GNA15 predicts poor outcomes as a novel biomarker related to M2 macrophage infiltration in ovarian cancer by Qin Liu, Qin Liu, Yabing Sun, Yabing Sun, Tao Zhang, Wanrun Lin, Jing Zhang, Huijuan Zhang, Huijuan Zhang, Wenxin Zheng, Hong Xu, Hong Xu, Feng Zhou, Feng Zhou

“…BackgroundThe exploration of genetic signatures within the ovarian cancer (OC) tumor microenvironment (TME) remains limited. …”
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Betula pendula Roth. survival and growth in treeline is affected by genotype and environment by Kari Saikkonen, Otto Saikkonen, Marjo Helander, Irma Saloniemi

“…These results demonstrate that the acclimation capacity of B. pendula allows its distribution to expand north from the present range; however, local abiotic environmental conditions (soil fertility and winter temperatures) and other selection pressures (herbivory) are likely to affect the genetic structure and growth of B. pendula populations.…”
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Genomic insights and comparative analysis of Colletotrichum species associated with anthracnose fruit rot and crown rot of strawberry in North Carolina by Tika B. Adhikari, Norman Muzhinji, Ashley N. Philbrick, Frank J. Louws, Frank J. Louws

“…These pathogens exhibit varying host specificities; some have a broad host range, while others are more limited. To explore the genetic composition and underlying factors of fungal virulence and pathogenicity, we sequenced the genomes of seven isolates of Colletotrichum spp.: three from the C. acutatum and four from the C. gloeosporioides. …”
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Associations between sleep traits and colorectal cancer: a mendelian randomization analysis by Xiangyue Meng, Enshuo Fan, Dan Lv, Yongjing Yang, Shixin Liu

“…Hence, this study used Mendelian randomization (MR) to robustly assess whether five primary sleep characteristics are directly linked with the risk of CRC occurrence.MethodsIn the performed study, the main Mendelian randomization analysis was conducted using approaches such as Inverse Variance Weighting (IVW), MR Egger, and weighted median method. To this end, five genetically independent variants associated with the sleep-related characteristics (chronotype, sleep duration, insomnia, daytime napping, and daytime fatigue) were identified and used as instrumental variables. …”
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A New Reference Plasmid “pGMT27” Provides an Efficient Transgenic Detection Method for Flue-Cured Tobacco by Jing Yu, Xiaolian Zhang, Muhammad Faheem Adil, Bo Lei, Mengao Jia, Huina Zhao, Shizhou Yu, Jiemin Liu, Yushuang Guo, Imran Haider Shamsi

“…For the detection of genetically modified (GM) tobacco, there is a lack of universal standard material which ultimately limits the detection methods because the accuracy and comparability of the results cannot be ensured. …”
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The association between primary frozen shoulder and serum lipids may be overestimated: evidence based on retrospective observational studies and Mendelian randomization by Yongchao Zhang, Wenhao Fan, Yichang Wang, Tengjing Dong, Deding Liu, Yiming Shao

“…We compared total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) between the two groups. Genetic variants for the serum lipids and frozen shoulder were then extracted from large-scale genome-wide association studies. …”
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The Challenges of Distinguishing Different Causes of TMA in a Pregnant Kidney Transplant Recipient by A. Krelle, S. Price, M. M. Law, S. Kranz, P. Shamdasani, S. Kane, J. Unterscheider, P. Champion de Crespigny

“…TMA disorders are well-recognised in kidney transplant recipients, often due to an underlying genetic predisposition related to complement dysregulation, or de novo due to infection, immunosuppression toxicity, or antibody-mediated rejection. …”
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Physicochemical and Biological Indicators of Soils in an Organic Farming System by Beybit Nasiyev, Tursunay Vassilina, Ainur Zhylkybay, Vladimir Shibaikin, Akmarzhan Salykova

“…., the widespread use of biological preparations, a high proportion of legumes (sources of nitrogen), and avoiding chemical plant protection products, transgenic plants, and genetically modified organisms (GMOs). This study aims to increase the productivity of safflower and improve the physicochemical and biological indicators of dark chestnut soils through the use of biologized technologies in the organic farming system. …”
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Two novel entomopathogenic fungal species of Lecanicillium isolated from soil in China by Tongyi Liu, Wei Chen, Yanhong Tang, Fen Liu, Liyan Yao, Qiongbo Hu, Ke Zhang, Qunfang Weng

“…This research enhances the species diversity within the genus Lecanicillium and provides valuable genetic resources for the biological control of pests and the development of biocontrol agents.…”
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Stochastic demethylation and redundant epigenetic suppressive mechanisms generate highly heterogeneous responses to pharmacological DNA methyltransferase inhibition by Mie K. Jakobsen, Sofie Traynor, Aaraby Y. Nielsen, Christina Dahl, Mette Staehr, Simon T. Jakobsen, Maria S. Madsen, Rasmus Siersbaek, Mikkel G. Terp, Josefine B. Jensen, Christina B. Pedersen, Anup Shrestha, Jonathan R. Brewer, Pascal H. G. Duijf, Odd L. Gammelgaard, Henrik J. Ditzel, Alexei F. Kirkin, Per Guldberg, Morten F. Gjerstorff

“…The observed variability in response to DNA methyltransferase inhibitors was independent of cancer-associated aberrations and clonal genetic diversity. Instead, these variations were attributed to stochastic demethylation of regulatory CpG sites and the DNA methylation-independent suppressive function of histone deacetylases. …”
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Chromatin environment-dependent effects of DOT1L on gene expression in male germ cells by Manon Coulée, Alberto de la Iglesia, Mélina Blanco, Clara Gobé, Clémentine Lapoujade, Côme Ialy-Radio, Lucia Alvarez-Gonzalez, Guillaume Meurice, Aurora Ruiz-Herrera, Pierre Fouchet, Julie Cocquet, Laïla El Khattabi

“…Taken together, our results show that H3K79me2 positively correlates with male germ cell genetic program throughout spermatogenesis, with DOT1L predominantly inhibiting rather than activating gene expression. …”
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The Passage of Chaperonins to Extracellular Locations in <i>Legionella pneumophila</i> Requires a Functional Dot/Icm System by Peter Robertson, David S. Allan, Rafael A. Garduño

“…The analysis of periplasmic extracts and outer membrane vesicles of these mutants, where HtpB co-localized with bona fide periplasmic proteins, confirmed the elevated levels of periplasmic HtpB. Genetic complementation of the mutants recovered parent strain levels of surface-exposed and periplasmic HtpB. …”
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The effect of coagulation traits on the risk of retinal vein occlusion: a mendelian randomization study by Chaoyi Yuan, Chao He, Ling Zuo, Baoxing Liu, Hui Qi

“…The research suggests that genetically predicted plasma levels of FIII, FVII, MPV, and PCT may be potentially causative for reducing the risk of RVO, and that levels of FVIII may be potentially causative for increasing the risk of RVO. …”
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Perilipin2-dependent lipid droplets accumulation promotes metastasis of oral squamous cell carcinoma via epithelial-mesenchymal transition by Jiayu Zhang, Jianmin Peng, Siyu Wang, Li Wang, Yutong Sun, Juan Xia, Bin Cheng, Qinchao Hu

“…In this study, the influence of palmitic acid (PA) and oleic acid (OA) on the migration and invasion ability of OSCC cells was determined by in vitro experiments. Genetic manipulation of PLIN2 was performed to explore its effect on the accumulation of LDs and OSCC metastasis. …”
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RNA-Targeting CRISPR/CasRx system relieves disease symptoms in Huntington’s disease models by Yingqi Lin, Caijuan Li, Yizhi Chen, Jiale Gao, Jiawei Li, Chunhui Huang, Zhaoming Liu, Wei Wang, Xiao Zheng, Xichen Song, Jianhao Wu, Jiaxi Wu, Oscar Junhong Luo, Zhuchi Tu, Shihua Li, Xiao-Jiang Li, Liangxue Lai, Sen Yan

“…Furthermore, the success of this approach provides valuable insights and novel avenues for the treatment of other genetic disorders caused by gene mutations.…”
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Joint Optimization of Berths and Quay Cranes Considering Carbon Emissions: A Case Study of a Container Terminal in China by Houjun Lu, Xiao Lu

“…This study presents an integrated model that incorporates tidal factors into the joint optimization of berth and quay crane operations, addressing both service standards and emissions during port stays and crane activities, and further designs a PSO-GA hybrid algorithm, combining particle swarm optimization (PSO) with crossover and mutation operators from a genetic algorithm (GA), to enhance optimization accuracy and efficiency. …”
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An efficient binary spider wasp optimizer for multi-dimensional knapsack instances: experimental validation and analysis by Mohamed Abdel-Basset, Reda Mohamed, Karam M. Sallam, Ibrahim Alrashdi, Ibrahim A. Hameed

“…The experimental findings demonstrate that BSWO-RO4 can achieve exceptional results for the small and medium-scale instances, while the genetic algorithm integrated with RO4 can be superior for the large-scale instances. …”
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The possible effects of chili peppers on ADHD in relation to the gut microbiota by Yinyue Li, Jing Feng, GuangYao Ding, Lin Deng, Ying He, Qiongqiong Zhang, Jianhui Wang, Xia Chen

“…Although the etiology and pathogenesis of ADHD are not fully understood, existing studies have shown that it may be related to genetic factors, environmental factors, abnormal brain development, and psychosocial factors. …”
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Deep Learning-Based Home Energy Management Incorporating Vehicle-to-Home and Home-to-Vehicle Technologies for Renewable Integration by Marwan Mahmoud, Sami Ben Slama

“…By utilizing data from a Tunisian weather database, smart cities significantly reduce electricity costs compared to traditional energy management methods, such as Dynamic Programming (DP), Rule-Based Systems, and Genetic Algorithms. The system’s performance is validated through robust AI models, performance metrics, and simulation scenarios, which test the system’s effectiveness under various energy demand patterns and changing weather conditions. …”
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Risk Factors and Consequent Diseases of Atherosclerosis in a Population Treated in a Medical Office by Luis Ángel Felicó Riverón, Georgia Díaz-Perera Fernández, Yomeidis Felicó Riverón

“…<strong>Foundation</strong>: atherosclerosis is a disease of multifactorial origin with great genetic and family dependence, susceptible to aggravation depending on the lifestyle and the influence of the environment on the person. …”
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