Human inborn errors of immunity underlying Talaromyces marneffei infections: a multicenter, retrospective cohort study by Huifeng Fan, Zhiyong Yang, Yuhui Wu, Xiulan Lu, Tian Li, Xuyang Lu, Gen Lu, Liming He, Guoping Lu, Li Huang

“…We aimed to investigate the clinical and genetic features of T. marneffei infection in Chinese pediatric patients.Materials and methodsWe retrospectively reviewed 18 pediatric patients with IEIs who were diagnosed with T. marneffei infections at five public hospitals in China from January 2015 to January 2023.ResultsThe common clinical features among the patients were fever, cough, and hepatomegaly. …”
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Interferon gamma‐mediated prevention of tumor progression in a mouse model of multiple myeloma by Zoltán Kellermayer, Sabrin Tahri, Madelon M. E. deJong, Natalie Papazian, Cathelijne Fokkema, Elodie C. G. Stoetman, Remco Hoogenboezem, Gregory vanBeek, Mathijs A. Sanders, Louis Boon, Chelsea Den Hollander, Annemiek Broijl, Pieter Sonneveld, Tom Cupedo

“…In conclusion, we provide a framework for studying immune responses to multiple myeloma progression in immunocompetent and genetically modifiable mice and highlight the importance of bone marrow immunity in tumor control.…”
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Cholestatic Hepatocellular Injury with Azathioprine: A Case Report and Review of the Mechanisms of Hepatotoxicity by Joseph Romagnuolo, DC Sadowski, E Lalor, L Jewell, ABR Thomson

“…The strong association with male sex, and perhaps with human leukocyte antigen type, suggests a genetic predisposition of unknown type. Many of the symptoms of hepatotoxicity, such as nausea, abdominal pain and diarrhea, can be nonspecific and can be confused with a flare-up of inflammatory bowel disease. …”
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Postrecruitment Function of Yeast Med6 Protein during the Transcriptional Activation by Mediator Complex by Gwang Sik Kim, Young Chul Lee

“…For the functional analysis of Saccharomyces cerevisiae Med6p (scMed6p), we generated a series of scMed6p mutants harboring a small internal deletion. Genetic analysis of these mutants revealed that three regions (amino acids 33–42 (Δ2), 125–134 (Δ5), and 157–166 (Δ6)) of scMed6p are required for cell viability and are located at highly conserved regions of Med6 homologs. …”
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Identification of EXPA4 as a key gene in cotton salt stress adaptation through transcriptomic and coexpression network analysis of root tip protoplasts by Qiankun Liu, Pengtao Li, Muhammad Jawad Umer, Mubashir Abbas, Yongqing Zhao, Yu Chen, Yanfang Li, Aiming Zhang, Yuling Liu, Yangyang Wei, Quanwei Lu, Mengying Yang, Yiman Liu, Xiaoyan Cai, Zhongli Zhou, Shuxun Yu, Fang Liu, Renhai Peng

“…Integrating multi-omics approaches could further expand the genetic resources available for improving cotton cultivation in saline environments.…”
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Seroprevalence of bovine Herpesvirus-1, bovine viral diarrhoea virus, Neospora caninum and Coxiella burnetii in dairy cows in Ethiopia by Gebrerufael Girmay, Bezina Arega Emeru, Desiye Tesfaye Tegegne, Shelema Kelbesa Bora, Workitu Firomsa Gudeta, Betelhem Seyoum Dersso, Beksisa Urge Hurrisa, Gebremeskel Mamu Werid, Shimels Tikuye Yalew, Yohannes Equar Messele

“…Abstract Background The reproductive problem is an animal health-related bottleneck that constrains livestock genetic improvement efforts in tropical countries such as Ethiopia. …”
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Degenerated vision, altered lipid metabolism, and expanded chemoreceptor repertoires enable Lindaspio polybranchiata to thrive in deep-sea cold seeps by Yujie Yan, Inge Seim, Yang Guo, Xupeng Chi, Zhaoshan Zhong, Dantong Wang, Mengna Li, Haining Wang, Huan Zhang, Minxiao Wang, Chaolun Li

“…We sequenced and assembled the genome of L. polybranchiata and performed comparative genomic analyses to investigate the genetic basis of adaptation to the deep sea. Supporting this, transcriptomic and fatty acid data further corroborate our findings. …”
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Multi-omic and machine learning analysis of mitochondrial RNA modification genes in lung adenocarcinoma for prognostic and therapeutic implications by Xiao Zhang, Jiatao Liu, Yaolin Cao, Wei Wang, Haoran Lin, Yue Yu

“…Our findings uniquely link MRMS to increased tumor mutational burden, genetic instability, and an immunosuppressive tumor microenvironment characterized by reduced immune cell infiltration and elevated tumor purity. …”
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The Neoproterozoic Ediacaran Kaijiang-Xuanhan paleo-uplift in the Sichuan Basin, Western China by Ran Guo, Ran Guo, Zeqi Li, Jianxue Wu, Shugen Liu, Wei Sun, Peng Wang, Bin Deng, Liwei You, Zhiyi Liu

“…The Dengying Formation in the Kaijiang-Xuanhan region and the Mianyang-Anyue-Changning region both exhibit a thinning trend, but the genetic mechanisms are different. The thinning in the former is the result of sedimentary control during the early stages of paleouplift, with the lower parts of the first and second stages being absent; in the latter region, this is due to subsequent erosion. …”
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Thermal performance and MHD peristaltic flow of hybrid nanofluid (Au-Ta/Blood) in an asymmetric conduit with electro-osmosis and shape factor effects by K. Thirunavukarasan, G. Sucharitha

“…The current research aims to create a mathematical model for targeted drug delivery systems, applicable in areas like cancer treatment, genetic disorder therapies, and infection management. …”
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An Iterative Heuristic Optimization Method for the Optimum Sizing of Battery Energy Storage System to Augment the Dispatchability of Wind Generators by Shubham Kashyap, Tirthadip Ghose

“…This analysis results in shorter payback period for scenario 1. Validation using Genetic Algorithm (GA) is done by comparing the costs of BESSs, emphasizing the suitability of the proposed technique.…”
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A Two-Layer Network Dynamic Congestion Pricing Based on Macroscopic Fundamental Diagram by Bangyang Wei, Daniel(Jian) Sun

“…The upper level model aims at minimizing the total travel time, while the lower level focuses on the MFD-based traffic assignment, which extends the link-based traffic assignment to network wide level. Genetic algorithm (GA) and the method of successive average were adopted for solving the proposed model, on which an online experimental platform was established using VISSIM, MATLAB, and Visual Studio software packages. …”
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The Unforeseen Diagnosis: Hyperparathyroidism-Jaw Tumour Syndrome Case Report and Review of the Literature by Maxim Barnett, Farhan Ahmed, Radu Mihai, Asha Rattan, Malik Asif Humayun

“…Medical professionals must avoid diagnostic overshadowing and display a low threshold for genetic testing in younger patients with primary hyperparathyroidism. …”
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Taenia asiatica: Mitochondrial signatures based analysis of an emerging public health threat in India by Aman D. Moudgil, Anil K. Nehra, Pallavi Moudgil

“…The present study aimed at genetic characterization and population structure analysis of T. asiatica metacestodes in slaughtered pigs in Haryana, north India. …”
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In silico identification of chilli genome encoded MicroRNAs targeting the 16S rRNA and secA genes of “Candidatus phytoplasma trifolii” by Vineeta Pandey, Aarshi Srivastava, Ramwant Gupta, Haitham E. M. Zaki, Haitham E. M. Zaki, Muhammad Shafiq Shahid, Rajarshi K. Gaur

“…A total of four common CA-miRNAs were picked according to genetic consensus. Three algorithms applied in the present study suggested that the physiologically relevant, top-ranked miR169b_2 has a possibly specific site at nucleotide position 1,006 for targeting the ‘Ca. …”
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Research Progress on a Wide and Narrow Row Cropping System for Crops by Liqun Tang, Jian Song, Yongtao Cui, Honghuan Fan, Jianjun Wang

“…This study reviews the development and implementation of WNRC technology, focusing on its effects on crop growth, development, and environmental optimization. (1) Crop growth and environmental optimization: Modifying the row spacing in WNRC enhances light interception, air circulation, and the soil moisture distribution, creating an optimized growth environment that improves the photosynthetic efficiency and water use. (2) Genetic variation and yield performance: The performance of different crop varieties in WNRC systems varies, with specific varieties showing better adaptation to the altered spatial arrangement, leading to improved growth uniformity and higher yields. (3) Weed management: The planting density is optimized, reducing the need for herbicides and fostering more sustainable weed control methods. (4) Efficient input management: WNRC systems enhance the uniform application of fertilizers and pesticides, optimizing nutrient uptake, minimizing input wastage, and lowering the environmental impact. …”
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An Active-Learning Framework for Educating Medical Students on SARS-CoV-2 Variants and COVID-19 Epidemiology [version 1; peer review: 2 approved] by Samiksha Prasad, Amanda J Chase

“…The post-session survey data showed an increase in students’ understanding of the classification of COVID-19 variants and the role of genetic mutations in viral pathogenesis. Qualitative data yielded positive feedback for the session, notably in students' ability to interpret phylogenetic trees and understand the role of variants. …”
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Molecular Circuits of Resolution in the Eye by Elvira L. Liclican, Karsten Gronert

“…Protective endogenous roles of LXA4 and NPD1 have been established utilizing lipidomic analysis, knockout mice, and pharmacological, genetic, and dietary manipulation, providing compelling evidence that these intrinsic lipid autacoid circuits play essential roles in restraining inflammation, promoting wound healing, inhibiting pathological angiogenesis, and providing neuroprotection in the delicate visual axis.…”
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Functional divergence caused by ancient positive selection of a Drosophila hybrid incompatibility locus. by Daniel A Barbash, Philip Awadalla, Aaron M Tarone

“…The exceptional level of divergence at Hmr cannot be explained by neutral processes because we use phylogenetic methods and population genetic analyses to show that the elevated amino-acid divergence in both lineages is due to positive selection in the distant past-at least one million generations ago. …”
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A national framework for transition to precision medicine by Samaneh Karimi Esboei, Sepehr Ghazinoory, Fatemeh Saghafi

“…PM is based on providing health-oriented services according to genetic characteristics, individual and family medical history, lifestyle, place of residence, and other personalized characteristics. …”
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