Tgfbr1 regulates lateral plate mesoderm and endoderm reorganization during the trunk to tail transition by Anastasiia Lozovska, Ana Casaca, Ana Novoa, Ying-Yi Kuo, Arnon D Jurberg, Gabriel G Martins, Anna-Katerina Hadjantonakis, Moises Mallo

“…During the trunk to tail transition the mammalian embryo builds the outlets for the intestinal and urogenital tracts, lays down the primordia for the hindlimb and external genitalia, and switches from the epiblast/primitive streak (PS) to the tail bud as the driver of axial extension. Genetic and molecular data indicate that Tgfbr1 is a key regulator of the trunk to tail transition. …”
Get full text

Cognitive and Emotional Resilience in Parents with Children with Autism Spectrum Disorder During COVID-19: The Role of Promoting Variables by Aziz Sarhani-Robles, María Guillot-Valdés, María Auxiliadora Robles-Bello, David Sánchez-Teruel

“…The pandemic resulting from the coronavirus disease (COVID-19) has entailed social and psychological consequences for the Spanish population, with children with autism spectrum disorder (ASD) being particularly vulnerable due to their genetic characteristics. The present study focuses on the efforts of parents of children with autism spectrum disorder to improve their situation during the pandemic. …”
Get full text

Prospective Evaluation of Unprocessed Core Needle Biopsy DNA and RNA Yield from Lung, Liver, and Kidney Tumors: Implications for Cancer Genomics by Mikhail T. Silk, Nina Mikkilineni, Tarik C. Silk, Emily C. Zabor, Irina Ostrovnaya, Ari A. Hakimi, James J. Hsieh, Etay Ziv, Natasha Rekhtman, Stephen B. Solomon, Jeremy C. Durack

“…Targeted needle biopsies are increasingly performed for the genetic characterization of cancer. While the nucleic acid content of core needle biopsies after standard pathology processing (i.e., formalin fixation and paraffin embedding (FFPE)) has been previously reported, little is known about the potential yield for molecular analysis at the time of biopsy sample acquisition. …”
Get full text

Exploration of the molecular mechanism behind a novel natural genic male-sterile mutation of 1205A in Brassica napus by Lijing Xiao, Jinze Zhang, Shaomin Guo, Hairun Jin, Qingjing Ouyang, Xu Long, Zhongbin Yan, Entang Tian

“…This study not only offers valuable insights into the research and practical application of plant male sterility but also serves as a case study on the genetic regulatory mechanisms governing male sterility.…”
Get full text

6-Gingerol Normalizes the Expression of Biomarkers Related to Hypertension via PPARδ in HUVECs, HEK293, and Differentiated 3T3-L1 Cells by Yong-Jik Lee, Yoo-Na Jang, Yoon-Mi Han, Hyun-Min Kim, Hong Seog Seo

“…In addition, various factors, such as genetic predisposition, lifestyle factors, and the abnormality of organs related to blood pressure, are involved in the development of hypertension. …”
Get full text

Development of Speech and Communication in Polish Children with 22q11.2 Deletion Syndrome: A Cross-Sectional Study by Natalia Moćko, Marcin Rudzki, Zuzanna Miodońska, Julia Olesiak, Katarzyna Jochymczyk-Woźniak, Michał Kręcichwost

“…Background/Objectives: 22q11.2 microdeletion syndrome (22q11DS) is a genetic disease caused by aberration of chromosome 22 that results in some phenotypic features and developmental disorders. …”
Get full text

Biodegradation of rice husks for glucose production using Streptomyces coelicolor STRP-19 by Waleed M. Abdulkhair, Younes M. Rashad, Mohamed Hafez, Ahmed M. Abd-ElGawad, Mohamed Bourouah

“…Although several Streptomyces isolates showed rice husks-degrading activity, STRP-19 isolate was the most potent and was identified as S. coelicolor using phenotypic and genetic methods based on 16S rRNA gene sequencing. …”
Get full text

Unveiling the Texture Secrets of <i>Morchella</i> Germplasm: Advanced Grading and Quality Assessment Through Texture Profile Analysis (TPA) by Jialiang Li, Ying Chen, Xuelian Cao, Jie Tang, Liyuan Xie, Lixu Liu, Yan Wan, Rongping Hu

“…Variation analysis indicated abundant genetic variation in each characteristic. Furthermore, the coefficient of variation for the characteristics of <i>Morchella sextalata</i> was higher than those of other species. …”
Get full text

Comparison of the MicroRNA Expression Profiles of Male and Female Avian Primordial Germ Cell Lines by Bence Lázár, Mahek Anand, Roland Tóth, Eszter Patakiné Várkonyi, Krisztina Liptói, Elen Gócza

“…Primordial germ cells (PGCs) are the precursors of adult germ cells, and among the embryonic stem-like cells in the bird embryo, only they can transmit the genetic information to the next generation. Despite the wide range of applications, very little is known about the mechanism that governs primordial germ cell self-renewal and differentiation. …”
Get full text

Study on an Intelligent Prediction Method of Ticket Price in a Subway System with Public-Private Partnership by Shengmin Wang, Jun Fang, Lanjun Liu, Han Wu

“…Compared with other prediction methods (the price adjustment method based on PPP contract, the traditional BP algorithm, the BP neural network improved by the genetic algorithm, the BP algorithm improved by the particle swarm optimization, and the support vector machine), the model proposed in this paper showed better prediction accuracy and calculation stability.…”
Get full text

Identification of QTL for Pre-harvest Sprouting Resistance by Using Chromosome Segment Substitution Lines of Dongxiang Common Wild Rice by Jiaxiao HU, Jin LIU, Xiaoding MA, Hang TU, Huiying ZHOU, Bingxin MENG, Di CUI, Maomao LI, Longzhi HAN, Liqin YU

“…Identification and screening of germplasm or genetic resources is a fundamental pathway for developing new varieties resistant to PHS and eliminating PHS damage.…”
Get full text

Pharmacological Inhibition of Caspase-1 Ameliorates Cisplatin-Induced Nephrotoxicity through Suppression of Apoptosis, Oxidative Stress, and Inflammation in Mice by Jung-Yeon Kim, Jae-Hyung Park, Kiryeong Kim, Jungmin Jo, Jaechan Leem, Kwan-Kyu Park

“…It was reported that genetic deficiency of caspase-1 prevented cisplatin-induced nephrotoxicity. …”
Get full text

Symbiotic diversity of Portunus pelagicus (Linnaeus, 1758) in Vietnam - implication for species and geographic variations by Binh Thuy Dang, Oanh Thi Kieu Le, Sang Quang Tran, Oanh Thi Truong

“…Symbiont species of the crabs were determined using morphological and genetic characters, and the temporal and spatial variation pattern in the symbiont were examined. …”
Get full text

Effects of Polymorphisms in Myc-Related Genes on Bleeding Complications in Patients with Stable Warfarin Responses by Jeong Yee, Woorim Kim, Byung Chul Chang, Jee Eun Chung, Kyung Eun Lee, Hye Sun Gwak

“…Univariate and multivariate analyses were conducted to evaluate the associations between genetic polymorphisms and bleeding complications. …”
Get full text

Novel Role of Pin1-Cis P-Tau-ApoE Axis in the Pathogenesis of Preeclampsia and Its Connection with Dementia by Emmanuel Amabebe, Zheping Huang, Sukanta Jash, Balaji Krishnan, Shibin Cheng, Akitoshi Nakashima, Yitong Li, Zhixong Li, Ruizhi Wang, Ramkumar Menon, Xiao Zhen Zhou, Kun Ping Lu, Surendra Sharma

“…This review will also cover genetic polymorphisms in the ApoE alleles leading to dyslipidemia induction that may regulate the pathways causing preE or dementia-like features in the reproductive age or later in life, respectively.…”
Get full text

Predicting autoimmune thyroiditis in primary Sjogren’s syndrome patients using a random forest classifier: a retrospective study by Jia-yun Wu, Jing-yu Zhang, Wen-qi Xia, Yue-ning Kang, Ru-yi Liao, Yu-ling Chen, Xiao-min Li, Ya Wen, Fan-xuan Meng, Li-ling Xu, Sheng-hui Wen, Hui-fen Liu, Yuan-qing Li, Jie-ruo Gu, Qing Lv, Yong Ren

“…Abstract Background Primary Sjogren’s syndrome (pSS) and autoimmune thyroiditis (AIT) share overlapping genetic and immunological profiles. This retrospective study evaluates the efficacy of machine learning algorithms, with a focus on the Random Forest Classifier, to predict the presence of thyroid-specific autoantibodies (TPOAb and TgAb) in pSS patients. …”
Get full text

The Analysis of the Fetal Abdominal Wall and Gastrointestinal Tract Abnormalities in a Single Tertiary Center by Gokhan Bolluk, Suleyman Cemil Oglak, Merih Cetinkaya, Isil Turan Bakirci, Oyhan Demirali, Mehmet Cok, Handan Turhan Karakus, Yasin Onur, Emine Zeynep Yilmaz

“…The most common anterior abdominal wall malformations were omphalocele (n=29, 43.3%) and gastroschisis (6 cases, 9.0%), and the most common fetal gastrointestinal tract anomalies were duodenal atresia (n=10, 14.9%), dilated bowel (n=5, 7.4%), and intestinal atresia (n=4, 5.9%). While genetic testing was carried out in 18 cases (27%), chromosomal abnormality was found in 6 (9.0%) cases. …”
Get full text

SymbolNet: neural symbolic regression with adaptive dynamic pruning for compression by Ho Fung Tsoi, Vladimir Loncar, Sridhara Dasu, Philip Harris

“…However, finding compact expressions for high-dimensional datasets remains challenging due to the inherent limitations of genetic programming (GP), the search algorithm of most symbolic regression (SR) methods. …”
Get full text

Mitochondrial genome insights into the phylogenetics and biogeographic evolution of snow trout (Cyprinidae, Schizothorax) in the Tien Shan Mountains by Akbarjon Rozimov, Yufan Wang, Min Wang, Ming Zou, Jobir Sobirov, Erkin Karimov, Bakhtiyor Kholmatov, Jörg Freyhof, Sirojiddin Namozov, Chongnv Wang, Xinxin Li, Baocheng Guo

“…We classified Schizothorax sp. as a valid independent species based on comprehensive phylogenetic trees and DNA barcode genetic distance. The dramatic uplift of the Tien Shan Mountains during the Late Miocene to the Pliocene, followed by periods of isolation on its eastern and western flanks, has driven extensive speciation, contributing to the rich diversity observed today. …”
Get full text

Closing the loop: establishing an autonomous test-learn cycle to optimize induction of bacterial systems using a robotic platform by Jan Benedict Spannenkrebs, Aron Eiermann, Thomas Zoll, Silke Hackenschmidt, Johannes Kabisch, Johannes Kabisch, Johannes Kabisch

“…One goal of synthetic biology is to provide well-characterised biological parts that behave predictably in genetic assemblies. To achieve this, each part must be characterised in a time-resolved manner under relevant conditions. …”
Get full text