The important roles of ERAP1, ERAP2 genes polymorphisms and their DNA methylation levels in pulmonary tuberculosis by Shi-Hong Su, Xue-Qian Cai, Yong-Huai Li, Ai-Hui Xu, Qian Huang, Hua Niu, Qing-Hai You, Geng-Yun Sun

“…Abstract Background Genetic variations in endoplasmic reticulum aminopeptidase (ERAP1, ERAP2) genes are associated with the pathogenesis of multiple diseases, including infectious diseases. …”
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Leveraging genomic insights from the neglected malaria parasites P. malariae and P. ovale using selective whole genome amplification (SWGA) approach by Fathia Ben-Rached, Amit Kumar Subudhi, Chang Li, Mariah Alawi, Rohit Satyam, Sui Xu, Guoding Zhu, Raeece Naeem, Sara Mfarrej, Di Liu, Zenaida Stead, Caroline Askonas, Yaobao Liu, Jun Cao, Arnab Pain

“…Abstract Background Systematic genomics-guided population-based studies on the neglected malaria parasites, P. malariae, P. ovale curtisi, and P. ovale wallikeri species remain challenging due to their low parasitemia, underestimation, and lack of comprehensive genetic analysis. Techniques that cost-effectively allow the enriching of the genome of interest from complex genome backgrounds for sequencing studies help immensely to perform genomic analyses. …”
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A novel virulent core genome multilocus sequence type CT 11424 of Listeria monocytogenes isolate causing stillbirth in Bangladesh by Muntasir Alam, Md Saiful Islam, M. Ishrat Jahan, Arpita Shyama Deb, Afruna Rahman, Zahidul Islam, Atique Iqbal Chowdhury, Kazi Munisul Islam, Mohammad Zahid Hossain, Dilruba Ahmed, Shams El Arifeen, Emily S. Gurley, Mustafizur Rahman

“…Genomic characterization included multilocus sequence typing (MLST), core genome MLST (cgMLST), serotyping, and the presence or absence of virulence genes. Genetic divergence and phylogenetic analyses were conducted to determine the relationship with other reported isolates globally. …”
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Integrating whole-genome re-sequencing and transcriptome data to reveal the molecular mechanism of TBX5 gene regulating feathered feet in Guangxi native chickens by Zhuliang Yang, Yongcui Liu, Jintang Luo, Cong Xiao, Hong Yuan, Wenya Du, Xiurong Yang

“…This study combined whole-genome re-sequencing (WGS) data, transcriptomic analysis, and cellular experiments to investigate the genetic basis of feathered feet in Guangxi native chickens. …”
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Genome-wide association analysis and KASP markers development for protein quality traits in winter wheat by Yousheng Tian, Pengpeng Liu, Dezhen Kong, Yingbin Nie, Hongjun Xu, Xinnian Han, Wei Sang, Weihua Li

“…To expedite the breeding of wheat cultivars with high protein quality, it is necessary to genetically analyze the traits related to quality. A genome-wide association study (GWAS) was conducted to identify the genomic regions responsible for protein quality traits in winter wheat. …”
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Phenotypic and transcriptomic analyses reveal major differences between apple and pear scab nonhost resistance by Vergne, Emilie, Chevreau, Elisabeth, Ravon, Elisa, Gaillard, Sylvain, Pelletier, Sandra, Bahut, Muriel, Perchepied, Laure

“…This first deciphering of the molecular mechanisms underlying a nonhost scab resistance in pear offers new possibilities for the genetic engineering of sustainable scab resistance in this species. …”
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Sustainable synthesis and advanced optimization of Prosopis juliflora biomass catalyst for efficient biodiesel production and environmental impact assessment by Thota S S Bhaskara Rao, Manikandaraja Gnanaprakasam, Rajayokkiam Manimaran, Dhinesh Balasubramanian, Utku Kale, Artūras Kilikevičius

“…Abstract The present research focuses on developing an innovative biochar-based heterogeneous catalyst from Prosopis Juliflora biomass waste using response surface methodology and genetic algorithm (GA) to optimize pyrolysis parameters, achieving a 46.31% PJBC yield from 60 mg of biomass at 790 °C for 60 min. …”
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Comparison of clinical and pharmacodynamic features of proton pump inhibitors efficacy in gastroesophageal reflux disease by O. A. Storonova, A. S. Trukhmanov

“…Intensity of acid-suppressive action of PPI depends on drug metabolic pathways and genetically determined features of cytochrome P450 system. …”
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Heterosis and combining ability among promising single-cross hybrids in Lilium formolongi Hort. for major growth and flowering traits by Rameshwar Rai, Jong-Hwa Kim

“…The performance of all 16 genotypes (4 parent SCF1s, 6 DCF1s, and 6 reciprocal DCF1s) was evaluated by maintaining three replications in a randomized complete block design. This significant genetic variability is a key point of interest, as it paves the way for further exploration and understanding of the inheritance of these traits. …”
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Prevalence of malocclusion and orthodontic treatment need in a sample of 12-15-year-old kurdish schoolchildren in Ranyia district by Zana Qadir Omer, Hashem Omer Karim

“…Background and objectives: In recent years, much attention has been focused on measuring the severity and prevalence of malocclusion and orthodontic treatment need worldwide,in particular, the aetiological importance of genetic factors has been reduced, considering that many malocclusions recognize a post-natal origin related to habits at early stages of life and trauma.This study aimed to determine the prevalence of malocclusion and to evaluate the need for orthodontic treatment in school going children in Ranyia district in Kurdistan region of Iraq. …”
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Protocol to study the impact of breast cancer on colonization resistance of mouse microbiota using network node manipulation by Ana Laura Cano-Argüelles, Alejandra Wu-Chuang, Lourdes Mateos-Hernandez, Lianet Abuin-Denis, Apolline Maitre, Janet Avellanet, Arlem García, Dasha Fuentes, Alejandro Cabezas-Cruz

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Transitioning from wet lab to artificial intelligence: a systematic review of AI predictors in CRISPR by Ahtisham Fazeel Abbasi, Muhammad Nabeel Asim, Andreas Dengel

“…This groundbreaking technology holds immense potential for the development of targeted therapies for a wide range of diseases, including cancers, genetic disorders, and hereditary diseases. CRISPR-Cas9 based genome editing is a multi-step process such as designing a precise gRNA, selecting the appropriate Cas protein, and thoroughly evaluating both on-target and off-target activity of the Cas9-gRNA complex. …”
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Genome Characteristic of NDM-5-Producing Klebsiella Quasipneumoniae and Klebsiella Pneumoniae in China by Chen L, Liu R, Ye H, Qian J, Lou D

“…Comparative analyses showed high genetic similarity with previously reported NDM-5 plasmids from Salmonella enterica and Escherichia coli in China, underscoring the ease of horizontal transfer and potential for broader dissemination. …”
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Heterologous expression of SpsTAC2 in Arabidopsis affected branch angle and secondary vascular system development by Fangshu Niu, Mengru Yuan, Hongxia Zhao, Zhi Pang, Jie Yan, RuiXie Ning, Lin Shi, Fengqiang Yu, Dongshan Wei, Rong Yang, Runming Zhang, Haifeng Yang

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Prevalence and spectrum of haemoglobinopathies in females of reproductive age group- A first tertiary care center experience in Punjab, North India by Vikram Narang, Anshul Jain, Sumit Grover, Ankita Soni, Monika Narang, Ashima Taneja

“…Conclusion: Preventive strategies are cost-effective and include population screening, premarital screening, screening of spouses, genetic counseling, and prenatal diagnosis. Educating the carrier females about the potential risk and various screening methods may help in controlling the disease.…”
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Successful management of refractory epilepsy in creatine transporter deficiency with cannabidiol and clobazam: A case report by Maria Borrell‐Pichot, Carmen Fons, Susana Boronat, Alba Sierra‐Marcos

“…Plain Language Summary Creatine transporter deficiency (CRTR‐D) is a rare genetic disorder causing mental, behavioral, and movement problems. …”
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Significance of immune factors in Crohn's disease development by D. S. Stavtsev, T. A. Astrelina, O. V. Knyazev, T. V. Pukhlikova

“…Main histocompatibility complex (MHC) plays the leading role in immune response as well as in development of CD, therefore occurrence of disease is related to changes at genetic level. Many studies indicate relation of Crohn's disease to specific genes of HLA-system. …”
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Endosperm culture-based allotriploid hybrid production from an interspecific cross of Haemanthus spp.: new insights into polyploidization and hybridization by Arisa Nakano, Masahiro Mii, Yoichiro Hoshino

“…Conclusions This study is the first to demonstrate the production of allotriploid hybrid plants through endosperm culture using seeds from interspecific crosses, as supported by cellular and genetic analyses. Additionally, the study established a novel system for simultaneously producing diploid and allotriploid hybrids from a single seed, providing valuable materials to study the effects of polyploidization and hybridization in allopolyploid plants. …”
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A mechanistic-statistical approach to infer dispersal and demography from invasion dynamics, applied to a plant pathogen by Saubin, Méline, Coville, Jérome, Xhaard, Constance, Frey, Pascal, Soubeyrand, Samuel, Halkett, Fabien, Fabre, Frédéric

“…Dispersal, and in particular the frequency of long-distance dispersal (LDD) events, has strong implications for population dynamics with possibly the acceleration of the colonisation front, and for evolution with possibly the conservation of genetic diversity along the colonised domain. However, accurately inferring LDD is challenging as it requires both large-scale data and a methodology that encompasses the redistribution of individuals in time and space. …”
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Diagnostics and treatment of cardiac achalasia and cardiospasm: guidelines of the Russian gastroenterological association by V. T. Ivashkin, A. S. Trukhmanov, E. A. Godzhello, I. V. Mayev, Yu. V. Evsyutina, T. L. Lapina, O. A. Storonova

“…Three main hypotheses of disease etiology are discussed: genetic, contagious and autoimmune. Clinical symptoms of disease: difficulty of passage of solid and liquid food through the esophagus, vomiting, in certain cases - chest pain; severe disease is accompanied by cough and weight loss. …”
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