High clinical burden of classical homocystinuria in the United States: a retrospective analysis by Mahim Jain, Mehul Shah, Kamlesh M. Thakker, Andrew Rava, Agnes Pelts Block, Colette Ndiba-Markey, Lionel Pinto

“…Abstract Background Classical homocystinuria (HCU) is a rare genetic metabolic disorder resulting in elevated homocysteine and methionine levels. …”
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Phylogenomic analysis reveals exceptions to the co-evolution of ZAR1 and ZRK immune gene families in plants by Li Yang, Shengyi Liu, M. Eric Schranz, Klaas Bouwmeester

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FoxA1 knockdown promotes BMSC osteogenesis in part by activating the ERK1/2 signaling pathway and preventing ovariectomy-induced bone loss by Lijun Li, Renjin Lin, Yang Xu, Lingdi Li, Zhijun Pan, Jian Huang

“…Osteoporosis is a significant global health issue, and the current treatment options are highly restricted. Transplanting genetically engineered MSCs has been acknowledged as a highly promising therapy for osteoporosis. …”
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Domperidone inhibits dengue virus infection by targeting the viral envelope protein and nonstructural protein 1 by Nuttapong Kaewjiw, Thanawat Thaingtamtanha, Damini Mehra, Wanida Chawnawa, Tanapan Prommool, Chunya Puttikhunt, Adisak Songjaeng, Kessiri Kongmanas, Panisadee Avirutnan, Prasit Luangaram, Chatchawan Srisawat, Sittiruk Roytrakul, Stephan A. Bäurle, Sansanee Noisakran

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The Escalating Magnitude of COVID-19 Infections among the Northeastern Ethiopia Region: A Community-Based Cross-Sectional Study by Zeleke Geto, Saba Gebremichael, Melaku Ashagrie Belete, Alemu Gedefie, Genet Molla, Melkam Tesfaye, Wondmagegn Demsiss, Daniel Gebretsadik

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The association between serum albumin levels and metabolic syndrome based on the NHANES and two sample Mendelian randomization study by Yile Tang, Yong Fan, Jin Su, Zisen Yang, Zaoling Liu

“…In the forward MR study, the IVW method revealed that genetic predicted increased levels of serum albumin were positively correlated with metabolic syndrome (OR: 1.149, 95% CI: 1.016–1.299) and its components, including hypertension (OR: 1.130, 95% CI: 1.013–1.260) and triglycerides (OR: 1.343, 95% CI: 1.209–1.492). …”
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Cardiovascular Disease Screening in Primary School Children by Alena Bagkaki, Fragiskos Parthenakis, Gregory Chlouverakis, Emmanouil Galanakis, Ioannis Germanakis

“…Abnormal CVD findings were present in 69 (7.3%) of the study population, including minor/trivial structural heart disease in 23 (2.4%) and 17 (1.8%), respectively, referred due to abnormal cardiac auscultation, and ECG abnormalities in 29 (3%), of which 6 (0.6%) were considered potentially significant (including 1 case of genetically confirmed channelopathy-LQT syndrome). Conclusions: CVD screening programs in school children can be very helpful for the early detection of CVD risk factors and of their general health as well. …”
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Clinical and endoscopical and morphofunctional scores in evaluation of development of gastroesophageal reflux disease in various age groups by M. A. Osadchuk, A. M. Zolotovitskaya, N. V. Kireyeva, S. N. Nikolenko, I. M. Kvetnoy

“…Its development at patients of all age groups is observed on a background of gastritis with, probably, genetically determined hyperplasia of gastric epithelial cells producing NO-synthase and endothelin-1. …”
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How to publish a new fungal species, or name, version 3.0 by M. Catherine Aime, Andrew N. Miller, Takayuki Aoki, Konstanze Bensch, Lei Cai, Pedro W. Crous, David L. Hawksworth, Kevin D. Hyde, Paul M. Kirk, Robert Lücking, Tom W. May, Elaine Malosso, Scott A. Redhead, Amy Y. Rossman, Marc Stadler, Marco Thines, Andrey M. Yurkov, Ning Zhang, Conrad L. Schoch

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Diversity in Adaptive Evolution of Methicillin-Resistant Staphylococcus aureus Clinical Isolates Under Exposure to Continuous Linezolid Stress in vitro by Han T, Jia T, Wang J

“…Tala Han,1 Ting Jia,1 Junrui Wang1,2 1Department of Laboratory Medicine, Affiliated Hospital of Inner Mongolian Medical University, Hohhot, 010050, People’s Republic of China; 2Inner Mongolia Key Laboratory of Clinical Pathogenic Microorganism, The Affiliated Hospital of Inner Mongolian Medical University, Hohhot, 010050, People’s Republic of ChinaCorrespondence: Junrui Wang, Clinical Laboratory, Affiliated hospital of Inner Mongolian Medical University, Hohhot, 010050, People’s Republic of China, Tel +86 04713451315, Email wangjunrui123@yeah.netBackground: Linezolid resistance in methicillin-resistant Staphylococcus aureus (MRSA) was reported frequently in recent years, but the mechanism underlying this process was less reported, especially for clinical isolates with different genetic background. Thus, this study aims to explore the adaptive evolution characteristics underlying linezolid resistance in MRSA clinical isolates exposed to continuous induction stress of linezolid in vitro.Methods: The in vitro susceptibility of 1032 MRSA clinical isolates to linezolid was detected using commercial VITEK-2 equipment via broth microdilution. …”
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Progression of ampC amplification during de novo amoxicillin resistance development in E. coli by Luyuan Nong, Martijs Jonker, Wim de Leeuw, Meike T. Wortel, Benno ter Kuile

“…An IS1 insertion is identified in the amplification junction after resistance induction in the wild type (WT) and the ampC gene complementation strain (CompA), but not in ∆ampC, suggesting that the amplification depends on mobile genetic element transposition. In order to elucidate the correlation between gene mutations and ampC amplification, the DNA mutations acquired during resistance evolution by the WT, ∆ampC, and CompA were analyzed. …”
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Effect of Third-Generation Beta Blockers on Weight Loss in a Population of Overweight-Obese Subjects in a Controlled Dietary Regimen by Maria Alessandra Gammone, Konstantinos Efthymakis, Nicolantonio D’Orazio

“…Overweight and obesity often develop in individuals with genetic susceptibility and concomitant risk factors; however, medications can represent precipitating factors in some cases: evidence suggests that some antihypertensive drugs can adversely affect energy homeostasis and metabolism. …”
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Efficacy of natural and synthetic inhibitors in the elimination of viruses in potato (<i>Solanum tuberosum</i> L.) by E. V. Shishchenko, I. V. Kim, E. N. Barsukova, I. M. Yermak, A. O. Kravchenko, A. G. Klykov

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Overt Hypothyroidism and Severe Growth Retardation in a Preschool Girl with Poorly Controlled Nephrotic Syndrome: Case Report and Literature Review by Joana Mikulevič, Karolina Tumelienė, Robertas Kemežys, Augustina Jankauskienė

“…Kidney biopsy revealed minimal change disease, and genetic testing was negative. Intensive NS treatment with methylprednisolone pulse therapy, enlarged doses of MMF and albumin infusion were started and L-thyroxine dose was increased to 75 mcg. …”
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Prediction model for unfavorable treatment outcome for complicated sever acute malnutrition (SAM) in under five children admitted in hospitals at Amhara Region by Almaw Genet Yeshiwas, Zelalem Alamrew Anteneh, Tilahun Degu Tsega, Ahmed Fentaw Ahmed, Chalachew Yenew

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Structural insights into dynamics of the BMV TLS aminoacylation by Wen Yang, Ran Yi, Jing Yao, Yongxiang Gao, Shanshan Li, Qingguo Gong, Kaiming Zhang

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THE EFFECT OF THE AGE OF SMOOTH BROME (BROMOPSIS INERMIS) STANDS ON THEIR HERBAGE YIELD IN TYUMEN PROVINCE by N. A. Feoktistova

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MCT1 lactate transporter blockade re-invigorates anti-tumor immunity through metabolic rewiring of dendritic cells in melanoma by Camille Niveau, Mélanie Cettour-Cave, Stéphane Mouret, Eleonora Sosa Cuevas, Mylene Pezet, Benoît Roubinet, Hugo Gil, Florence De Fraipont, Ludovic Landemarre, Julie Charles, Philippe Saas, Caroline Aspord

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Diagnostic value of interleukins 23 and 17 in the assessment of ulcerative colitis severity by M.V. Stoikevych, O.M. Tatarchuk, T.S. Tarasova

“…Ulcerative colitis (UC) is a chronic bowel disease with a complex aetiology that includes immune, genetic and environmental factors. Its progression and severity vary greatly, suggesting that different cytokine pathways may be responsible for the heterogeneity of clinical outcomes. …”
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Biochemical Pattern of Methylmalonyl-CoA Epimerase Deficiency Identified in Newborn Screening: A Case Report by Evelina Maines, Roberto Franceschi, Francesca Rivieri, Giovanni Piccoli, Björn Schulte, Jessica Hoffmann, Andrea Bordugo, Giulia Rodella, Francesca Teofoli, Monica Vincenzi, Massimo Soffiati, Marta Camilot

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