Multi-Objective Optimization Design for Cold-Region Office Buildings Balancing Outdoor Thermal Comfort and Building Energy Consumption by Fei Guo, Shiyu Miao, Sheng Xu, Mingxuan Luo, Jing Dong, Hongchi Zhang

“…The Non-dominated Sorting Genetic Algorithm II (NSGA-II) is applied to coordinate two performance metrics—outdoor thermal comfort and building energy loads—for the multi-objective optimization of architectural design. …”
Get full text

Neurosurgical aspects of marble bone disease: treatment modalities and outcome by Mahmoud Mohammed Gamal, Roshdy Elkhayat, Hassan Mohammed Hassan

“…Osteopetrosis has 3 types of genetic inheritance either malignant autosomal recessive (ARO) which occur in childhood, intermediate ARO which occur in adolescence, and benign autosomal dominant osteopetrosis which occur in adults. …”
Get full text

Chemical signatures of social information in Barbary macaques by Brigitte M. Weiß, Claudia Birkemeyer, Marlen Kücklich, Anja Widdig

“…In particular, we related socially relevant attributes (identity, genetic relatedness, rank, sex, age, group membership) to chemical profiles of body odor. …”
Get full text

DNA metabarcoding technology for the identification of the fecal microbiome in patients with chronic stress by Abraham Eudes Pérez Urruchi, Lucy Eliana Ramírez Elizalde, Flor de María Zapata Cornejo, María Luisa Matalinares Calvet, Miluska Vanessa Baylon Cuba, Fredy Fabian Dominguez

“…Next Generation Illumina genetic sequencing targeting the 16S rDNA gene was then performed, followed by bioinformatic analysis using QUIME II software. …”
Get full text

Toll-like receptors in atopic dermatitis: pathogenesis and therapeutic implications by Ahmad Vafaeian, Fateme Rajabi, Nima Rezaei

“…The dysregulation of proinflammatory and immunomodulatory effects of TLRs can be attributed to their ligand structures, receptor heterodimerization, the relative frequency of each TLR, interactions with other receptors/signalling pathways, cytokine milieu, and genetic polymorphisms. Current AD treatments like vitamin-D analogs, tacrolimus, and cyclosporine partially work through TLR modulation. …”
Get full text

Female urethral diverticular carcinoma: a case report and review of the literature by Dan Li, Fan Hua Meng, Xu Yang

“…For patients with distant metastasis, a combination of surgery, chemotherapy, and radiotherapy may be considered.Genetic testing and targeted immunotherapy offer new approaches for future treatment.…”
Get full text

Evaluation of acitretin side effects on Iraqi psoriatic patients by Ahmed H. Kadhim‎, Dhia'a A. Hassan‎, Amer H. Chyad‎, Abdulstaar M. Khudyar‎

“…There is other  important factors should be consider before evaluation the physiological changes may be caused by acitretin like smoking , alcohol intake , obesity and genetic association between psoriasis and other physiological change. …”
Get full text

Pathogenic PDE12 variants impair mitochondrial RNA processing causing neonatal mitochondrial disease by Lindsey Van Haute, Petra Páleníková, Jia Xin Tang, Pavel A Nash, Mariella T Simon, Angela Pyle, Monika Oláhová, Christopher A Powell, Pedro Rebelo-Guiomar, Alexander Stover, Michael Champion, Charulata Deshpande, Emma L Baple, Karen L Stals, Sian Ellard, Olivia Anselem, Clémence Molac, Giulia Petrilli, Laurence Loeuillet, Sarah Grotto, Tania Attie-Bitach, Jose E Abdenur, Robert W Taylor, Michal Minczuk

“…Within this group, an increasing number of families have been identified, where Mendelian genetic disorders implicate defective mitochondrial RNA biology. …”
Get full text

Advanced Ai Tools for Predicting Mechanical Properties of Self-Compacting Concrete by AGRAWAL Achal, CHANDAK Narayan

“…The present study utilizes advanced numerical evaluation techniques like Artificial Intelligence (AI), including Support Vector Machines (SVM), Artificial Neural Networks (ANN), Adaptive Neuro-Fuzzy Inference Systems with Genetic Algorithms (ANFIS-GA), Gene Expression Programming (GEP), and Multiple Linear Regression (MLR) to develop and compare the predictive models for determination of compressive and tensile strength. …”
Get full text

A Novel Hybrid Die Design for Enhanced Grain Refinement: Vortex Extrusion–Equal-Channel Angular Pressing (Vo-CAP) by Hüseyin Beytüt, Kerim Özbeyaz, Şemsettin Temiz

“…The optimization process utilized an integrated approach combining Finite Element Analysis (FEA), artificial neural networks (ANNs), and the non-dominated sorting genetic algorithm II (NSGA-II). The optimized die successfully achieved a balance between maximizing effective strain while minimizing pressing load and strain inhomogeneity. …”
Get full text

Short-Term Prediction of Traffic State for a Rural Road Applying Ensemble Learning Process by Arash Rasaizadi, Seyedehsan Seyedabrishami, Mohammad Saniee Abadeh

“…As there are many influential features on traffic state, the genetic algorithm (GA) has been used to identify 25 of 32 features, which are the most influential on models’ fitness. …”
Get full text

A multi-objective mathematical model for optimization design of humanitarian logistics network using meta-heuristic algorithm: a model to enhance actors’ coordination by Behzad Masoomi, Hassanali Aghajani, Ahmad Jafarnejad, Mohammad Mehdi Movahedi

“…The proposed model has been solved using two metaheuristic algorithms named multi-objective genetic algorithm and multi-objective particle swarm optimization.Findings: The implementation of this study will lead to a reduction in the costs of locating, routing and reconstruction in the humanitarian supply chain, as well as reducing the time of providing aid to the affected people and increasing their satisfaction. …”
Get full text

Molecular pathways in reproductive cancers: a focus on prostate and ovarian cancer by Ayodeji Folorunsho Ajayi, Mega Obukohwo Oyovwi, Oyedayo Phillips Akano, Grace Bosede Akanbi, Florence Bukola Adisa

“…This review aims to provide an overview of the molecular pathways implicated in prostate and ovarian cancers, highlighting key genetic alterations, signaling cascades, and epigenetic modifications. …”
Get full text

Expression of cell-wall related genes is highly variable and correlates with sepal morphology by Hartasánchez, Diego A., Kiss, Annamaria, Battu, Virginie, Soraru, Charline, Delgado-Vaquera, Abigail, Massinon, Florian, Brasó-Vives, Marina, Mollier, Corentin, Martin-Magniette, Marie-Laure, Boudaoud, Arezki, Monéger, Françoise

“…We produced a dataset composed of morphological parameters and genome-wide transcriptome obtained from 27 individual sepals from wild-type plants with nearly identical genetic backgrounds, environment, and developmental stage. …”
Get full text

Comparative study of conventional and process intensification by reactive distillation designs for glycerol carbonate production from glycerol and diethyl carbonate by Bushra Chalermthai, Chayanin Sriharuethai, Bradley D. Olsen, Kanokwan Ngaosuwan, Apinan Soottitantawat, Suttichai Assabumrungrat, Pongtorn Charoensuppanimit

“…In both cases, the process optimizations were carried out by connecting the process models in Aspen Plus to MATLAB, using the Genetic Algorithm as the optimizer. The results showed that Case II was superior to Case I in terms of energy utilization, CO2 emissions, and economics with the specific energy consumption of 1.92 kWh/kg of diethyl carbonate, % internal rate of return of 274, payback period of 1.44 years, and CO2 emissions of 0.26 kg CO2/kg DEC. …”
Get full text

Data analysis of high-throughput sequencing and microarray to identify key signatures of microribonucleic acids in glioblastoma by A. A. Pushkin, E. A. Dzenkova, N. N. Timoshkina, D. Yu. Gvaldin

“…This research was devoted to study of mRNA and miRNA expression patterns in glioglastomas using The Cancer Genome Atlas (TCGA) data, to search for genetic determinants that determine the prognosis of patient survival and to create of interaction networks for glioblastomas.Materials and methods. …”
Get full text

Case Study of Somaclonal Variation in Resistance Genes Mlo and Pme3 in Flaxseed (Linum usitatissimum L.) Induced by Nanoparticles by Inese Kokina, Ilona Mickeviča, Marija Jermaļonoka, Linda Bankovska, Vjačeslavs Gerbreders, Andrejs Ogurcovs, Inese Jahundoviča

“…Gene region specific primers were developed for resistance genes such as Mlo and Pme3 to define the genetic variability in tissue culture of L. usitatissimum. …”
Get full text

Phytochemical Characterisation of <i>Sorbus</i> Species: Unveiling Flavonoid Profiles Related to Ploidy and Hybrid Origin by Emina Korić, Violeta Milutinović, Alma Hajrudinović-Bogunić, Faruk Bogunić, Tatjana Kundaković-Vasović, Irma Gušić, Jelena Radović Selgrad, Kemal Durić, Haris Nikšić

“…The genetic, morphological and taxonomic diversity of the genus <i>Sorbus</i> is due to homoploid and polyploid hybridisation, autopolyploidy and apomixis, which also influence the production and diversity of secondary metabolites, especially flavonoids. …”
Get full text

Multispanning membrane protein SIDT2 increases knockdown activity of gapmer antisense oligonucleotides by Kohshi Kusumoto, Kiyomi Sasaki, Yasunori Uchida, Ayaka Utsumi, Tokuyuki Yoshida, Satoshi Obika, Takao Inoue, Keiichiro Okuhira

“…Abstract Recent advances in the clinical development of oligonucleotide therapeutics, such as antisense oligonucleotides (ASOs) and small interfering RNAs, have attracted attention as promising therapeutic modalities for genetic and intractable diseases. These oligonucleotide therapeutics exert their efficacy by binding to target RNAs present within cells; however, the mechanisms underlying their cellular uptake, especially their passage through membranes, remain largely unclear. …”
Get full text

How energy determines spatial localisation and copy number of molecules in neurons by Cornelius Bergmann, Kanaan Mousaei, Silvio O. Rizzoli, Tatjana Tchumatchenko

“…Abstract In neurons, the quantities of mRNAs and proteins are traditionally assumed to be determined by functional, electrical or genetic factors. Yet, there may also be global, currently unknown computational rules that are valid across different molecular species inside a cell. …”
Get full text