Origin and Affinities of the Malmberget Iron Oxide-Apatite Deposit, Northern Sweden: Insights From Magnetite Chemistry and Fe-O Isotopes by Jens S. Henriksson, Valentin R. Troll, Ellen Kooijman, Ilya Bindeman, Tomas Naeraa, Tobias E. Bauer

“…The Malmberget rock association is characterised by multiple phases of deformation, metamorphism, and alteration that resulted in a geometrically and petrologically complex deposit that is genetically ambiguous. Primary ore textures and emplacement structures of the Malmberget iron oxide-apatite deposit have largely been recrystallised during metamorphic overprinting and now comprise dominantly medium- to coarse-grained granoblastic magnetite. …”
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Association between P2RY12 Gene Polymorphisms and IVIG Resistance in Kawasaki Patients by Zhouping Wang, Yufen Xu, Huazhong Zhou, Yanfei Wang, Wei Li, Zhaoliang Lu, Zhiyong Jiang, Xueping Gu, Hao Zheng, Lanlan Zeng, Ping Huang, Li Zhang, Xiaoqiong Gu

“…Despite the association between Purinergic receptor P2Y12 (P2RY12) polymorphism, KD genetic susceptibility, and CAL complications being proved, few studies have assessed the relationship between P2RY12 polymorphisms and IVIG resistance in patients with KD. …”
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Variations in rumen microbiota and host genome impacted feed efficiency in goat breeds by Alaa Emara Rabee, Ibrahim Abou-souliman, Ahmed I. Yousif, Mebarek Lamara, Mohamed A. El-Sherbieny, Eman Ali Elwakeel, Ahmed M. Sallam

“…These genes contributed to FE traits in Egyptian goats, as they are involved in obesity, metabolism, and the transport of energy, vitamins, fatty acids, proteins, and lipids through diverse biological pathways.DiscussionThis study suggests that specific genetic markers and rumen microbial traits could be used to identify high-efficient individuals in Egyptian goat breeds, and improving breeding strategies for FE.…”
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Integrating univariate and multivariate stability indices for breeding clime-resilient barley cultivars by Ammar Elakhdar, Ahmed A. El-Naggar, Sally El-Wakeell, Anas H. Ahmed

“…Abstract Studying genetic variability through the phenotypic performance of genotypes is crucial in the breeding program. …”
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Global prevalence of platelet-type von Willebrand disease by Omid Seidizadeh, Andrea Cairo, Maha Othman, Flora Peyvandi

“…Conclusion: This population-based genetic epidemiology analysis indicates a substantially higher than expected frequency of PT-VWD. …”
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Key wound healing genes as diagnostic biomarkers and therapeutic targets in uterine corpus endometrial carcinoma: an integrated in silico and in vitro study by Fuchuan Jiang, Sajjad Ahmad, Sadia kanwal, Yasir Hameed, Qian Tang

“…Promoter methylation analysis showed significantly higher methylation levels in UCEC, correlating with decreased mRNA expression and poor survival outcomes. Genetic alteration analysis indicated frequent mutations in FN1 and KDM6A, although these did not significantly affect survival. …”
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CD2AP deficiency aggravates Alzheimer’s disease phenotypes and pathology through p38 MAPK activation by Yan-Yan Xue, Zhe-Sheng Zhang, Rong-Rong Lin, Hui-Fen Huang, Ke-Qing Zhu, Dian-Fu Chen, Zhi-Ying Wu, Qing-Qing Tao

“…Genome-wide association and clinicopathological studies have demonstrated that the CD2-associated protein (CD2AP) gene is one of the most important genetic risk factors for AD. However, the precise mechanisms by which CD2AP is linked to AD pathogenesis remain unclear. …”
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Coincidental or Connected: Synchronous Giant Gastric GIST and Malignant Colonic Polyp: A Case Report by Terukumar Chandrasekaran, Lim Li Yi, JJ Mah, RK Sriram, Nik Amin Sahid

“…However, it is crucial to consider the possibility of genetic predisposition in patients with such tumors. …”
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Disorders of circadian rhythms of heart rate variability in diabetic cardiac autonomic neuropathy: mechanisms and consequences by V.A. Serhiyenko, M.I. Dolynay, V.B. Sehin, Y.V. Lazur, A.A. Serhiyenko

“…Particular attention is paid to the risk factors of diabetic CAN; insights into the mechanisms of excess mortality associated with CAN; the pathogenesis of diabetic CAN; possible pathogenic pathways binding CAN and atherosclerosis progression; genetic and epigenetic factors and CAN; DM and circadian rhythms of HRV; diabetic CAN and circadian rhythm disorders. …”
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APOEε4 alters ApoE and Fabp7 in frontal cortex white matter in prodromal Alzheimer's disease by Marta Moreno-Rodriguez, Sylvia E. Perez, Michael Malek-Ahmadi, Elliott J. Mufson

“…Abstract The ApoE ε4 allele (APOEε4) is a major genetic risk factor for sporadic Alzheimer's disease (AD) and is linked to demyelination and cognitive decline. …”
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Multi-Trait Index-Based Selection of Drought Tolerant Wheat: Physiological and Biochemical Profiling by Mohammed Mohi-Ud-Din, Md. Alamgir Hossain, Md. Motiar Rohman, Md. Nesar Uddin, Md. Sabibul Haque, Mahmudul Hasan Tahery, Mirza Hasanuzzaman

“…The identified genotypes with superior drought tolerance offer valuable genetic resources for enhancing wheat productivity in water-limiting environments. …”
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Single-cell RNA-sequencing and genome-wide Mendelian randomisation along with abundant machine learning methods identify a novel B cells signature in gastric cancer by Qi Ma, Jie Gao, Yuan Hui, Zhi-Ming Zhang, Yu-Jie Qiao, Bin-Feng Yang, Ting Gong, Duo-Ming Zhao, Bang-Rong Huang

“…The Mendelian randomisation study demonstrated that individuals with a genetic predisposition for elevated NFKBIE levels exhibited a heightened likelihood of acquiring GC. …”
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Role of Prothrombin and Methylenetetrahydrofolate Reductase Gene Polymorphisms as well as Thrombophilia Markers, as Risk Factors for Unexplained Recurrent Miscarriage: A Case-Contr... by Zeinab Ahmed Abd Elhameed, Omar M Shaaban, Hanan G Abd Elazeem, Azza Abouelfadle, Tarek Farghaly, Ghada Mahran, Mohamed Ismail Seddik

“…We also evaluated association between protein C (PC), protein S (PS), antithrombin III (ATIII), and homocystienewith RM.Materials and Methods: We conducted a case-control study on women with history of miscarriages and healthycontrols. Genetic analysis was done using (TaqMan) polymerase chain reaction (PCR) technique and the othertests were performed to check general health indications and thrombophilia markers.Results: In this study, 195 RM group (group I) participants and 90 healthy controls (group II), PC, PS, ATIII deficiencyand Hyperhomocysteinemia were in 7.2, 65.6, 9.2, 10.8% of group I respectively, but was 1.1, 7.8, 2.2, 2.2% of groupII. …”
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Field Performance of Tissue Culture and Standard Propagated Raspberry Under Different Irrigation Regimes by Tatjana Anđelić, Jelena Tomić, Boris Rilak, Žaklina Karaklajić-Stajić, Jasminka Milivojević, Dragan Radivojević, Tatjana Vujović

“…Healthy plant material that is uniform and genetically pure is essential for the successful raspberries production since it guarantees quality and consistent yields. …”
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Successful management of refractory epilepsy in creatine transporter deficiency with cannabidiol and clobazam: A case report by Maria Borrell‐Pichot, Carmen Fons, Susana Boronat, Alba Sierra‐Marcos

“…Plain Language Summary Creatine transporter deficiency (CRTR‐D) is a rare genetic disorder causing mental, behavioral, and movement problems. …”
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Residual analysis for the identification of potential mid-infrared-derived biomarkers of heat stress in dairy cattle by Pauline Lemal, Clément Grelet, Frédéric Dehareng, Hélène Soyeurt, Martine Schroyen, Nicolas Gengler

“…However, in the context of genetic evaluation, which requires variability, milk MIR MUFA, C18:1 cis-9, or citrate concentration variations, if they are heritable, could be of great interest. …”
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Detection of low frequency artemisinin resistance mutations, C469Y, P553L and A675V, and fixed antifolate resistance mutations in asymptomatic primary school children in Kenya by Victor Osoti, Kevin Wamae, Leonard Ndwiga, Paul M. Gichuki, Collins Okoyo, Stella Kepha, Kibor Keitany, Regina Kandie, Stephen Aricha, Rosebella Kiplagat, Charles Mwandawiro, Philip Bejon, Robert W. Snow, Lynette Isabella Ochola-Oyier

“…Methods In this study, we used Targeted Amplicon Deep Sequencing (TADS) to characterise the genetic diversity of the Pfk13, Pfdhfr, Pfdhps, and Pfmdr1 genes among primary school-going children in 15 counties in Kenya (Bungoma, Busia, Homa Bay, Migori, Kakamega, Kilifi, Kirinyaga, Kisii, Kisumu, Kwale, Siaya, Tana River, Turkana, Vihiga and West Pokot). …”
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Neighborhood environment associations with cognitive function and structural brain measures in older African Americans by Dima L. Chaar, Le Tu, Kari Moore, Jiacong Du, Lauren A Opsasnick, Scott M Ratliff, Thomas H Mosley, Sharon L. R. Kardia, Wei Zhao, Xiang Zhou, Ana V Diez Roux, Fazlay S Faruque, Kenneth R Butler, Jennifer A Smith

“…Methods In this study, we examined whether DNA methylation in peripheral blood leukocytes mediates the relationship between neighborhood characteristics and cognitive function (N = 542) or WMH (N = 466) in older African American (AA) participants without preliminary evidence of dementia from the Genetic Epidemiology Network of Arteriopathy (GENOA). …”
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Sustainability metrics targeted optimization and electric discharge process modelling by neural networks by Muhammad Sana, Muhammad Asad, Muhammad Umar Farooq, Mehdi Tlija, Rodolfo Haber

“…Moreover, multi-response optimization through the non-dominated sorting genetic algorithm (NSGA-II) has also been performed. …”
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PD-L1 positive platelets mediate resistance to immune checkpoint inhibitors in patients with colorectal cancer by Jiacheng Li, Jia Liu, Shifeng Yang, Yu Xia, Qingzhe Meng, Biying Sun, Yansong Liu, Bin Zhao, Jiaqi Jin, Hui Xu, Lihong Wang, Pengxia Zhang, Zhuoxin Cheng

“…Animal experiments revealed that antiplatelet pharmacological agents and genetic knockout of platelets potentiated the antitumour effect of the PD-L1 mAb treatment in a CD8 + T cell dependent manner. …”
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