Phenotypic and transcriptomic analyses reveal major differences between apple and pear scab nonhost resistance by Vergne, Emilie, Chevreau, Elisabeth, Ravon, Elisa, Gaillard, Sylvain, Pelletier, Sandra, Bahut, Muriel, Perchepied, Laure

“…This first deciphering of the molecular mechanisms underlying a nonhost scab resistance in pear offers new possibilities for the genetic engineering of sustainable scab resistance in this species. …”
Get full text

The efficacy of chelated micronutrient fertilisers in tomato cultivation by Volodymyr Sievidov, Oksana Serhienko, Ivan Lebedynskyi, Igor Sievidov

“…These measures ensure the maximum realisation of the crop’s genetic potential …”
Get full text

hnRNPU-mediated pathogenic alternative splicing drives gastric cancer progression by Guoguo Jin, Yanming Song, Shaobo Fang, Mingyang Yan, Zhaojie Yang, Yang Shao, Kexin Zhao, Meng Liu, Zhenwei Wang, Zhiping Guo, Zigang Dong

“…Results We found that hnRNPU serves as a key splicing factor in GC, and its high expression is associated with poor clinical prognosis. Genetic depletion of hnRNPU significantly reduced GC progression. …”
Get full text

Development and validation of highly sensitive multiplex real-time RT-PCR assay for detection of classical swine fever virus genome by A. S. Sadchikova, A. S. Igolkin, R. S. Chernyshev, A. A. Kozlov, I. S. Kolbin, A. V. Sprygin, D. A. Biryuchenkov, I. A. Chvala, A. Mazloum

“…A set of anti-epidemic measures including mainly preventive vaccination and annual diagnostic monitoring using molecular-genetic and serological methods is required for CSF virus introduction prevention and rapid eradication of potential disease out breaks. …”
Get full text

Linking altered neuronal and synaptic properties to nicotinic receptor Alpha5 subunit gene dysfunction: a translational investigation in rat mPFC and human cortical layer 6 by Danqing Yang, Guanxiao Qi, Daniel Delev, Uwe Maskos, Dirk Feldmeyer

“…Abstract Genetic variation in the α5 nicotinic acetylcholine receptor (nAChR) subunit of mice results in behavioral deficits linked to the prefrontal cortex (PFC). rs16969968 is the primary Single Nucleotide Polymorphism (SNP) in CHRNA5 strongly associated with nicotine dependence and schizophrenia in humans. …”
Get full text

Cannabinoid type-1 receptors in CaMKII neurons drive impulsivity in pathological eating behavior by Elena Martin-Garcia, Laura Domingo-Rodriguez, Beat Lutz, Rafael Maldonado, Inigo Ruiz de Azua

“…Methods: We applied a genetic strategy to reconstitute cannabinoid type-1 receptor (CB1) expression at functional levels specifically in CaMKII+ neurons (CaMKII-CB1-RS) and adipocytes (Ati-CB1-RS), respectively, in a CB1 deficient background. …”
Get full text

Association between the ABCC11 gene polymorphism-determined earwax properties and external auditory canal microbiota in healthy adults by Yasunobu Amari, Masahiro Hosonuma, Takuya Mizukami, Junya Isobe, Yuki Azetsu, Eiji Funayama, Yuki Maruyama, Toshiaki Tsurui, Kohei Tajima, Aya Sasaki, Yoshitaka Yamazaki, Ryota Nakano, Yutaka Sano, Atsushi Ishida, Tatsuya Nakanishi, Seiji Mochizuki, Yuri Yoshizawa, Sumito Kumagai, Sakiko Yasuhara, Kakei Ryu, Tatsunori Oguchi, Atsuo Kuramasu, Kiyoshi Yoshimura, Takehiko Sambe, Sei Kobayashi, Naoki Uchida

“…ABSTRACT The concept of genome–microbiome interactions, in which the microenvironment determined by host genetic polymorphisms regulates the local microbiota, is important in the pathogenesis of human disease. …”
Get full text

Morphological and Molecular Characterization of a New Isospora (Apicomplexa: Eimeriidae) Species From a Singing Honeyeater (Gavicalis virescens Vieillot, 1817) (Passeriformes: Meli... by Yinhua Chen, Belinda Brice, Bruno P. Berto, Rongchang Yang

“…Molecular analysis of the 18S rRNA, 28S rRNA, and COI gene loci showed a 99.5% genetic similarity to Isospora neochmiae at the 18S rRNA locus and 99.2% and 97.7% similarities to Isospora manorinae at the 28S rRNA and COI loci, respectively. …”
Get full text

Sustainable synthesis and advanced optimization of Prosopis juliflora biomass catalyst for efficient biodiesel production and environmental impact assessment by Thota S S Bhaskara Rao, Manikandaraja Gnanaprakasam, Rajayokkiam Manimaran, Dhinesh Balasubramanian, Utku Kale, Artūras Kilikevičius

“…Abstract The present research focuses on developing an innovative biochar-based heterogeneous catalyst from Prosopis Juliflora biomass waste using response surface methodology and genetic algorithm (GA) to optimize pyrolysis parameters, achieving a 46.31% PJBC yield from 60 mg of biomass at 790 °C for 60 min. …”
Get full text

Virulence is not directly related to strain success in planta in Clavibacter nebraskensis by Molly Veregge, Cory D. Hirsch, Matthew J. Moscou, Liana Burghardt, Peter Tiffin, Devanshi Khokhani

“…Our survey of 41 strains revealed that more recently sampled strains tended to have higher virulence than strains sampled before 2010 and tended to be more genetically divergent from the reference strain, isolated in 1971. …”
Get full text

Appraisal of cowpea cropping systems and farmers’ perceptions of production constraints and preferences in the dry savannah areas of Nigeria by Saba Baba Mohammed, Daniel Kwadjo Dzidzienyo, Muhammad Lawan Umar, Mohammad Faguji Ishiyaku, Pangirayi Bernard Tongoona, Vernon Gracen

“…Conclusions Findings indicate a need for increased education and training of cowpea farmers on the importance of growing cowpeas in sole cropping and or improved intercropping systems. Genetic improvement efforts should focus on developing cowpea varieties that address farmers production constraints and reflect the diversity of consumers’ preferences for the crop. …”
Get full text

Preparation and characterization of new silica-based heterofunctional biocatalysts utilizing low-cost lipase Eversa® Transform 2.0 and evaluation of their catalytic performance in... by Wagner C. A. Carvalho, Rayane A. S. Freitas, Milson S. Barbosa, Ariela V. Paula, Ernandes B. Pereira, Adriano A. Mendes, Elton Franceschi, Cleide M. F. Soares

“…This work offers the opportunity to understand and synthesize new biocatalysts with a low-cost genetically modified lipase using a renewable raw material, opening new possibilities to fill gaps that still exist in the use of lipases for biolubricant production.…”
Get full text

Exploring the impact of APOE ɛ4 on functional connectivity in Alzheimer’s disease across cognitive impairment levels by Kangli Dong, Wei Liang, Ting Hou, Zhijie Lu, Yixuan Hao, Chenrui Li, Yue Qiu, Nan Kong, Yan Cheng, Yaqi Wen, Wanyin Ma, Wenbin Zheng, Jitian Guan, Yan Lin, Kai Huang, Lu Zhang, Siya Chen, Xiangyuan Ma, Renhua Wu, Naili Wei

“…The apolipoprotein E (APOE) ɛ4 allele is a recognized genetic risk factor for Alzheimer’s Disease (AD). …”
Get full text

Four cardiomyopathy patients with a heterozygous DSG2 p.Arg119Ter variant by Takuya Sumida, Shou Ogawa, Shuichiro Higo, Yuki Kuramoto, Ryo Eto, Yoshihiko Ikeda, Congcong Sun, Junjun Li, Li Liu, Tomoka Tabata, Yoshihiro Asano, Mikio Shiba, Yasuhiro Akazawa, Daisuke Nakamura, Takafumi Oka, Tomohito Ohtani, Yasushi Sakata

“…The patients also exhibited reduced left ventricular contractile function and varying clinical courses. Genetic analysis identified additional possible causative variants, DSG2 p.Arg292Cys in Pt-1 and BAG3 p.His166SerfsTer6 in Pt-3. …”
Get full text

A novel homozygous intronic variant in CDT1 that alters splicing causes Meier–Gorlin syndrome, and a review of published mutations and growth hormone treatments by Qing Li, Yichi Wu, Fucheng Meng, Zhuxi Li, Di Zhan, Xiaoping Luo

“…Conclusions We reported a novel pathogenic homozygous intronic variant (c.352–30 A > C) of CDT1 in a girl with MGORS, and this mutation extended the genetic spectrum of the disease. GH therapy may be beneficial for height outcomes in children with MGORS with normal IGF-1 levels.…”
Get full text

Evaluation of genomic and phenomic prediction for application in apple breeding by Michaela Jung, Marius Hodel, Andrea Knauf, Daniela Kupper, Markus Neuditschko, Simone Bühlmann-Schütz, Bruno Studer, Andrea Patocchi, Giovanni AL Broggini

“…The predictive ability of these models depends on factors like trait genetic architecture, training set size, relatedness of the selected material to the training set, and the validation method used. …”
Get full text

Evaluation of Yellow Fever Virus Infection in <i>Aedes aegypti</i> Mosquitoes from Pakistan with Distinct Knockdown Resistance Genotypes by Carlucio Rocha dos Santos, Caleb Guedes Miranda dos Santos, Dinair Couto-Lima, Bárbara Silva Souza, Rafi Ur Rahman, Marcos Dornelas Ribeiro, José Bento Pereira Lima, Ademir Jesus Martins

“…Factors such as environmental conditions and genetic variations in the yellow fever virus (YFV) strains and mosquito populations may explain this absence. …”
Get full text

Effectiveness of implementation of sickle cell disease referral guidelines and other measures in paediatric department at a tertiary hospital in Saudi Arabia by Muhammad Matloob Alam, Abdulrhman Alathaibi, Hamdan Alghamdi, Jean Barrientos De Asis, Reynan Bautista, Mansour Aladwani, Mustafa Mohamed Selim

“…Background Sickle cell disease (SCD) is an autosomal recessive genetic blood disorder. It affects up to 2.6% of the Kingdom of Saudi Arabia population.Local problem The paediatric haematology/oncology (PHO) team noticed that 75% of paediatric patients were inappropriately referred to the PHO department. …”
Get full text

Discovery and characterization of complete genomes of 38 head-tailed proviruses in four predominant phyla of archaea by Tianqi Xu, Yimin Ni, Hailing Li, Shuang Wu, Shuling Yan, Lanming Chen, Yongxin Yu, Yongjie Wang

“…In addition to the 14 proviruses of halophilic archaea related to the Graaviviridae family, the remaining proviruses exhibited limited genetic similarities to known (pro)viruses, suggesting the existence of 14 potential novel families. …”
Get full text

Using Targeted Virotherapy to Treat a Resistant Ewing Sarcoma Model: From the Bedside to the Bench and Back by Hesham Abdelbary, Christopher W. Brown, Joel Werier, John Bell

“…The established EWS cell line shared similar molecular and genetic traits to the patient’s original tumor specimen. …”
Get full text