A sensitive ERK fluorescent probe reveals the significance of minimal EGF-induced transcription by Zhang Weisheng, Jun Nakayama, Yukino Inomata, Shigeki Higashiyama, Toru Hiratsuka

“…Extracellular signal-regulated kinase (ERK) regulates multiple cellular functions through distinct activation patterns. Genetically encoded fluorescent probes are instrumental in dissecting the ERK activity dynamics in living cells. …”
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Effect of the B chromosome-located long non-coding RNAs on gene expression in maize by Xin Liu, Wenjie Yue, Shiqi Lin, Yuxian Yang, Tong Chen, Xiaowen Shi

“…However, recent studies have demonstrated that the maize B chromosome can impact gene expression and recombination on the A chromosome. Understanding the genetic characteristics of the B chromosomes and their impact on gene expression is essential for their application in artificial chromosome construction. …”
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Parkinson’s Disease Prevalence and Proximity to Agricultural Cultivated Fields by Maayan Yitshak Sade, Yair Zlotnik, Itai Kloog, Victor Novack, Chava Peretz, Gal Ifergane

“…The risk for developing Parkinson’s disease (PD) is a combination of multiple environmental and genetic factors. The Negev (Southern Israel) contains approximately 252.5 km2 of agricultural cultivated fields (ACF). …”
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Introduction of Eucalyptus spp. into the United States with Special Emphasis on the Southern United States by R. C. Kellison, Russ Lea, Paul Marsh

“…The results were sufficiently promising that a contingent of forest products companies formed a cooperative to work with the USDA Forest Service, Lehigh Acres, FL, USA, on genetic improvement of selected species for fiber production. …”
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Analysis of single nucleotide polymorphism of p16 gene in cytological samples of patients with oral potentially malignant disorders (OPMD) and oral squamous cell carcinoma (OSCC) by Neetu Oommen, Vasanthi V, Ramya Ramadoss, Rajkumar Krishnan

“…Conclusion: Our study showed that cytological samples yield sufficient amount of DNA, which showed 100 % positivity with exon 1, 2, 3 of p16 gene, but the percentage of genetic alteration of p16 gene seems to be less when compared with other related studies.…”
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Nutrition Education and Vitamin D Supplementation Improving Nutrition Intake, Body Composition, and Vitamin D Status of Soccer Athlete by Weni Kurdanti, Agus Wijanarka, Mirza Hapsari Sakti Titis Penggalih

“…Background: The success of soccer athletes is influenced by physical, mental, and genetic factors, with nutritional status significantly affects youth soccer performance in Indonesia by 69.8%. …”
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Attenuation and Immunogenicity of a Live High Pathogenic PRRSV Vaccine Candidate with a 32-Amino Acid Deletion in the nsp2 Protein by Wenhui Lu, Baoli Sun, Jianyue Mo, Xiduo Zeng, Guanqun Zhang, Lianxiang Wang, Qingfeng Zhou, Ling Zhu, Zhili Li, Qingmei Xie, Yinzuo Bi, Jingyun Ma

“…Such deletions were genetically stable in vivo. Following PRRSV experimental challenge, pigs inoculated with a single dose of QY1 P100 developed no significant clinic symptoms and well tolerated lethal challenge, while QY1 P80 group still developed mild fever in the clinic trial after challenge. …”
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Description of the New Species <i>Laccaria albifolia</i> (Hydnangiaceae, Basidiomycota) and a Reassessment of <i>Laccaria affinis</i> Based on Morphological and Phylogenetic Analys... by Francesco Dovana, Roberto Para, Gabriel Moreno, Edoardo Scali, Matteo Garbelotto, Bernardo Ernesto Lechner, Luigi Forte

“…Phylogenetic analyses indicate that <i>L. affinis</i> occupies a distinct clade within Northern Hemisphere <i>Laccaria</i> species, although minimal genetic differences challenge its independence from <i>L. macrocystidiata</i>. …”
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Alzheimer’s disease and antibody-mediated immune responses to infectious diseases agents: a mendelian randomization study by Jiayuan Zhang, Mingming Wang, Dong Wang, Linwen Deng, Yao Peng

“…Methods A two-sample Mendelian randomization (MR) analysis was conducted to investigate the causal link between antibody-mediated immune responses to infectious diseases agents and the risk of AD. Genetic variations associated with these antibodies obtained from UK Biobank, and data on AD were obtained from the Finnish databases, utilizing its extensive repository of genome-wide association studies (GWAS) for a comprehensive analysis. …”
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An Exploration of Gene-Gene Interactions and Their Effects on Hypertension by Ying Meng, Susan Groth, Jill R. Quinn, John Bisognano, Tong Tong Wu

“…Overall, our study provides evidence that the genome-wide gene-gene interaction analysis has the possibility to identify new susceptibility genes, which can provide more insights into the genetic background of blood pressure regulation.…”
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Insulinomas: Comprehensive Review of Epidemiology, Pathophysiology, Clinical Manifestations, Diagnostic Approaches, and Treatment Options by Joanna Rychlewska-Duda, Justyna Lisiecka, Mateusz Janik, Barbara Ufnalska, Anna Konarska, Artur Fabijański, Anna Machowiak, Michał Nowak, Wojciech Firlej, Adriana Daria Dukacz

“…Insulinomas can be sporadic or associated with Multiple Endocrine Neoplasia Type 1 (MEN-1) syndrome, a genetic disorder caused by mutations in the MEN1 gene. …”
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Short communication: Genomic prediction based on unbiased estimation of the genomic relationship matrix in pigs by M.Y. Li, L.Y. Shi, D.E. MacHugh, X.Q. Wang, J.J. Tian, L.G. Wang, Y.J. Deng, L.X. Wang, F.P. Zhao

“…The traditional genomic relationship matrix (GRM) has shown to be a biased estimation of true kinship, which can affect subsequent genetic analyses. In this study, we employed an unbiased kinship (UKin) estimation method within the genomic best linear unbiased prediction framework to evaluate its prediction performance on both a simulated dataset and a Large White pig dataset. …”
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EDUCATION AND EDUCATIONAL SYSTEM MANAGEMENT: STATUS, TRENDS, PROBLEMS AND PROSPECTS by V. P. Panasyuk

“…Detailed analysis of paradigmatic foundations of management is carried out; its systemacity and balance are presented from the positions of management members and a specific variety of the functions realized by them. System-genetic foundations of management, its recurrence, compliance with the principles of system inheritance are analysed; effectiveness, equifinality, management efficiency in its social, economic, pedagogical and organizational measurements are studied.Scientific novelty concludes in the reasons identification of a gap between the proper and existing management of an educational system. …”
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ALTERNATIVES FOR PSYCHOLOGICAL ILLNESS TREATMENT AND PREVENTION IN MALAYSIA FROM THE PERSPECTIVE OF SHARIAH by Muneer Ali Abdul Rab, Abdul Manan Ismail, Hamidin Awang, Mesbahul Hoque, Nasser Ahmad Aljabri, Abdullah Ali Salim AlShibli

“…The study concluded that psychiatrists have not clarified the exact causes of mental illness, but they suggested that they are the result of genetic, biological, environmental and psychological factors. …”
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Whole transcriptomic and proteomic analyses of an isogenic M. tuberculosis clinical strain with a naturally occurring 15 Kb genomic deletion. by Carla Duncan, Frances B Jamieson, JoLynn Troudt, Linda Izzo, Helle Bielefeldt-Ohmann, Angelo Izzo, Carolina Mehaffy

“…These include the ability of the host to control the infection which may directly relate to nutritional status, presence of co-morbidities and genetic predisposition. Pathogen factors, in particular the ability of different Mycobacterium tuberculosis strains to respond to the harsh environment of the host granuloma, which includes low oxygen and nutrient availability and the presence of damaging radical oxygen and nitrogen species, also play an important role in the success of different strains to cause disease. …”
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A guide to selecting high-performing antibodies for Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PPP2R5D) for use in Western Blot, immunoprecipi... by Carl Laflamme, Kathleen Southern, Riham Ayoubi, Maryam Fotouhi, Charles Alende

“…The etiology of these genetic disorders remains unknown, which can partly be due to the lack of independently characterized antibodies. …”
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Lifestyle and Chronic Constipation in Medical Students by Mehmet Aykut Yildirim, Murat Cakir, Mehmet Bicer, Mustafa Senturk, Harun Yonar, Merve Nur Gur, Zeliha Nur Akiner, Ayse Guldiken, H. Kaan Karagul, Bugra Ceri

“…Environmental, personal, and genetic factors may be affecting constipation although the affecting factors have not yet been thoroughly explained. …”
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Epigenetics and Inflammatory Markers: A Systematic Review of the Current Evidence by Valentina Gonzalez-Jaramillo, Eliana Portilla-Fernandez, Marija Glisic, Trudy Voortman, Mohsen Ghanbari, Wichor Bramer, Rajiv Chowdhury, Tamar Nijsten, Abbas Dehghan, Oscar H. Franco, Jana Nano

“…Epigenetic mechanisms have been suggested to play a role in the genetic regulation of pathways related to inflammation. …”
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X-Linked Lymphoproliferative Syndrome and Common Variable Immunodeficiency May Not Be Differentiated by SH2D1A and XIAP/BIRC4 Genes Sequence Analysis by Nesrin Gulez, Guzide Aksu, Afig Berdeli, Neslihan Karaca, Sema Tanrıverdi, Necil Kutukculer, Elif Azarsiz

“…The distinction from primary immunodeficiencies with a defined genetic cause is mandatory. A six-year-old male patient was admitted with the complaints of persistent general lymphadenopathy, for two years had fever, bilateral cervical multiple microlymphadenopathy, hepatic/splenic enlargement with laboratory findings as decreased serum immunoglobulins, negative EBV VCA IgM (viral capsid antigen) and anti-EBV EA (antibody to early D antigen), positive EBV VCA IgG (viral capsid antigen) and EBV EBNA (antibody to nuclear antigen). …”
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Development of a Semiconductor Sequencing-based Panel for Screening Individuals with Lynch Syndrome by Ryia-Illani Mohd Yunos, Nurul-Syakima Ab Mutalib, Janice Khor Sheau Sean, Sazuita Saidin, Mohd Ridhwan Abd Razak, Isa Md. Rose, Ismail Sagap, Luqman Mazlan, Rahman Jamal

“… Lynch syndrome is a genetic disorder associated with mutations in mismatch repair (MMR) genes that are linked to the development of colorectal cancer. …”
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