Causal relationship between gastroesophageal reflux disease and chronic obstructive respiratory disease: A bidirectional Mendelian randomization study by Shan Lin, Dingfeng Lai, Wanmei He, Qingyuan Zhan

“…Results: Our analysis elucidated a notable causal relationship, with individuals genetically inclined towards GERD exhibiting a significantly elevated propensity to develop COPD (odds ratio [OR] = 1.520, 95 % confidence interval [CI] 1.376−1.680, P = 2.173 × 10−16) and asthma (OR = 1.420, 95 % CI 1.340−1.504, P = 1.269 × 10−32). …”
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Knockdown ATG5 gene by rAAV9 alleviates doxorubicin-induced cardiac toxicity by inhibiting GATA4 autophagic degradation by Ai-Li Xu, Zheng Shen, Shi-Hao Wang, Hai-Yun Luan, Yong Xu, Ze-Chun Kang, Zi-Qi Liao, Jie Liu, Xiao-Lei Duan, Wei-Hua Bian, Hui Sun, Xin Xie

“…We demonstrated that genetic ATG5 knockdown or autophagy inhibition by chemical inhibitors increased GATA4 protein expression, which was reduced by ATG5 overexpression or autophagy activator in vitro and in vivo, suggesting that ATG5-mediated autophagy promoted GATA4 degradation. …”
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A Biphasic Pleural Tumor with Features of an Epithelioid and Small Cell Mesothelioma: Morphologic and Molecular Findings by Sarah Hackman, Richard D. Hammer, Lester Layfield

“…Herein, we report novel complex CGH findings in a biphasic tumor and review the molecular genetic alterations in both mesothelioma and DSRCTs.…”
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Development of Genome-Wide Unique Indel Markers for a Heat-Sensitive Genotype in Wheat (<i>Triticum aestivum</i> L.) by Huijie Zhai, Kunpeng Xu, Meng Wang, Zhenchuang Wang, Ziyang Cai, Ao Li, Anxin He, Xiaoming Xie, Lingling Chai, Mingjiu Liu, Xingqi Ou, Zhongfu Ni

“…Collectively, these primer pairs are ideal DNA markers for inter-varietal CSSL development and more broad applications, like germplasm classification, seed purity testing, genetic linkage mapping, and marker-assisted breeding in wheat, owing to their uniqueness, polymorphism, and easy-to-use characteristics.…”
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Long-term correction of hemophilia A via integration of a functionally enhanced FVIII gene into the AAVS1 locus by nickase in patient-derived iPSCs by Do-Hun Kim, Sang-Hwi Choi, Jin Jea Sung, Sieun Kim, Hanui Yi, Sanghyun Park, Chan Wook Park, Young Woo Oh, Jungil Lee, Dae-Sung Kim, Jong-Hoon Kim, Chul-Yong Park, Dong-Wook Kim

“…Genome editing in conjunction with patient-derived induced pluripotent stem cells (iPSCs) is a promising cell therapy strategy, as it replaces dysfunctional proteins resulting from genetic mutations with normal proteins. However, the low expression level and short half-life of FVIII still remain significant limiting factors in the efficacy of these approaches in HA. …”
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Genome‐Wide Analysis of the APETALA2/Ethylene‐Responsive Factor Gene Family in Carthamus tinctorius L. by Zheng‐Wei Tan, Dan‐Dan Lu, Yong‐Liang Yu, Lei Li, Lan‐Jie Xu, Wei Dong, Chun‐Ming Li, Qing Yang, Hui‐Zhen Liang

“…This study aimed to elucidate the roles of these transcription factors in plant growth, metabolic regulation, and environmental adaptation in safflower, providing foundational information and theoretical support for genetic improvement and stress resilience research in this crop. …”
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Zero-day exploits detection with adaptive WavePCA-Autoencoder (AWPA) adaptive hybrid exploit detection network (AHEDNet) by Ahmed A. Mohamed, Abdullah Al-Saleh, Sunil Kumar Sharma, Ghanshyam G. Tejani

“…Additionally, a novel “Meta-Attention Transformer Autoencoder (MATA)” for enhancing feature extraction which address the subtlety issue, and improves the model’s ability and flexibility to detect new security threats, and a novel “Genetic Mongoose-Chameleon Optimization (GMCO)” was introduced for effective feature selection in the case of addressing the efficiency challenges. …”
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Immunohistochemical evaluation of P53 in squamous cell carcinoma of the esophagus by Kala K, Sarumathy G, Nithya I, Prathiba A

“…The etiology of ESCC is complex, involving a combination of genetic, environmental, and lifestyle factors. Among the molecular alterations associated with ESCC, mutations and dysregulation of the p53 tumor suppressor gene have garnered significant attention. …”
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Circadian rhythm related genes signature in glioma for drug resistance prediction: a comprehensive analysis integrating transcriptomics and machine learning by Junbo Liao, Yingxing Duan, Xiangwang Xu, Yaxue Liu, Chaohong Zhan, Gelei Xiao

“…The studies of immune cell infiltration, genetic variations, differential gene expression pattern, and single cell analysis were performed for exploring the mechanisms of chemotherapy resistance in glioma. …”
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Metaheuristic algorithm for parametric optimization of liquid nitrogen pumping in hydrocarbon and allied fluids piping systems by S. Isaac, C. Kadurumba, H. Ugwu, F. Abam

“…Since the models are multiparametric, multi-objective genetic algorithms were utilized to provide global optimal solution sets for the models. …”
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Biotechnology of Lactulose Production: Progress, Challenges, and Prospects by Svetlana A. Ryabtseva, Andrey G. Khramtsov, Maria A. Shpak, Alexey D. Lodygin, Georgy S. Anisimov, Serafima N. Sazanova, Yulia A. Tabakova

“…However, these enzymes are associated with genetic engineering and mutagenesis, which challenges their safety status. …”
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North American avian species that migrate in flocks show greater long-term non-breeding range shift rates by Stephen H. Vickers, Timothy D. Meehan, Nicole L. Michel, Aldina M. A. Franco, James J. Gilroy

“…Therefore, in some cases range-shifts may be limited by the capacity for novel migratory programmes to be transferred between generations, which can be genetically and socially mediated. Methods Here we used 50 years of North American Breeding Bird Survey and Audubon Christmas Bird Count data to test the prediction that breeding and/or non-breeding range-shifts are more prevalent among flocking migrants, which possess a capacity for rapid social transmission of novel migration routes. …”
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Artisanal and farmer bread making practices differently shape fungal species community composition in French sourdoughs by Michel, Elisa, Masson, Estelle, Bubbendorf, Sandrine, Lapicque, Léocadie, Nidelet, Thibault, Segond, Diego, Guézenec, Stéphane, Marlin, Thérèse, Devillers, Hugo, Rué, Olivier, Onno, Bernard, Legrand, Judith, Sicard, Delphine

“…Although industrialization led to the selection and spread of specific fermenting microbial strains, there are still ongoing artisanal processes that may allow the conservation of a wider species diversity and genetic diversity. We examined whether the diversity of artisanal practices could lead to an increased level in fungal species diversity for bread making. …”
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Variation in APOL1 Contributes to Ancestry-Level Differences in HDLc-Kidney Function Association by Amy Rebecca Bentley, Ayo P. Doumatey, Guanjie Chen, Hanxia Huang, Jie Zhou, Daniel Shriner, CongQing Jiang, Zhenjian Zhang, Guozheng Liu, Olufemi Fasanmade, Thomas Johnson, Johnnie Oli, Godfrey Okafor, Benjamin A. Eghan, Kofi Agyenim-Boateng, Jokotade Adeleye, Williams Balogun, Clement Adebamowo, Albert Amoah, Joseph Acheampong, Adebowale Adeyemo, Charles N. Rotimi

“…Given the APOL1 × HDLc interaction among AA, genetic factors may contribute to this paradoxical association. …”
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Exploration of the shared diagnostic genes and molecular mechanism between obesity and atherosclerosis via bioinformatic analysis by Wenrong An, Kegong Tang, Juan Liu, Wenfei Zheng, Guoxia Li, Yunsheng Xu

“…Abstract Obesity (OB) and atherosclerosis (AS) represent two highly prevalent and detrimental chronic diseases that are intricately linked. However, the shared genetic signatures and molecular pathways underlying these two conditions remain elusive. …”
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Retrieval of water quality parameters based on IOA-ML models and their response to short-term hydrometeorological factors by Wentong Hu, Donghao Miao, Chi Zhang, Zixian He, Wenquan Gu, Dongguo Shao

“…The best IOA-ML model for total phosphorus (TP), total nitrogen (TN), and permanganate index (CODMn) was extreme gradient boosting optimized by genetic algorithm (GA-XGB), while that for dissolved oxygen (DO) and turbidity was categorical boosting regression optimized by GA (GA-CBR). …”
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Advancing the Taxonomy of the Diatom <i>Pseudo-nitzschia</i> Through an Integrative Study Conducted in the Central and Southeastern Adriatic Sea by Tina Bonačić, Jasna Arapov, Ivana Bušelić, Ivana Lepen Pleić, Blanka Milić Roje, Tina Tomašević, Mia Bužančić, Marija Mladinić, Silvia Casabianca, Antonella Penna, Sanda Skejić, Živana Ninčević Gladan

“…Our findings underscore the value of a combined approach for reliable species identification and contribute to the development of genetic sequence databases that support the advancement of next-generation methods such as metabarcoding. …”
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JK-1, a useful erythroleukemic cell line model to study a controlled erythroid differentiation from progenitors to terminal erythropoiesis by Sylvain Metral, Sandrine Genetet, Benoît Gamain, Isabelle Mouro-Chanteloup

“…The possibility of obtaining large quantities of JK-1 cells at each stage of differentiation, as shown in this study, as well as the potential to genetically modify these cells, via CrisprCas9, makes their use of considerable interest for studying pathologies occurring during erythropoiesis.…”
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Facilitation of Tumor Stroma-Targeted Therapy: Model Difficulty and Co-Culture Organoid Method by Qiu-Shi Feng, Xiao-Feng Shan, Vicky Yau, Zhi-Gang Cai, Shang Xie

“…PDTOs, derived from tumor tissues or cancer-specific stem cells, accurately mimic the tissue-specific and genetic features of primary tumors, making them valuable for drug screening. …”
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Oxidative stress-driven enhanced iron production and scavenging through Ferroportin reorientation worsens anemia in antimony-resistant Leishmania donovani infection. by Souradeepa Ghosh, Krishna Vamshi Chigicherla, Shirin Dasgupta, Yasuyuki Goto, Budhaditya Mukherjee

“…This antimony-unresponsiveness points towards a genetic adaptation that underpins LD-R's evolutionary persistence and dominance over sensitive counterparts (LD-S). …”
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