Advancing Radiobiology: Investigating the Effects of Photon, Proton, and Carbon-Ion Irradiation on PANC-1 Cells in 2D and 3D Tumor Models by Alexandra Charalampopoulou, Amelia Barcellini, Giuseppe Magro, Anna Bellini, Sara Sevan Borgna, Giorgia Fulgini, Giovanni Battista Ivaldi, Alessio Mereghetti, Ester Orlandi, Marco Giuseppe Pullia, Simone Savazzi, Paola Tabarelli De Fatis, Gaia Volpi, Angelica Facoetti

“…Three-dimensional (3D) models become a paradigm shift, surpassing the constraints of traditional models by accurately re-creating morphological, histological, and genetic characteristics as well as the interaction of tumour cells with the microenvironment. …”
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Development and evaluation of a recombinant monoclonal human antibody with virus-neutralizing activity against the F glycoprotein of respiratory syncytial virus by Sergey A. Klotchenko, Ekaterina A. Romanovskaya-Romanko, Marina A. Plotnikova, Anastasia A. Pulkina, Aram A. Shaldzhyan, Dmitry S. Balabashin, Victoria A. Toporova, Teimur K. Aliev, Natalia E. Gyulikhandanova, Dmitry A. Lioznov

“…Constructs encoding the recombinant antibody FM1 were designed using genetic engineering. Recombinant antibodies were produced in the CHO-K1 cell line through transient expression. …”
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Assessing the success of breeding maize inbred lines with contrasting diferulate concentrations by Ana López-Malvar, Rosa Ana Malvar, Ana Butrón, Xose Carlos Souto, Rogelio Santiago

“…However, these relationships were based on studies performed using diverse unrelated inbred lines and/or populations, so genetic background could interfere on these associations. …”
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Modelling height to crown base using non-parametric methods for mixed forests in China by Zeyu Zhou, Huiru Zhang, Ram P. Sharma, Xiaohong Zhang, Linyan Feng, Manyi Du, Lianjin Zhang, Huanying Feng, Xuefan Hu, Yang Yu

“…Because of the different genetic characteristics and growth patterns of different tree species, species-specific tree groups were formed, and the HCB of each species-specific group was simulated by the different models. …”
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Sorafenib enhanced the function of myeloid-derived suppressor cells in hepatocellular carcinoma by facilitating PPARα-mediated fatty acid oxidation by Chunxiao Li, Liting Xiong, Yuhan Yang, Ping Jiang, Junjie Wang, Mengyuan Li, Shuhua Wei, Suqing Tian, Yuexuan Wang, Mi Zhang, Jie Tang

“…In addition, tumor-bearing mice fed a high-fat diet (HFD) at the beginning of sorafenib administration had worse outcomes than mice fed a regular diet. Genetic deficiency of PPARα weakens the effect of sorafenib on MDSCs in mice with HCC. …”
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Patch-Level and Neighborhood-Dependency Spatial Optimization Method (PNO): Application to Urban Land-Use Planning to Facilitate Both Socio-Economic and Environmental Development in... by Yuhan Cheng, Xiuyuan Zhang, Qi Zhou, Xiaoyan Dong, Shihong Du

“…The PNO represents land-use patterns in a graph structure, quantifies land-use patterns’ impacts on the population, economy, and land surface temperature, defines the spatiotemporal constraints of land-use optimization considering neighborhood-dependency and optimization sequences, and finally optimizes land uses and their spatial layouts based on a multi-objective genetic algorithm. Experiments were conducted in the urban area of Beijing, and the results suggested that, after optimization, the population and GDP can be improved by 667,323 people (4.72%) and USD 10.69 billion in products (2.75%) in the study area; meanwhile, the land surface temperature can be reduced by 0.12 °C (−0.32%). …”
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Interleukin-10 Polymorphisms in Association with Prognosis in Patients with B-Cell Lymphoma Treated by R-CHOP by Min Kyeong Kim, Kyong-Ah Yoon, Eun Young Park, Jungnam Joo, Eun Young Lee, Hyeon-Seok Eom, Sun-Young Kong

“…Cell lineage, IPI, and extra-nodal involvement were predictors of prognosis. In the additive genetic model results for each IL10 polymorphism, the rs1800871 and rs1800872 polymorphisms represented a marginal association with OS (p = 0.09 and p = 0.06) and PFS (p = 0.05 and p = 0.08) in B-cell lymphoma patients treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP). …”
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Combination of Gilbert's syndrome and gastrointestinal diseases by G. M. Dubrovina, O. K. Botvinyev, A. I. Kolotilina

“…Mutation of encoding gene — A (TA) 7TAA A is the principal cause of insufficiency of this enzyme, however development of clinical syndrome and severity of symptoms is related to other factors as well (male gender, additional genetic mutations, et al.). Provoking factors of jaundice attacks include fasting, infectious diseases, overstrain, effect of drugs and xenobiotics. …”
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Transcriptomic Profile Analysis of Brain Tissue in the Absence of Functional TRPM8 Calcium Channel by Erick B. Saldes, Alexandra Erdmier, Jai Velpula, Timothy E. Koeltzow, Michael X. Zhu, Swapna Asuthkar

“…The activation and deactivation of TRPM8 occur through genetic modifications, channel interactions, and signaling cascades. …”
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A survey of the Sli gene in wild and cultivated potato by Mercedes Ames, Andy Hamernik, William Behling, David S. Douches, Dennis A. Halterman, Paul C. Bethke

“…Our study demonstrated that genetic factors besides the Sli gene must be important for conditioning a switch in the mating system from self‐incompatible to self‐compatible in wild potatoes.…”
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Enhanced NSGA-II algorithm based on novel hybrid crossover operator to optimise water supply and ecology of Fenhe reservoir operation by Qinglai Xiong, Ling Dong, Hu Chen, Xueping Zhu, Xuehua Zhao, Xuerui Gao

“…This study addresses bi-objective optimisation problems by proposing a novel crossover evolution operator, known as the hybrid simulated binary and improved arithmetic crossover (SBAX) operator, based on the simulated binary cross (SBX) and arithmetic crossover operators, and applies it to the Non-dominated Sorting Genetic Algorithms-II (NSGA-II) algorithm to improve the algorithm. …”
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Colorectal cancer in Lynch syndrome families: consequences of gene germline mutations and the gut microbiota by Xuexin Wang, Zhijun Zheng, Dongliang Yu, Xiaojue Qiu, Ting Yang, Ruoran Li, Jing Liu, Xin Wang, Peng Jin, Jianqiu Sheng, Nan Qin, Na Li, Junfeng Xu

“…A greater difference (both alpha and beta diversity indices) was shown between the AS and DS groups, demonstrating the combined impact of the gut microbiota and genetic germline mutations on the occurrence of CRC in LS families. …”
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RNA sequence analysis landscape: A comprehensive review of task types, databases, datasets, word embedding methods, and language models by Muhammad Nabeel Asim, Muhammad Ali Ibrahim, Tayyaba Asif, Andreas Dengel

“…Aberrations in RNA sequence such as dysregulation and mutations can drive a diverse spectrum of diseases including cancers, genetic disorders, and neurodegenerative conditions. …”
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Evaluation of the relatedness between the biofilm-associated genes and antimicrobial resistance among Acinetobacter baumannii isolates in the southwest Iran by Nafiseh Hosseinzadeh Shakib, Zahra Hashemizadeh, Abolfazl Rafati Zomorodi, Reza Khashei, Yeganeh Sadeghi, Abdollah Bazargani

“…The REP-PCR technique was utilized to analyze the genetic relatedness of the isolates (Fig. 4). Results: All isolates displayed multi-drug resistance, with the highest resistance rates observed against ceftazidime, cefotaxime, and trimethoprim/sulfamethoxazole (100%). …”
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Cost-efficient assignment panel for ducks. Setup of a cost-efficient assignment panel for duck populations.  by Chapuis, Hervé, Brard-Fudulea, Sophie, Hazard, Azélie, Vignal, Alain, Demars, Julie, Rouger, Romuald, Teissier, Marc, Gilbert, Hélène

“…This new design impacted the population structure, creating more sire x dam combinations, offering possibilities for a better estimation of non-additive genetic effects, which could prove relevant in the foie gras sector. …”
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Machine learning assisted prediction with data driven robust optimization: Machining process modeling of hard part turning of DC53 for tooling applications supporting semiconductor... by Mehdi Tlija, Muhammad Sana, Anamta Khan, Sana Hassan, Muhammad Umar Farooq

“…The optimized architectures are used as prediction models to a non-sorting genetic algorithm (NSGA-II) to determine the optimal compromise among all conflicting responses. …”
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Prevalence of Fabry Disease among Patients with Parkinson’s Disease by Alexandra Lackova, Christian Beetz, Sebastian Oppermann, Peter Bauer, Petra Pavelekova, Tatiana Lorincova, Miriam Ostrozovicova, Kristina Kulcsarova, Jana Cobejova, Martin Cobej, Petra Levicka, Simona Liesenerova, Daniela Sendekova, Viktoria Sukovska, Zuzana Gdovinova, Vladimir Han, Mie Rizig, Henry Houlden, Matej Skorvanek

“…In 126 subsequently genetically tested patients, four heterozygous p.(Asp313Tyr) GLA variants (3.2%, MAF 0.016) were identified; all were females. …”
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The pilot study of the features of HIV-1 resistant variants spread using molecular clusters by Alina A. Kirichenko, Dmitry E. Kireev, Yulia N. Sidorina, Natalia D. Abashina, Elena E. Brusentseva, Vasily G. Akimkin

“…HIV-1 nucleotide sequences were obtained from 899 HIV-infected patients who were registered at the Oryol AIDS Center in 2016–2021. HIV-1 genetic variants were determined using the Stanford University database, REGA and HIV BLAST. …”
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High clinical utility of long-read sequencing for precise diagnosis of congenital adrenal hyperplasia in 322 probands by Yunpeng Wang, Gaohui Zhu, Danhua Li, Yu Pan, Rong Li, Ting Zhou, Aiping Mao, Libao Chen, Jing Zhu, Min Zhu

“…Abstract Background The molecular genetic diagnosis of congenital adrenal hyperplasia (CAH) is very challenging due to the high homology between the CYP21A2 gene and its pseudogene CYP21A1P. …”
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Anti-PL-7/PL-12 antisynthetase syndrome associated with interstitial lung disease following SARS-COV-2 infection and vaccination: A case study review by Laura García-Bravo, Ángela Villegas, Bárbara López Uceda, Anaís Mariscal, Cristina Vadillo, M Asunción Nieto Barbero, Juan Luis Rodríguez-Hermosa, Beatriz Mediero Valeros, José Carlos Plaza-Hernández, Miguel Fernández-Arquero, María Guzmán-Fulgencio, Gloria Candelas-Rodríguez, Silvia Sánchez-Ramón, Juliana Ochoa-Grullón

“…Understanding the involvement of specific anti-ARS autoantibodies (PL-7 and PL-12) and the identification of genetic predispositions (HLA-B∗08:01 and HLA-DRB1∗03:01) in these patients may be key to underpinning these autoimmune manifestations. …”
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