Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM. by Frances M Bashore, Vittorio L Katis, Yuhong Du, Arunima Sikdar, Dongxue Wang, William J Bradshaw, Karolina A Rygiel, Tina M Leisner, Rod Chalk, Swati Mishra, C Andrew Williams, Opher Gileadi, Paul E Brennan, Jesse C Wiley, Jake Gockley, Gregory A Cary, Gregory W Carter, Jessica E Young, Kenneth H Pearce, Haian Fu, Emory-Sage-SGC TREAT-AD Center, Alison D Axtman

“…RNA sequencing and genetic data support spleen tyrosine kinase (SYK) and high affinity immunoglobulin epsilon receptor subunit gamma (FCER1G) as putative targets to be modulated for Alzheimer's disease (AD) therapy. …”
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Endothelial STAT3 Modulates Protective Mechanisms in a Mouse Ischemia-Reperfusion Model of Acute Kidney Injury by Shataakshi Dube, Tejasvi Matam, Jessica Yen, Henry E. Mang, Pierre C. Dagher, Takashi Hato, Timothy A. Sutton

“…Consequently, we used a mouse with a genetic deletion of Stat3 restricted to the endothelium to examine the role of STAT3 signaling in the pathophysiology of ischemic AKI. …”
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The Construction of Regulatory Network for Insulin-Mediated Genes by Integrating Methods Based on Transcription Factor Binding Motifs and Gene Expression Variations by Hyeim Jung, Seonggyun Han, Sangsoo Kim

“…Type 2 diabetes mellitus is a complex metabolic disorder associated with multiple genetic, developmental and environmental factors. …”
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Psoriasis: Unraveling Disease Mechanisms and Advancing Pharmacological and Nanotechnological Treatments by Miao M, Yan J, Sun Y, Liu J, Guo S

“…The identification of age, gender, and genetic factors contributing to these complex conditions has been pivotal in developing novel pharmacological and technological treatments. …”
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Efficient identification of genomic insertions and surrounding regions in two transgenic maize events using third-generation single-molecule nanopore sequencing technology by Qing Liu, Qi Wang, Lihua Ning, Ziqi Chen, Chuang Zhang, Yang Liu, Buxuan Qian, Jia Guo, Yuejia Yin

“…Abstract The increasing development of new genetically modified organisms underscores the critical need for comprehensive safety assessments, emphasizing the significance of molecular evidence such as gene integration, copy numbers, and adjacent sequences. …”
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An Efficient Tourism Path Approach Based on Improved Ant Colony Optimization in Hilly Areas by Mohamed A. Damos, Wenbo Xu, Jun Zhu, Ali Ahmed, Abdolraheem Khader

“…The limitations of the traditional ACO and the Genetic Algorithm (GA) are addressed by improving pheromone updating techniques and implementing new initialization parameters. …”
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Optimization Design and Simulation of Single Degree of Freedom Legs of Quadruped Robots by Shi Huiwen, He Jing, Wang Zhijun

“…The optimal motion size and initial position of each component of the mechanism are optimized by using the genetic algorithm and the general nonlinear optimization method with the approximation degree of non-impact foot trajectory as the objective. …”
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Insights on the utilisation of tissue culture to aid new breeding techniques for cowpea (Vigna unguiculata L.) improvement by Malizukiswe Vincent Vacu, Promise Sifiso Nzama, Muyiwa Seyi Adegbaju

“…Conventional plant breeding techniques have produced new varieties of cowpeas, yet the limited genetic diversity within cultivated cowpeas poses challenges for future conventional breeding efforts. …”
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Gray matter volume and asymmetry in Broca's and Wernicke's area homologs in chimpanzees (Pan troglodytes) using a probabilistic region of interest approach by William D Hopkins, Muhammad A Spocter, Michele M Mulholland, Chet C Sherwood

“…Lastly, using quantitative genetic analyses, we found significant heritability in the average gray matter volume for BA44 and BA45 but not BA22. …”
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The Critical Role of Bach2 in Shaping the Balance between CD4+ T Cell Subsets in Immune-Mediated Diseases by Lingyi Yang, Shuli Chen, Qiuyu Zhao, Ying Sun, Hong Nie

“…Bach2 is also critical for the formation and function of CD4+ T cell lineages (Th1, Th2, Th9, Th17, T follicular helper (Tfh), and regulatory T (Treg) cells). Genetic variations within Bach2 locus are associated with numerous immune-mediated diseases including multiple sclerosis (MS), rheumatoid arthritis (RA), chronic pancreatitis (CP), type 2 chronic airway inflammation, inflammatory bowel disease (IBD), and type 1 diabetes. …”
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Nutritional and Phytochemical Variation of Marula (Sclerocarya birrea) (Subspecies caffra and birrea) Fruit among Nine International Provenances Tested in Malawi by Mussa Kamanula, Chimuleke Yagontha Munthali, John Finias Kamanula

“…Variations observed in nutritional and phytochemical composition could be attributed to genetic make-up and origin of the genotypes, since all genotypes were planted in the same environment. …”
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The Association between Adiponectin Single Nucleotide Polymorphisms and Side Effects of Isotretinoin in Acne Patients by Munir Garba, Omar F. Khabour, Karem H. Alzoubi, Ahmed Abu-Siniyeh, Firas Al-Qarqaz

“…In this study, the effect of genetic polymorphisms, rs2241766 and rs1501299, of the adiponectin gene was investigated in relation to the side effects of isotretinoin-treated young adult acne patients (n = 230). …”
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Systematic analysis of the pharmacogenomics landscape towards clinical implementation of precision therapeutics in Greece by George P. Patrinos, Kariofyllis Karamperis, Margarita-Ioanna Koufaki, Maria Skokou, Zoe Kordou, Eirini Sparaki, Margarita Skaraki, Christina Mitropoulou

“…Abstract Pharmacogenomics (PGx) aims to delineate a patient’s genetic profile with differences in drug efficacy and/or toxicity, particularly focusing on genes encoding for drug-metabolizing enzymes and transporters. …”
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Clinico-epidemiology and aetiopathogenesis of gallstone disease in the South Asian region: a scoping review protocol by Harshi Weerakoon, Ishari Vithanage, Oshadhi Alahakoon, Kosala Weerakoon

“…Introduction Pathogenesis of gallstones (GS) is multifactorial and is influenced by numerous environmental and genetic risk factors. As a result, clinico-epidemiology and aetiopathogenesis of GS vary in different populations. …”
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Cytoskeletal Vimentin Directs Cell‐Cell Transmission of Hepatitis C Virus by Yifan Xing, Zeyu Wen, Jie Mei, Xinyi Huang, Shuangshuang Zhao, Jin Zhong, Yaming Jiu

“…Here, we demonstrated that vimentin, a host intermediate filaments protein, is dispensable for HCV infection in cell models but essential for simulated in vivo infection in differentiated hepatocytes. Genetic removal of vimentin markedly and specifically disrupts HCV cell–cell transmission without influencing cell‐free infection. …”
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Evolutionary Computation with Spatial Receding Horizon Control to Minimize Network Coding Resources by Xiao-Bing Hu, Mark S. Leeson

“…The minimization of network coding resources, such as coding nodes and links, is a challenging task, not only because it is a NP-hard problem, but also because the problem scale is huge; for example, networks in real world may have thousands or even millions of nodes and links. Genetic algorithms (GAs) have a good potential of resolving NP-hard problems like the network coding problem (NCP), but as a population-based algorithm, serious scalability and applicability problems are often confronted when GAs are applied to large- or huge-scale systems. …”
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Selective Herbicides for Cultivation of Eucalyptus urograndis Clones by Patrick J. Minogue, Anna Osiecka

“…Five herbicides, flumioxazin, imazamox, imazapic, oxyfluorfen, and sulfometuron methyl, were evaluated for selective weed control in the establishment of genetically modified frost tolerant Eucalyptus urograndis clones. …”
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Atherosclerosis and Rheumatoid Arthritis: More Than a Simple Association by Lorenzo Cavagna, Nicola Boffini, Giovanni Cagnotto, Flora Inverardi, Vittorio Grosso, Roberto Caporali

“…On the other hand, also the increase of oxidative processes, frequently observed in RA, induces atherosclerosis. Interestingly, some genetic polymorphisms associated with RA occurrence enhance atherosclerosis, however, other polymorphisms associated with RA susceptibility do not increase CVD risk. …”
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Challenges in Emerging Vaccines and Future Promising Candidates against SARS-CoV-2 Variants by Tanmay Ghildiyal, Nishant Rai, Janhvi Mishra Rawat, Maargavi Singh, Jigisha Anand, Gaurav Pant, Gaurav Kumar, Amrullah Shidiki

“…Therefore, understanding the amount and characteristics of coronavirus genetic diversity in historical and contemporary strains can help researchers get an edge over upcoming variants.…”
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Understanding the complex function of gut microbiota: its impact on the pathogenesis of obesity and beyond: a comprehensive review by Aref Yarahmadi, Hamed Afkhami, Ali Javadi, Mojtaba Kashfi

“…Abstract Obesity is a multifactorial condition influenced by genetic, environmental, and microbiome-related factors. …”
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