The role of CGIAR Germplasm Health Units in averting endemic crop diseases: the example of rice blast in Bangladesh by Yuji Enriquez, Melinda Smale, Nelissa Jamora, Mohammod Hossain, Lava Kumar

“…Conclusions The study reinforces the important, and often overlooked, role of the GHUs in the international agricultural research that aims to enhance genetic gains in crops through efficient and timely access to clean and healthy germplasm.…”
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The Role of Extracts of Edible Parts and Production Wastes of Globe Artichoke (<i>Cynara cardunculus</i> L. var. <i>scolymus</i> (L.)) in Counteracting Oxidative Stress by Valentina Laghezza Masci, Irene Mezzani, Enrica Alicandri, William Tomassi, Anna Rita Paolacci, Stefano Covino, Vittorio Vinciguerra, Elisabetta Catalani, Davide Cervia, Mario Ciaffi, Stefania Garzoli, Elisa Ovidi

“…In the search for new biomolecules with antioxidant properties, this research focused on a globe artichoke landrace at risk of genetic erosion, still cultivated in the northern part of the Lazio region, known as the “Carciofo Ortano”. …”
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Methicillin-Resistant <i>Staphylococcus aureus</i>: The Shifting Landscape in the United Arab Emirates by Syrine Boucherabine, Rania Nassar, Lobna Mohamed, Maya Habous, Anju Nabi, Riyaz Amirali Husain, Mubarak Alfaresi, Seema Oommen, Hamda Hassan Khansaheb, Mouza Al Sharhan, Handan Celiloglu, Mubarak Hussain Raja, Eman Abdelkarim, Nishi Ali, Salman Tausif, Victory Olowoyeye, Nelson Cruz Soares, Mahmood Hachim, Danesh Moradigaravand, Dean Everett, Elke Mueller, Stefan Monecke, Ralf Ehricht, Abiola Senok

“…The COVID-19 pandemic, with its increased hospitalization rates and antibiotic use, may have further influenced MRSA’s genetic evolution and epidemiology in the country. …”
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Impact of predictive selection of LbCas12a CRISPR RNAs upon on‐ and off‐target editing rates in soybean by Linda Rymarquis, Chenxi Wu, Diane Hohorst, Miguel Vega‐Sanchez, Thomas E. Mullen, Vijetha Vemulapalli, Douglas R. Smith

“…Abstract Clustered regularly interspaced short palindromic repeats (CRISPR) technology has revolutionized creating targeted genetic variation in crops. Although CRISPR enzymes have been reported to have high sequence‐specificity, careful design of the editing reagents can also reduce unintended edits at highly homologous sites. …”
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Markers of Glomerular and Tubular Damage in the Early Stage of Kidney Disease in Type 2 Diabetic Patients by Agnieszka Żyłka, Paulina Dumnicka, Beata Kuśnierz-Cabala, Agnieszka Gala-Błądzińska, Piotr Ceranowicz, Jakub Kucharz, Anna Ząbek-Adamska, Barbara Maziarz, Ryszard Drożdż, Marek Kuźniewski

“…Diabetic kidney disease develops in half of genetically predisposed patients with type 2 diabetes (T2DM). …”
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Bridging the gap: understanding the perspective of healthcare professional students towards precision medicine in a Nigerian tertiary institution (a cross-sectional study) by Ezinwanne Jane Ugochukwu, Jennifer Chinwe Edom, Faith Olanrewaju Omotayo, Agatha Adaeze Amaechi, Chinedu Benneth Obetta, Chibueze Anosike, AbdulMuminu Isah, Chukwuemeka Michael Ubaka

“…Abstract Background Individuals often respond differently to medications, giving rise to the field of precision medicine (PM), which focuses on tailoring treatments to individual genetic, environmental, and lifestyle factors. This study examined the level of comfort healthcare professional students have with their knowledge of precision medicine, alongside their attitudes and perceptions toward precision medicine, at a tertiary institution in Nigeria. …”
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Association Between Single-Nucleotide Polymorphisms in <i>Toll-like Receptor 3</i> (<i>tlr3</i>), <i>tlr7</i>, <i>tlr8</i> and <i>tirap</i> Genes with Severe Symptoms in Children P... by Adriana Souza Andrade, Aline Almeida Bentes, Lilian Martins Diniz, Silvia Hees Carvalho, Erna Geessien Kroon, Marco Antonio Campos

“…Studies indicate that comorbidities and genetic factors, such as polymorphisms in immune response genes, can influence the severity of COVID-19. …”
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Investigating the Pulmonary Host Response of <i>Acinetobacter baumannii</i> Infection-Associated Pneumonia by Metagenomic Next-Generation Sequencing by Mu-Jung Chou, Chih-Hung Cheng, Hui-Ching Wang, Ming-Ju Tsai, Chau-Chyun Sheu, Wei-An Chang

“…<b>Background:</b> For investigating the host response in <i>Acinetobacter baumannii</i> associated pneumonia, we analyzed the host genetic sequences obtained from metagenomic next-generation sequencing (mNGS). …”
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Hepatic and renal functions of paediatric patients with thalassaemia: a cross-sectional study from two large thalassaemia centres in Sri Lanka by Meranthi Fernando, Anuja Premawardhena, Sachith Mettananda, Hashan Pathiraja, Wasana Wijenayake, Raveen Thennakoon, Dayananda Bandara, Roshitha De Silva

“…Objectives Thalassaemia is a genetic disorder of haemoglobin synthesis characterised by life-long chronic anaemia. …”
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Prevalence and Molecular Characterization of Cysticercus tenuicollis Isolated from Some Intermediate Host in Kurdistan-Iraq by Abdullah Ahmed Hama, Rostam Hama Zorab, Fatima Mohammed Ali, Awaz M. Salih, Amer Abdullah Hassan

“…The selected cysts were preserved in 70% Ethanol for DNA extraction and molecular study,  The mt-CO1 gene was amplified with a conventional polymerase chain reaction (PCR), the PCR product purified and DNA sequencing for reverse and forward strands was determined by a genetic analyzer, the obtained sequences aligned with the DNA sequences of T. hydatigena in Iran, Turkey and Palestine, which deposited in GenBank under the following accession number (JQ710588), (JN827307) and ( KM032284) respectively. …”
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Associations between a polygenic risk score and the risk of gestational diabetes mellitus in a Chinese population: a case-control study by Ying Li, Mengjiao Yang, Lu Yuan, Ting Li, Xinli Zhong, Yanying Guo

“…The maximally adjusted β coefficients and their corresponding 95% CIs were 0.181 (0.041, 0.320) for FPG, 0.225 (0.103, 0.346) for 1hPG, and 0.172 (0.036, 0.307) for 2hPG. Among the genetic variants examined, TCF7L2 rs7903146 displayed the strongest association with GDM risk (logOR = 0.18, p = 2.37 × 10–19), followed by ADAMTSL1 rs10963767 (logOR = 0.14, p = 3.58 × 10–15). …”
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Resting state EEG in young children with Tuberous Sclerosis Complex: associations with medications and seizures by Caitlin C. Clements, Anne-Michelle Engelstad, Carol L. Wilkinson, Carly Hyde, Megan Hartney, Alexandra Simmons, Helen Tager-Flusberg, Shafali Jeste, Charles A. Nelson

“…Abstract Background Tuberous Sclerosis Complex (TSC) is a rare genetic condition caused by mutation to TSC1 or TSC2 genes, with a population prevalence of 1/7000 births. …”
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A novel USP4 inhibitor that suppresses colorectal cancer stemness by promoting β-catenin and Twist1 degradation by Fengtian Li, Yi Zhou, Xinyue Lin, Yaxin Zhang, Qingyong Hu, Enen Zhao, Huali Li, Xingyan Pan, Feng Shu, Kun Zhang, Chengmei Huang, Na Tang, Wenting Liao

“…Treatment with U4-I05 also inhibited tumor metastasis and extended survival in a genetically engineered CRC mouse model. Conclusions This study identifies U4-I05 as a USP4 inhibitor with significant therapeutic efficacy against CRC, offering a promising avenue for the development of new treatments targeting cancer stemness and chemotherapy resistance. …”
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Prenatal ultrasound diagnosis, associated anomalies and pregnancy outcomes of fetal right aortic arch by Yuting Xie, Zongjie Weng, Ronghua Wang, Qiumei Wu, Wen Ling, Jinwen Chen, Shan Guo

“…It is also necessary to classify RAA types as accurately as possible and detect the presence of potential cardiac and extracardiac anomalies and genetic abnormalities, which facilitates prenatal counselling and prognostic assessment of fetuses with RAA.…”
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TERT de novo mutation-associated dyskeratosis congenita and porto-sinusoidal vascular disease: a case report by Ge Yu, Guijie Xin, Xu Liu, Wanyu Li, Chen Shao, Runping Gao

“…Abstract Background Dyskeratosis congenita is a rare genetic disease due to telomere biology disorder and characterized by heterogeneous clinical manifestations and severe complications. …”
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Identifying corridors for Asiatic black bear (Ursus thibetanus) in a part of Eastern Himalayas, India by Malyasri Bhattacharya, Debanjan Sarkar, Sneha Pandey, Indranil Mondal, Sambandam Sathyakumar, R. Suresh Kumar, Gautam Talukdar

“…In such fragmented landscapes, connecting corridors play a crucial role in maintaining wildlife movement and genetic diversity. We assessed connectivity between eight protected areas in Sikkim using MaxENT and Circuitscape. 65 black bear presence locations (collected through Camera traps and sign surveys) and 24 environmental variables were used to model the corridors. …”
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Molecular Mechanisms of Grain Chalkiness Variation in Rice Panicles by Zhong Li, Min Xi, Youzun Xu, Xueyuan Sun, Debao Tu, Yongjin Zhou, Yalan Ji, Linsheng Yang

“…This study conducted a genetic and physiological analysis of grains situated at distinct positions (upper, middle, and bottom primary branches of the rice panicle, denoted as Y1, Y2, and Y3) within a rice panicle using the Yangdao 6 variety. …”
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Analysis of Nucleotide Alterations in the E6 Genomic Region of Human Papillomavirus Types 6 and 11 in Condyloma Acuminatum Samples from Brazil by Marina Carrara Dias, Bruna Stuqui, Paola Jocelan Scarin Provazzi, Cíntia Bittar, Natália Maria Candido, Renata Prandini Adum de Matos, Rodolfo Miglioli Badial, Caroline Measso do Bonfim, Patricia Pereira dos Santos Melli, Silvana Maria Quintana, José Antônio Cordeiro, Paula Rahal, Marilia de Freitas Calmon

“…Based on this criterion, HPV6 and 11 variant lineages have been studied, and there are ongoing attempts to correlate these genetic variants with different clinical findings of infection. …”
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Study on Intelligent Classing of Public Welfare Forestland in Kunyu City by Meng Sha, Hua Yang, Jianwei Wu, Jianning Qi

“…Unlike previous approaches, the SVM model is optimized with Grid Search (GS), Genetic Algorithm (GA), and Particle Swarm Optimization (PSO) to automatically determine classification parameters, overcoming the limitations of manual rule-based methods. …”
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Enhancement of CD8+T cell cytotoxicity activity by IFN-α implies alternative pathologic role in systemic lupus erythematosus by Chen-xing Zhang, You-ying Mao, Yu-pin Tan, Mei-yu Zhang, Kang Shao, Shu-jun Wang, Ping Ji, Jia-yuan Wang, Lei Yin, Ying Wang

“…Objective: Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease which is affected by the environmental, genetic factors as well as the immune system. Previous reports have implicated IFN-α in the pathogenesis of SLE. …”
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