Tracing the paths of modular evolution by quantifying rearrangement events of protein domains by Abdulbaki Coban, Erich Bornberg-Bauer, Carsten Kemena

“…Abstract Background Protein evolution is central to molecular adaptation and largely characterized by modular rearrangements of domains, the evolutionary and structural building blocks of proteins. Genetic events underlying protein rearrangements are relatively rare compared to changes of amino-acids. …”
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Identification of Candidate Genes Associated with Meat Production of Aberdeen Angus Cattle by Vladimir Kolpakov, Elena Bukareva, Dianna Kosyan, Alexey Ruchay, Vitaly Ryazanov

“…Blood samples from Aberdeen Angus bulls (n = 260) were used as material for SNP genotyping. Genetic architecture for the kill yield trait showed the presence of 31 SNPs. …”
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Pivotal role of Helicobacter pylori virulence genes in pathogenicity and vaccine development by Ayman Elbehiry, Eman Marzouk, Adil Abalkhail, Wael Sindi, Yasir Alzahrani, Salem Alhifani, Turki Alshehri, Nuha Abdulaziz Anajirih, Turki ALMutairi, Ahmad Alsaedi, Feras Alzaben, Abdullah Alqrni, Abdelmaged Draz, Abdulaziz M. Almuzaini, Sahar N. Aljarallah, Abdulrahman Almujaidel, Akram Abu-Okail

“…Different types of vaccines, including vector-based vaccines, inactivated whole cells, genetically modified protein-based subunits, and multiepitope nucleic acid (DNA) vaccines, have been explored. …”
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Sprawność fizyczna dzieci wiejskich i miejskich z niskiej grupy społeczno-ekonomicznej na Jukatanie (Meksyk) by Maryla Aftanasiuk

“…However, differences in stature are observed between ethnic as well as between rural and urban groups. This may have the genetic origin (Creoles and Mayas), and in the case of different localities, it may also be caused by more various nutrition in towns than in villages.…”
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Biomarker discovery and phytochemical interventions in Alzheimer's disease: A path to therapeutic advances by Mithila Debnath, Mahir Azmal, Rashid Taqui, Moshiul Alam Mishu, Ajit Ghosh

“…There is an urgent need to identify novel molecular markers for the diagnosis and treatment of AD. Genetic biomarkers hold promising potential in this regard. …”
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Food hardness preference reveals multisensory contributions of fly larval gustatory organs in behaviour and physiology. by Nikita Komarov, Cornelia Fritsch, G Larisa Maier, Johannes Bues, Marjan Biočanin, Clarisse Brunet Avalos, Andrea Dodero, Jae Young Kwon, Bart Deplancke, Simon G Sprecher

“…Here, we identified that larvae ingest and navigate towards specific food substrate hardnesses and probed the role of gustatory organs in this behaviour. By developing a genetic tool targeting specifically gustatory organs, we show that these organs are major contributors for evaluation of food hardness and ingestion decision-making. …”
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Genome-wide association mapping of bruchid resistance loci in soybean. by Clever Mukuze, Ulemu M Msiska, Afang Badji, Tonny Obua, Sharon V Kweyu, Selma N Nghituwamhata, Evalyne C Rono, Mcebisi Maphosa, Faizo Kasule, Phinehas Tukamuhabwa

“…In this study, 6 multi-locus methods of the mrMLM model for genome-wide association study were used to dissect the genetic architecture of bruchid resistance on 4traits: percentage adult bruchid emergence (PBE), percentage weight loss (PWL), median development period (MDP), and Dobie susceptibility index (DSI) on 100 diverse soybean genotypes, genotyped with 14,469 single-nucleotide polymorphism (SNP) markers. …”
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Metaheuristics Approach for Hyperparameter Tuning of Convolutional Neural Network by Hindriyanto Purnomo, Tad Gonsalves, Evangs Mailoa, Fian Julio Santoso, Muhammad Rizky Pribadi

“…Three metaheuristic methods are used in this research: ant colony optimization (ACO), genetic algorithm (GA), and Harmony Search (HS). The metaheuristics methods are used to find the best combination of 8 hyperparameters with 8 options each which creates 1.6. 107 of solution space. …”
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中国人D＿13S＿31位点多态性及与肝豆状核变性的连锁关系

“…ＴｈｅＷｉｌｓｏｎ＇ｓｄｉｓ－ｅａｓｅｇｅｎｅｉｓａｐｕｔａｔｉｖｅｃｏｐｐｅｒｔｒａｎｓｐｏｒｔｉｎｇＰ－ｔｙｐｅＡＴＰａｓｅｓｉｍｉｌａｒｔｏｔｈｅＭｅｎｋｅｓｇｅｎｅ．Ｎａ－ｔｕｒｅＧｅｎｅｔ，１９９３，６４：１３…”
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Transcriptome-wide association study identifies genes associated with bladder cancer risk by Siting Li, Jiang Gui, Margaret R. Karagas, Michael N. Passarelli

“…Findings from this TWAS enhance our understanding of how genetically-regulated gene expression affects bladder cancer development and point to potential prevention and treatment targets.…”
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Utility of Integrated Analysis of Pharmacogenomics and Pharmacometabolomics in Early Phase Clinical Trial: A Case Study of a New Molecular Entity by Jaeseong Oh, Sojeong Yi, Namyi Gu, Dongseong Shin, Kyung-Sang Yu, Seo Hyun Yoon, Joo-Youn Cho, In-Jin Jang

“…The pharmacogenomics screening was performed from whole blood samples using the Affymetrix DMET (Drug-Metabolizing Enzymes and Transporters) Plus microarray, and confirmation of genetic variants was performed using real-time polymerase chain reaction. …”
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A comprehensive analysis of the epidemiological and genomic characteristics of global Serratia Marcescens by Wenqin Chen, Zheqian Li, Jie Zheng, Danwei Wang, Shuo Gao, Wanqing Zhou, Han Shen, Yan Zhang, Xiaoli Cao

“…Phylogenetic analysis highlighted significant genetic diversity and distinct evolutionary lineages. …”
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Integrated singlecell and bulk RNA-seq analysis identifies a prognostic signature related to inflammation in colorectal cancer by Wen Yin, Yanting Ao, Qian Jia, Chao Zhang, Liping Yuan, Sha Liu, Wanmeng Xiao, Gang Luo, Xiaomin Shi, Chen Xin, Maolin Chen, Muhan Lü, Zehui Yu

“…We identified two molecular subtypes and three genetic subtypes, two risk subgroups according to median risk values, constructed a prognostic model including thirteen genes (TIMP1, GDF15, UCN, KRT4, POU4F1, NXPH1, SIX2, NPC1L1, KLK12, IGFL1, FOXD1, ASPG, and CYP4F8), and validated the performance of each aspect of the model in an external database. …”
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Melanin-like nanoparticles slow cyst growth in ADPKD by dual inhibition of oxidative stress and CREB by Yongzhan Sun, Quan Zou, Huizheng Yu, Xiaoping Yi, Xudan Dou, Yu Yang, Zhiheng Liu, Hong Yang, Junya Jia, Yupeng Chen, Shao-Kai Sun, Lirong Zhang

“…Autosomal dominant polycystic kidney disease (ADPKD) is a chronic genetic disorder closely associated with increased oxidative stress and featured by the progressive enlargement of cysts originating from various segments of the renal tubules. …”
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JAK2, STAT3 Gene Polymorphisms in Turkish Patients with Behçet’s Disease by Darya Farhoomand Aksoy, Rahime Aksoy, Sevim Gönen, Ümit Ölmez

“…These results suggest that a JAK2 genetic polymorphism may be associated with BD susceptibility.…”
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Tracking the correlation of mineral intakes among family pairs over nine years: a longitudinal study by Farshad Teymoori, Mahdi Akbarzadeh, Niloufar Saber, Mitra Kazemi Jahromi, Ebrahim Mokhtari, Parisa Riahi, Hossein Farhadnejad, Hamid Ahmadirad, Asiyeh Sadat Zahedi, Sajedeh Masjoudi, Danial Habibi, Maryam Zarkesh, Mohammadreza Vafa, Parvin Mirmiran, Maryam S. Daneshpour, Fereidoun Azizi

“…Methods FCOR command of the Statistical Analysis for Genetic Epidemiology software was used to determine the correlation coefficients of minerals in relative pairs. …”
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The oncogenic roles of GPR176 in ovarian cancer: a molecular target for aggressiveness and gene therapy by Ning Yang, Wen-jing Yun, Zheng-guo Cui, Hua-chuan Zheng

“…It might be used as a biomarker to indicate the aggressive behaviour and poor prognosis of ovarian cancer and a target of genetic therapy.…”
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Aspiration of acidified milk induces milk allergy by activating alveolar macrophages in mice by Akiko Nakaoka, Takayasu Nomura, Atsushi Suzuki, Kazuyoshi Ozeki, Hirohito Kita, Shinji Saitoh

“…The immunological mechanisms were investigated using comprehensive single-cell RNA sequencing (scRNA-seq) analysis of the lungs, combined with the use of genetically modified mice. Results: Mice exposed to CM mixed with hydrochloric acid via airway sensitization developed CMA, as evidenced by the production of antigen-specific IgE and IgG antibodies, and the induction of anaphylaxis upon systemic antigen administration. …”
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PLASMABLASTIC LYMPHOMA. A STATE-OF-THE-ART REVIEW (1) by Michele Bibas

“…This condition is frequently associated with infections caused by the Epstein-Barr virus and genetic alterations involving the MYC gene. Despite advances in our comprehension of this disease, the prognosis remains dismal, resulting in a low overall survival rate, although recent reports suggest an apparent tendency towards substantial improvement. …”
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Waterlogging Effect on Growth, Yield and Physiological Responses of Blackgram (Vigna Mungo L.) Genotypes by Sayma Binta Alam, Nasrin Sultana, Saosan Zannat, Nazmun Naher

“…In the future, waterlogging stress tolerant varieties with more suitable genetic base of blackgram plants needed to identify and utilize the novel traits of donors are now required in breeding programs.…”
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