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11821
Laser-Induced Thermal Therapy in the Management of Low-Grade Gliomas: A Narrative Review
Published 2025-01-01“…Future studies should focus on optimiz-ing protocols, integrating molecular and genetic in-sights, and assessing long-term outcomes to enhance therapeutic efficacy and patient quality of life. …”
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11822
Transcriptomic analysis reinforces the implication of spatacsin in neuroinflammation and neurodevelopment
Published 2025-01-01“…Abstract Hereditary spastic paraplegia (HSP) encompasses a group of rare genetic diseases primarily affecting motor neurons. …”
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11823
MOPHOLOGICAL CHARACTERIZATION OF POTATO (SOLANUM TUBEROSUM L) GERMPLASM FROM AZAD JAMMU AND KASHMIR
Published 2024-12-01“…Results reveal that the investigative varieties exhibit significant morphological variations which reflect genetic diversity as well as adaptation of these varieties in diverse aggregate conditions of the region. …”
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11824
Red flags to suspect inborn errors of immunity in patients with autoimmune diseases
Published 2024-12-01“…An early diagnosis of a monogenic disorder allows for the tailoring of effective treatment plans, providing prognostic information to families, and offering genetic counseling.…”
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11825
Vascular involvement in idiopathic pulmonary fibrosis
Published 2024-11-01“…Results The main molecular pathogenetic mechanisms involving vasculature (i.e. endothelial-to-mesenchymal transition, vascular remodelling, endothelial permeability, occult alveolar haemorrhage, vasoconstriction and hypoxia) and the genetic basis of vascular remodelling are described. …”
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11826
A pan-cancer analysis of MARCH8: molecular characteristics, clinical relevance, and immuno-oncology features
Published 2025-12-01“…The study investigated the role of MARCH8 in tumor immunity through pan-cancer analysis of multiple databases. MARCH8 genetic alternations and expression were explored with the cBioPortal, GTEx, and TCGA databases. …”
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11827
Phylodynamic reconstruction of major chicken infectious anemia virus clades epidemiology, dispersal, and evolution
Published 2025-01-01“…CIAV, recognized globally for decades, shows a significant genetic diversity, but its implications remain underexplored.MethodsThis study analyzed over 1,000 VP1 sequences and examined CIAV’s epidemiology, evolution, and spread with various phylodynamic and phylogeographic approaches.ResultsFindings suggest that CIAV likely originated in Japan in the early 20th century, followed by worldwide diversification in two main clades. …”
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11828
Bi-targeting of thioredoxin 1 and telomerase by thiotert promotes cell death of myelodysplastic syndromes and lymphoma
Published 2025-01-01“…Meanwhile, pharmacological administration of glutathione (GSH), N-acetylcysteine (NAC), and mitoquinone (MitoQ), or genetic overexpression of TRX1 or TERT in MDS and cells could dampen the toxicity caused by thiotert. …”
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11829
Neonatal Tactile Stimulation Downregulates Dendritic Spines in Layer V Pyramidal Neurons of the WAG/Rij Rat Somatosensory Cortex
Published 2022-01-01“…The aim of our study is to examine the effects of neonatal tactile stimulations on the brain structures that previously defined as the focus of epilepsy in the Wistar-Albino-Glaxo from Rijswijk (WAG/Rij) rat brain with genetic absence epilepsy. Methods. In the present research, morphology and density of dendritic spines were analyzed in layer V pyramidal neurons of the somatosensory cortex (SoCx) of WAG/Rij rats (nonstimulated control, tactile-stimulated, and maternal separated rats) and healthy Wistar (nonepileptic) rats. …”
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11830
Chromosome-level reference genome and annotation of the Arctic fish Anisarchus medius
Published 2025-01-01“…This high-quality genome provides valuable genetic resources for understanding Arctic adaptations and supporting polar ecological conservation and management.…”
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11831
A four‐stage yield optimization technique for analog integrated circuits using optimal computing budget allocation and evolutionary algorithms
Published 2022-09-01“…Then in the second and third stages, the shuffled frog‐leaping algorithm and the Non‐dominated Sorting Genetic Algorithm‐III are proposed to improve the performance. …”
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11832
Underutilized and neglected crop species and their role in enhancing household food security amid climate change, Wolaita Zone, Ethiopia
Published 2025-02-01“…It focuses on NUCS, which are at risk of genetic loss or negative perceptions by growers and consumers. …”
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11833
Optimal Matching Metaheuristic Algorithm for Potential Areas of Agricultural Economic Resources Development Based on Spatial Relationship
Published 2022-01-01“…Based on this multiobjective model, the optimal matching model for potential areas of agricultural economic resource development is constructed, and the improved genetic algorithm is used to solve the model to realize the optimal matching of potential areas of agricultural productivity and economic resource development. …”
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11834
Mathematical Development and Evaluation of Forecasting Models for Accuracy of Inflation in Developing Countries: A Case of Vietnam
Published 2015-01-01“…In this study, both clarified value calculation and use of a genetic algorithm to find the optimal parameters are adopted simultaneously to construct improved models: ARIMA, GM(1,1), Verhulst, DGM(1,1), and DGM(2,1) by using data of Vietnamese inflation output from January 2005 to November 2013. …”
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11835
A Green Demand-Responsive Airport Shuttle Service Problem with Time-Varying Speeds
Published 2020-01-01“…Since this task is an NP-hard problem, a heuristic-based nondominated sorting genetic algorithm (NSGA-II) is also presented to find Pareto optimal solutions in a reasonable amount of time. …”
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11836
Optimization of Urban Fire Emergency Resource Allocation Based on Pre-Allocated Swarm Algorithm
Published 2025-01-01“…Additionally, a pre-allocated bee swarm algorithm is introduced to mitigate the issue of local incident points being unable to participate in rescue due to low weights, and a comparison of traditional genetic algorithms and particle swarm optimization algorithms is conducted. …”
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11837
Changes to Intermediary Metabolites in Sporadic and LRRK2 Parkinson’s Disease Demonstrated by Proton Magnetic Resonance Spectroscopy
Published 2015-01-01“…Parkinson’s disease (PD) remains a clinical diagnosis and biomarkers are needed to detect the disease as early as possible. Genetically determined PD provides an opportunity for studying metabolic differences in connection with disease development. …”
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11838
The Pathogenesis of Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis Syndrome: A Review of Current Research
Published 2015-01-01“…The results were classified into categories regarding three areas of interest: familial occurrence, genetic basis, and immunological mechanisms of PFAPA. …”
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11839
Homozygous mice with mutant protein FUS[1-359] overexpression: Innovative possibilities for ALS treatment
Published 2024-12-01“…Conclusion: Mice with hyperexpression of the mutant FUS[1-359] protein represent a promising genetic model for evaluating therapeutic approaches to ALS treatment. …”
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11840
Insights into <i>Solea senegalensis</i> Reproduction Through Gonadal Tissue Methylation Analysis and Transcriptomic Integration
Published 2025-01-01“…In <i>S. senegalensis</i> aquaculture, reproductive issues in captivity pose significant challenges, particularly the lack of fertilization capabilities in captive-bred males, hindering genetic improvement measures. This study analyzed the methylation patterns and transcriptomic profiles in gonadal tissue DNA from groups differing in rearing conditions and sexual maturity stages. …”
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