Molecular Xenomonitoring (MX) allows real-time surveillance of West Nile and Usutu virus in mosquito populations. by Clément Bigeard, Laura Pezzi, Raphaelle Klitting, Nazli Ayhan, Grégory L'Ambert, Nicolas Gomez, Géraldine Piorkowski, Rayane Amaral, Guillaume André Durand, Agathe M G Colmant, Cynthia Giraud, Katia Ramiara, Camille Migné, Gilda Grard, Thierry Touzet, Stéphan Zientara, Rémi Charrel, Gaëlle Gonzalez, Alexandre Duvignaud, Denis Malvy, Xavier de Lamballerie, Albin Fontaine

“…Entomological surveillance is a method of choice for identifying virus circulation ahead of the first human and animal cases and to reveal their genetic identity, but performing molecular screening of vectors is expensive, and time-consuming. …”
Get full text

A Nodulation-Proficient Nonrhizobial Inhabitant of Pueraria phaseoloides by W. M. M. Wedage, A. H. M. N. R. Aberathne, I. N. Harischandra, D. Gunawardana

“…Sub1 too possesses the basic genetic foundation (nifH and nifD) to produce a molybdenum-dependent nitrogenase enzyme. …”
Get full text

Awareness, attitude, and acceptance of newborn screening for sickle cell disease among health workers and caregivers at primary healthcare centers in Gwagwalada Area Council, Feder... by Isa Hezekiah A, Chisomaga Ifeanyi Oparaugo, Grace Doyin Ajetomobi, Ayomide Esther Fasina, Reuben Ikechukwu Chianumba, Obiageli Eunice Nnodu, Obiageli Eunice Nnodu

“…IntroductionNewborn Screening (NBS) is a public health program designed to identify and provide early interventions for infants with genetic disorders such as Sickle Cell Disease (SCD). …”
Get full text

PDIA3 rs2788: An Independent Risk Factor for Hypertension and Its Interaction With Antihypertensive Medications by Hongtao Lan, Yingbin Xi, Baoxu Kang, Zhoujie Tong, Jie Peng, Wei Zhang, Ming Zhong, Huiping Gong, Zhihao Wang

“…ABSTRACT Hypertension is a multifactorial condition influenced by both genetic and environmental factors. Protein disulfide isomerase family A member 3 (PDIA3) is a key endoplasmic reticulum protein which may contribute to increased blood pressure. …”
Get full text

Difference in Antibody Responses to Mycobacterium tuberculosis Antigens in Japanese Tuberculosis Patients Infected with the Beijing/Non-Beijing Genotype by Jingge Zhao, Beata Shiratori, Masao Okumura, Hideki Yanai, Makoto Matsumoto, Chie Nakajima, Kazue Mizuno, Kenji Ono, Tetsuya Oda, Haorile Chagan-Yasutan, Yugo Ashino, Takashi Matsuba, Takashi Yoshiyama, Yasuhiko Suzuki, Toshio Hattori

“…The Beijing genotype Mycobacterium tuberculosis (MTB), notorious for its virulence and predisposition to relapse, could be identified by spoligotyping based on genetic heterogeneity. The plasma samples from 20 cases of Beijing and 16 cases of non-Beijing MTB infected individuals and 24 healthy controls (HCs) were collected, and antibodies against 11 antigens (Rv0679c142Asn, Rv0679c142Lys, Ag85B, Ag85A, ARC, TDM-M, TDM-K, HBHA, MDP-1, LAM, and TBGL) were measured by ELISA. …”
Get full text

GENOTYPIC DIVERSITY OF DENGUE VIRUS IN AEDES MOSQUITOES COLLECTED FROM DENGUE HOTSPOT AREAS IN KUALA LUMPUR AND SELANGOR, MALAYSIA by Wan Najdah Wan Mohamad Ali, Zurainee Mohamed Nor, Rafidah Ali, Rohani Ahmad, Yvonne Ai-Lian Lim

“…The findings from this study can be utilized to the search for novel genotypes, to the observation of potential genetic alterations in dengue viruses, and to the development of vaccines.…”
Get full text

Antimicrobial Susceptibility Profiles of Commensal <i>Staphylococcus</i> spp. Isolates from Chickens in Hungarian Poultry Farms Between 2022 and 2023 by Ábel Szabó, Ákos Jerzsele, László Kovács, Ádám Kerek

“…To uncover the underlying causes of multidrug resistance, next-generation sequencing can be employed to elucidate the genetic basis of phenotypic resistance.…”
Get full text

Adiponectin Expression Is Modulated by Long-Term Physical Activity in Adult Patients Affected by Cystic Fibrosis by Rita Polito, Ersilia Nigro, Ausilia Elce, Maria Ludovica Monaco, Paola Iacotucci, Vincenzo Carnovale, Marika Comegna, Monica Gelzo, Federica Zarrilli, Gaetano Corso, Giuseppe Castaldo, Aurora Daniele

“…Cystic fibrosis (CF) is a genetic disease characterized by progressive decline of lung function and chronic airway inflammation. …”
Get full text

Direct and Indirect Methods for Studying Human Gut Microbiota by V. T. Ivashkin, O. S. Medvedev, E. A. Poluektova, A. V. Kudryavtseva, I. R. Bakhtogarimov, A. E. Karchevskaya

“…Currently, molecular genetic methods are used mainly for basic research and do not have a unified protocol for data analysis, which makes it difficult to implement them in clinical practice. …”
Get full text

Association of Visceral Adipose Tissue With Hypertension: Results From the NHANES 2011–2018 and Mendelian Randomization Analyses by Jia Liao, Miaohan Qiu, Jing Li, Yi Li, Yaling Han

“…Data from the National Health and Nutrition Examination Survey (NHANES) 2011–2018 were used, applying multivariable logistic regression analysis to investigate the association between VAT mass and hypertension risk. Independent genetic variants related to VAT mass were derived from genome‐wide association studies (GWAS) in 325 153 UK Biobank participants. …”
Get full text

Between-Subject and Within-Subject Variation of Muscle Atrophy and Bone Loss in Response to Experimental Bed Rest by Jonas Böcker, Marie-Therese Schmitz, Marie-Therese Schmitz, Uwe Mittag, Jens Jordan, Jens Jordan, Jörn Rittweger, Jörn Rittweger

“…These results demonstrate the existence of substantial bone BSV, and that it is partly driven by WSV, and likely also by physical activity and dietary habits prior to bed rest. In addition, genetic and epigenetic variation could potentially explain BSV, but not WSV. …”
Get full text

Fluorescence In Situ Hybridization (FISH) Signal Analysis Using Automated Generated Projection Images by Xingwei Wang, Xiaodong Chen, Yuhua Li, Hong Liu, Shibo Li, Roy R. Zhang, Bin Zheng

“…Fluorescence in situ hybridization (FISH) tests provide promising molecular imaging biomarkers to more accurately and reliably detect and diagnose cancers and genetic disorders. Since current manual FISH signal analysis is low-efficient and inconsistent, which limits its clinical utility, developing automated FISH image scanning systems and computer-aided detection (CAD) schemes has been attracting research interests. …”
Get full text

Prepancreatic postduodenal portal vein discovered in a pediatric patient undergoing total pancreatectomy with islet autotransplantation: a case report and review of literature by Muhammed Ali Colak, Andrew T. Trout, Christie Heinzman, A Jay Freeman, A Jay Freeman, Sara K. Rasmussen, Sara K. Rasmussen, Maisam Abu-El-Haija, Jaimie D. Nathan, Jaimie D. Nathan

“…We report the first case of PPPV in a pediatric patient discovered intraoperatively during total pancreatectomy with islet autotransplantation (TPIAT) and the third known case in which the PPPV could be isolated intraoperatively.CaseA 10-year-old girl with debilitating acute recurrent pancreatitis requiring daily pain medication was admitted for elective TPIAT operation. Genetic workup for hereditary causes of pancreatitis was negative. …”
Get full text

Multiplex real-time PCR for detection of <i>qac A/B</i> and <i>smr</i> genes in Gram-positive bacteria by Svetlana N. Kovalchuk, Anna L. Arkhipova, Svetlana Yu. Kovylkova, Elena N. Ilina, Lyudmila S. Fedorova

“…To monitor the spread of clinically significant microorganisms resistant to disinfectants, the development of methods for their detection, including molecular genetic methods, remains relevant. The aim of the study was to develop a multiplex real-time PCR for the identification of qacA/B and smr genes, the determinants of resistance to cationic biocides, in Gram-positive bacteria. …”
Get full text

Salvage pathway of vitamin B12 absorption in chickens with mutant tumor virus a receptor by Yun Ji Shin, Jin-Kyoo Kim, Seung Je Woo, Byung Chul Park, Jae Yong Han

“…The tumor virus A receptor (TVA), a member of the low-density lipoprotein receptor (LDLR) family, serves as an entry receptor for Avian Leukosis Virus (ALV) subgroups A and K, as well as a receptor for vitamin B12 bound to transcobalamin. Naturally occurring genetic variants in the TVA gene determine susceptibility or resistance to ALV-A and -K, but the effects of these mutated TVA on vitamin B12 uptake have not been investigated systemically. …”
Get full text

Antipseudomonal β-Lactams Resistance in Iran by Mohammad Mahdi Rabiei, Keivan Asadi, Shervin Shokouhi, Mohammad Javad Nasiri, Ilad Alavi Darazam

“…The results of this study illustrate that the methods enabling clinics to identify the bacterium resistance pattern and its genetic basis and to have the opportunity of empiric therapies through access to updated local data of antimicrobial susceptibility pattern are the most effective methods. …”
Get full text

Exploration and comparison of the effectiveness of swarm intelligence algorithm in early identification of cardiovascular disease by Tiantian Bai, Mengru Xu, Taotao Zhang, Xianjie Jia, Fuzhi Wang, Xiuling Jiang, Xing Wei

“…This study focuses on integrating swarm intelligence feature selection algorithms (including whale optimization algorithm, cuckoo search algorithm, flower pollination algorithm, Harris hawk optimization algorithm, particle swarm optimization algorithm, and genetic algorithm) with machine learning technology to improve the early diagnosis of cardiovascular disease. …”
Get full text

Promoting epithelial regeneration in chemically induced acute lung injury through Sox9-positive alveolar type 2 epithelial cells by Chao Cao, Obulkasim Memete, Yu Dun, Lin Zhang, Fuli Liu, Daikun He, Jian Zhou, Yiru Shao, Jie Shen

“…Conclusion These results provide compelling in vivo genetic evidence supporting the characterization of Sox9+AEC2 cells as bona fide lung epithelial stem cells, demonstrating their multipotency and self-renewal capabilities during lung repair and regeneration. …”
Get full text

A two-sample bidirectional Mendelian randomization analysis between telomere length and hyperthyroidism by Shiben Zhu, Ziyu Hao, Qihang Chen, Xiaoliu Liu, Wenyan Wu, Fang Zhang

“…The risk of hyperthyroidism decreased as genetically predicted TL increased by one standard deviation, as determined by the IVW form GWAS Catalog (OR:0.659,95%CI: 0.541-0.802, p &lt;0.001) and IVW from FinnGen(OR:0.634, 95%CI: 0.479-0.840, p = 0.001). …”
Get full text

Association between TCF7L2 Genotype and Glycemic Control in Diabetic Patients Treated with Gliclazide by Martin Javorský, Eva Babjaková, Lucia Klimčáková, Zbynek Schroner, Jozef Židzik, Mária Štolfová, Ján Šalagovič, Ivan Tkáč

“…Analyses using the dominant genetic model showed significantly higher effect of gliclazide in the CC genotype group in comparison with combined CT + TT genotype group (1.32±0.15% versus 0.73±0.11%, Padj=0.005). …”
Get full text