The association between the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio and delirium in ischemic stroke patients by Pangbo Wang, Pangbo Wang, Jing Huang, Liwei Xu, Rong Hu

“…Two-sample Mendelian randomization (MR) analysis was performed to further explore their causal relationship at the genetic level.ResultsA total of 1,436 patients with IS were included in this study, of whom 214 (14.9%) had delirium. …”
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Transcriptome Analysis of the Effect of Acute Ammonia Stress on <i>Pseudobagrus ussuriensis</i> Liver Tissue by Shun Shi, Xiaohui Sun, Chunnuan Zhang, Chenran Lv, Yajuan Liu, Juan Du, Qian Qi

“…These results suggest that ammonia stress induces liver damage in <i>P. ussuriensis</i>, causing genetic mutations and cellular carcinogenesis, thereby accelerating cell apoptosis.…”
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The presence of risk factors in the home environment that influences the fall of people of the third age by Ratko Zlatičanin, Amila Jaganjac, Arzija Pašalić, Amra Mačak Hadžiomerović

“… Introduction: Aging is a natural, irreversible physiological process that depends on genetic, environmental, and lifestyle factors. Many physiological, biological, psychological, and other factors play a major role. …”
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A randomized, double‐blind, placebo‐controlled, multiple dose, parallel study to investigate the effects of a cathepsin S inhibitor in celiac disease by Darren Bentley, Marie Mannino, Marianne Manchester, Priscila Camillo Teixeira, Bernhard Reis, Malcolm Boyce, Sandra Nagel

“…Abstract Celiac disease is a chronic, immune‐mediated enteropathy with symptoms triggered by exposure to dietary gluten in genetically predisposed individuals. The only available management option is lifelong adherence to a gluten‐free diet. …”
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Molecular Mechanism of Germinated Foxtail Millet Bioactive Peptides in Attenuating Copper-induced Oxidative Damage in Caenorhabditis elegans by Huiqi ZHANG, Xiao CHEN, Xueling JIN, Jingjing LI, Juanli YUAN, Jinyan GAO, Hongbing CHEN, Yong WU

“…Results: GRBPs obviously improved the survival rate and mobility of C. elegans after copper treatment, and a concentration of 1 mg/mL of GRBPs extremely significantly reduced the levels of MDA (P<0.0001), increased the activities of CAT and SOD, and regulated the expression of specific genes (such as upregulation of ctl-1, ctl-2, and downregulation of sod-1, sod-2). At the genetic level, GRBPs mainly regulated the structural constituent of cuticle and the expression of genes related to cytochrome enzyme P450 in C. elegans. …”
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Analysis of a mouse germ cell tumor model establishes pluripotency-associated miRNAs as conserved serum biomarkers for germ cell cancer detection by Amanda R. Loehr, Dennis M. Timmerman, Michelle Liu, Ad J. M. Gillis, Melia Matthews, Jordana C. Bloom, Peter K. Nicholls, David C. Page, Andrew D. Miller, Leendert H. J. Looijenga, Robert S. Weiss

“…We previously developed a genetically engineered mouse model featuring malignant mixed TGCTs consisting of pluripotent embryonal carcinoma (EC) and differentiated teratoma that, like the corresponding human malignancies, originate in utero and are highly chemosensitive. …”
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Development of a Mobile Application Platform for Self-Management of Obesity Using Artificial Intelligence Techniques by Sylvester M. Sefa-Yeboah, Kwabena Osei Annor, Valencia J. Koomson, Firibu K. Saalia, Matilda Steiner-Asiedu, Godfrey A. Mills

“…In this work, we present an artificial intelligence- (AI-) based application that is driven by a genetic algorithm (GA) as a potential tool for tracking a user’s energy balance and predicting possible calorie intake required to meet daily calorie needs for obesity management. …”
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Multiplex Community Detection in Social Networks Using a Chaos-Based Hybrid Evolutionary Approach by Bagher Zarei, Bahman Arasteh, Mehdi Asadi, Vahid Majidnezhad, Saeid Taghavi Afshord, Asgarali Bouyer

“…In the community structure detection phase, the community structure of the resulting weighted monoplex network is determined using the Improved Genetic Algorithm (IGA). The main aspects that differentiate IGA from other algorithms presented in the literature are as follows: (a) instead of randomly generating the initial population, it is smartly generated using the concept of diffusion. …”
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Investigating the causal effects of childhood and adulthood adiposity on later life mental health outcome: a Mendelian randomization study by Sweta Pathak, Tom G. Richardson, Eleanor Sanderson, Bjørn Olav Åsvold, Laxmi Bhatta, Ben M. Brumpton

“…Results Univariable MR did not indicate genetically predicted effects of childhood body size with later life anxiety (beta = − 0.05, 95% CI = − 0.13, 0.02) and depression (OR = 1.06, 95% CI = 0.94, 1.20). …”
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An automated platform for simultaneous, longitudinal analysis of engineered neuromuscular tissues for applications in neurotoxin potency testing by Jacob W. Fleming, Molly C. McCloskey, Kevin Gray, David R. Nash, Vincent Leung, Christos Michas, Shawn M. Luttrell, Christopher Cavanaugh, Julie Mathieu, Shawn Mcquire, Mark Bothwell, David L. Mack, Nicholas A. Geisse, Alec S.T. Smith

“…Engineered models have emerged as alternatives for studying NMJ functionality in response to genetic and/or pharmacological challenge. However, these models have faced challenges associated with their poorly scalable creation, sourcing suitable cells, and the extraction of reliable, quantifiable metrics. …”
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Structure of a Sulfated Capsular Polysaccharide from the Marine Bacterium <i>Cobetia marina</i> KMM 1449 and a Genomic Insight into Its Biosynthesis by Maxim S. Kokoulin, Yulia V. Savicheva, Alina P. Filshtein, Ludmila A. Romanenko, Marina P. Isaeva

“…The following new structure of the CPS from <i>C. marina</i> KMM 1449 was established and consisted of sulfated and simultaneously phosphorylated disaccharide repeating units: →4)-α-L-Rha<i>p</i>2S-(1→3)-β-D-Man<i>p</i>6PGro-(1→. To elucidate the genetic basis of the CPS biosynthesis, the whole genomic sequence of <i>C. marina</i> KMM 1449 was obtained. …”
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Poplar transformation with variable explant sources to maximize transformation efficiency by Haiwei Lu, Sara Jawdy, Jin-Gui Chen, Xiaohan Yang, Udaya C. Kalluri

“…Overall, our study shows that explants from above- and belowground organs of a Populus plant are suitable for genetic transformation and tissue culture regeneration, and together with the underlying transcriptome data open new routes to maximize plant explant utilization, stable transformation productivity, and plant transformation efficiency.…”
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Heterochrony in orthodenticle expression is associated with ommatidial size variation between Drosophila species by Montserrat Torres-Oliva, Elisa Buchberger, Alexandra D. Buffry, Maike Kittelmann, Genoveva Guerrero, Lauren Sumner-Rooney, Pedro Gaspar, Georg C. Bullinger, Javier Figueras Jimenez, Fernando Casares, Saad Arif, Nico Posnien, Maria D. S. Nunes, Alistair P. McGregor, Isabel Almudi

“…However, very little is known about the genetic and developmental bases of differences in eye size. …”
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Ambient fine particulate matter provokes multiple modalities of cell death via perturbation of subcellular structures by Yán Wāng

“…Furthermore, PM2.5 exposure disrupts genetic and epigenetic regulation, often resulting in cell cycle arrest and exacerbating cellular damage. …”
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MGATAF: multi-channel graph attention network with adaptive fusion for cancer-drug response prediction by Dhekra Saeed, Huanlai Xing, Barakat AlBadani, Li Feng, Raeed Al-Sabri, Monir Abdullah, Amir Rehman

“…Traditional prediction methods relying on demographic and genetic data often fall short in accuracy and robustness. …”
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GsMTx-4 venom toxin antagonizes biophysical modulation of metastatic traits in human osteosarcoma cells by Arianna Buglione, Giulia Alloisio, Chiara Ciaccio, David Becerril Rodriguez, Simone Dogali, Marco Luce, Stefano Marini, Antonio Cricenti, Magda Gioia

“…Despite their genetic diversity, metastatic cells converge on similar physical constraints during tumor progression. …”
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Screening of two efficient phosphorus-solubilizing bacteria, strain X42 (Bacillus_A_bombysepticus) and strain G62 (Bacillus velezensis) for their ability to promote Gan Nan navel o... by Wenyuan Zhao, Tao Peng, Haojie Cao, Huimin Huang, Shuijing Yu

“…Conclusion This study not only confirms the positive impact of two highly efficient phosphate-solubilizing Bacillus strains on the growth of navel oranges in southern Jiangxi but also deepens the understanding of the genetic basis of phosphate-solubilizing traits through whole-genome analysis. …”
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Serological Detection of Rh-Del Phenotype among Rh-Negative Blood Donors at National Blood Center, Yangon, Myanmar by Saw Thu Wah, Saung Nay Chi, Kyi Kyi Kyaing, Aye Aye Khin, Thida Aung

“…Red cell Rhesus (Rh) antigen expression is influenced by the genetic polymorphism of RHD and RHCE genes and reveals serologically different reactions of RhD variants such as partial D, weak D, and Rh-Del. …”
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The Prediction of Metro Shield Construction Cost Based on a Backpropagation Neural Network Improved by Quantum Particle Swarm Optimization by Lanjun Liu, Denghui Liu, Han Wu, Xinyu Wang

“…The determination coefficient, mean absolute percentage error, root mean square error, and mean absolute error, which are frequently used error analysis tools, were used to analyse the calculation errors of different models (the proposed model, a multiple regression method, a traditional BP model, a BP model optimized by the genetic algorithm, and the BP model optimized by the particle swarm optimization). …”
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Molecular Characterization of a Multidrug-Resistant Klebsiella pneumoniae Strain R46 Isolated from a Rabbit by Fei Wu, Yuanyuan Ying, Min Yin, Yi Jiang, Chongyang Wu, Changrui Qian, Qianqian Chen, Kai Shen, Cong Cheng, Licheng Zhu, Kewei Li, Teng Xu, Qiyu Bao, Junwan Lu

“…The plasmid-encoded resistance genes were mostly associated with mobile genetic elements. The plasmid with the most similarity to the floR gene-harboring plasmid pR46-27 was pCTXM-2271, a plasmid from Escherichia coli. …”
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