly between 2-5 cm (141, 67.8%). Genetically, 43.3% patients (90 cases) had EGFR mutations, and immunohistochemical analysis showed that most patients were PD-L1 positive (160, 76.9%) and Ki67 > 30% (137, 65.9%). …”
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New multilocus sequence typing scheme for Enterococcus faecium reveals sequential outbreaks of vancomycin-resistant E. faecium ST1162 and ST610 in a Japanese tertiary medical cente...
Published 2025-01-01“…Therefore, the new Bezdíček MLST scheme, which offers more accurate genetic similarity based on genome-wide data, has recently been proposed. …”
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13956
Molecular characterization of ST15 carbapenem-resistant Klebsiella pneumoniae isolated in a single patient
Published 2025-01-01“…The 9 KP isolates share a high degree of genetic similarity. The plasmid p2-KP3762–1, harbouring the carbapenem resistance gene blaKPC-2, may undergo inter-strain and inter-clone transfer via conjugation in the patient during treatment. …”
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Mitochondrial targeting of Candida albicans SPFH proteins and requirement of stomatins for SDS-induced stress tolerance
Published 2025-01-01“…These phenotypes were not observed in slp2Δ/Δ or slp3Δ/Δ single mutants, indicating a possible indirect genetic interaction between SLP2 and SLP3. In addition, slp2Δ/Δ and slp2Δ/Δ/slp3Δ/Δ mutant strains were slightly resistant to the antifungal drug, fluconazole. …”
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First study on molecular identification of Anaplasma ovis in sheep in southern Kazakhstan
Published 2025-01-01“…There were no reliable data on the prevalence and genetic diversity of Anaplasma spp. in sheep in Kazakhstan. …”
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Correlation between aboveground vegetation composition and soil seed bank of Raudhat desert habitat: a case study of Raudhat Alkhafs, Saudi Arabia
Published 2025-02-01“…Therophytes are distinguished as major (45.8%) because of their ability to tolerate arid environments, high reproduction rate, ecological flexibility, and genetic plasticity. Vegetation analysis showed three plant communities in the winter-spring season dominated by Plantago ciliata, Calotropis procera, and Heliotropium ramosissimum, while in the summer-fall season, Calotropis procera dominated one community, while two other plant communities were dominated by Heliotropium ramosissimum. …”
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Dysfunctional β-cell autophagy induces β-cell stress and enhances islet immunogenicity
Published 2025-01-01“…BackgroundType 1 Diabetes (T1D) is caused by a combination of genetic and environmental factors that trigger autoimmune-mediated destruction of pancreatic β-cells. …”
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