Calibration of Microscopic Traffic Flow Simulation Models considering Subsets of Links and Parameters by Alexander Paz, Kul Shrestha, Cristian Arteaga, Douglas Baker

“…Traffic volume and speed are the performance measures used in this study, and the methodology is developed without considering the characteristics of a specific traffic flow model. A genetic algorithm was implemented to find a solution to the proposed mathematical program. …”
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New insights into the salt-responsive regulation in eelgrass at transcriptional and post-transcriptional levels by Huan Zhao, Huan Zhao, Xu Dong, Xu Dong, Dazuo Yang, Dazuo Yang, Qingchao Ge, Qingchao Ge, Peng Lu, Peng Lu, Chang Liu, Chang Liu

“…These conserved gene resources may provide targets for genetic engineering to improve the salt tolerance of crops.…”
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A robust multi-objective multi-priodic planning approach to the problem of locating the allocation of organ transplant centers under conditions of uncertainty by Elham Nejati, Mahdi Yousefi Nejad Attari, Asgar Hajibadali

“…On the other hand, due to the rapid growth of the demand for organ transplantation and the lack of resources, the patient's waiting time to complete the transplantation process plays a vital role in the organ transplantation system.Methodology: This study presents a robust bi-objective mathematical model for the location problem of allocating organ transplant centers under uncertainty, which includes the total costs of the organ transplant system as well as the average patient waiting time for organ transplantation, which follows a G/G/m queuing system.Findings: To solve this model, the Non-Dominated Sorting Genetic Algorithm II (NSGA-II) has been used. Finally, the applicability of this model and the efficiency of the mentioned algorithm compared to the defined indicators have been shown through numerical experiments.Originality/Value: Since each organ can spend a certain amount of time outside the body and there is a possibility of corruption or a decrease in the quality of the transplant, the time between the organ leaving the body and the completion of the transplant operation plays an essential role in the transplant system.…”
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The Pro12Ala Polymorphism of PPAR-γ Gene Is Associated with Sepsis Disease Severity and Outcome in Chinese Han Population by Guoda Ma, Haiyang Wang, Guixi Mo, Lili Cui, You Li, Yiming Shao, Xin Liu, Yuliu Xie, Jia Li, Jiawu Fu, Hua Tao, Bin Zhao, Liangqing Zhang, Keshen Li

“…In the survivors, the PPAR-γ Pro12Ala genotype was significantly associated with decreased disease severity and recovery time (all P<0.001). Thus, genetic polymorphism is thought to play a role in the development and outcome of sepsis.…”
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Construction and efficacy of recombinant Newcastle disease virus co-expressing VP2 and VP3 proteins of very virulent infectious bursal disease virus by Tongfei Liu, Lin Lin, Yun Pan, Xiaoling Lin, Ming Liang, Guanming Shao, Keyu Feng, Yaxin Liu, Xinheng Zhang, Qingmei Xie

“…The recombinant Newcastle disease virus (rNDV) expressing both VP2 and VP3 (rNDV-VP2-VP3) was generated and compared to rNDV expressing VP2 alone (rNDV-VP2). The genetic stability and growth pattern of rNDV were evaluated and its immunogenicity was assessed in specific pathogen free (SPF) chickens. rNDV-VP2-VP3 vaccines induced higher levels of neutralising antibodies, no damage to immune organs, and significantly lower viral loads in the bursa of the falciparum. rNDV-VP2 group showed partial protection, while the placebo group exhibited severe lesions and higher mortality, suggesting that the vaccine was effective in preventing IBDV-induced damage. …”
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A Novel Nonsense Mutation of POU4F3 Gene Causes Autosomal Dominant Hearing Loss by Chi Zhang, Mingming Wang, Yun Xiao, Fengguo Zhang, Yicui Zhou, Jianfeng Li, Qingyin Zheng, Xiaohui Bai, Haibo Wang

“…Routine examination of POU4F3 is necessary for the genetic diagnosis of hereditary hearing loss in the future.…”
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Identification of mitochondrial carrier homolog 2 as an important therapeutic target of castration-resistant prostate cancer by Yankui Liu, Anjie Chen, Yufan Wu, Jiang Ni, Rong Wang, Yong Mao, Ning Sun, Yuanyuan Mi

“…MTCH2 is also upregulated in locally treated CRPC tissue and various primary human CRPC cells. Using genetic silencing via shRNA and knockout (KO) through the CRISPR-sgRNA approach, we showed that the depletion of MTCH2 impaired mitochondrial function, resulting in a reduced oxygen consumption rate, diminished complex I activity, and decreased ATP levels, mitochondrial depolarization, and increased reactive oxygen species production in primary CRPC cells. …”
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Unraveling TEOSINTE BRANCHED1/CYCLOIDEA/PROLIFERATING CELL FACTOR Transcription Factors in Safflower: A Blueprint for Stress Resilience and Metabolic Regulation by Lili Yu, Xintong Ma, Mingran Dai, Yue Chang, Nan Wang, Jian Zhang, Min Zhang, Na Yao, Abdul Wakeel Umar, Xiuming Liu

“….), a versatile medicinal and economic crop, harbors untapped genetic resources essential for stress resilience and metabolic regulation. …”
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A fungus-eat-fungus world: Digitopodium, with particular reference to mycoparasites of the coffee leaf rust, Hemileia vastatrix by Adans A. Colmán, Harry C. Evans, Sara S. Salcedo-Sarmiento, Uwe Braun, Kifle Belachew-Bekele, Robert W. Barreto

“…These isolates were found to be morphologically and genetically identical to H. tectonae, described previously from Brazil. …”
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Thyroid disorders and inflammatory bowel disease: an association present in adults but also in children and adolescents by Valeria Calcaterra, Valeria Calcaterra, Francesca Penagini, Virginia Rossi, Luisa Abbattista, Alice Bianchi, Massimiliano Turzi, Lucia Cococcioni, Gianvincenzo Zuccotti, Gianvincenzo Zuccotti

“…A thyroid function monitoring and future research exploring the genetic and immunologic connections are essential to enhance our understanding of the interrelation between IBD and thyroid disorders.…”
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Priapism in a Child from Homocystinuria from Methylenetetrahydrofolate Reductase MTHFR (C677T) Mutation by Ameer Kakaje, Ammar Fadel, Osama Hosam Aldeen, Othman Hamdan

“…Doppler ultrasonography found decreased cavernous blood flow, and warm 0.9% saline lavage of the cavernosa was indicated and successfully treated the priapism. Genetic testing for the homozygous MTHFR (C677T) mutation was later confirmed, and warfarin was indicated. …”
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A Group-Based Signal Timing Optimization Model Considering Safety for Signalized Intersections with Mixed Traffic Flows by Fen Wang, Keshuang Tang, Keping Li, Zhigang Liu, Lin Zhu

“…Then, the multiobjective optimization issue was formulated as a nonlinear program and solved by a Nondominated Sorting Genetic Algorithm. A numerical study was performed to demonstrate the applicability and performance of the proposed model. …”
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Mycotoxic effects of entomopathogenic fungi of fall armyworm (Spodoptera frugiperda J.E. Smith) on poultry feed safety by Sharai Silipiwe, Alice Nakhumicha Muriithi, Christopher Ochieng Ojiewo

“…Sequenced data was analyzed and processed using Molecular Evolutionary Genetic Analysis 6.0 software. The results showed relative diversity of fall armyworm larvae with 11 species isolated belonging to Aspergillus, Penicillium, Fusarium, Trichoderma, Bipolaris and Irpex genus. …”
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COEXISTENCE OF MULTIPLE GENE VARIANTS IN SOME PATIENTS WITH ERYTHROCYTOSES by Andrea Benetti, Irene Bertozzi, PhD, MD, Giulio Ceolotto, Irene Cortella, Daniela Regazzo, Giacomo Biagetti, Elisabetta Cosi, Maria Luigia Randi, MD, Prof

“…In 23 patients (19.45%), more than 1 putative variant was found in multiple genes. Conclusions: Genetic variants in patients with erythrocytosis were detected in about 2/3 of our cohort. …”
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PARP Inhibitors in the Treatment of Ovarian Cancer by Andrzej Paweł Zuzak, Magdalena Cieślik-Porębska, Krzysztof Kułak, Jagoda Niewiadomska

“…Summary PARP inhibitors represent a significant advancement in ovarian cancer treatment, offering improved survival outcomes for patients with specific genetic profiles. Their integration into standard care protocols underscores their importance and efficacy, providing valuable therapeutic options in the fight against ovarian cancer. …”
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Perioperative Management of a Patient with Hereditary Angioedema and Intestinal Obstruction Secondary to an Ileal Tumor: A Case Report by Antony Peter Gatheru, Anne Kasyoka Barasa, Isaac Karogo Mwangi, Stanley Ngare, Dan Kiptoon, Edwin Oloo Walong

“…Hereditary angioedema (HAE) is a rare genetic disorder resulting from deficiency or dysfunction of the C1-esterase inhibitor (C1-INH, C1-inhibitor) protein. …”
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Human Umbilical Cord Blood-Derived Serum for Culturing the Supportive Feeder Cells of Human Pluripotent Stem Cell Lines by Ruttachuk Rungsiwiwut, Praewphan Ingrungruanglert, Pranee Numchaisrika, Pramuan Virutamasen, Tatsanee Phermthai, Kamthorn Pruksananonda

“…Although human pluripotent stem cells (hPSCs) can proliferate robustly on the feeder-free culture system, genetic instability of hPSCs has been reported in such environment. …”
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Fluoride-induced testicular and ovarian toxicity: evidence from animal studies by Seyedeh Fahimeh Talebi, Mohammad Seify, Ramji Kumar Bhandari, Hamed Shoorei, Shahram Dabiri Oskuei

“…In both males and females, F exerts its adverse effects by triggering apoptosis, autophagy, inflammation, mitochondrial dysfunction, reduction in ATP synthesis, and modulation of important genes involved in steroidogenesis. Furthermore, genetic susceptibility and individual variations in F metabolism may contribute to different responses to fluoride exposure.…”
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Dias-Logan syndrome with a p.Leu360Profs*212 heterozygous pathogenic variant of in a Chinese patient: A case report by Yizhuo Shu, Xiaoling Chen, Zhuoqun Wei, Chunyue Chen

“…Therefore, our case report enriches the existing literature on the clinical spectrum and genotype–phenotype correlations of BCL11A -related syndrome and provides some helpful information for diagnosis, management, and genetic counseling.…”
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The Anthropocene and the biodiversity crisis: an eco-evolutionary perspective by Jarne, Philippe

“…This crisis does not only affect the ecological dynamics of biodiversity, but also its evolutionary dynamics, including genetic diversity, an aspect that is generally neglected. …”
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